Anthony J Capobianco

Professor

  • 4286 Citations
1990 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1990 2019

  • 4286 Citations
  • 78 Article
  • 1 Editorial
2019
1 Citation (Scopus)

A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma

Rodriguez-Blanco, J., Li, B., Long, J., Shen, C., Yang, F., Orton, D., Collins, S., Kasahara, N., Ayad, N., McCrea, H. J., Roussel, M. F., Weiss, W. A., Capobianco, A. J. & Robbins, D. J., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1379-1388 10 p.

Research output: Contribution to journalArticle

Casein Kinases
Medulloblastoma
Hedgehogs
Brain
Pharmaceutical Preparations
1 Citation (Scopus)

Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1114 Paediatrics and Reproductive Medicine

Winterbottom, E. F., Moroishi, Y., Halchenko, Y., Armstrong, D. A., Beach, P. J., Nguyen, Q. P., Capobianco, A. J., Ayad, N. G., Marsit, C. J., Li, Z., Karagas, M. R. & Robbins, D. J., Feb 28 2019, In : Environmental Health: A Global Access Science Source. 18, 1, 18.

Research output: Contribution to journalArticle

Open Access
Reproductive Medicine
Biological Science Disciplines
Medical Genetics
Arsenic
Epigenomics

Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study

Winterbottom, E. F., Ban, Y., Sun, X., Capobianco, A. J., Marsit, C. J., Chen, X., Wang, L., Karagas, M. R. & Robbins, D. J., Nov 21 2019, In : Environmental Health: A Global Access Science Source. 18, 1, 100.

Research output: Contribution to journalArticle

Open Access
Arsenic
Gene Expression Profiling
Placenta
Cohort Studies
Parturition
2018
5 Citations (Scopus)

Exposure of Barrett’s and esophageal adenocarcinoma cells to bile acids activates EGFR–STAT3 signaling axis via induction of APE1

Bhat, A. A., Lu, H., Soutto, M., Capobianco, A. J., Rai, P., Zaika, A. & El-Rifai, W., Jul 10 2018, (Accepted/In press) In : Oncogene. p. 1-14 14 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Oxidation-Reduction
Adenocarcinoma
Barrett Esophagus
Phosphorylation

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma

Lohse, I., Al-Ali, H., Volmar, C. H., Alvarez Trotta, A. D., Brothers, S. P., Capobianco, A. J. & Wahlestedt, C. R., Sep 1 2018, In : PLoS One. 13, 9, e0203173.

Research output: Contribution to journalArticle

Drug Repositioning
esophageal neoplasms
adenocarcinoma
Adenocarcinoma
Cells
2017
6 Citations (Scopus)

Acetylation of mastermind-like 1 by p300 drives the recruitment of NACK to initiate Notch-dependent transcription

Jin, K., Zhou, W., Han, X., Wang, Z., Li, B., Jeffries, S., Tao, W., Robbins, D. J. & Capobianco, A. J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4228-4237 10 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Acetylation
Adenocarcinoma
Phosphotransferases
Amino Acids
4 Citations (Scopus)

Differential abundance of CK1a provides selectivity for pharmacological CK1a activators to target WNT-dependent tumors

Li, B., Orton, D., Neitzel, L. R., Astudillo, L., Shen, C., Long, J., Chen, X., Kirkbride, K. C., Doundoulakis, T., Guerra, M. L., Zaias, J., Fei, D. L., Rodriguez-Blanco, J., Thorne, C., Wang, Z., Jin, K., Nguyen, D., Sands, L., Marchetti, F., Abreu, M. T. & 4 others, Cobb, M. H., Capobianco, A. J., Lee, E. & Robbin, D. J., Jun 27 2017, In : Science Signaling. 10, 485, aak9916.

Research output: Contribution to journalArticle

Casein Kinases
Tumors
Pharmacology
Colorectal Neoplasms
Neoplasms
5 Citations (Scopus)

Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma

Rodriguez-Blanco, J., Pednekar, L., Penas, C., Li, B., Martin, V., Long, J., Lee, E., Weiss, W. A., Rodriguez, C., Nadji, M., Nguyen, D., Ayad, N., Rai, P., Capobianco, A. J. & Robbins, D. J., Nov 9 2017, In : Oncogene. 36, 45, p. 6306-6314 9 p.

Research output: Contribution to journalArticle

HhAntag691
Medulloblastoma
Neoplasms
Basal Cell Carcinoma
Recurrence
1 Citation (Scopus)

Notch represses transcription by PRC2 recruitment to the ternary complex

Han, X., Ranganathan, P., Tzimas, C., Weaver, K. L., Jin, K., Astudillo, L., Zhou, W., Zhu, X., Li, B., Robbins, D. J. & Capobianco, A. J., Sep 1 2017, In : Molecular Cancer Research. 15, 9, p. 1173-1183 11 p.

Research output: Contribution to journalArticle

Epigenomics
Carcinogenesis
Gene Expression
Enzymes
Therapeutics
1 Citation (Scopus)

p16 loss rescues functional decline of Brca1-deficient mammary stem cells

Scott, A., Bai, F., Chan, H. L., Liu, S., Slingerland, J. M., Robbins, D. J., Capobianco, A. J. & Pei, X-H., Mar 10 2017, (Accepted/In press) In : Cell Cycle. p. 1-6 6 p.

Research output: Contribution to journalArticle

Breast
Stem Cells
DNA Damage
DNA Repair
Epithelial Cells
10 Citations (Scopus)

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression

Winterbottom, E. F., Koestler, D. C., Fei, D. L., Wika, E., Capobianco, A. J., Marsit, C. J., Karagas, M. R. & Robbins, D. J., Jun 14 2017, In : Environmental Health: A Global Access Science Source. 16, 1, 59.

Research output: Contribution to journalArticle

Aquaglyceroporins
Arsenic
Gene Expression
Placenta
Developmental Genes
5 Citations (Scopus)

Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma

Sant, D. W., Tao, W., Field, M. G., Pelaez, D., Jin, K., Capobianco, A. J., Dubovy, S., Tse, D. & Wang, G., May 1 2017, In : Investigative ophthalmology & visual science. 58, 6, p. BIO240-BIO246

Research output: Contribution to journalArticle

Exome
Lacrimal Apparatus
Adenoid Cystic Carcinoma
Mutation
Luciferases
2016
5 Citations (Scopus)

Arsenic attenuates gli signaling, increasing or decreasing its transcriptional program in a context-dependent manner

Li, B., Giambelli, C., Tang, B., Winterbottom, E., Long, J., Jin, K., Wang, Z., Fei, D. L., Nguyen, D. M., Athar, M., Wang, B., Pochi, S., Wang, L., Rai, P., Ardalan, B., Capobianco, A. J. & Robbins, D. J., Feb 1 2016, In : Molecular Pharmacology. 89, 2, p. 226-232 7 p.

Research output: Contribution to journalArticle

Arsenic
Hedgehogs
Colorectal Neoplasms
Hedgehog Proteins
Metalloids
3 Citations (Scopus)

Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis

Liu, S., Chan, H. L., Bai, F., Ma, J., Scott, A., Robbins, D. J., Capobianco, A. J., Zhu, P. & Pei, X-H., 2016, In : Oncotarget. 7, 39, p. 64007-64020 14 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Cell Proliferation
Haploidy
B-Cell Lymphoma
T-Lymphocytes
7 Citations (Scopus)

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Broadus, M. R., Chen, T. W., Neitzel, L. R., Ng, V. H., Jodoin, J. N., Lee, L. A., Salic, A., Robbins, D. J., Capobianco, A. J., Patton, J. G., Huppert, S. S. & Lee, E., May 31 2016, In : Cell Reports. 15, 9, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

Zebrafish
Degradation
Mutation
Ovum
Cultured Cells
4 Citations (Scopus)

p16INK4a suppresses BRCA1-deficient mammary tumorigenesis

Scott, A., Bai, F., Chan, H. L., Liu, S., Ma, J., Slingerland, J. M., Robbins, D. J., Capobianco, A. J. & Pei, X-H., 2016, In : Oncotarget. 7, 51, p. 84496-84507 12 p.

Research output: Contribution to journalArticle

Carcinogenesis
Breast
Breast Neoplasms
Methylation
p16 Genes
14 Citations (Scopus)

The small molecule IMR-1 inhibits the notch transcriptional activation complex to suppress tumorigenesis

Astudillo, L., Da Silva, T. G., Wang, Z., Han, X., Jin, K., VanWye, J., Zhu, X., Weaver, K., Oashi, T., Lopes, P. E. M., Orton, D., Neitzel, L. R., Lee, E., Landgraf, R., Robbins, D. J., MacKerell, A. D. & Capobianco, A. J., Jun 15 2016, In : Cancer Research. 76, 12, p. 3593-3603 11 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Carcinogenesis
Computer-Aided Design
Neoplasms
Neoplastic Stem Cells
2015

Editor's Choice: Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. iii

Research output: Contribution to journalArticle

5 Citations (Scopus)

Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 351-363 13 p.

Research output: Contribution to journalArticle

DNA sequences
Cell proliferation
Drug Combinations
Glioblastoma
Epigenomics
11 Citations (Scopus)

GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth

Winterbottom, E. F., Fei, D. L., Koestler, D. C., Giambelli, C., Wika, E., Capobianco, A. J., Lee, E., Marsit, C. J., Karagas, M. R. & Robbins, D. J., Jun 1 2015, In : EBioMedicine. 2, 6, p. 536-543 8 p.

Research output: Contribution to journalArticle

Environmental Exposure
Arsenic
Fetal Development
Health
Placenta
18 Citations (Scopus)

Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties

Long, J., Tokhunts, R., Old, W. M., Houel, S., Rodgriguez-Blanco, J., Singh, S., Schilling, N., Capobianco, A. J., Ahn, N. G. & Robbins, D. J., Mar 3 2015, In : Cell Reports. 10, 8, p. 1280-1287 8 p.

Research output: Contribution to journalArticle

Hedgehog Proteins
Fatty Acids
Lipids
Palmitates
Proteins
8 Citations (Scopus)

Notch1 pathway activity determines the regulatory role of cancer-associated fibroblasts in melanoma growth and invasion

Shao, H., Kong, R., Ferrari, M. L., Radtke, F., Capobianco, A. J. & Liu, Z-J., Nov 1 2015, In : PLoS One. 10, 11, e0142815.

Research output: Contribution to journalArticle

Fibroblasts
melanoma
fibroblasts
Melanoma
neoplasms
17 Citations (Scopus)

The notch signaling pathway in esophageal adenocarcinoma

Wang, Z., Chen, J. & Capobianco, A. J., 2015, In : Cellular and Molecular Biology. 61, 6, p. 24-32 9 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Stem cells
Amyloid Precursor Protein Secretases
Chemotherapy
Tumors
2014
30 Citations (Scopus)

BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development

Bai, F., Chan, H. L., Scott, A., Smith, M. D., Fan, C., Herschkowitz, J. I., Perou, C. M., Livingstone, A., Robbins, D. J., Capobianco, A. J. & Pei, X-H., Nov 1 2014, In : Cancer Research. 74, 21, p. 6161-6172 12 p.

Research output: Contribution to journalArticle

Cell Dedifferentiation
Epithelial-Mesenchymal Transition
Mesenchymal Stromal Cells
Breast Neoplasms
Stem Cells
13 Citations (Scopus)

NACK is an integral component of the notch transcriptional activation complex and is critical for development and tumorigenesis

Weaver, K. L., Alves-Guerra, M. C., Jin, K., Wang, Z., Han, X., Ranganathan, P., Zhu, X., DaSilva, T., Liu, W., Ratti, F., Demarest, R. M., Tzimas, C., Rice, M., Vasquez-Del Carpio, R., Dahmane, N., Robbins, D. J. & Capobianco, A. J., Sep 1 2014, In : Cancer Research. 74, 17, p. 4741-4751 11 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Carcinogenesis
Phosphotransferases
Notch Receptors
Genes
24 Citations (Scopus)

Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL

Pelullo, M., Quaranta, R., Talora, C., Checquolo, S., Cialfi, S., Felli, M. P. I., te Kronnie, G., Borga, C., Besharat, Z. M. E., Palermo, R., Di Marcotullio, L., Capobianco, A. J., Gulino, A., Screpanti, I. & Bellavia, D., Dec 1 2014, In : Neoplasia (United States). 16, 12, p. 1007-1017 11 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Ligands
T-Cell Lymphoma
Transcriptional Activation
Lymphoma
40 Citations (Scopus)

Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma

Wang, Z., Da Silva, T. G., Jin, K., Han, X., Ranganathan, P., Zhu, X., Sanchez-Mejias, A., Bai, F., Li, B., Fei, D. L., Weaver, K., Vasquez-Del Carpio, R., Moscowitz, A. E., Koshenkov, V. P., Sanchez, L., Sparling, L., Pei, X-H., Franceschi, D., Ribeiro, A., Robbins, D. J. & 2 others, Livingstone, A. & Capobianco, A. J., Nov 1 2014, In : Cancer Research. 74, 21, p. 6364-6374 11 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Amyloid Precursor Protein Secretases
Drug Therapy
Neoplastic Stem Cells
Heterografts
34 Citations (Scopus)

Pyrvinium attenuates hedgehog signaling downstream of smoothened

Li, B., Fei, D. L., Flaveny, C. A., Dahmane, N., Baubet, V., Wang, Z., Bai, F., Pei, X-H., Rodriguez-Blanco, J., Hang, B., Orton, D., Han, L., Wang, B., Capobianco, A. J., Lee, E. & Robbins, D. J., Sep 1 2014, In : Cancer Research. 74, 17, p. 4811-4821 11 p.

Research output: Contribution to journalArticle

Hedgehogs
HhAntag691
Casein Kinase I
Pyrvinium Compounds
Neoplasms
20 Citations (Scopus)

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis

Li, B., Flaveny, C. A., Giambelli, C., Liang Fei, D., Han, L., Hang, B. I., Bai, F., Pei, X-H., Nose, V., Burlingame, O., Capobianco, A. J., Orton, D., Lee, E. & Robbins, D. J., Jul 8 2014, In : PLoS One. 9, 7, e101969.

Research output: Contribution to journalArticle

Intestinal Polyposis
Enterobius
Adenomatous Polyposis Coli
colorectal neoplasms
adenoma
55 Citations (Scopus)

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers

Long, J., Li, B., Rodriguez-Blanco, J., Pastori, C., Volmar, C. H., Wahlestedt, C. R., Capobianco, A. J., Bai, F., Pei, X-H., Ayad, N. & Robbins, D. J., Dec 19 2014, In : Journal of Biological Chemistry. 289, 51, p. 35494-35502 9 p., A32.

Research output: Contribution to journalArticle

Hedgehog Proteins
Hedgehogs
Medulloblastoma
Growth
Epigenomics
2013
63 Citations (Scopus)

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53

Licciulli, S., Avila, J. L., Hanlon, L., Troutman, S., Cesaroni, M., Kota, S., Keith, B., Simon, M. C., Puré, E., Radtke, F., Capobianco, A. J. & Kissil, J. L., Oct 1 2013, In : Cancer Research. 73, 19, p. 5974-5984 11 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Survival
Neoplasms
Oncogenes
Carcinogenesis
27 Citations (Scopus)

The Hedgehog processing pathway is required for NSCLC growth and survival

Rodriguez-Blanco, J., Schilling, N. S., Tokhunts, R., Giambelli, C., Long, J., Liang Fei, D., Singh, S., Black, K. E., Wang, Z., Galimberti, F., Bejarano, P. A., Elliot, S., Glassberg Csete, M. K., Nguyen, D., Lockwood, W. W., Lam, W. L., Dmitrovsky, E., Capobianco, A. J. & Robbins, D. J., May 2 2013, In : Oncogene. 32, 18, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

Hedgehogs
Non-Small Cell Lung Carcinoma
Survival
Growth
Neoplasms
41 Citations (Scopus)

Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

Azzam, D. J., Zhao, D., Sun, J., Minn, A. J., Ranganathan, P., Drews-Elger, K., Han, X., Picon-Ruiz, M., Gilbert, C. A., Wander, S. A., Capobianco, A. J., El-Ashry, D. & Slingerland, J. M., Oct 1 2013, In : EMBO Molecular Medicine. 5, 10, p. 1502-1522 21 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Amyloid Precursor Protein Secretases
Neoplastic Stem Cells
Pharmaceutical Preparations
Breast Neoplasms
2012
28 Citations (Scopus)

Hedgehog signaling regulates bladder cancer growth and tumorigenicity

Fei, D. L., Sanchez-Mejias, A., Wang, Z., Flaveny, C., Long, J., Singh, S., Rodriguez-Blanco, J., Tokhunts, R., Giambelli, C., Briegel, K., Schulz, W. A., Gandolfi, A. J., Karagas, M., Zimmers, T. A., Jorda, M., Bejarano, P., Capobianco, A. J. & Robbins, D. J., Sep 1 2012, In : Cancer Research. 72, 17, p. 4449-4458 10 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Growth
Carcinoma
Cell Line
Tumor Suppressor Genes
2011
15 Citations (Scopus)

Assembly of a notch transcriptional activation complex requires multimerization

Vasquez-Del Carpio, R., Kaplan, F. M., Weaver, K. L., VanWye, J. D., Alves-Guerra, M. C., Robbins, D. J. & Capobianco, A. J., Apr 1 2011, In : Molecular and Cellular Biology. 31, 7, p. 1396-1408 13 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Notch Receptors
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
DNA-Binding Proteins
Cell Communication
32 Citations (Scopus)

Hedgehog-producing cancer cells respond to and require autocrine hedgehog activity

Singh, S., Wang, Z., Fei, D. L., Black, K. E., Goetz, J. A., Tokhunts, R., Giambelli, C., Rodriguez-Blanco, J., Long, J., Lee, E., Briegel, K., Bejarano, P. A., Dmitrovsky, E., Capobianco, A. J. & Robbins, D. J., Jul 1 2011, In : Cancer Research. 71, 13, p. 4454-4463 10 p.

Research output: Contribution to journalArticle

Neoplasms
Autocrine Communication
Stromal Cells
Growth
Antineoplastic Agents
27 Citations (Scopus)

Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates notch transcriptional activity

Ranganathan, P., Vasquez-Del Carpio, R., Kaplan, F. M., Wang, H., Gupta, A., VanWye, J. D. & Capobianco, A. J., Aug 19 2011, In : Journal of Biological Chemistry. 286, 33, p. 28844-28857 14 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Phosphorylation
Threonine
Casein Kinase II
Serine
30 Citations (Scopus)

Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia

Demarest, R. M., Dahmane, N. & Capobianco, A. J., Mar 10 2011, In : Blood. 117, 10, p. 2901-2909 9 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-cells
Tumors
Neoplasms
Genes

Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia (Blood (2011) 117, 10, (2901-2909))

Demarest, R. M., Dahmane, N. & Capobianco, A. J., Jun 16 2011, In : Blood. 117, 24

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
471 Citations (Scopus)

Notch signalling in solid tumours: A little bit of everything but not all the time

Ranganathan, P., Weaver, K. L. & Capobianco, A. J., May 1 2011, In : Nature Reviews Cancer. 11, 5, p. 338-351 14 p.

Research output: Contribution to journalArticle

Neoplasms
Hematologic Neoplasms
Drosophila melanogaster
Oncogenes
2010
16 Citations (Scopus)

Epimorphic regeneration in mice is p53-independent

Arthur, L. M., Demarest, R. M., Clark, L., Gourevitch, D., Bedelbaeva, K., Anderson, R., Snyder, A., Capobianco, A. J., Lieberman, P., Feigenbaum, L. & Heber-Katz, E., Sep 15 2010, In : Cell Cycle. 9, 18, p. 3667-3673 7 p.

Research output: Contribution to journalArticle

Regeneration
Ear
DNA Damage
Cell Cycle
Ear Auricle
100 Citations (Scopus)

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

Hanlon, L., Avila, J. L., Demarest, R. M., Troutman, S., Allen, M., Ratti, F., Rustgi, A. K., Stanger, B. Z., Radtke, F., Adsay, V., Long, F., Capobianco, A. J. & Kissil, J. L., Jun 1 2010, In : Cancer Research. 70, 11, p. 4280-4286 7 p.

Research output: Contribution to journalArticle

Oncogenes
Adenocarcinoma
Notch Receptors
Tumor Suppressor Genes
Pancreatic Neoplasms
13 Citations (Scopus)

Sp100 as a potent tumor suppressor: Accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program

Negorev, D. G., Vladimirova, O. V., Kossenkov V, A., Nikonova V, E., Demarest, R. M., Capobianco, A. J., Showe, M. K., Rauscher, F. J., Showe, L. C. & Maul, G. G., Dec 1 2010, In : Cancer Research. 70, 23, p. 9991-10001 11 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Fibroblasts
Neoplasms
Protein Isoforms
Proteins
2009
88 Citations (Scopus)

Active Notch1 confers a transformed phenotype to primary human melanocytes

Pinnix, C. C., Lee, J. T., Liu, Z-J., McDaid, R., Balint, K., Beverly, L. J., Brafford, P. A., Xiao, M., Himes, B., Zabierowski, S. E., Yashiro-Ohtani, Y., Nathanson, K. L., Bengston, A., Pollock, P. M., Weeraratna, A. T., Nickoloff, B. J., Pear, W. S., Capobianco, A. J. & Herlyn, M., Jul 1 2009, In : Cancer Research. 69, 13, p. 5312-5320 9 p.

Research output: Contribution to journalArticle

Melanocytes
Melanoma
Phenotype
Oncogenes
Mitogen-Activated Protein Kinases
105 Citations (Scopus)

Notch signaling mediates G 1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

Joshi, I., Minter, L. M., Telfer, J., Demarest, R. M., Capobianco, A. J., Aster, J. C., Sicinski, P., Fauq, A., Golde, T. E. & Osborne, B. A., Feb 19 2009, In : Blood. 113, 8, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

Cyclin D3
T-cells
Cell Cycle
Phosphotransferases
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
114 Citations (Scopus)

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

Rustighi, A., Tiberi, L., Soldano, A., Napoli, M., Nuciforo, P., Rosato, A., Kaplan, F., Capobianco, A. J., Pece, S., Di Fiore, P. P. & Del Sal, G., Jan 19 2009, In : Nature Cell Biology. 11, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

Peptidylprolyl Isomerase
Notch Receptors
Breast Neoplasms
Amyloid Precursor Protein Secretases
Neoplasms
2008

Guest editor

Capobianco, A. J., Sep 1 2008, In : Oncogene. 27, 38, p. 5081 1 p.

Research output: Contribution to journalEditorial

85 Citations (Scopus)

It's T-ALL about Notch

Demarest, R. M., Ratti, F. & Capobianco, A. J., Sep 1 2008, In : Oncogene. 27, 38, p. 5082-5091 10 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Apoptosis
Mutation
p53 Genes
Neoplasms
2007
65 Citations (Scopus)

Mastermind-like 1 is a specific coactivator of β-catenin transcription activation and is essential for colon carcinoma cell survival

Alves-Guerra, M. C., Ronchini, C. & Capobianco, A. J., Sep 15 2007, In : Cancer Research. 67, 18, p. 8690-8698 9 p.

Research output: Contribution to journalArticle

Catenins
Transcriptional Activation
Cell Survival
Colon
Carcinoma
35 Citations (Scopus)

Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas

Spaulding, C., Reschly, E. J., Zagort, D. E., Yashiro-Ohtani, Y., Beverly, L. J., Capobianco, A. J., Pear, W. S. & Kee, B. L., Oct 1 2007, In : Blood. 110, 7, p. 2650-2658 9 p.

Research output: Contribution to journalArticle

TCF Transcription Factors
T-cells
T-Cell Lymphoma
Survival
Cell death