Molecular and Cellular Pharmacology

Research Output 1974 2019

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2008
337 Citations (Scopus)

Brief report: A GPR54-activating mutation in a patient with central precocious puberty

Teles, M. G., Bianco, S. D. C., Brito, V. N., Trarbach, E. B., Kuohung, W., Xu, S., Seminara, S. B., Mendonca, B. B., Kaiser, U. B. & Latronico, A. C., Feb 14 2008, In : New England Journal of Medicine. 358, 7, p. 709-715 7 p.

Research output: Contribution to journalArticle

Kisspeptins
Mutation
G-Protein-Coupled Receptors
Gonadotropins
Proline
3 Citations (Scopus)

EST express: PHP/MySQL based automated annotation of ESTs from expression libraries

Smith, R. P., Buchser, W. J., Lemmon, M. B., Pardinas, J. R., Bixby, J. & Lemmon, V., Apr 10 2008, In : BMC Bioinformatics. 9, 186.

Research output: Contribution to journalArticle

Expressed Sequence Tags
Annotation
CDNA
Express
Genes
44 Citations (Scopus)

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

Wen, Y., Pinto, J. R., Gomes, A. V., Xu, Y., Wang, Y., Wang, Y., Potter, J. D. & Kerrick, W. G., Jul 18 2008, In : Journal of Biological Chemistry. 283, 29, p. 20484-20494 11 p.

Research output: Contribution to journalArticle

Troponin I
Hypertrophic Cardiomyopathy
Transgenic Mice
Adenosine Triphosphatases
Mutation
31 Citations (Scopus)

Glucocorticoid receptor binding: A biphasic dependence on molecular size as revealed by the bilinear LinBiExp model

Buchwald, P., Feb 1 2008, In : Steroids. 73, 2, p. 193-208 16 p.

Research output: Contribution to journalArticle

Acetals
Mometasone Furoate
Glucocorticoid Receptors
Free energy
Halogenation
36 Citations (Scopus)

High-throughput screening for human galactokinase inhibitors

Wierenga, K. J., Lai, K., Buchwald, P. & Tang, M., Aug 1 2008, In : Journal of Biomolecular Screening. 13, 5, p. 415-423 9 p.

Research output: Contribution to journalArticle

Galactokinase
Galactosemias
Screening
Throughput
Galactose
38 Citations (Scopus)

Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer

Lyons, L. S., Rao, S., Balkan, W. E., Faysal, J., Maiorino, C. A. & Burnstein, K. L., Mar 1 2008, In : Molecular Endocrinology. 22, 3, p. 597-608 12 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Androgen Receptors
Prostatic Neoplasms
Androgens
Ligands
48 Citations (Scopus)

Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: Interaction-restricted diffusion

Slepak, V. Z. & Hurley, J. B., Dec 1 2008, In : IUBMB Life. 60, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

Transducin
Arrestin
Light
Retinal Rod Photoreceptor Cells
Proteins
45 Citations (Scopus)

MsrA protects cardiac myocytes against hypoxia/reoxygenation induced cell death

Prentice, H. M., Moench, I. A., Rickaway, Z. T., Dougherty, C. J., Webster, K. A. & Weissbach, H., Feb 15 2008, In : Biochemical and Biophysical Research Communications. 366, 3, p. 775-778 4 p.

Research output: Contribution to journalArticle

Methionine Sulfoxide Reductases
Cell death
Cardiac Myocytes
Cell Death
Adenoviridae
137 Citations (Scopus)

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

Zhai, R. G., Zhang, F., Hiesinger, P. R., Cao, Y., Haueter, C. M. & Bellen, H. J., Apr 17 2008, In : Nature. 452, 7189, p. 887-891 5 p.

Research output: Contribution to journalArticle

Nicotinamide-Nucleotide Adenylyltransferase
HSP70 Heat-Shock Proteins
Spinocerebellar Ataxias
Proteasome Endopeptidase Complex
Heat-Shock Proteins
8 Citations (Scopus)

Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats

Wu, W. M., Huang, F., Lee, Y., Buchwald, P. & Bodor, N., Mar 1 2008, In : Journal of Pharmacy and Pharmacology. 60, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Acids
Bile
Urine
Loteprednol Etabonate
31 Citations (Scopus)

Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gβ5 complexes in brain

Grabowska, D., Jayaraman, M., Kaltenbronn, K. M., Sandiford, S. L., Wang, Q., Jenkins, S., Slepak, V. Z., Smith, Y. & Blumer, K. J., Feb 19 2008, In : Neuroscience. 151, 4, p. 969-982 14 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Carrier Proteins
Membrane Proteins
Brain
G-Protein-Coupled Receptors
51 Citations (Scopus)

Proteomics in Trypanosoma cruzi- Localization of novel proteins to various organelles

Ferella, M., Nilsson, D., Darban, H., Rodrigues, C. D., Bontempi, E. J., Docampo, R. & Andersson, B., Jul 1 2008, In : Proteomics. 8, 13, p. 2735-2749 15 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Organelles
Proteomics
Proteins
Proteome
75 Citations (Scopus)

Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300

Wei, J., Shehadeh, L., Mitrani, J. M., Pessanha, M., Slepak, T. I., Webster, K. A. & Bishopric, N., Aug 26 2008, In : Circulation. 118, 9, p. 934-946 13 p.

Research output: Contribution to journalArticle

Cardiomegaly
Acetylation
Hypertrophy
Histone Deacetylases
Growth
13 Citations (Scopus)

Retrometabolic drug design: Principles and recent developments

Bodor, N. & Buchwald, P., Aug 1 2008, In : Pure and Applied Chemistry. 80, 8, p. 1669-1682 14 p.

Research output: Contribution to journalArticle

Metabolism
Pharmaceutical Preparations
Metabolites
Brain
Molecules
14 Citations (Scopus)

Robust hypoxia-selective regulation of a retinal pigment epithelium-specific adeno-associated virus vector

Dougherty, C. J., Smith, G. W., Dorey, C. K., Prentice, H. M., Webster, K. A. & Blanks, J. C., Mar 7 2008, In : Molecular Vision. 14, p. 471-480 10 p.

Research output: Contribution to journalArticle

Dependovirus
Retinal Pigment Epithelium
Green Fluorescent Proteins
Hypoxia
Firefly Luciferases
9 Citations (Scopus)

Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle

Kato, H., Matsunaga, F., Miyazaki, S., Yin, L., D'urso, G., Tanaka, K. & Murakami, Y., Apr 15 2008, In : Cell Cycle. 7, 8, p. 1085-1096 12 p.

Research output: Contribution to journalArticle

Origin Recognition Complex
Schizosaccharomyces
Genomic Instability
Cell Cycle
Genes
15 Citations (Scopus)

Soft corticosteroids for local immunosuppression: Exploring the possibility for the use of loteprednol etabonate for islet transplantation

Bocca, N., Pileggi, A., Molano, R., Marzorati, S., Wu, W., Bodor, N., Ricordi, C. & Buchwald, P., Mar 1 2008, In : Pharmazie. 63, 3, p. 226-232 7 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Immunosuppression
Adrenal Cortex Hormones
Equipment and Supplies
Immunosuppressive Agents
4 Citations (Scopus)

Stereoisomers of N-substituted soft anticholinergics and their zwitterionic metabolite based on glycopyrrolate - Syntheses and pharmacological evaluations

Wu, W. M., Wu, J., Mori, N., Buchwald, P. & Bodor, N., Mar 1 2008, In : Pharmazie. 63, 3, p. 200-209 10 p.

Research output: Contribution to journalArticle

Glycopyrrolate
Mydriatics
Stereoisomerism
Cholinergic Antagonists
Metabolites
17 Citations (Scopus)

Stress hyperglycemia and enhanced sensitivity to myocardial infarction

Webster, K. A., Feb 1 2008, In : Current Hypertension Reports. 10, 1, p. 78-84 7 p.

Research output: Contribution to journalArticle

Hyperglycemia
Myocardial Infarction
Reperfusion Injury
Type 2 Diabetes Mellitus
Infarction
124 Citations (Scopus)

Thyroid-adrenergic interactions: Physiological and clinical implications

Silva, J. E. & Bianco, S. D. C., Feb 1 2008, In : Thyroid. 18, 2, p. 157-165 9 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Adrenergic Agents
Thyroid Gland
Catecholamines
Adrenal Medulla
21 Citations (Scopus)

Zinc potentiates neuronal nicotinic receptors by increasing burst duration

Hsiao, B., Mihalak, K. B., Magleby, K. & Luetje, C. W., Feb 1 2008, In : Journal of Neurophysiology. 99, 2, p. 999-1007 9 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Zinc
Hexamethonium
Xenopus
Oocytes
2007
26 Citations (Scopus)

A general bilinear model to describe growth or decline time profiles

Buchwald, P., Jan 1 2007, In : Mathematical Biosciences. 205, 1, p. 108-136 29 p.

Research output: Contribution to journalArticle

Bilinear Model
Linear Models
Cellular Spheroids
Agricultural Crops
Schizosaccharomyces
125 Citations (Scopus)

A honey bee odorant receptor for the queen substance 9-oxo-2-decenoic acid

Wanner, K. W., Nichols, A. S., Walden, K. K. O., Brockmann, A., Luetje, C. W. & Robertson, H. M., Sep 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 36, p. 14383-14388 6 p.

Research output: Contribution to journalArticle

Odorant Receptors
Honey
Bees
Pheromones
Sex Attractants
83 Citations (Scopus)

Arrestin Mobilizes Signaling Proteins to the Cytoskeleton and Redirects their Activity

Hanson, S. M., Cleghorn, W. M., Francis, D. J., Vishnivetskiy, S. A., Raman, D., Song, X., Nair, K. S., Slepak, V. Z., Klug, C. S. & Gurevich, V. V., Apr 27 2007, In : Journal of Molecular Biology. 368, 2, p. 375-387 13 p.

Research output: Contribution to journalArticle

Arrestin
Cytoskeleton
Microtubules
Arrestins
Proteins
5 Citations (Scopus)

Computer-aided retrometabolic drug design: Soft drugs

Buchwald, P., Jul 1 2007, In : Expert Opinion on Drug Discovery. 2, 7, p. 923-933 11 p.

Research output: Contribution to journalArticle

Drug Design
Digital Libraries
Pharmaceutical Preparations
Software
Therapeutics
18 Citations (Scopus)

Coping with cyclic oxygen availability: Evolutionary aspects

Flück, M., Webster, K. A., Graham, J., Giomi, F., Gerlach, F. & Schmitz, A., Oct 1 2007, In : Integrative and Comparative Biology. 47, 4, p. 524-531 8 p.

Research output: Contribution to journalArticle

oxygen
insect flight
hyperoxia
lung function
organisms
17 Citations (Scopus)

Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development

Wang, Y., Szczesna-Cordary, D., Craig, R., Diaz-Perez, Z., Guzman, G., Miller, T. & Potter, J. D., Jul 1 2007, In : FASEB Journal. 21, 9, p. 2205-2214 10 p.

Research output: Contribution to journalArticle

Muscle Development
muscle development
Muscle
skeletal muscle
Skeletal Muscle
19 Citations (Scopus)

From critters to cancers: Bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

Hoogewijs, D., Terwilliger, N. B., Webster, K. A., Powell-Coffman, J. A., Tokishita, S., Yamagata, H., Hankeln, T., Burmester, T., Rytknen, K. T., Nikinmaa, M., Abele, D., Heise, K., Lucassen, M., Fandrey, J., Maxwell, P. H., Phlman, S. & Gorr, T. A., Oct 1 2007, In : Integrative and Comparative Biology. 47, 4, p. 552-577 26 p.

Research output: Contribution to journalArticle

hypoxia
oxygen
neoplasms
communication (human)
biologists
131 Citations (Scopus)

Genetic elucidation of human hyperosmia to isovaleric acid.

Menashe, I., Abaffy, T., Hasin, Y., Goshen, S., Yahalom, V., Luetje, C. W. & Lancet, D., Oct 30 2007, In : PLoS Biology. 5, 11

Research output: Contribution to journalArticle

Medical Genetics
odor compounds
acids
Polymorphism
Genes
20 Citations (Scopus)

Hypoxia: Life on the edge

Webster, K. A., Sep 1 2007, In : Antioxidants and Redox Signaling. 9, 9, p. 1303-1307 5 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxygen
Trimming
Waste management
Nutrients
37 Citations (Scopus)

Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy

Gomez, L. A., De Las Pozas, A., Reiner, T., Burnstein, K. L. & Perez-Stable, C., May 1 2007, In : Molecular Cancer Therapeutics. 6, 5, p. 1534-1543 10 p.

Research output: Contribution to journalArticle

Cyclin B1
Prostatic Neoplasms
Apoptosis
Drug Therapy
docetaxel
28 Citations (Scopus)

Intramolecular interaction between the DEP domain of RGS7 and the Gβ5 subunit

Narayanan, V., Sandiford, S. L., Wang, Q., Keren-Raifman, T., Levay, K. & Slepak, V. Z., Jun 12 2007, In : Biochemistry. 46, 23, p. 6859-6870 12 p.

Research output: Contribution to journalArticle

Conformations
Fusion reactions
RGS Proteins
Muscarinic M3 Receptors
1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride
49 Citations (Scopus)

Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model

Slepak, T. I., Tang, M., Slepak, V. Z. & Lai, K., Sep 1 2007, In : Molecular Genetics and Metabolism. 92, 1-2, p. 78-87 10 p.

Research output: Contribution to journalArticle

Galactosemias
Endoplasmic Reticulum Stress
Galactose
Metabolites
UTP-Hexose-1-Phosphate Uridylyltransferase
31 Citations (Scopus)

Jun kinase delays caspase-9 activation by interaction with the apoptosome

Tran, T. H., Andreka, P., Rodrigues, C. D., Webster, K. A. & Bishopric, N., Jul 13 2007, In : Journal of Biological Chemistry. 282, 28, p. 20340-20350 11 p.

Research output: Contribution to journalArticle

Apoptosomes
Mitogen-Activated Protein Kinase 9
Mitogen-Activated Protein Kinase 8
Caspase 9
Phosphotransferases
193 Citations (Scopus)

Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene

Bianco, S. D. C., Peng, J. B., Takanaga, H., Suzuki, Y., Crescenzi, A., Kos, C. H., Zhuang, L., Freeman, M. R., Gouveia, C. H. A., Wu, J., Luo, H., Mauro, T., Brown, E. M. & Hediger, M. A., Feb 1 2007, In : Journal of Bone and Mineral Research. 22, 2, p. 274-285 12 p.

Research output: Contribution to journalArticle

Calcium Channels
Homeostasis
Calcium
Intestinal Absorption
Genes
5 Citations (Scopus)

Myocyte deficiency as a target in the treatment of cardiomyopathy

Rodrigues, C. D., Shehadeh, L., Webster, K. A. & Bishopric, N., Sep 1 2007, In : Progress in Pediatric Cardiology. 23, 1-2, p. 49-59 11 p.

Research output: Contribution to journalArticle

Cardiomyopathies
Muscle Cells
Heart Failure
Cell- and Tissue-Based Therapy
Genetic Therapy
87 Citations (Scopus)

Myosin essential light chain in health and disease

Hernandez, O. M., Jones, M., Guzman, G. & Szczesna-Cordary, D., Apr 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 4

Research output: Contribution to journalArticle

Myosin Light Chains
Myosins
Health
Protein Isoforms
Striated Muscle
30 Citations (Scopus)

Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients

Szczesna-Cordary, D., Jones, M., Moore, J. R., Watt, J., Kerrick, W. G., Xu, Y., Wang, Y., Wagg, C. & Lopaschuk, G. D., Dec 1 2007, In : FASEB Journal. 21, 14, p. 3974-3985 12 p.

Research output: Contribution to journalArticle

myosin light chains
Myosin Light Chains
Transgenic Mice
Muscle
Calcium
7 Citations (Scopus)

Novel, cell-penetrating molecular transporters with flexible backbones and permanently charged side-chains

Bodor, N., Tóth-Sarudy, É., Holm, T., Pallagi, I., Vass, E., Buchwald, P. & Langel, Ü., Aug 1 2007, In : Journal of Pharmacy and Pharmacology. 59, 8, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Arginine
Basic Amino Acids
Cell-Penetrating Peptides
Aminocaproic Acid
Amino Acids
25 Citations (Scopus)

PKC-α and TAK-1 are intermediates in the activation of c-Jun NH 2-terminal kinase by hypoxia-reoxygenation

Frazier, D. P., Wilson, A., Dougherty, C. J., Li, H., Bishopric, N. & Webster, K. A., Apr 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 4

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Protein Kinase C
Phosphotransferases
Oxygen
Proline
39 Citations (Scopus)

Programmed death as a therapeutic target to reduce myocardial infarction

Webster, K. A., Sep 1 2007, In : Trends in Pharmacological Sciences. 28, 9, p. 492-499 8 p.

Research output: Contribution to journalArticle

Salvaging
Mitochondria
Oxidative stress
Cell death
Surgery
31 Citations (Scopus)

Regulation of Bnip3 death pathways by calcium, phosphorylation, and hypoxia-reoxygenation

Graham, R. M., Thompson, J. W., Wei, J., Bishopric, N. & Webster, K. A., Sep 1 2007, In : Antioxidants and Redox Signaling. 9, 9, p. 1309-1315 7 p.

Research output: Contribution to journalArticle

Phosphorylation
Calcium
Okadaic Acid
Acidosis
Proteins
50 Citations (Scopus)

Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p

Das, M., Wiley, D. J., Medina, S., Vincent, H. A., Larrea, M., Oriolo, A. & Verde, F., Jun 1 2007, In : Molecular Biology of the Cell. 18, 6, p. 2090-2101 12 p.

Research output: Contribution to journalArticle

Schizosaccharomyces
Growth
Normal Distribution
Actin Cytoskeleton
Actins
51 Citations (Scopus)

Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins

Rosenzweig, D. H., Saidas Nair, K., Wei, J., Wang, Q., Garwin, G., Saari, J. C., Chen, C. K., Smrcka, A. V., Swaroop, A., Lem, J., Hurley, J. B. & Slepak, V. Z., May 16 2007, In : Journal of Neuroscience. 27, 20, p. 5484-5494 11 p.

Research output: Contribution to journalArticle

Transducin
Vertebrate Photoreceptor Cells
Membranes
Light
GTP-Binding Proteins
38 Citations (Scopus)

Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression

Levay, K. & Slepak, V. Z., Sep 4 2007, In : Journal of Clinical Investigation. 117, 9, p. 2672-2683 12 p.

Research output: Contribution to journalArticle

K562 Cells
Proto-Oncogene Protein c-ets-1
Gene Expression
Megakaryocytes
MAP Kinase Signaling System
58 Citations (Scopus)

The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model

Layman, H., Spiga, M. G., Brooks, T., Pham, S., Webster, K. A. & Andreopoulos, F. M., Jun 1 2007, In : Biomaterials. 28, 16, p. 2646-2654 9 p.

Research output: Contribution to journalArticle

Hydrogels
Fibroblast Growth Factor 2
Fibroblasts
Gelatin
Extremities
78 Citations (Scopus)

The molecular basis for ligand specificity in a mouse olfactory receptor: A network of functionally important residues

Abaffy, T., Malhotra, A. & Luetje, C. W., Jan 12 2007, In : Journal of Biological Chemistry. 282, 2, p. 1216-1224 9 p.

Research output: Contribution to journalArticle

Odorant Receptors
Dicarboxylic Acids
Ligands
Assays
Binding Sites
2006
25 Citations (Scopus)

96-Well electroporation method for transfection of mammalian central neurons

Buchser, W. J., Pardinas, J. R., Shi, Y., Bixby, J. & Lemmon, V., Nov 1 2006, In : BioTechniques. 41, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

Electroporation
Neurons
Transfection
Plasmids
Poisons
28 Citations (Scopus)

Acidosis regulates the stability, hydrophobicity, and activity of the BH3-only protein Bnip3

Frazier, D. P., Wilson, A., Graham, R. M., Thompson, J. W., Bishopric, N. & Webster, K. A., Sep 1 2006, In : Antioxidants and Redox Signaling. 8, 9-10, p. 1625-1634 10 p.

Research output: Contribution to journalArticle

Hydrophobicity
Acidosis
Hydrophobic and Hydrophilic Interactions
Monomers
Oligomers
6 Citations (Scopus)

Antibodies and antibody-fusion proteins as anti-angiogenic, anti-tumor agents

Calfa, C., Rosenblatt, J. D., Cho, H. M., Webster, K. A. & Shin, S-U., Jun 1 2006, In : Update on Cancer Therapeutics. 1, 2, p. 159-173 15 p.

Research output: Contribution to journalArticle

Endostatins
Antibodies
Angiogenic Proteins
Neoplasms
Proteins