Molecular and Cellular Pharmacology

Research Output 1974 2019

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2011
325 Citations (Scopus)

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury

Hellal, F., Hurtado, A., Ruschel, J., Flynn, K. C., Laskowski, C. J., Umlauf, M., Kapitein, L. C., Strikis, D., Lemmon, V., Bixby, J., Hoogenraad, C. C. & Bradke, F., Feb 18 2011, In : Science. 331, 6019, p. 928-931 4 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Microtubules
Cicatrix
Axons
Regeneration
2 Citations (Scopus)

Mutagenesis and analysis of genetic mutations in the GC-rich KISS1 receptor sequence identified in humans with reproductive disorders

da Silva, L. M., Vandepas, L. & Bianco, S. D. C., Sep 1 2011, In : Journal of Visualized Experiments. 55, e2897.

Research output: Contribution to journalArticle

Mutagenesis
GC Rich Sequence
Degradation
Mutation
Proteasome Endopeptidase Complex

Mutagenesis and analysis of genetic mutations in the GC-rich KISS1 receptor sequence identified in humans with reproductive disorders.

Madeira da Silva, L., Vandepas, L. & Bianco, S. D. C., Dec 1 2011, In : Journal of visualized experiments : JoVE. 55

Research output: Contribution to journalArticle

Mutagenesis
GC Rich Sequence
Degradation
Mutation
Proteasome Endopeptidase Complex
25 Citations (Scopus)

Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1α pathway

Ali, Y. O., McCormack, R., Darrand, A. & Zhai, R. G., May 27 2011, In : Journal of Biological Chemistry. 286, 21, p. 19089-19099 11 p.

Research output: Contribution to journalArticle

Nicotinamide-Nucleotide Adenylyltransferase
Hypoxia-Inducible Factor 1
Heat-Shock Proteins
Shock
Hot Temperature
28 Citations (Scopus)

Nmnat exerts neuroprotective effects in dendrites and axons

Wen, Y., Parrish, J. Z., He, R., Zhai, R. G. & Kim, M. D., Sep 1 2011, In : Molecular and Cellular Neuroscience. 48, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Nicotinamide-Nucleotide Adenylyltransferase
Neuronal Plasticity
Neuroprotective Agents
Dendrites
Axons
34 Citations (Scopus)
Cell- and Tissue-Based Therapy
Regeneration
Stem Cells
Heart Failure
Multipotent Stem Cells
20 Citations (Scopus)

Quantification of the islet product: Presentation of a standardized current good manufacturing practices compliant system with minimal variability

Friberg, A. S., Brandhorst, H., Buchwald, P., Goto, M., Ricordi, C., Brandhorst, D. & Korsgren, O., Mar 27 2011, In : Transplantation. 91, 6, p. 677-683 7 p.

Research output: Contribution to journalArticle

Microspheres
Computer-Assisted Image Processing
51 Citations (Scopus)

Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease

Maiguel, D., Faridi, M. H., Wei, C., Kuwano, Y., Balla, K. M., Hernandez, D., Barth, C. J., Lugo, G., Donnelly, M., Nayer, A., Moita, L. F., Schuerer, S. C., Traver, D., Ruiz, P., Vazquez-Padron, R. I., Ley, K., Reiser, J. & Gupta, V., Sep 6 2011, In : Science Signaling. 4, 189

Research output: Contribution to journalArticle

Integrins
Leukocytes
Adhesion
Chemical activation
Molecules
31 Citations (Scopus)

Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction

Muthu, P., Wang, L., Yuan, C. C., Kazmierczak, K., Huang, W., Hernandez, O. M., Kawai, M., Irving, T. C. & Szczesna-Cordary, D., Dec 1 2011, In : FASEB Journal. 25, 12, p. 4394-4405 12 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Muscle Contraction
Muscle
Myocardium
Light
51 Citations (Scopus)

Subunit contributions to insect olfactory receptor function: Channel block and odorant recognition

Nichols, A. S., Chen, S. & Luetje, C. W., Nov 1 2011, In : Chemical Senses. 36, 9, p. 781-790 10 p.

Research output: Contribution to journalArticle

Odorant Receptors
Insects
Ligand-Gated Ion Channels
Ruthenium Red
Odorants
309 Citations (Scopus)

Suppression of TH 17 differentiation and autoimmunity by a synthetic ROR ligand

Solt, L. A., Kumar, N., Nuhant, P., Wang, Y., Lauer, J. L., Liu, J., Istrate, M. A., Kamenecka, T. M., Roush, W. R., Vidović, D., Schuerer, S. C., Xu, J., Wagoner, G., Drew, P. D., Griffin, P. R. & Burris, T. P., Apr 28 2011, In : Nature. 472, 7344, p. 491-494 4 p.

Research output: Contribution to journalArticle

Th17 Cells
Autoimmunity
Ligands
Autoimmune Diseases
Interleukin-17
16 Citations (Scopus)

Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice

Wang, Q., Levay, K., Chanturiya, T., Dvoriantchikova, G., Anderson, K. L., Bianco, S. D. C., Ueta, C. B., Molano, R., Pileggi, A., Gurevich, E. V., Gavrilova, O. & Slepak, V. Z., Nov 1 2011, In : FASEB Journal. 25, 11, p. 3949-3957 9 p.

Research output: Contribution to journalArticle

Protein Subunits
Nutrition
GTP-Binding Proteins
Genes
RGS Proteins
37 Citations (Scopus)

The food colorant erythrosine is a promiscuous protein-protein interaction inhibitor

Ganesan, L., Margolles-Clark, E., Song, Y. & Buchwald, P., Mar 15 2011, In : Biochemical Pharmacology. 81, 6, p. 810-818 9 p.

Research output: Contribution to journalArticle

Food Coloring Agents
Erythrosine
Xanthenes
Proteins
Epidermal Growth Factor
4 Citations (Scopus)

The location of olfactory receptors within olfactory epithelium is independent of odorant volatility and solubility

Abaffy, T. & DeFazio, A. R., May 10 2011, In : BMC Research Notes. 4, 137.

Research output: Contribution to journalArticle

Odorant Receptors
Olfactory Mucosa
Volatilization
Solubility
Chemical properties
39 Citations (Scopus)

Transcriptional profiling of intrinsic PNS factors in the postnatal mouse

Smith, R. P., Lerch-Haner, J. K., Pardinas, J. R., Buchser, W. J., Bixby, J. & Lemmon, V., Jan 1 2011, In : Molecular and Cellular Neuroscience. 46, 1, p. 32-44 13 p.

Research output: Contribution to journalArticle

Peripheral Nervous System
Transcription Factors
Neurons
STAT3 Transcription Factor
Systems Biology
2010
45 Citations (Scopus)

A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration

Usher, L. C., Johnstone, A., Ertürk, A., Hu, Y., Strikis, D., Wanner, I. B., Moorman, S., Lee, J. W., Min, J., Ha, H. H., Duan, Y., Hoffman, S., Goldberg, J. L., Bradke, F., Chang, Y. T., Lemmon, V. & Bixby, J., Mar 31 2010, In : Journal of Neuroscience. 30, 13, p. 4693-4706 14 p.

Research output: Contribution to journalArticle

Neuroglia
Regeneration
Axons
Myelin Sheath
Microtubules
2 Citations (Scopus)

A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe

Locovei, A. M., Yin, L. & D'urso, G., Aug 27 2010, In : Cell Division. 5, 20.

Research output: Contribution to journalArticle

Schizosaccharomyces
DNA Replication
DNA
Cells
DNA Damage
98 Citations (Scopus)

Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells

Wilson, A., Shehadeh, L., Yu, H. & Webster, K. A., Apr 7 2010, In : BMC Genomics. 11, 1, 229.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Molecular Biology
Stem Cells
Cell Aging
Bone Marrow
14 Citations (Scopus)

A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice

Tapanes-Castillo, A., Weaver, E. J., Smith, R. P., Kamei, Y., Caspary, T., Hamilton-Nelson, K. L., Slifer, S. H., Martin, E. R., Bixby, J. & Lemmon, V., Feb 1 2010, In : Neurogenetics. 11, 1, p. 53-71 19 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecule L1
Chromosomes, Human, Pair 5
Hydrocephalus
Mutation
Quantitative Trait Loci
75 Citations (Scopus)

An odorant receptor from the Southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants

Pelletier, J., Hughes, D. T., Luetje, C. W. & Leal, W. S., Sep 10 2010, In : PLoS One. 5, 4, e10090.

Research output: Contribution to journalArticle

oviposition attractants
Odorant Receptors
Oviposition
Culex
Culex quinquefasciatus
44 Citations (Scopus)

A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism

Teles, M. G., Trarbach, E. B., Noel, S. D., Guerra, G., Jorge, A., Beneduzzi, D., Bianco, S. D., Mukherjee, A., Baptista, M. T., Costa, E. M., De Castro, M., Mendonça, B. B., Kaiser, U. B. & Latronico, A. C., Jul 1 2010, In : European Journal of Endocrinology. 163, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

RNA Splice Sites
Hypogonadism
Siblings
Mutation
Puberty
9 Citations (Scopus)

A novel mouse model of in-stent restenosis

Rodriguez-Menocal, L., Wei, Y., Pham, S. M., St-Pierre, M., Li, S., Webster, K. A., Goldschmidt-Clermont, P. & Vazquez-Padron, R. I., Apr 1 2010, In : Atherosclerosis. 209, 2, p. 359-366 8 p.

Research output: Contribution to journalArticle

Stents
Apolipoproteins E
Matrix Metalloproteinases
Aorta
Acoustic Microscopy
18 Citations (Scopus)

Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites

GrÖtsch, H., Giblin, J. P., Idrissi, F. Z., Fernández-Golbano, I. M., Collette, J. R., Newpher, T. M., Robles, V., Lemmon, S. & Geli, M. I., Sep 1 2010, In : EMBO Journal. 29, 17, p. 2899-2914 16 p.

Research output: Contribution to journalArticle

Myosin Type I
Calmodulin
Actins
Polymerization
Yeast
51 Citations (Scopus)

Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry

Greenberg, M. J., Kazmierczak, K., Szczesna-Cordary, D. & Moore, J. R., Oct 5 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 40, p. 17403-17408 6 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Myosins
Cardiomyopathies
Biochemistry
Familial Hypertrophic Cardiomyopathy
69 Citations (Scopus)

Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction

Takeuchi, R., Tziomalos, K., Takeuchi, L. M., Treuer, A. V., Lamirault, G., Dulce, R., Hurtado, M., Song, Y., Block, N. L., Rick, F., Klukovits, A., Hu, Q., Varga, J. L., Schally, A. V. & Hare, J., Feb 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2604-2609 6 p.

Research output: Contribution to journalArticle

Growth Hormone-Releasing Hormone
Growth Hormone
Myocardial Infarction
Somatomedins
Muscle Cells
10 Citations (Scopus)

Choice of immunosuppression influences cytomegalovirus DNAemia in cynomolgus monkey (Macaca fascicularis) islet allograft recipients

Han, D., Berman-Weinberg, D., Willman, M., Buchwald, P., Rothen, D. E., Kenyon, N. M. & Kenyon, N. S., Dec 1 2010, In : Cell Transplantation. 19, 12, p. 1547-1561 15 p.

Research output: Contribution to journalArticle

Macaca fascicularis
Cytomegalovirus
Lymphocytes
Immunosuppression
Allografts
42 Citations (Scopus)

Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy

Li, Y., Charles, P. Y. J., Nan, C., Pinto, J. R., Wang, Y., Liang, J., Wu, G., Tian, J., Feng, H. Z., Potter, J. D., Jin, J. P. & Huang, X., Sep 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 3, p. 402-411 10 p.

Research output: Contribution to journalArticle

Restrictive Cardiomyopathy
Troponin
Troponin I
Transgenic Mice
Myofibrils
30 Citations (Scopus)

Dealing with misfolded proteins: Examining the neuroprotective role of molecular chaperones in neurodegeneration

Ali, Y. O., Kitay, B. M. & Zhai, R. G., Oct 1 2010, In : Molecules. 15, 10, p. 6859-6887 29 p.

Research output: Contribution to journalArticle

Molecular Chaperones
proteins
Proteins
Neurodegenerative diseases
Neurodegenerative Diseases
45 Citations (Scopus)

Differential volatile signatures from skin, naevi and melanoma: A novel approach to detect a pathological process

Abaffy, T., Duncan, R., Riemer, D. D., Tietje, O., Elgart, G., Milikowski, C. & Anthony Defazio, R., Nov 18 2010, In : PLoS One. 5, 11, e13813.

Research output: Contribution to journalArticle

Nevi and Melanomas
Pathologic Processes
melanoma
Melanoma
Skin
33 Citations (Scopus)

Discovery of potent and selective urea-based ROCK inhibitors and their effects on intraocular pressure in rats

Yin, Y., Cameron, M. D., Lin, L., Khan, S., Schröter, T., Grant, W., Pocas, J., Chen, Y. T., Schuerer, S. C., Pachori, A., Lograsso, P. & Feng, Y., Aug 27 2010, In : ACS Medicinal Chemistry Letters. 1, 4, p. 175-179 5 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Intraocular Pressure
Solubility
Urea
Rats
14 Citations (Scopus)
Derivatives
Transplants
CD40 Ligand
Acids
T-cells
7 Citations (Scopus)

Explicit targeting of transformed cells by VSV in ovarian epithelial tumor-bearing Wv mouse models

Capo-chichi, C. D., Yeasky, T. M., Heiber, J. F., Wang, Y., Barber, G. N. & Xu, X., Feb 1 2010, In : Gynecologic Oncology. 116, 2, p. 269-275 7 p.

Research output: Contribution to journalArticle

Vesicular Stomatitis
Viruses
Neoplasms
Epithelial Cells
Oncolytic Viruses
8 Citations (Scopus)

Expression of PTPRO in the interneurons of adult mouse olfactory bulb

Kotani, T., Murata, Y., Ohnishi, H., Mori, M., Kusakari, S., Saito, Y., Okazawa, H., Bixby, J. & Matozaki, T., Jan 15 2010, In : Journal of Comparative Neurology. 518, 2, p. 119-136 18 p.

Research output: Contribution to journalArticle

Olfactory Bulb
Interneurons
Calbindin 2
Brain
Neurocalcin
34 Citations (Scopus)

Expression of the Argonaute protein PiwiL2 and piRNAs in adult mouse mesenchymal stem cells

Wu, Q., Ma, Q., Shehadeh, L., Wilson, A., Xia, L., Yu, H. & Webster, K. A., Jun 11 2010, In : Biochemical and Biophysical Research Communications. 396, 4, p. 915-920 6 p.

Research output: Contribution to journalArticle

Argonaute Proteins
Stem cells
Mesenchymal Stromal Cells
Germ Cells
Testis
75 Citations (Scopus)

Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-β isoform specific and required for adaptive thermogenesis

Ribeiro, M. O., Bianco, S. D. C., Kaneshige, M., Schultz, J. J., Cheng, S. Y., Bianco, A. C. & Brent, G. A., Jan 1 2010, In : Endocrinology. 151, 1, p. 432-440 9 p.

Research output: Contribution to journalArticle

Thyroid Hormone Receptors
Brown Adipose Tissue
Thermogenesis
Protein Isoforms
Adrenergic Agents
7 Citations (Scopus)

Familial hypertrophic cardiomyopathy can be characterized by a specific pattern of orientation fluctuations of actin molecules

Borejdo, J., Szczesna-Cordary, D., Muthu, P. & Calander, N., Jun 29 2010, In : Biochemistry. 49, 25, p. 5269-5277 9 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Actins
Molecules
Muscle
Myocardium
8 Citations (Scopus)

Feasibility of localized immunosuppression: 2. PLA microspheres for the sustained local delivery of a soft immunosuppressant

Pinto, E., Zhang, B., Song, S., Bodor, N., Buchwald, P. & Hochhaus, G., Jun 1 2010, In : Pharmazie. 65, 6, p. 429-435 7 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Microspheres
Immunosuppression
glycolic acid
Equipment and Supplies
15 Citations (Scopus)

Feasibility of localized immunosuppression: 1. Exploratory studies with glucocorticoids in a biohybrid device designed for cell transplantation

Buchwald, P., Bocca, N., Marzorati, S., Hochhaus, G., Bodor, N., Stabler, C., Kenyon, N. S., Inverardi, L. A., Molano, R., Ricordi, C. & Pileggi, A., Jun 1 2010, In : Pharmazie. 65, 6, p. 421-428 8 p.

Research output: Contribution to journalArticle

Cell Transplantation
Immunosuppression
Glucocorticoids
Equipment and Supplies
dexamethasone 21-phosphate
15 Citations (Scopus)

GADD45γ: A new vitamin D-regulated gene that is antiproliferative in prostate cancer cells

Flores, O. & Burnstein, K. L., Oct 1 2010, In : Endocrinology. 151, 10, p. 4654-4664 11 p.

Research output: Contribution to journalArticle

Vitamin D
Prostatic Neoplasms
Calcitriol Receptors
Genes
Androgen Receptors
74 Citations (Scopus)

High content screening of cortical neurons identifies novel regulators of axon growth

Blackmore, M. G., Moore, D. L., Smith, R. P., Goldberg, J. L., Bixby, J. & Lemmon, V., May 1 2010, In : Molecular and Cellular Neuroscience. 44, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

Axons
Neurons
Growth
Genes
Kruppel-Like Transcription Factors
3 Citations (Scopus)

High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding

Faridi, M. H., Maiguel, D., Brown, B. T., Suyama, E., Barth, C. J., Hedrick, M., Vasile, S., Sergienko, E., Schuerer, S. C. & Gupta, V., Mar 26 2010, In : Biochemical and Biophysical Research Communications. 394, 1, p. 194-199 6 p.

Research output: Contribution to journalArticle

Integrins
Screening
Throughput
Ligands
Molecules
45 Citations (Scopus)

Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology

Buchser, W. J., Slepak, T. I., Gutierrez-Arenas, O., Bixby, J. & Lemmon, V., Aug 6 2010, In : Molecular Systems Biology. 6, 391.

Research output: Contribution to journalArticle

neurites
Phosphatases
Phosphoric Monoester Hydrolases
Neurons
Neuron
17 Citations (Scopus)

Methionine sulfoxide reductase A (MsrA) protects cultured mouse embryonic stem cells from H2O2-mediated oxidative stress

Zhang, C., Jia, P., Jia, Y., Weissbach, H., Webster, K. A., Huang, X., Lemanski, S. L., Achary, M. & Lemanski, L. F., Sep 1 2010, In : Journal of Cellular Biochemistry. 111, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

Methionine Sulfoxide Reductases
Oxidative stress
Stem cells
Oxidative Stress
Genes
14 Citations (Scopus)

Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gβ5-RGS7

Sandiford, S. L., Wang, Q., Levay, K., Buchwald, P. & Slepak, V. Z., Jun 22 2010, In : Biochemistry. 49, 24, p. 4998-5006 9 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Muscarinic M3 Receptors
GTP-Binding Proteins
Dimers
Signal transduction
175 Citations (Scopus)

Mutations of the KISS1 gene in disorders of puberty

Silveira, L. G., Noel, S. D., Silveira-Neto, A. P., Abreu, A. P., Brito, V. N., Santos, M. G., Bianco, S. D. C., Kuohung, W., Xu, S., Gryngarten, M., Escobar, M. E., Arnhold, I. J. P., Mendonca, B. B., Kaiser, U. B. & Latronico, A. C., May 1 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2276-2280 5 p.

Research output: Contribution to journalArticle

Kisspeptins
Puberty
Genes
Mutation
Hypogonadism
31 Citations (Scopus)

Neonatal asphyxia induces the nitration of cardiac myosin light chain 2 that is associated with cardiac systolic dysfunction

Doroszko, A., Polewicz, D., Cadete, V. J. J., Sawicka, J., Jones, M., Szczesna-Cordary, D., Cheung, P. Y. & Sawicki, G., Dec 1 2010, In : Shock. 34, 6, p. 592-600 9 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Myosin Light Chains
Asphyxia
Tyrosine
Peroxynitrous Acid
19 Citations (Scopus)

Novel role of Egr-1 in nicotine-related neointimal formation

Vazquez-Padron, R. I., Mateu, D., Rodriguez-Menocal, L., Wei, Y., Webster, K. A. & Pham, S. M., Nov 1 2010, In : Cardiovascular Research. 88, 2, p. 296-303 8 p.

Research output: Contribution to journalArticle

Nicotine
Growth
Vascular Smooth Muscle
Cell Proliferation
Smooth Muscle Myocytes
37 Citations (Scopus)

Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition

Flores, O., Wang, Z., Knudsen, K. E. & Burnstein, K. L., Mar 1 2010, In : Endocrinology. 151, 3, p. 896-908 13 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 2
Cyclin E
Vitamin D
Growth
Prostatic Neoplasms
49 Citations (Scopus)

Odorant receptor from the Southern House mosquito narrowly tuned to the oviposition attractant skatole

Hughes, D. T., Pelletier, J., Luetje, C. W. & Leal, W. S., Jul 12 2010, In : Journal of Chemical Ecology. 36, 8, p. 797-800 4 p.

Research output: Contribution to journalArticle

oviposition attractants
Skatole
Odorant Receptors
skatole
Oviposition
10 Citations (Scopus)
Coloring Agents
Proteins
Tumor Necrosis Factor-alpha
Suramin
Protein Binding