Molecular and Cellular Pharmacology

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2012

Sequencing and characterizing odorant receptors of the cerambycid beetle Megacyllene caryae

Mitchell, R. F., Hughes, D. T., Luetje, C. W., Millar, J. G., Soriano-Agatón, F., Hanks, L. M. & Robertson, H. M., Jul 1 2012, In : Insect Biochemistry and Molecular Biology. 42, 7, p. 499-505 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy

Percival, J. M., Whitehead, N. P., Adams, M. E., Adamo, C. M., Beavo, J. A. & Froehner, S. C., Sep 1 2012, In : Journal of Pathology. 228, 1, p. 77-87 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Single molecule detection approach to muscle study: kinetics of a single cross-bridge during contraction of muscle.

Borejdo, J., Szczesna-Cordary, D., Muthu, P., Metticolla, P., Luchowski, R., Gryczynski, Z. & Gryczynski, I., Sep 11 2012, In : Methods in molecular biology (Clifton, N.J.). 875, p. 311-334 24 p.

Research output: Contribution to journalArticle

6 Scopus citations

Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells

Liapis, E., Sandiford, S., Wang, Q., Gaidosh, G., Motti, D., Levay, K. & Slepak, V. Z., Aug 1 2012, In : Journal of neurochemistry. 122, 3, p. 568-581 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2′-fluoro-3′-(substituted phenyl)deschloroepibatidine analogues of 2′-fluoro-3′-(4- nitrophenyl)deschloroepibatidine

Ondachi, P., Castro, A., Luetje, C. W., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Jul 26 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6512-6522 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

The effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse hearts

Muthu, P., Kazmierczak, K., Jones, M. & Szczesna-Cordary, D., Dec 1 2012, In : Journal of Cellular and Molecular Medicine. 16, 4, p. 911-919 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation

Pinto, J. R., Gomes, A. V., Jones, M. A., Liang, J., Nguyen, S., Miller, T., Parvatiyar, M. S. & Potter, J. D., Oct 26 2012, In : Journal of Biological Chemistry. 287, 44, p. 37362-37370 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

The microRNA -23b/-27b Cluster Suppresses the Metastatic Phenotype of Castration-Resistant Prostate Cancer Cells

Ishteiwy, R. A., Ward, T. M., Dykxhoorn, D. M. & Burnstein, K. L., Dec 29 2012, In : PloS one. 7, 12, e52106.

Research output: Contribution to journalArticle

64 Scopus citations

Vav3 enhances androgen receptor splice variant activity and is critical for castration-resistant prostate cancer growth and survival

Peacock, S. O., Fahrenholtz, C. D. & Burnstein, K. L., Dec 1 2012, In : Molecular Endocrinology. 26, 12, p. 1967-1979 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Whole-mount imaging of the mouse hindlimb vasculature using the lipophilic carbocyanine dye DiI

Boden, J., Wei, J., McNamara, G., Layman, H., Abdulreda, M. H., Andreopoulos, F. M. & Webster, K. A., Jul 1 2012, In : BioTechniques. 53, 1

Research output: Contribution to journalArticle

5 Scopus citations

Will periodic intravenous injections of conditioned bone marrow cells effectively reduce atherosclerosis?

Song, X., Ma, Q., Liu, X., Seo, P., Herderick, E., Webster, K., Goldschmidt-Clermont, P. J. & Seo, D., Jan 1 2012, In : Antioxidants and Redox Signaling. 16, 1, p. 85-91 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schürer, S. C., Nomura, D. K., Rosen, H., Fu, G. C. & Cravatt, B. F., Apr 26 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 6811-6816 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

A case report-volatile metabolomic signature of malignant melanoma using matching skin as a control

Abaffy, T., Möller, M., Riemer, D. D., Milikowski, C. & Defazio, R. A., Dec 1 2011, In : Journal of Cancer Science and Therapy. 3, 6, p. 140-144 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

A Combined Ligand- and Structure-Based Virtual Screening Protocol Identifies Submicromolar PPARγPartial Agonists

Vidović, D., Busby, S. A., Griffin, P. R. & Schürer, S. C., Jan 3 2011, In : ChemMedChem. 6, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
56 Scopus citations

A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity

Isom, D. G., Marguet, P. R., Oas, T. G. & Hellinga, H. W., Apr 1 2011, In : Proteins: Structure, Function and Bioinformatics. 79, 4, p. 1034-1047 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

An essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in ApoE-/- mice

Cesar, L., Suarez, S. V., Adi, J., Adi, N., Vazquez-Padron, R., Yu, H., Ma, Q., Goldschmidt-Clermont, P. J., Agatston, A., Kurlansky, P. & Webster, K. A., Feb 28 2011, In : PloS one. 6, 2, e17263.

Research output: Contribution to journalArticle

15 Scopus citations

An Open-Label, Single-Dose, Crossover Study of the Pharmacokinetics and Metabolism of Two Oral Formulations of 1-Octanol in Patients with Essential Tremor

Nahab, F. B., Wittevrongel, L., Ippolito, D., Toro, C., Grimes, G. J., Starling, J., Potti, G., Haubenberger, D., Bowen, D., Buchwald, P., Dong, C., Kalowitz, D. & Hallett, M., Oct 1 2011, In : Neurotherapeutics. 8, 4, p. 753-762 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Anoxia, acidosis, and intergenic interactions selectively regulate methionine sulfoxide reductase transcriptions in mouse embryonic stem cells

Zhang, C., Jia, P., Jia, Y., Li, Y., Webster, K. A., Huang, X., Achary, M., Lemanski, S. L. & Lemanski, L. F., Jan 1 2011, In : Journal of cellular biochemistry. 112, 1, p. 98-106 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Choi, J. H., Banks, A. S., Kamenecka, T. M., Busby, S. A., Chalmers, M. J., Kumar, N., Kuruvilla, D. S., Shin, Y., He, Y., Bruning, J. B., Marciano, D. P., Cameron, M. D., Laznik, D., Jurczak, M. J., Schürer, S. C., Vidović, D., Shulman, G. I., Spiegelman, B. M. & Griffin, P. R., Sep 22 2011, In : Nature. 477, 7365, p. 477-481 5 p.

Research output: Contribution to journalArticle

330 Scopus citations

A Protocol for Characterizing the Impact of Collateral Flow after Distal Middle Cerebral Artery Occlusion

DeFazio, R. A., Levy, S., Morales, C. L., Levy, R. V., Lin, H. W., Abaffy, T., Dave, K. R., Watson, B. D., Perez-Pinzon, M. A. & Ohanna, V., Mar 1 2011, In : Translational stroke research. 2, 1, p. 112-127 16 p.

Research output: Contribution to journalArticle

18 Scopus citations

Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo

Wang, J., Han, X., Saha, S., Xu, T., Rai, R., Zhang, F., Wolf, Y. I., Wolfson, A., Yates, J. R. & Kashina, A., Jan 28 2011, In : Chemistry and Biology. 18, 1, p. 121-130 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration

Ali, Y. O., Escala, W., Ruan, K. & Zhai, R. G., Mar 2011, In : Journal of Visualized Experiments. 49, e2504.

Research output: Contribution to journalArticle

77 Scopus citations

BioAssay Ontology (BAO): A semantic description of bioassays and high-throughput screening results

Visser, U., Abeyruwan, S., Vempati, U., Smith, R. P., Lemmon, V. & Schürer, S. C., Jun 24 2011, In : BMC Bioinformatics. 12, 257.

Research output: Contribution to journalArticle

72 Scopus citations

BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets

Schürer, S. C., Vempati, U., Smith, R., Southern, M. & Lemmon, V., Apr 1 2011, In : Journal of Biomolecular Screening. 16, 4, p. 415-426 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins

Goldsmith, B. R., Mitala, J. J., Josue, J., Castro, A., Lerner, M. B., Bayburt, T. H., Khamis, S. M., Jones, R. A., Brand, J. G., Sligar, S. G., Luetje, C. W., Gelperin, A., Rhodes, P. A., Discher, B. M. & Johnson, A. T. C., Jul 26 2011, In : ACS Nano. 5, 7, p. 5408-5416 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

Challenges in small screening laboratories: Implementing an on-demand laboratory information management system

Lemmon, V. P., Jia, Y., Shi, Y., Holbrook, S. D., Bixby, J. L. & Buchser, W., Nov 1 2011, In : Combinatorial Chemistry and High Throughput Screening. 14, 9, p. 742-748 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

C-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction

Wei, J., Wang, W., Chopra, I., Li, H. F., Dougherty, C. J., Adi, J., Adi, N., Wang, H. & Webster, K. A., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 13995-14006 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin

Boettner, D. R., Friesen, H., Andrews, B. & Lemmon, S. K., Oct 1 2011, In : Molecular biology of the cell. 22, 19, p. 3699-3714 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Computational modeling of substrate specificity and catalysis of the β-secretase (BACE1) enzyme

Barman, A., Schürer, S. & Prabhakar, R., May 24 2011, In : Biochemistry. 50, 20, p. 4337-4349 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Cross-bridge kinetics in myofibrils containing familial hypertrophic cardiomyopathy R58Q mutation in the regulatory light chain of myosin

Mettikolla, P., Calander, N., Luchowski, R., Gryczynski, I., Gryczynski, Z., Zhao, J., Szczesna-Cordary, D. & Borejdo, J., Sep 7 2011, In : Journal of theoretical biology. 284, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Defective CXCR4 expression in aged bone marrow cells impairs vascular regeneration

Shao, H., Xu, Q., Wu, Q., Ma, Q., Salgueiro, L., Wang, JA., Eton, D., Webster, K. A. & Yu, H., Oct 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 10, p. 2046-2056 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Chowdhury, S., Sessions, E. H., Pocas, J. R., Grant, W., Schröter, T., Lin, L., Ruiz, C., Cameron, M. D., Schürer, S., Lograsso, P., Bannister, T. D. & Feng, Y., Dec 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 23, p. 7107-7112 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype

Vidović, D., Xie, Y., Rinderspacher, A., Deng, S. X., Landry, D. W., Chung, C., Smith, D. H., Tautz, L. & Schürer, S. C., Sep 1 2011, In : Journal of Computer-Aided Molecular Design. 25, 9, p. 873-883 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Diversity of bacteria at healthy human conjunctiva

Dong, Q., Brulc, J. M., Iovieno, A., Bates, B., Garoutte, A., Miller, D., Revanna, K. V., Gao, X., Antonopoulos, D. A., Slepak, V. Z. & Shestopalov, V. I., Jul 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5408-5413 6 p.

Research output: Contribution to journalArticle

125 Scopus citations

Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging

Shehadeh, L. A., Webster, K. A., Hare, J. M. & Vazquez-Padron, R. I., Oct 7 2011, In : PloS one. 6, 10, e25855.

Research output: Contribution to journalArticle

22 Scopus citations

Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation

Wang, Y., Smedberg, J. L., Cai, K. Q., Capo-Chichi, D. C. & Xu, X. X., Mar 1 2011, In : Developmental Dynamics. 240, 3, p. 566-576 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: A clinical, genetic, and functional approach

Pinto, J. R., Yang, S. W., Hitz, M. P., Parvatiyar, M. S., Jones, M. A., Liang, J., Kokta, V., Talajic, M., Tremblay, N., Jaeggi, M., Andelfinger, G. & Potter, J. D., Jun 10 2011, In : Journal of Biological Chemistry. 286, 23, p. 20901-20912 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy

Pinto, J. R., Siegfried, J. D., Parvatiyar, M. S., Li, D., Norton, N., Jones, M. A., Liang, J., Potter, J. D. & Hershberger, R. E., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34404-34412 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin

Lu, X., Kazmierczak, K., Jiang, X., Jones, M., Watt, J., Helfman, D. M., Moore, J. R., Szczesna-Cordary, D. & Lossos, I. S., Jun 1 2011, In : FEBS Journal. 278, 11, p. 1922-1931 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1

Chan, Y. M., Broder-Fingert, S., Paraschos, S., Lapatto, R., Au, M., Hughes, V., Bianco, S. D. C., Min, L., Plummer, L., Cerrato, F., De Guillebon, A., Wu, I. H., Wahab, F., Dwyer, A., Kirsch, S., Quinton, R., Cheetham, T., Ozata, M., Ten, S., Chanoine, J. P. & 8 others, Pitteloud, N., Martin, K. A., Schiffmann, R., Van Der Kamp, H. J., Nader, S., Hall, J. E., Kaiser, U. B. & Seminara, S. B., Nov 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 11, p. E1771-E1781

Research output: Contribution to journalArticle

41 Scopus citations

Heterogeneity in SDF-1 expression defines the vasculogenic potential of adult cardiac progenitor cells

Rodrigues, C. O., Shehadeh, L. A., Hoosien, M., Otero, V., Chopra, I., Tsinoremas, N. F. & Bishopric, N. H., Aug 24 2011, In : PloS one. 6, 8, e24013.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of a truncated form of methionine sulfoxide reductase a expressed in mouse embryonic stem cells

Jia, P., Zhang, C., Jia, Y., Webster, K. A., Huang, X., Kochegarov, A. A., Lemanski, S. L. & Lemanski, L. F., Jun 24 2011, In : Journal of Biomedical Science. 18, 1, 46.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening

Bialkowska, A. B., Crisp, M., Bannister, T., He, Y., Chowdhury, S., Schur̈er, S., Chase, P., Spicer, T., Madoux, F., Tian, C., Hodder, P., Zaharevitz, D. & Yang, V. W., Nov 1 2011, In : Molecular cancer therapeutics. 10, 11, p. 2043-2051 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Impaired CXCR4 expression and cell engraftment of bone marrow-derived cells from aged atherogenic mice

Xu, Q., Wang, JA., He, J., Zhou, M., Adi, J., Webster, K. A. & Yu, H., Nov 1 2011, In : Atherosclerosis. 219, 1, p. 92-99 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids

Vang, T., Xie, Y., Liu, W. H., Vidović, D., Liu, Y., Wu, S., Smith, D. H., Rinderspacher, A., Chung, C., Gong, G., Mustelin, T., Landry, D. W., Rickert, R. C., Schürer, S. C., Deng, S. X. & Tautz, L., Jan 27 2011, In : Journal of Medicinal Chemistry. 54, 2, p. 562-571 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer

Rosenblatt, A. E., Garcia, M. I., Lyons, L., Xie, Y., Maiorino, C., Désiré, L., Slingerland, J. & Burnstein, K. L., Apr 1 2011, In : Endocrine-Related Cancer. 18, 2, p. 207-219 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
13 Scopus citations

Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction

Polewicz, D., Cadete, V. J. J., Doroszko, A., Hunter, B. E., Sawicka, J., Szczesna-Cordary, D., Light, P. E. & Sawicki, G., May 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 5, p. 1136-1147 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

KISS1R intracellular trafficking and degradation: Effect of the Arg386Pro disease-associated mutation

Bianco, S. D. C., Vandepas, L., Correa-Medina, M., Gereben, B., Mukherjee, A., Kuohung, W., Carroll, R., Teles, M. G., Latronico, A. C. & Kaiser, U. B., Apr 1 2011, In : Endocrinology. 152, 4, p. 1616-1626 11 p.

Research output: Contribution to journalArticle

38 Scopus citations