Molecular and Cellular Pharmacology

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2012

Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism

Jo, S., Kalló, I., Bardóczi, Z., e Drigo, R. A., Zeöld, A., Liposits, Z., Oliva, A., Lemmon, V. P., Bixby, J. L., Gereben, B. & Bianco, A., Jun 20 2012, In : Journal of Neuroscience. 32, 25, p. 8491-8500 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy

Ali, Y. O., Ruan, K. & Zhai, R. G., Jan 1 2012, In : Human molecular genetics. 21, 2, p. 237-250 14 p., ddr449.

Research output: Contribution to journalArticle

64 Scopus citations

Novel kinase inhibitors by reshuffling ligand functionalities across the human kinome

Vidović, D., Muskal, S. M. & Schürer, S. C., Dec 21 2012, In : Journal of Chemical Information and Modeling. 52, 12, p. 3107-3115 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Novel selective allosteric and bitopic ligands for the S1P3 receptor

Jo, E., Bhhatarai, B., Repetto, E., Guerrero, M., Riley, S., Brown, S. J., Kohno, Y., Roberts, E., Schürer, S. C. & Rosen, H., Dec 21 2012, In : ACS Chemical Biology. 7, 12, p. 1975-1983 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth

Das, M., Drake, T., Wiley, D. J., Buchwald, P., Vavylonis, D. & Verde, F., Jul 13 2012, In : Science. 337, 6091, p. 239-243 5 p.

Research output: Contribution to journalArticle

85 Scopus citations

Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates

Buchser, W. J., Smith, R. P., Pardinas, J. R., Haddox, C. L., Hutson, T., Moon, L., Hoffman, S. R., Bixby, J. L. & Lemmon, V. P., Jun 6 2012, In : PloS one. 7, 6, e38101.

Research output: Contribution to journalArticle

16 Scopus citations

Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle

Chopra, I., Li, H. F., Wang, H. & Webster, K. A., Mar 1 2012, In : Diabetologia. 55, 3, p. 783-794 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini

Ouyang, H., Ali, Y. O., Ravichandran, M., Dong, A., Qiu, W., MacKenzie, F., Dhe-Paganon, S., Arrowsmith, C. H. & Zhai, R. G., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2317-2327 11 p.

Research output: Contribution to journalArticle

114 Scopus citations

RegIIA: An α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs

Franco, A., Kompella, S. N., Akondi, K. B., Melaun, C., Daly, N. L., Luetje, C. W., Alewood, P. F., Craik, D. J., Adams, D. J. & Marí, F., Feb 1 2012, In : Biochemical Pharmacology. 83, 3, p. 419-426 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis

Chi, R. J., Torres, O. T., Segarra, V. A., Lansley, T., Chang, J. S., Newpher, T. M. & Lemmon, S. K., 2012, In : Journal of Cell Science. 125, 20, p. 4728-4739 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Sequencing and characterizing odorant receptors of the cerambycid beetle Megacyllene caryae

Mitchell, R. F., Hughes, D. T., Luetje, C. W., Millar, J. G., Soriano-Agatón, F., Hanks, L. M. & Robertson, H. M., Jul 1 2012, In : Insect Biochemistry and Molecular Biology. 42, 7, p. 499-505 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Single molecule detection approach to muscle study: kinetics of a single cross-bridge during contraction of muscle.

Borejdo, J., Szczesna-Cordary, D., Muthu, P., Metticolla, P., Luchowski, R., Gryczynski, Z. & Gryczynski, I., Sep 11 2012, In : Methods in molecular biology (Clifton, N.J.). 875, p. 311-334 24 p.

Research output: Contribution to journalArticle

6 Scopus citations

Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells

Liapis, E., Sandiford, S., Wang, Q., Gaidosh, G., Motti, D., Levay, K. & Slepak, V. Z., Aug 1 2012, In : Journal of neurochemistry. 122, 3, p. 568-581 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2′-fluoro-3′-(substituted phenyl)deschloroepibatidine analogues of 2′-fluoro-3′-(4- nitrophenyl)deschloroepibatidine

Ondachi, P., Castro, A., Luetje, C. W., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Jul 26 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6512-6522 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

The effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse hearts

Muthu, P., Kazmierczak, K., Jones, M. & Szczesna-Cordary, D., Dec 1 2012, In : Journal of Cellular and Molecular Medicine. 16, 4, p. 911-919 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation

Pinto, J. R., Gomes, A. V., Jones, M. A., Liang, J., Nguyen, S., Miller, T., Parvatiyar, M. S. & Potter, J. D., Oct 26 2012, In : Journal of Biological Chemistry. 287, 44, p. 37362-37370 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

The microRNA -23b/-27b Cluster Suppresses the Metastatic Phenotype of Castration-Resistant Prostate Cancer Cells

Ishteiwy, R. A., Ward, T. M., Dykxhoorn, D. M. & Burnstein, K. L., Dec 29 2012, In : PloS one. 7, 12, e52106.

Research output: Contribution to journalArticle

66 Scopus citations

Vav3 enhances androgen receptor splice variant activity and is critical for castration-resistant prostate cancer growth and survival

Peacock, S. O., Fahrenholtz, C. D. & Burnstein, K. L., Dec 1 2012, In : Molecular Endocrinology. 26, 12, p. 1967-1979 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Whole-mount imaging of the mouse hindlimb vasculature using the lipophilic carbocyanine dye DiI

Boden, J., Wei, J., McNamara, G., Layman, H., Abdulreda, M., Andreopoulos, F. & Webster, K. A., Jul 1 2012, In : BioTechniques. 53, 1

Research output: Contribution to journalArticle

5 Scopus citations

Will periodic intravenous injections of conditioned bone marrow cells effectively reduce atherosclerosis?

Song, X., Ma, Q., Liu, X., Seo, P., Herderick, E., Webster, K., Goldschmidt-Clermont, P. J. & Seo, D., Jan 1 2012, In : Antioxidants and Redox Signaling. 16, 1, p. 85-91 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

A case report-volatile metabolomic signature of malignant melanoma using matching skin as a control

Abaffy, T., Möller, M., Riemer, D. D., Milikowski, C. & Defazio, R. A., Dec 1 2011, In : Journal of Cancer Science and Therapy. 3, 6, p. 140-144 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

A Combined Ligand- and Structure-Based Virtual Screening Protocol Identifies Submicromolar PPARγPartial Agonists

Vidović, D., Busby, S. A., Griffin, P. R. & Schürer, S. C., Jan 3 2011, In : ChemMedChem. 6, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
59 Scopus citations

An essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in ApoE-/- mice

Cesar, L., Suarez, S. V., Adi, J., Adi, N., Vazquez-Padron, R., Yu, H., Ma, Q., Goldschmidt-Clermont, P. J., Agatston, A., Kurlansky, P. & Webster, K. A., 2011, In : PloS one. 6, 2, e17263.

Research output: Contribution to journalArticle

16 Scopus citations

An Open-Label, Single-Dose, Crossover Study of the Pharmacokinetics and Metabolism of Two Oral Formulations of 1-Octanol in Patients with Essential Tremor

Nahab, F. B., Wittevrongel, L., Ippolito, D., Toro, C., Grimes, G. J., Starling, J., Potti, G., Haubenberger, D., Bowen, D., Buchwald, P., Dong, C., Kalowitz, D. & Hallett, M., Oct 1 2011, In : Neurotherapeutics. 8, 4, p. 753-762 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Anoxia, acidosis, and intergenic interactions selectively regulate methionine sulfoxide reductase transcriptions in mouse embryonic stem cells

Zhang, C., Jia, P., Jia, Y., Li, Y., Webster, K. A., Huang, X., Achary, M., Lemanski, S. L. & Lemanski, L. F., Jan 1 2011, In : Journal of cellular biochemistry. 112, 1, p. 98-106 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Choi, J. H., Banks, A. S., Kamenecka, T. M., Busby, S. A., Chalmers, M. J., Kumar, N., Kuruvilla, D. S., Shin, Y., He, Y., Bruning, J. B., Marciano, D. P., Cameron, M. D., Laznik, D., Jurczak, M. J., Schürer, S. C., Vidović, D., Shulman, G. I., Spiegelman, B. M. & Griffin, P. R., Sep 22 2011, In : Nature. 477, 7365, p. 477-481 5 p.

Research output: Contribution to journalArticle

334 Scopus citations

A Protocol for Characterizing the Impact of Collateral Flow after Distal Middle Cerebral Artery Occlusion

DeFazio, R. A., Levy, S., Morales, C. L., Levy, R. V., Lin, H. W., Abaffy, T., Dave, K. R., Watson, B. D., Perez-Pinzon, M. A. & Ohanna, V., Mar 1 2011, In : Translational stroke research. 2, 1, p. 112-127 16 p.

Research output: Contribution to journalArticle

18 Scopus citations

Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration

Ali, Y. O., Escala, W., Ruan, K. & Zhai, R. G., Mar 2011, In : Journal of Visualized Experiments. 49, e2504.

Research output: Contribution to journalArticle

82 Scopus citations

BioAssay Ontology (BAO): A semantic description of bioassays and high-throughput screening results

Visser, U., Abeyruwan, S., Vempati, U., Smith, R. P., Lemmon, V. & Schürer, S. C., Jun 24 2011, In : BMC Bioinformatics. 12, 257.

Research output: Contribution to journalArticle

75 Scopus citations

BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets

Schürer, S. C., Vempati, U., Smith, R., Southern, M. & Lemmon, V., Apr 1 2011, In : Journal of Biomolecular Screening. 16, 4, p. 415-426 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins

Goldsmith, B. R., Mitala, J. J., Josue, J., Castro, A., Lerner, M. B., Bayburt, T. H., Khamis, S. M., Jones, R. A., Brand, J. G., Sligar, S. G., Luetje, C. W., Gelperin, A., Rhodes, P. A., Discher, B. M. & Johnson, A. T. C., Jul 26 2011, In : ACS Nano. 5, 7, p. 5408-5416 9 p.

Research output: Contribution to journalArticle

115 Scopus citations

Challenges in small screening laboratories: Implementing an on-demand laboratory information management system

Lemmon, V. P., Jia, Y., Shi, Y., Holbrook, S. D., Bixby, J. L. & Buchser, W., Nov 1 2011, In : Combinatorial Chemistry and High Throughput Screening. 14, 9, p. 742-748 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

C-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction

Wei, J., Wang, W., Chopra, I., Li, H. F., Dougherty, C. J., Adi, J., Adi, N., Wang, H. & Webster, K. A., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 13995-14006 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin

Boettner, D. R., Friesen, H., Andrews, B. & Lemmon, S. K., Oct 1 2011, In : Molecular biology of the cell. 22, 19, p. 3699-3714 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Computational modeling of substrate specificity and catalysis of the β-secretase (BACE1) enzyme

Barman, A., Schürer, S. & Prabhakar, R., May 24 2011, In : Biochemistry. 50, 20, p. 4337-4349 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Cross-bridge kinetics in myofibrils containing familial hypertrophic cardiomyopathy R58Q mutation in the regulatory light chain of myosin

Mettikolla, P., Calander, N., Luchowski, R., Gryczynski, I., Gryczynski, Z., Zhao, J., Szczesna-Cordary, D. & Borejdo, J., Sep 7 2011, In : Journal of theoretical biology. 284, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Defective CXCR4 expression in aged bone marrow cells impairs vascular regeneration

Shao, H., Xu, Q., Wu, Q., Ma, Q., Salgueiro, L., Wang, JA., Eton, D., Webster, K. A. & Yu, H., Oct 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 10, p. 2046-2056 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Chowdhury, S., Sessions, E. H., Pocas, J. R., Grant, W., Schröter, T., Lin, L., Ruiz, C., Cameron, M. D., Schürer, S., Lograsso, P., Bannister, T. D. & Feng, Y., Dec 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 23, p. 7107-7112 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype

Vidović, D., Xie, Y., Rinderspacher, A., Deng, S. X., Landry, D. W., Chung, C., Smith, D. H., Tautz, L. & Schürer, S. C., Sep 1 2011, In : Journal of Computer-Aided Molecular Design. 25, 9, p. 873-883 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Diversity of bacteria at healthy human conjunctiva

Dong, Q., Brulc, J. M., Iovieno, A., Bates, B., Garoutte, A., Miller, D., Revanna, K. V., Gao, X., Antonopoulos, D. A., Slepak, V. Z. & Shestopalov, V. I., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5408-5413 6 p.

Research output: Contribution to journalArticle

134 Scopus citations

Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging

Shehadeh, L. A., Webster, K. A., Hare, J. M. & Vazquez-Padron, R. I., Oct 7 2011, In : PloS one. 6, 10, e25855.

Research output: Contribution to journalArticle

24 Scopus citations

Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation

Wang, Y., Smedberg, J. L., Cai, K. Q., Capo-Chichi, D. C. & Xu, X. X., Mar 1 2011, In : Developmental Dynamics. 240, 3, p. 566-576 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: A clinical, genetic, and functional approach

Pinto, J. R., Yang, S. W., Hitz, M. P., Parvatiyar, M. S., Jones, M. A., Liang, J., Kokta, V., Talajic, M., Tremblay, N., Jaeggi, M., Andelfinger, G. & Potter, J. D., Jun 10 2011, In : Journal of Biological Chemistry. 286, 23, p. 20901-20912 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy

Pinto, J. R., Siegfried, J. D., Parvatiyar, M. S., Li, D., Norton, N., Jones, M. A., Liang, J., Potter, J. D. & Hershberger, R. E., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34404-34412 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin

Lu, X., Kazmierczak, K., Jiang, X., Jones, M., Watt, J., Helfman, D. M., Moore, J. R., Szczesna-Cordary, D. & Lossos, I. S., Jun 1 2011, In : FEBS Journal. 278, 11, p. 1922-1931 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1

Chan, Y. M., Broder-Fingert, S., Paraschos, S., Lapatto, R., Au, M., Hughes, V., Bianco, S. D. C., Min, L., Plummer, L., Cerrato, F., De Guillebon, A., Wu, I. H., Wahab, F., Dwyer, A., Kirsch, S., Quinton, R., Cheetham, T., Ozata, M., Ten, S., Chanoine, J. P. & 8 others, Pitteloud, N., Martin, K. A., Schiffmann, R., Van Der Kamp, H. J., Nader, S., Hall, J. E., Kaiser, U. B. & Seminara, S. B., Nov 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 11, p. E1771-E1781

Research output: Contribution to journalArticle

43 Scopus citations

Heterogeneity in SDF-1 expression defines the vasculogenic potential of adult cardiac progenitor cells

Rodrigues, C. O., Shehadeh, L. A., Hoosien, M., Otero, V., Chopra, I., Tsinoremas, N. F. & Bishopric, N. H., Aug 24 2011, In : PloS one. 6, 8, e24013.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of a truncated form of methionine sulfoxide reductase a expressed in mouse embryonic stem cells

Jia, P., Zhang, C., Jia, Y., Webster, K. A., Huang, X., Kochegarov, A. A., Lemanski, S. L. & Lemanski, L. F., Jun 24 2011, In : Journal of Biomedical Science. 18, 1, 46.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening

Bialkowska, A. B., Crisp, M., Bannister, T., He, Y., Chowdhury, S., Schur̈er, S., Chase, P., Spicer, T., Madoux, F., Tian, C., Hodder, P., Zaharevitz, D. & Yang, V. W., Nov 1 2011, In : Molecular cancer therapeutics. 10, 11, p. 2043-2051 9 p.

Research output: Contribution to journalArticle

32 Scopus citations