Molecular and Cellular Pharmacology

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2013

Receptors: Chemical courtship in mice

Luetje, C. W., Mar 1 2013, In : Nature Chemical Biology. 9, 3, p. 140-141 2 p.

Research output: Contribution to journalArticle

Regulation of phospholipase C-β1 GTPase-activating protein (GAP) function and relationship to Gq efficacy

Litosch, I., Nov 1 2013, In : IUBMB life. 65, 11, p. 936-940 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Role of Cdc42 dynamics in the control of fission yeast cell polarization

Das, M. & Verde, F., Dec 1 2013, In : Biochemical Society transactions. 41, 6, p. 1745-1749 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Silent, generic and plant kairomone sensitive odorant receptors from the Southern house mosquito

Xu, P., Choo, Y. M., Pelletier, J., Sujimoto, F. R., Hughes, D. T., Zhu, F., Atungulu, E., Cornel, A. J., Luetje, C. W. & Leal, W. S., Sep 1 2013, In : Journal of Insect Physiology. 59, 9, p. 961-966 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells

Gomes, S. A., Rangel, E. B., Premer, C., Dulce, R. A., Cao, Y., Florea, V., Balkan, W., Rodrigues, C. O., Schally, A. V. & Hare, J. M., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8, p. 2834-2839 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Stem cell factor improves lung recovery in rats following neonatal hyperoxia-induced lung injury

Miranda, L. F., Rodrigues, C. O., Ramachandran, S., Torres, E., Huang, J., Klim, J., Hehre, D., McNiece, I., Hare, J. M., Suguihara, C. Y. & Young, K. C., Dec 1 2013, In : Pediatric Research. 74, 6, p. 682-688 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes

Shi, H., Chen, L., Wang, H., Zhu, S., Dong, C., Webster, K. A. & Wei, J., Jan 11 2013, In : Biochemical and biophysical research communications. 430, 2, p. 827-832 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
16 Scopus citations

The promiscuous protein binding ability of erythrosine B studied by metachromasy (metachromasia)

Ganesan, L. & Buchwald, P., Apr 1 2013, In : Journal of Molecular Recognition. 26, 4, p. 181-189 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The role of autophagy in Nmnat-mediated protection against hypoxia-induced dendrite degeneration

Wen, Y., Zhai, R. G. & Kim, M. D., Jan 1 2013, In : Molecular and Cellular Neuroscience. 52, p. 140-151 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

A broadly tuned mouse odorant receptor that detects nitrotoluenes

Li, J., Haddad, R., Chen, S., Santos, V. & Luetje, C. W., Jun 1 2012, In : Journal of neurochemistry. 121, 6, p. 881-890 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates

Johnstone, A. L., Reierson, G. W., Smith, R. P., Goldberg, J. L., Lemmon, V. P. & Bixby, J. L., Jun 1 2012, In : Molecular and Cellular Neuroscience. 50, 2, p. 125-135 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Activation of growth hormone releasing hormone (GHRH) receptor stimulates cardiac reverse remodeling after myocardial infarction (MI)

Kanashiro-Takeuchi, R. M., Takeuchi, L. M., Rick, F. G., Dulce, R., Treuer, A. V., Florea, V., Rodrigues, C. O., Paulino, E. C., Hatzistergos, K. E., Selem, S. M., Gonzalez, D. R., Block, N. L., Schally, A. V. & Hare, J. M., Jan 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 2, p. 559-563 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation

Parvatiyar, M. S., Landstrom, A. P., Figueiredo-Freitas, C., Potter, J. D., Ackerman, M. J. & Pinto, J. R., Sep 14 2012, In : Journal of Biological Chemistry. 287, 38, p. 31845-31855 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer

Rao, S., Lyons, L. S., Fahrenholtz, C. D., Wu, F., Farooq, A., Balkan, W. & Burnstein, K. L., Feb 1 2012, In : Oncogene. 31, 6, p. 716-727 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion

Zhang, F., Saha, S. & Kashina, A., Jun 11 2012, In : Journal of Cell Biology. 197, 6, p. 819-836 18 p.

Research output: Contribution to journalArticle

36 Scopus citations

Conserved rules govern genetic interaction degree across species

Koch, E. N., Costanzo, M., Bellay, J., Deshpande, R., Chatfield-Reed, K., Chua, G., D'Urso, G., Andrews, B. J., Boone, C. & Myers, C. L., Jul 2 2012, In : Genome biology. 13, 7, R57.

Research output: Contribution to journalArticle

28 Scopus citations

CREB-activity and NMNAT2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

Ljungberg, M. C., Ali, Y. O., Zhu, J., Wu, C. S., Oka, K., Zhai, R. G. & Lu, H. C., Jan 1 2012, In : Human molecular genetics. 21, 2, p. 251-267 17 p., ddr492.

Research output: Contribution to journalArticle

61 Scopus citations

Crystal structure of a lipid G protein-coupled receptor

Hanson, M. A., Roth, C. B., Jo, E., Griffith, M. T., Scott, F. L., Reinhart, G., Desale, H., Clemons, B., Cahalan, S. M., Schuerer, S. C., Sanna, M. G., Han, G. W., Kuhn, P., Rosen, H. & Stevens, R. C., Feb 17 2012, In : Science. 335, 6070, p. 851-855 5 p.

Research output: Contribution to journalArticle

453 Scopus citations

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Wang, L., Perera, B. G. K., Hari, S. B., Bhhatarai, B., Backes, B. J., Seeliger, M. A., Schürer, S. C., Oakes, S. A., Papa, F. R. & Maly, D. J., Dec 1 2012, In : Nature Chemical Biology. 8, 12, p. 982-989 8 p.

Research output: Contribution to journalArticle

104 Scopus citations

DNase activation by hypoxia-acidosis parallels but is independent of programmed cell death

Thompson, J. W., Graham, R. M. & Webster, K. A., Sep 17 2012, In : Life Sciences. 91, 7-8, p. 223-229 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology

Slepak, T. I., Salay, L. D., Lemmon, V. P. & Bixby, J. L., Jul 1 2012, In : Cytoskeleton. 69, 7, p. 514-527 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Evidence for Multiple Phototransduction Pathways in a Reef-Building Coral

Mason, B., Schmale, M., Gibbs, P., Miller, M. W., Wang, Q., Levay, K., Shestopalov, V. & Slepak, V. Z., Dec 5 2012, In : PloS one. 7, 12, e50371.

Research output: Contribution to journalArticle

22 Scopus citations

Exploratory computational assessment of possible binding modes for small molecule inhibitors of the CD40-CD154 co-stimulatory interaction

Ganesan, L., Vidović, D., Schürer, S. C. & Buchwald, P., Jun 21 2012, In : Pharmazie. 67, 5, p. 374-379 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fanconi anemia complementation group A (FANCA) protein has intrinsic affinity for nucleic acids with preference for single-stranded forms

Yuan, F., Qian, L., Zhao, X., Liu, J. Y., Song, L., D'Urso, G., Jain, C. & Zhang, Y., Feb 10 2012, In : Journal of Biological Chemistry. 287, 7, p. 4800-4807 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Feasibility of localized immunosuppression: 3. Preliminary evaluation of organosilicone constructs designed for sustained drug release in a cell transplant environment using dexamethasone

Song, Y., Margolles-Clark, E., Fraker, C. A., Weaver, J. D., Ricordi, C., Pileggi, A., Stabler, C. L. & Buchwald, P., Jun 21 2012, In : Pharmazie. 67, 5, p. 394-399 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Formalization, Annotation and Analysis of Diverse Drug and Probe Screening Assay Datasets Using the BioAssay Ontology (BAO)

Vempati, U. D., Przydzial, M. J., Chung, C., Abeyruwan, S., Mir, A., Sakurai, K., Visser, U., Lemmon, V. P. & Schürer, S. C., Nov 14 2012, In : PloS one. 7, 11, e49198.

Research output: Contribution to journalArticle

37 Scopus citations

Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy

Wang, Y., Pinto, J. R., Solis, R. S., Dweck, D., Liang, J., Diaz-Perez, Z., Ge, Y., Walker, J. W. & Potter, J. D., Jan 13 2012, In : Journal of Biological Chemistry. 287, 3, p. 2156-2167 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury

Dvoriantchikova, G., Ivanov, D., Barakat, D., Grinberg, A., Wen, R., Slepak, V. Z. & Shestopalov, V. I., Feb 23 2012, In : PloS one. 7, 2, e31991.

Research output: Contribution to journalArticle

70 Scopus citations

Getting in Touch with the Clathrin Terminal Domain

Lemmon, S. K. & Traub, L. M., Apr 1 2012, In : Traffic. 13, 4, p. 511-519 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries

Nelersa, C. M., Barreras, H., Runko, E., Ricard, J., Shi, Y., Glass, S. J., Bixby, J. L., Lemmon, V. P. & Liebl, D. J., Jul 1 2012, In : Journal of Biomolecular Screening. 17, 6, p. 785-795 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit

Chen, S. & Luetje, C. W., May 8 2012, In : PloS one. 7, 5, e36784.

Research output: Contribution to journalArticle

42 Scopus citations

Influence of diet on visceral adipose remodeling in NONcNZO10 mice with polygenic susceptibility for type 2 diabetes

Adi, N. C., Adi, J. N., Cesar, L., Agatston, A. S., Kurlansky, P. & Webster, K. A., Oct 1 2012, In : Obesity. 20, 10, p. 2142-2146 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

In vivo 17β-estradiol treatment contributes to podocyte actin stabilization in female db/db mice

Catanuto, P., Fornoni, A., Pereira-Simon, S., Wu, F., Burnstein, K. L., Xia, X., Conti, F., Lenzi, A. & Elliot, S., Dec 1 2012, In : Endocrinology. 153, 12, p. 5888-5895 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2

Cadete, V. J. J., Sawicka, J., Jaswal, J. S., Lopaschuk, G. D., Schulz, R., Szczesna-Cordary, D. & Sawicki, G., Jul 1 2012, In : FEBS Journal. 279, 13, p. 2444-2454 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Isoform diversity and its importance for axon regeneration

Lerch, J. K., Bixby, J. L. & Lemmon, V. P., Aug 1 2012, In : Neuropathology. 32, 4, p. 420-431 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq

Lerch, J. K., Kuo, F., Motti, D., Morris, R., Bixby, J. L. & Lemmon, V. P., Jan 17 2012, In : PloS one. 7, 1, e30417.

Research output: Contribution to journalArticle

33 Scopus citations

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract

Blackmore, M. G., Wang, Z., Lerch, J. K., Motti, D., Zhang, Y. P., Shields, C. B., Lee, J. K., Goldberg, J. L., Lemmon, V. P. & Bixby, J. L., May 8 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7517-7522 6 p.

Research output: Contribution to journalArticle

136 Scopus citations

Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice

Kazmierczak, K., Muthu, P., Huang, W., Jones, M., Wang, Y. & Szczesna-Cordary, D., Feb 15 2012, In : Biochemical Journal. 442, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
5 Scopus citations

Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism

Jo, S., Kalló, I., Bardóczi, Z., e Drigo, R. A., Zeöld, A., Liposits, Z., Oliva, A., Lemmon, V. P., Bixby, J. L., Gereben, B. & Bianco, A. C., Jun 20 2012, In : Journal of Neuroscience. 32, 25, p. 8491-8500 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy

Ali, Y. O., Ruan, K. & Zhai, R. G., Jan 1 2012, In : Human molecular genetics. 21, 2, p. 237-250 14 p., ddr449.

Research output: Contribution to journalArticle

62 Scopus citations

Novel kinase inhibitors by reshuffling ligand functionalities across the human kinome

Vidović, D., Muskal, S. M. & Schürer, S. C., Dec 21 2012, In : Journal of Chemical Information and Modeling. 52, 12, p. 3107-3115 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Novel selective allosteric and bitopic ligands for the S1P3 receptor

Jo, E., Bhhatarai, B., Repetto, E., Guerrero, M., Riley, S., Brown, S. J., Kohno, Y., Roberts, E., Schürer, S. C. & Rosen, H., Dec 21 2012, In : ACS Chemical Biology. 7, 12, p. 1975-1983 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth

Das, M., Drake, T., Wiley, D. J., Buchwald, P., Vavylonis, D. & Verde, F., Jul 13 2012, In : Science. 337, 6091, p. 239-243 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates

Buchser, W. J., Smith, R. P., Pardinas, J. R., Haddox, C. L., Hutson, T., Moon, L., Hoffman, S. R., Bixby, J. L. & Lemmon, V. P., Jun 6 2012, In : PloS one. 7, 6, e38101.

Research output: Contribution to journalArticle

16 Scopus citations

Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle

Chopra, I., Li, H. F., Wang, H. & Webster, K. A., Mar 1 2012, In : Diabetologia. 55, 3, p. 783-794 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini

Ouyang, H., Ali, Y. O., Ravichandran, M., Dong, A., Qiu, W., MacKenzie, F., Dhe-Paganon, S., Arrowsmith, C. H. & Zhai, R. G., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2317-2327 11 p.

Research output: Contribution to journalArticle

107 Scopus citations

RegIIA: An α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs

Franco, A., Kompella, S. N., Akondi, K. B., Melaun, C., Daly, N. L., Luetje, C. W., Alewood, P. F., Craik, D. J., Adams, D. J. & Marí, F., Feb 1 2012, In : Biochemical Pharmacology. 83, 3, p. 419-426 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis

Chi, R. J., Torres, O. T., Segarra, V. A., Lansley, T., Chang, J. S., Newpher, T. M. & Lemmon, S. K., Dec 1 2012, In : Journal of Cell Science. 125, 20, p. 4728-4739 12 p.

Research output: Contribution to journalArticle

13 Scopus citations