Molecular and Cellular Pharmacology

Research Output 1974 2019

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2013
13 Citations (Scopus)

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration

Kuboyama, T., Luo, X., Park, K., Blackmore, M. G., Tojima, T., Tohda, C., Bixby, J., Lemmon, V. & Kamiguchi, H., Oct 1 2013, In : Experimental Neurology. 248, p. 157-169 13 p.

Research output: Contribution to journalArticle

Paxillin
Proteoglycans
Aggrecans
Axons
Regeneration
14 Citations (Scopus)

Phenylthiophenecarboxamide antagonists of the olfactory receptor co-receptor subunit from a mosquito

Chen, S. & Luetje, C. W., Dec 17 2013, In : PLoS One. 8, 12, e84575.

Research output: Contribution to journalArticle

Odorant Receptors
olfactory receptors
Culicidae
antagonists
receptors
15 Citations (Scopus)

Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and ret signaling

Gatto, G., Dudanova, I., Suetterlin, P., Davies, A. M., Drescher, U., Bixby, J. & Klein, R., Mar 20 2013, In : Journal of Neuroscience. 33, 12, p. 5399-5410 12 p.

Research output: Contribution to journalArticle

Class 3 Receptor-Like Protein Tyrosine Phosphatases
Trigeminal Ganglion
Axons
EphA1 Receptor
Glial Cell Line-Derived Neurotrophic Factor

Receptors: Chemical courtship in mice

Luetje, C. W., Mar 1 2013, In : Nature Chemical Biology. 9, 3, p. 140-141 2 p.

Research output: Contribution to journalArticle

Odorant Receptors
Fatty Alcohols
Courtship
Biological Factors
4 Citations (Scopus)

Role of Cdc42 dynamics in the control of fission yeast cell polarization

Das, M. & Verde, F., Dec 1 2013, In : Biochemical Society Transactions. 41, 6, p. 1745-1749 5 p.

Research output: Contribution to journalArticle

Schizosaccharomyces
Yeast
Cells
Polarization
Feedback
14 Citations (Scopus)

Silent, generic and plant kairomone sensitive odorant receptors from the Southern house mosquito

Xu, P., Choo, Y. M., Pelletier, J., Sujimoto, F. R., Hughes, D. T., Zhu, F., Atungulu, E., Cornel, A. J., Luetje, C. W. & Leal, W. S., Sep 1 2013, In : Journal of Insect Physiology. 59, 9, p. 961-966 6 p.

Research output: Contribution to journalArticle

Odorant Receptors
kairomones
Culex quinquefasciatus
Pheromones
Culicidae
54 Citations (Scopus)

S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells

Gomes, S. A., Rangel, E. B., Premer, C., Dulce, R. A., Cao, Y., Florea, V., Balkan, W. E., Rodrigues, C. D., Schally, A. V. & Hare, J., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8, p. 2834-2839 6 p.

Research output: Contribution to journalArticle

glutathione-independent formaldehyde dehydrogenase
Mesenchymal Stromal Cells
Platelet-Derived Growth Factor Receptors
Nitric Oxide
Vascular Endothelial Growth Factor A
13 Citations (Scopus)

Stem cell factor improves lung recovery in rats following neonatal hyperoxia-induced lung injury

Miranda, L. F., Rodrigues, C. D., Ramachandran, S., Torres, E., Huang, J., Klim, J., Hehre, D., McNiece, I., Hare, J., Suguihara, C. Y. & Young, K., Dec 1 2013, In : Pediatric Research. 74, 6, p. 682-688 7 p.

Research output: Contribution to journalArticle

Hyperoxia
Stem Cell Factor
Lung Injury
Lung
Right Ventricular Hypertrophy
18 Citations (Scopus)

Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes

Shi, H., Chen, L., Wang, H., Zhu, S., Dong, C., Webster, K. A. & Wei, J., Jan 11 2013, In : Biochemical and Biophysical Research Communications. 430, 2, p. 827-832 6 p.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Cardiac Myocytes
Mitogen-Activated Protein Kinase 3
MicroRNAs
16 Citations (Scopus)
Heterografts
Androgens
Castration
Prostatic Neoplasms
Carcinogenesis
9 Citations (Scopus)

The promiscuous protein binding ability of erythrosine B studied by metachromasy (metachromasia)

Ganesan, L. & Buchwald, P., Apr 1 2013, In : Journal of Molecular Recognition. 26, 4, p. 181-189 9 p.

Research output: Contribution to journalArticle

Erythrosine
Protein Binding
CD40 Ligand
Bovine Serum Albumin
Proteins
12 Citations (Scopus)

The role of autophagy in Nmnat-mediated protection against hypoxia-induced dendrite degeneration

Wen, Y., Zhai, R. G. & Kim, M. D., Jan 1 2013, In : Molecular and Cellular Neuroscience. 52, p. 140-151 12 p.

Research output: Contribution to journalArticle

Nicotinamide-Nucleotide Adenylyltransferase
Autophagy
Dendrites
Neurons
Ischemia
2012
24 Citations (Scopus)

A broadly tuned mouse odorant receptor that detects nitrotoluenes

Li, J., Haddad, R., Chen, S., Santos, V. & Luetje, C. W., Jun 1 2012, In : Journal of Neurochemistry. 121, 6, p. 881-890 10 p.

Research output: Contribution to journalArticle

Odorant Receptors
Trinitrotoluene
Tuning
Mammals
Odors
17 Citations (Scopus)

A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates

Johnstone, A. L., Reierson, G. W., Smith, R. P., Goldberg, J. L., Lemmon, V. & Bixby, J., Jun 1 2012, In : Molecular and Cellular Neuroscience. 50, 2, p. 125-135 11 p.

Research output: Contribution to journalArticle

Neurites
Antipsychotic Agents
Central Nervous System
Neurons
Growth
34 Citations (Scopus)

Activation of growth hormone releasing hormone (GHRH) receptor stimulates cardiac reverse remodeling after myocardial infarction (MI)

Takeuchi, R., Takeuchi, L. M., Rick, F. G., Dulce, R., Treuer, A. V., Florea, V., Rodrigues, C. D., Paulino, E. C., Hatzistergos, K. E., Selem, S. M., Gonzalez, D. R., Block, N. L., Schally, A. V. & Hare, J., Jan 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 2, p. 559-563 5 p.

Research output: Contribution to journalArticle

Growth Hormone-Releasing Hormone
Myocardial Infarction
somatotropin releasing hormone receptor
Stem Cells
Hemodynamics
34 Citations (Scopus)

A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer

Rao, S., Lyons, L. S., Fahrenholtz, C. D., Wu, F., Farooq, A., Balkan, W. E. & Burnstein, K. L., Feb 1 2012, In : Oncogene. 31, 6, p. 716-727 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Nucleotides
Castration
Rho Guanine Nucleotide Exchange Factors
24 Citations (Scopus)
Kisspeptins
Puberty
Sex Characteristics
Incidence
Obesity
35 Citations (Scopus)

Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion

Zhang, F., Saha, S. & Kashina, A., Jun 11 2012, In : Journal of Cell Biology. 197, 6, p. 819-836 18 p.

Research output: Contribution to journalArticle

Talin
Cell Adhesion
Cadherins
arginyltransferase
Cell-Matrix Junctions
9 Citations (Scopus)

A sirtuin link between metabolism and heart disease

Webster, K. A., Nov 1 2012, In : Nature Medicine. 18, 11, p. 1617-1619 3 p.

Research output: Contribution to journalArticle

Oncogene Protein v-akt
Sirtuins
JNK Mitogen-Activated Protein Kinases
Metabolism
Animals
3 Citations (Scopus)

Cardiomyopathies: Classification, clinical characterization, and functional phenotypes

Szczesna-Cordary, D., Morimoto, S., Gomes, A. V. & Moore, J. R., Dec 26 2012, In : Biochemistry Research International. 870942.

Research output: Contribution to journalArticle

Cardiomyopathies
Phenotype
28 Citations (Scopus)

Conserved rules govern genetic interaction degree across species

Koch, E. N., Costanzo, M., Bellay, J., Deshpande, R., Chatfield-Reed, K., Chua, G., D'urso, G., Andrews, B. J., Boone, C. & Myers, C. L., Jul 2 2012, In : Genome Biology. 13, 7, R57.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
Schizosaccharomyces
Schizosaccharomyces pombe
Genes
gene
61 Citations (Scopus)

CREB-activity and NMNAT2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

Ljungberg, M. C., Ali, Y. O., Zhu, J., Wu, C. S., Oka, K., Zhai, R. G. & Lu, H. C., Jan 1 2012, In : Human Molecular Genetics. 21, 2, p. 251-267 17 p., ddr492.

Research output: Contribution to journalArticle

Nicotinamide-Nucleotide Adenylyltransferase
Tauopathies
Carrier Proteins
Frontotemporal Dementia
Neurofibrillary Tangles
103 Citations (Scopus)

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Wang, L., Perera, B. G. K., Hari, S. B., Bhhatarai, B., Backes, B. J., Seeliger, M. A., Schuerer, S. C., Oakes, S. A., Papa, F. R. & Maly, D. J., Dec 1 2012, In : Nature Chemical Biology. 8, 12, p. 982-989 8 p.

Research output: Contribution to journalArticle

Endoribonucleases
Ribonucleases
Endoplasmic Reticulum Stress
Phosphotransferases
Unfolded Protein Response
8 Citations (Scopus)

DNase activation by hypoxia-acidosis parallels but is independent of programmed cell death

Thompson, J. W., Graham, R. M. & Webster, K. A., Sep 17 2012, In : Life Sciences. 91, 7-8, p. 223-229 7 p.

Research output: Contribution to journalArticle

Deoxyribonucleases
Cell death
Acidosis
Cell Death
Chemical activation
16 Citations (Scopus)

Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology

Slepak, T. I., Salay, L. D., Lemmon, V. & Bixby, J., Jul 1 2012, In : Cytoskeleton. 69, 7, p. 514-527 14 p.

Research output: Contribution to journalArticle

Axons
Phosphotransferases
Phosphorylation
Dendrites
Neurons
22 Citations (Scopus)

Evidence for Multiple Phototransduction Pathways in a Reef-Building Coral

Mason, B., Schmale, M. C., Gibbs, P., Miller, M. W., Wang, Q., Levay, K., Shestopalov, V. I. & Slepak, V. Z., Dec 5 2012, In : PLoS One. 7, 12, e50371.

Research output: Contribution to journalArticle

Coral Reefs
Light Signal Transduction
phototransduction
Anthozoa
Reefs
3 Citations (Scopus)

Exploratory computational assessment of possible binding modes for small molecule inhibitors of the CD40-CD154 co-stimulatory interaction

Ganesan, L., Vidović, D., Schuerer, S. C. & Buchwald, P., Jun 21 2012, In : Pharmazie. 67, 5, p. 374-379 6 p.

Research output: Contribution to journalArticle

Binding Sites
Allosteric Site
Competitive Binding
Proteins
Coloring Agents
13 Citations (Scopus)

Fanconi anemia complementation group A (FANCA) protein has intrinsic affinity for nucleic acids with preference for single-stranded forms

Yuan, F., Qian, L., Zhao, X., Liu, J. Y., Song, L., D'urso, G., Jain, C. & Zhang, Y., Feb 10 2012, In : Journal of Biological Chemistry. 287, 7, p. 4800-4807 8 p.

Research output: Contribution to journalArticle

Fanconi Anemia Complementation Group A Protein
Fanconi Anemia
Nucleic Acids
RNA
DNA
8 Citations (Scopus)

Feasibility of localized immunosuppression: 3. Preliminary evaluation of organosilicone constructs designed for sustained drug release in a cell transplant environment using dexamethasone

Song, Y., Margolles-Clark, E., Fraker, C., Weaver, J. D., Ricordi, C., Pileggi, A., Stabler, C. L. & Buchwald, P., Jun 21 2012, In : Pharmazie. 67, 5, p. 394-399 6 p.

Research output: Contribution to journalArticle

Immunosuppression
Dexamethasone
Transplants
Equipment and Supplies
Islets of Langerhans Transplantation
37 Citations (Scopus)

Formalization, Annotation and Analysis of Diverse Drug and Probe Screening Assay Datasets Using the BioAssay Ontology (BAO)

Vempati, U. D., Przydzial, M. J., Chung, C., Abeyruwan, S., Mir, A., Sakurai, K., Visser, U. E., Lemmon, V. & Schuerer, S. C., Nov 14 2012, In : PLoS One. 7, 11, e49198.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Bioassay
Biological Assay
probes (equipment)
Ontology
31 Citations (Scopus)

Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy

Wang, Y., Pinto, J. R., Solis, R. S., Dweck, D., Liang, J., Diaz-Perez, Z., Ge, Y., Walker, J. W. & Potter, J. D., Jan 13 2012, In : Journal of Biological Chemistry. 287, 3, p. 2156-2167 12 p.

Research output: Contribution to journalArticle

Troponin I
Hypertrophic Cardiomyopathy
Phosphorylation
Mutation
Cyclic AMP-Dependent Protein Kinases
70 Citations (Scopus)

Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury

Dvoriantchikova, G., Ivanov, D. V., Barakat, D., Grinberg, A., Wen, R., Slepak, V. Z. & Shestopalov, V. I., Feb 23 2012, In : PLoS One. 7, 2, e31991.

Research output: Contribution to journalArticle

Retinal Neurons
Retinal Ganglion Cells
Ablation
Neurons
ischemia
28 Citations (Scopus)

Getting in Touch with the Clathrin Terminal Domain

Lemmon, S. & Traub, L. M., Apr 1 2012, In : Traffic. 13, 4, p. 511-519 9 p.

Research output: Contribution to journalArticle

Clathrin
Propellers
Clathrin Heavy Chains
Membranes
Endocytosis

GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1

Chan, Y. M., Broder-Fingert, S., Parachos, S., Lapatto, R., Au, M., Hughes, V., Bianco, S. D. C., Min, L., Plummer, L., Cerrato, F., De Guillebon, A., Wu, I. H., Wahab, F., Dwyer, A., Kirsch, S., Quinton, R., Cheetham, T., Ozata, M., Ten, S., Chanoine, J. P. & 8 others, Pitteloud, N., Martin, K. A., Schiffmann, R., Van Der Kamp, H. J., Nader, S., Hall, J. E., Kaiser, U. B. & Seminara, S. B., Sep 1 2012, In : Obstetrical and Gynecological Survey. 67, 9, p. 546-547 2 p.

Research output: Contribution to journalArticle

Gonadotropin-Releasing Hormone
Phenotype
10 Citations (Scopus)

High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries

Nelersa, C. M., Barreras, H., Runko, E., Ricard, J., Shi, Y., Glass, S. J., Bixby, J., Lemmon, V. & Liebl, D. J., Jul 1 2012, In : Journal of Biomolecular Screening. 17, 6, p. 785-795 11 p.

Research output: Contribution to journalArticle

EphA4 Receptor
Small Molecule Libraries
Cell Death
Molecules
Cell death
42 Citations (Scopus)

Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit

Chen, S. & Luetje, C. W., May 8 2012, In : PLoS One. 7, 5, e36784.

Research output: Contribution to journalArticle

Odorant Receptors
agonists
Insects
antagonists
odor compounds
1 Citation (Scopus)

Influence of diet on visceral adipose remodeling in NONcNZO10 mice with polygenic susceptibility for type 2 diabetes

Adi, N. C., Adi, J. N., Cesar, L., Agatston, A. S., Kurlansky, P. & Webster, K. A., Oct 1 2012, In : Obesity. 20, 10, p. 2142-2146 5 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Diet
Intra-Abdominal Fat
Vascular Endothelial Growth Factor C
Fish Oils
9 Citations (Scopus)

In vivo 17β-estradiol treatment contributes to podocyte actin stabilization in female db/db mice

Catanuto, P., Fornoni, A., Pereira-Simon, S., Wu, F., Burnstein, K. L., Xia, X., Conti, F., Lenzi, A. & Elliot, S., Dec 1 2012, In : Endocrinology. 153, 12, p. 5888-5895 8 p.

Research output: Contribution to journalArticle

Podocytes
Actins
Estradiol
Apoptosis
Therapeutics
25 Citations (Scopus)

Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2

Cadete, V. J. J., Sawicka, J., Jaswal, J. S., Lopaschuk, G. D., Schulz, R., Szczesna-Cordary, D. & Sawicki, G., Jul 1 2012, In : FEBS Journal. 279, 13, p. 2444-2454 11 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Phosphorylation
Matrix Metalloproteinase 2
Reperfusion
Ischemia
4 Citations (Scopus)

Isoform diversity and its importance for axon regeneration

Lerch, J. K., Bixby, J. & Lemmon, V., Aug 1 2012, In : Neuropathology. 32, 4, p. 420-431 12 p.

Research output: Contribution to journalArticle

Axons
Regeneration
Protein Isoforms
Gene Expression
RNA Isoforms
32 Citations (Scopus)

Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq

Lerch, J. K., Kuo, F., Motti, D., Morris, R., Bixby, J. & Lemmon, V., Jan 17 2012, In : PLoS One. 7, 1, e30417.

Research output: Contribution to journalArticle

Neurons
Protein Isoforms
neurons
RNA
Gene expression
134 Citations (Scopus)

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract

Blackmore, M. G., Wang, Z., Lerch, J. K., Motti, D., Zhang, Y. P., Shields, C. B., Lee, J., Goldberg, J. L., Lemmon, V. & Bixby, J., May 8 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7517-7522 6 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Transcriptional Activation
Axons
Regeneration
Neurons
73 Citations (Scopus)

Lessons from yeast for clathrin-mediated endocytosis

Boettner, D. R., Chi, R. J. & Lemmon, S., Jan 1 2012, In : Nature Cell Biology. 14, 1, p. 2-10 9 p.

Research output: Contribution to journalArticle

Clathrin-Coated Vesicles
Clathrin
Endocytosis
Membrane Proteins
Yeasts
21 Citations (Scopus)

MicroRNAs and neuronal development

Motti, D., Bixby, J. & Lemmon, V., Dec 1 2012, In : Seminars in Fetal and Neonatal Medicine. 17, 6, p. 347-352 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Biological Phenomena
Small Untranslated RNA
Untranslated RNA
Vertebrates
147 Citations (Scopus)

Mitochondrial membrane permeabilization and cell death during myocardial infarction: Roles of calcium and reactive oxygen species

Webster, K. A., Nov 1 2012, In : Future Cardiology. 8, 6, p. 863-884 22 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Reactive Oxygen Species
Cell Death
Myocardial Infarction
Calcium
22 Citations (Scopus)

Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice

Kazmierczak, K., Muthu, P., Huang, W., Jones, M., Wang, Y. & Szczesna-Cordary, D., Feb 15 2012, In : Biochemical Journal. 442, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Hypertrophic Cardiomyopathy
Transgenic Mice
Light
Myosins
41 Citations (Scopus)

Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism

Jo, S., Kalló, I., Bardóczi, Z., e Drigo, R. A., Zeöld, A., Liposits, Z., Oliva, A., Lemmon, V., Bixby, J., Gereben, B. & Bianco, A. C., Jun 20 2012, In : Journal of Neuroscience. 32, 25, p. 8491-8500 10 p.

Research output: Contribution to journalArticle

Iodide Peroxidase
Cell Nucleus Active Transport
Thyroid Hormones
Neurons
Ischemia
62 Citations (Scopus)

NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy

Ali, Y. O., Ruan, K. & Zhai, R. G., Jan 1 2012, In : Human Molecular Genetics. 21, 2, p. 237-250 14 p., ddr449.

Research output: Contribution to journalArticle

Nicotinamide Mononucleotide
Tauopathies
Drosophila
Frontotemporal Dementia
Proteins
4 Citations (Scopus)

Novel kinase inhibitors by reshuffling ligand functionalities across the human kinome

Vidović, D., Muskal, S. M. & Schuerer, S. C., Dec 21 2012, In : Journal of Chemical Information and Modeling. 52, 12, p. 3107-3115 9 p.

Research output: Contribution to journalArticle

functionality
Phosphotransferases
Ligands
workflow
Adenosinetriphosphate
38 Citations (Scopus)

Novel selective allosteric and bitopic ligands for the S1P3 receptor

Jo, E., Bhhatarai, B., Repetto, E., Guerrero, M., Riley, S., Brown, S. J., Kohno, Y., Roberts, E., Schuerer, S. C. & Rosen, H., Dec 21 2012, In : ACS Chemical Biology. 7, 12, p. 1975-1983 9 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Ligands
Molecular modeling
Allosteric Site
Lysophospholipids