Molecular and Cellular Pharmacology

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Complexes of the G protein subunit Gβ5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells

Witherow, D. S., Wang, Q., Levay, K., Cabrera, J. L., Chen, J., Willars, G. B. & Slepak, V. Z., Aug 11 2000, In : Journal of Biological Chemistry. 275, 32, p. 24872-24880 9 p.

Research output: Contribution to journalArticle

124 Scopus citations

Comprehensive metabolomics study to assess longitudinal biochemical changes and potential early biomarkers in nonobese diabetic mice that progress to diabetes

Buchwald, P., Tamayo-Garcia, A., Ramamoorthy, S., Garcia-Contreras, M., Mendez, A. J. & Ricordi, C., Oct 6 2017, In : Journal of Proteome Research. 16, 10, p. 3873-3890 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Computational modeling of substrate specificity and catalysis of the β-secretase (BACE1) enzyme

Barman, A., Schürer, S. & Prabhakar, R., May 24 2011, In : Biochemistry. 50, 20, p. 4337-4349 13 p.

Research output: Contribution to journalArticle

39 Scopus citations
Open Access
3 Scopus citations

Conserved NDR/LATS kinase controls RAS GTPase activity to regulate cell growth and chronological lifespan

Chen, C., Pino, M. R., Haller, P. R. & Verde, F., Sep 15 2019, In : Molecular biology of the cell. 30, 20, p. 2598-2616 19 p.

Research output: Contribution to journalArticle

Open Access

Conserved rules govern genetic interaction degree across species

Koch, E. N., Costanzo, M., Bellay, J., Deshpande, R., Chatfield-Reed, K., Chua, G., D'Urso, G., Andrews, B. J., Boone, C. & Myers, C. L., Jul 2 2012, In : Genome biology. 13, 7, R57.

Research output: Contribution to journalArticle

29 Scopus citations

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice

Yuan, C. C., Muthu, P., Kazmierczak, K., Liang, J., Huang, W., Irving, T. C., Takeuchi, R., Hare, J. & Szczesna-Cordary, D., Jul 28 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 30, p. E4138-E4146

Research output: Contribution to journalArticle

37 Scopus citations

Controlled Release of Dexamethasone from Organosilicone Constructs for Local Modulation of Inflammation in Islet Transplantation

Weaver, J. D., Song, Y., Yang, E. Y., Ricordi, C., Pileggi, A., Buchwald, P. & Stabler, C. L., Aug 1 2015, In : Tissue Engineering - Part A. 21, 15-16, p. 2250-2261 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Control of Cardiac-specific Transcription by p300 through Myocyte Enhancer Factor-2D

Slepak, T. I., Webster, K. A., Zang, J., Prentice, H., O'Dowd, A., Hicks, M. N. & Bishopric, N. H., Mar 9 2001, In : Journal of Biological Chemistry. 276, 10, p. 7575-7585 11 p.

Research output: Contribution to journalArticle

57 Scopus citations

Control of cell morphogenesis and the cell cycle in fission yeast

Wiley, D. & Verde, F., 1999, In : Nippon Nogeikagaku Kaishi. 73, p. 462-466 5 p.

Research output: Contribution to journalArticle

Control of Cell Polarity in Fission Yeast by Association of Orb6p Kinase with the Highly Conserved Protein Methyltransferase Skb1p

Wiley, D. J., Marcus, S., D'Urso, G. & Verde, F., Jul 4 2003, In : Journal of Biological Chemistry. 278, 27, p. 25256-25263 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts

Verde, F., Dogterom, M., Stelzer, E., Karsenti, E. & Leibler, S., Sep 1992, In : Journal of Cell Biology. 118, 5, p. 1097-1108 12 p.

Research output: Contribution to journalArticle

Open Access
314 Scopus citations

Coordinate and noncoordinate regulation of synaptic vesicle protein genes during embryonic development

Lou, X. & Bixby, J. L., Oct 1 1993, In : Developmental Biology. 159, 1, p. 327-337 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast

Isom, D. G., Page, S. C., Collins, L. B., Kapolka, N. J., Taghon, G. J. & Dohlman, H. G., Feb 16 2018, In : Journal of Biological Chemistry. 293, 7, p. 2318-2329 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts

Webster, K. A., Gunning, P., Hardeman, E., Wallace, D. C. & Kedes, L., Mar 1990, In : Journal of Cellular Physiology. 142, 3, p. 566-573 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Coping with cyclic oxygen availability: Evolutionary aspects

Flück, M., Webster, K. A., Graham, J., Giomi, F., Gerlach, F. & Schmitz, A., Oct 1 2007, In : Integrative and comparative biology. 47, 4, p. 524-531 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy

Li, Y., Charles, P. Y. J., Nan, C., Pinto, J. R., Wang, Y., Liang, J., Wu, G., Tian, J., Feng, H. Z., Potter, J. D., Jin, J. P. & Huang, X., Sep 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 3, p. 402-411 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Cortical recruitment and nuclear-cytoplasmic shuttling of Scd5p, a protein phosphatase-1-targeting protein involved in actin organization and endocytosis

Chang, J. S., Henry, K., Geli, M. I. & Lemmon, S. K., Jan 1 2006, In : Molecular biology of the cell. 17, 1, p. 251-262 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Co-translational protein aggregation after transient cerebral ischemia

Liu, C. L., Ge, P., Zhang, F. & Hu, B. R., Sep 5 2005, In : Neuroscience. 134, 4, p. 1273-1284 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain

Boettner, D. R., Segarra, V. A., Moorthy, B. T., de León, N., Creagh, J., Collette, J. R., Malhotra, A. & Lemmon, S., Jul 1 2016, In : Traffic. 17, 7, p. 754-768 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

CREB-activity and NMNAT2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

Ljungberg, M. C., Ali, Y. O., Zhu, J., Wu, C. S., Oka, K., Zhai, R. G. & Lu, H. C., Jan 1 2012, In : Human molecular genetics. 21, 2, p. 251-267 17 p., ddr492.

Research output: Contribution to journalArticle

65 Scopus citations

Cross-bridge kinetics in myofibrils containing familial hypertrophic cardiomyopathy R58Q mutation in the regulatory light chain of myosin

Mettikolla, P., Calander, N., Luchowski, R., Gryczynski, I., Gryczynski, Z., Zhao, J., Szczesna-Cordary, D. & Borejdo, J., Sep 7 2011, In : Journal of theoretical biology. 284, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

CRYP-2: A receptor-type tyrosine phosphatase selectively expressed by developing vertebrate neurons

Bodden, K. & Bixby, J. L., Nov 1 1996, In : Journal of Neurobiology. 31, 3, p. 309-324 16 p.

Research output: Contribution to journalArticle

34 Scopus citations

CRYP-2/cPTPRO is a neurite inhibitory repulsive guidance cue for retinal neurons in vitro

Stepanek, L., Sun, Q. L., Wang, J., Wang, C. & Bixby, J. L., Aug 20 2001, In : Journal of Cell Biology. 154, 4, p. 867-878 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Cyclin A is required at two points in the human cell cycle

Pagano, M., Pepperkok, R., Verde, F., Ansorge, W. & Draetta, G., Jan 1 1992, In : EMBO Journal. 11, 3, p. 961-971 11 p.

Research output: Contribution to journalArticle

1030 Scopus citations

Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis

Andreka, P., Zang, J., Dougherty, C., Slepak, T. I., Webster, K. A. & Bishopric, N. H., Feb 16 2001, In : Circulation research. 88, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations

Dansylaziridine-labeled troponin C. A fluorescent probe of Ca2+ binding to the Ca2+-specific regulatory sites

Johnson, J. D., Collins, J. H. & Potter, J. D., Dec 1 1978, In : Journal of Biological Chemistry. 253, 18, p. 6451-6458 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: Integrated access to diverse large-scale cellular perturbation response data

Koleti, A., Terryn, R., Stathias, V., Chung, C., Cooper, D. J., Turner, J. P., VidoviÄ ‡, D., Forlin, M., Kelley, T. T., D'Urso, A., Allen, B. K., Torre, D., Jagodnik, K. M., Wang, L., Jenkins, S. L., Mader, C., Niu, W., Fazel, M., Mahi, N., Pilarczyk, M. & 9 others, Clark, N., Shamsaei, B., Meller, J., Vasiliauskas, J., Reichard, J., Medvedovic, M., Ma'Ayan, A., Pillai, A. & Schürer, S. C., Jan 1 2018, In : Nucleic Acids Research. 46, D1, p. D558-D566

Research output: Contribution to journalArticle

35 Scopus citations

Defective CXCR4 expression in aged bone marrow cells impairs vascular regeneration

Shao, H., Xu, Q., Wu, Q., Ma, Q., Salgueiro, L., Wang, JA., Eton, D., Webster, K. A. & Yu, H., Oct 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 10, p. 2046-2056 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of duchenne muscular dystrophy are not alleviated by PDE5 inhibition

Percival, J. M., Siegel, M. P., Knowels, G. & Marcinek, D. J., Jan 1 2013, In : Human molecular genetics. 22, 1, p. 153-167 15 p., dds415.

Research output: Contribution to journalArticle

64 Scopus citations

Defining disease, diagnosis, and translational medicine within a homeostatic perturbation paradigm: The National Institutes of Health undiagnosed diseases program experience

Gall, T., Valkanas, E., Bello, C., Markello, T., Adams, C., Bone, W. P., Brandt, A. J., Brazill, J. M., Carmichael, L., Davids, M., Davis, J., Diaz-Perez, Z., Draper, D., Elson, J., Flynn, E. D., Godfrey, R., Groden, C., Hsieh, C. K., Fischer, R., Golas, G. A. & 31 others, Guzman, J., Huang, Y., Kane, M. S., Lee, E., Li, C., Links, A. E., Maduro, V., Malicdan, M. C. V., Malik, F. S., Nehrebecky, M., Park, J., Pemberton, P., Schaffer, K., Simeonov, D., Sincan, M., Smedley, D., Valivullah, Z., Wahl, C., Washington, N., Wolfe, L. A., Xu, K., Zhu, Y., Gahl, W. A., Tifft, C. J., Toro, C., Adams, D. R., He, M., Robinson, P. N., Haendel, M. A., Zhai, R. G. & Boerkoel, C. F., Jan 1 2017, In : Frontiers in Medicine. 4, MAY, 62.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: A new intracellular target for matrix metalloproteinase-2

Sawicki, G., Leon, H., Sawicka, J., Sariahmetoglu, M., Schulze, C. J., Scott, P. G., Szczesna-Cordary, D. & Schulz, R., Jul 26 2005, In : Circulation. 112, 4, p. 544-552 9 p.

Research output: Contribution to journalArticle

206 Scopus citations

Deletion of 1-43 amino acids in cardiac myosin essential light chain blunts length dependency of ca2+ sensitivity and cross-bridge detachment kinetics

Michael, J. J., Gollapudi, S. K., Ford, S. J., Kazmierczak, K., Szczesna-Cordary, D. & Chandra, M., Jan 15 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 2, p. H253-H259

Research output: Contribution to journalArticle

16 Scopus citations

Deletion of the first 45 NH2-terminal residues of rabbit skeletal troponin T strengthens binding of troponin to immobilized tropomyosin

Pan, B. S., Gordon, A. M. & Potter, J. D., Sep 23 1991, In : Journal of Biological Chemistry. 266, 19, p. 12432-12438 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21CIP1 levels in androgen-independent human prostate cancer cells

Knight-Krajewski, S., Welsh, C. F., Liu, Y., Lyons, L. S., Faysal, J. M., Yang, E. S. & Burnstein, K. L., Jul 15 2004, In : Oncogene. 23, 32, p. 5513-5522 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Design, synthesis, and evaluation of novel immunomodulatory small molecules targeting the CD40–CD154 costimulatory protein-protein interaction

Bojadzic, D., Chen, J., Alcazar, O. & Buchwald, P., Jan 1 2018, In : Molecules. 23, 5, 1153.

Research output: Contribution to journalArticle

3 Scopus citations

Detection of two classes of Ca2+ binding sites in troponin C with circular dichroism and tyrosine fluorescence.

Johnson, J. D. & Potter, J. D., Jun 10 1978, In : Journal of Biological Chemistry. 253, 11, p. 3775-3777 3 p.

Research output: Contribution to journalArticle

68 Scopus citations

Determinants of agonist binding affinity on neuronal nicotinic receptor β subunits

Parker, M. J., Harvey, S. C. & Luetje, C. W., Oct 9 2001, In : Journal of Pharmacology and Experimental Therapeutics. 299, 1, p. 385-391 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor β subunits

Harvey, S. C. & Luetje, C. W., Jan 1 1996, In : Journal of Neuroscience. 16, 12, p. 3798-3806 9 p.

Research output: Contribution to journalArticle

Open Access
142 Scopus citations

Determinants of Potency on α-Conotoxin MII, a Peptide Antagonist of Neuronal Nicotinic Receptors

Everhart, D., Cartier, G. E., Malhotra, A., Gomes, A. V., McIntosh, J. M. & Luetje, C. W., Mar 16 2004, In : Biochemistry. 43, 10, p. 2732-2737 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors

Harvey, S. C., Mcintosh, J. M., Cartier, G. E., Maddox, F. N. & Luetje, C. W., Feb 1997, In : Molecular Pharmacology. 51, 2, p. 336-342 7 p.

Research output: Contribution to journalArticle

105 Scopus citations

Determinants of zinc potentiation on the α4 subunit of neuronal nicotinic receptors

Hsiao, B., Mihalak, K. B., Repicky, S. E., Everhart, D., Mederos, A. H., Malhotra, A. & Luetje, C. W., Jan 1 2006, In : Molecular Pharmacology. 69, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Determinants of α-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor β subunit

Shiembob, D. L., Roberts, R. L., Luetje, C. W. & McIntosh, J. M., Sep 19 2006, In : Biochemistry. 45, 37, p. 11200-11207 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Determination of the amino acid sequence of troponin C from rabbit skeletal muscle

Collins, J. H., Greaser, M. L., Potter, J. D. & Horn, M. J., Jan 1 1977, In : Journal of Biological Chemistry. 252, 18, p. 6356-6362 7 p.

Research output: Contribution to journalArticle

135 Scopus citations

Determination of the Ca2+ and Mg2+ affinity constants of troponin C from eel skeletal muscle and positioning of the single tryptophan in the primary structure

François, J. M., Gerday, C., Prendergast, F. G. & Potter, J. D., Dec 1 1993, In : Journal of Muscle Research and Cell Motility. 14, 6, p. 585-593 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop

Jagodnik, K. M., Koplev, S., Jenkins, S. L., Ohno-Machado, L., Paten, B., Schurer, S. C., Dumontier, M., Verborgh, R., Bui, A., Ping, P., McKenna, N. J., Madduri, R., Pillai, A. & Ma'ayan, A., Jul 2017, In : Journal of biomedical informatics. 71, p. 49-57 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Development of compensatory thermogenesis in response to overfeeding in hypothyroid rats

Curcio, C., Lopes, A. M., Ribeiro, M. O., Francoso, O. A., Carvalho, S. D., Lima, F. B., Bicudo, J. E. & Bianco, A. C., Jan 1 1999, In : Endocrinology. 140, 8, p. 3438-3443 6 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties

Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schürer, S., Chen, W., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., Duckett, D. R., Cleveland, J. L. & Roush, W. R., Aug 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 15, p. 4374-4380 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice

Abraham, T. P., Jones, M., Kazmierczak, K., Liang, H. Y., Pinheiro, A. C., Wagg, C. S., Lopaschuk, G. D. & Szczesna-Cordary, D., Apr 1 2009, In : Cardiovascular Research. 82, 1, p. 84-92 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Differences in the glucocorticoid to the progesterone receptor selectivity of inhaled glucocorticoids

Issar, M., Sahasranaman, S., Buchwald, P. & Hochhaus, G., Mar 1 2006, In : European Respiratory Journal. 27, 3, p. 511-516 6 p.

Research output: Contribution to journalArticle

27 Scopus citations