Molecular and Cellular Pharmacology

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2017

Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues

Ondachi, P. W., Castro, A. H., Sherman, B., Luetje, C. W., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Jan 18 2017, In : ACS Chemical Neuroscience. 8, 1, p. 115-127 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting AR variant–coactivator interactions to exploit prostate cancer vulnerabilities

Magani, F., Peacock, S. O., Rice, M. A., Martinez, M. J., Greene, A. M., Magani, P. S., Lyles, R., Weitz, J. R. & Burnstein, K. L., Nov 1 2017, In : Molecular Cancer Research. 15, 11, p. 1469-1480 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Teaching an old drug new tricks: Agonism, antagonism, and biased signaling of pilocarpine through M3 muscarinic acetylcholine receptor

Pronin, A. N., Wang, Q. & Slepak, V. Z., Nov 2017, In : Molecular Pharmacology. 92, 5, p. 601-612 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

The mTOR substrate S6 kinase 1 (S6K1) is a negative regulator of axon regeneration and a potential drug target for central nervous system injury

Al-Ali, H., Ding, Y., Slepak, T., Wu, W., Sun, Y., Martinez, Y., Xu, X. M., Lemmon, V. & Bixby, J., Jul 26 2017, In : Journal of Neuroscience. 37, 30, p. 7079-7095 17 p.

Research output: Contribution to journalArticle

27 Scopus citations

Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer

Samaranayake, G. J., Troccoli, C. I., Huynh, M., Lyles, R. D. Z., Kage, K., Win, A., Lakshmanan, V., Kwon, D., Ban, Y., Chen, X., Zarco, E. R., Jorda, M., Burnstein, K. L. & Rai, P., Dec 1 2017, In : Nature Communications. 8, 1, 1204.

Research output: Contribution to journalArticle

12 Scopus citations

TIN-X: target importance and novelty explorer

Cannon, D. C., Yang, J. J., Mathias, S. L., Ursu, O., Mani, S., Waller, A., Schürer, S. C., Jensen, L. J., Sklar, L. A., Bologa, C. G. & Oprea, T. I., Aug 15 2017, In : Bioinformatics (Oxford, England). 33, 16, p. 2601-2603 3 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers

Rai, R., Zhang, F., Colavita, K., Leu, N. A., Kurosaka, S., Kumar, A., Birnbaum, M. D., Gyorffy, B., Dong, D. W., Shtutman, M. & Kashina, A., Aug 4 2016, In : Oncogene. 35, 31, p. 4058-4068 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging

Ruetenik, A. L., Ocampo, A., Ruan, K., Zhu, Y., Li, C., Grace Zhai, R. & Barrientos, A., Aug 2016, In : Microbial Cell. 3, 8, p. 338-351 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Auxilin facilitates membrane traffic in the early secretory pathway

Ding, J., Segarra, V. A., Chen, S., Cai, H., Lemmon, S. K. & Ferro-Novick, S., Jan 1 2016, In : Molecular biology of the cell. 27, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Building concordant ontologies for drug discovery

Küçük-McGinty, H., Mehta, S., Lin, Y., Nabizadeh, N., Stathias, V., Vidovic, D., Koleti, A., Mader, C., Duan, J., Visser, U. E. & Schuerer, S. C., 2016, In : CEUR Workshop Proceedings. 1747

Research output: Contribution to journalArticle

Cell length growth patterns in fission yeast reveal a novel size control mechanism operating in late G2 phase

Horváth, A., Rácz-Mónus, A., Buchwald, P. & Sveiczer, Á., Sep 1 2016, In : Biology of the Cell. 108, 9, p. 259-277 19 p.

Research output: Contribution to journalArticle

5 Scopus citations

Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain

Boettner, D. R., Segarra, V. A., Moorthy, B. T., de León, N., Creagh, J., Collette, J. R., Malhotra, A. & Lemmon, S., Jul 1 2016, In : Traffic. 17, 7, p. 754-768 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Dose-escalation study of octanoic acid in patients with essential tremor

Voller, B., Lines, E., McCrossin, G., Tinaz, S., Lungu, C., Grimes, G., Starling, J., Potti, G., Buchwald, P., Haubenberger, D. & Hallett, M., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Edelfosine promotes apoptosis in androgen-deprived prostate tumors by increasing atf3 and inhibiting androgen receptor activity

Udayakumar, T., Stoyanova, R., Shareef, M. M., Mu, Z., Philip, S., Burnstein, K. L. & Pollack, A., Jun 1 2016, In : Molecular Cancer Therapeutics. 15, 6, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Endothelial Mesenchymal Transition: Comparative Analysis of Different Induction Methods

Pinto, M. T., Covas, D. T., Kashima, S. & Rodrigues, C. D., Apr 27 2016, In : Biological Procedures Online. 18, 1, 40.

Research output: Contribution to journalArticle

17 Scopus citations

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System

Luo, X., Ribeiro, M., Bray, E. R., Lee, D. H., Yungher, B. J., Mehta, S. T., Thakor, K. A., Diaz, F., Lee, J. K., Moraes, C. T., Bixby, J. L., Lemmon, V. P. & Park, K. K., Apr 12 2016, In : Cell Reports. 15, 2, p. 398-410 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Follicle depletion provides a permissive environment for ovarian carcinogenesis

Wang, Y., Cai, K. Q., Smith, E. R., Yeasky, T. M., Moore, R., Ganjei-Azar, P., Klein-Szanto, A. J., Godwin, A. K., Hamilton, T. C. & Xua, X. X., Jan 1 2016, In : Molecular and cellular biology. 36, 18, p. 2418-2430 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fully automated islet cell counter (ICC) for the assessment of islet mass, purity, and size distribution by digital image analysis

Buchwald, P., Bernal, A., Echeverri, F., Tamayo-Garcia, A., Linetsky, E. & Ricordi, C., 2016, In : Cell Transplantation. 25, 10, p. 1747-1761 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

High quality, small molecule-activity datasets for kinase research [version 1; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

High quality, small molecule-activity datasets for kinase research [version 2; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

3 Scopus citations

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

Almaça, J., Molina, J., Menegaz, D., Pronin, A. N., Tamayo, A., Slepak, V., Berggren, P-O. Y. & Caicedo, A., Dec 20 2016, In : Cell Reports. 17, 12, p. 3281-3291 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Hyperactivated Stat3 boosts axon regeneration in the CNS

Mehta, S. T., Luo, X., Park, K. K., Bixby, J. L. & Lemmon, V. P., Jun 1 2016, In : Experimental neurology. 280, p. 115-120 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy

Hu, X., Chen, P., Wu, Y., Wang, K., Xu, Y., Chen, H., Zhang, L., Wu, R., Webster, K. A., Yu, H., Zhu, W. & Wang, J., Jul 1 2016, In : STEM CELLS. 34, 7, p. 1846-1858 13 p.

Research output: Contribution to journalArticle

20 Scopus citations
5 Scopus citations

N-Terminus of Cardiac Myosin Essential Light Chain Modulates Myosin Step-Size

Wang, Y., Ajtai, K., Kazmierczak, K., Szczesna-Cordary, D. & Burghardt, T. P., Jan 19 2016, In : Biochemistry. 55, 1, p. 186-198 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Physiological and hypoxic oxygen concentration differentially regulates human c-kit+ cardiac stem cell proliferation and migration

Bellio, M. A., Rodrigues, C. D., Landin, A. M., Hatzistergos, K. E., Kuznetsov, J., Florea, V., Valasaki, K., Khan, A., Hare, J. & Schulman, I. H., Dec 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 6, p. H1509-H1519

Research output: Contribution to journalArticle

15 Scopus citations

Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response

Kumar, A., Birnbaum, M. D., Patel, D. M., Morgan, W. M., Singh, J., Barrientos, A. & Zhang, F., Sep 29 2016, In : Cell Death and Disease. 7, 9, e2378.

Research output: Contribution to journalArticle

9 Scopus citations

Profound Actions of an Agonist of Growth Hormone–Releasing Hormone on Angiogenic Therapy by Mesenchymal Stem Cells

Ma, Q., Xia, X., Tao, Q., Lu, K., Shen, J., Xu, Q., Hu, X., Tang, Y., Block, N. L., Webster, K. A., Schally, A. V., Wang, J. & Yu, H., Feb 11 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

16 Scopus citations

RegenBase: A knowledge base of spinal cord injury biology for translational research

Callahan, A., Abeyruwan, S. W., Al-Ali, H., Sakurai, K., Ferguson, A. R., Popovich, P. G., Shah, N. H., Visser, U., Bixby, J. L. & Lemmon, V. P., 2016, In : Database. 2016, baw040.

Research output: Contribution to journalArticle

6 Scopus citations

Regulator of G protein signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein

Tayou, J., Wang, Q., Jang, G. F., Pronin, A. N., Orlandi, C., Martemyanov, K. A., Crabb, J. W. & Slepak, V. Z., Apr 22 2016, In : Journal of Biological Chemistry. 291, 17, p. 9133-9147 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1

Graham, R. M., Hernandez, F., Puerta, N., De Angulo, G., Webster, K. A. & Vanni, S., Feb 5 2016, In : Experimental and Molecular Medicine. 48, 2, e210.

Research output: Contribution to journalArticle

27 Scopus citations

Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

Nuñez, I., Pino, M. R., Wiley, D. J., Das, M. E., Chen, C., Goshima, T., Kume, K., Hirata, D., Toda, T. & Verde, F., Jul 30 2016, In : eLife. 5, JULY, e14216.

Research output: Contribution to journalArticle

7 Scopus citations

Synthesis, Nicotinic Acetylcholine Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(carbamoylpyridinyl)deschloroepibatidine Analogues

Ondachi, P. W., Castro, A. H., Luetje, C. W., Wageman, C. R., Marks, M. J., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Jul 20 2016, In : ACS Chemical Neuroscience. 7, 7, p. 1004-1012 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

The Cell Line Ontology integration and analysis of the knowledge of LINCS cell lines

Ong, E., Xie, J., Ni, Z., Liu, Q., Lin, Y., Stathias, V., Chung, C., Schuerer, S. C. & He, Y., 2016, In : CEUR Workshop Proceedings. 1747

Research output: Contribution to journalArticle

The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related

Rice, M. A., Ishteiwy, R. A., Magani, F., Udayakumar, T., Reiner, T., Yates, T. J., Miller, P., Perez-Stable, C., Rai, P., Verdun, R., Dykxhoorn, D. M. & Burnstein, K. L., Sep 8 2016, In : Oncogene. 35, 36, p. 4752-4761 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

The regulatory role of hepatoma-derived growth factor as an angiogenic factor in the eye

LeBlanc, M. E., Wang, W., Chen, X., Ji, Y., Shakya, A., Shen, C., Zhang, C., Gonzalez, V., Brewer, M., Ma, J. X., Wen, R., Zhang, F. & Li, W., Apr 23 2016, In : Molecular Vision. 22, p. 374-386 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Treatment with analgesics after mouse sciatic nerve injury does not alter expression of wound healingassociated genes

Danzi, M. C., Motti, D., Avison, D., Bixby, J. & Lemmon, V., Jan 1 2016, In : Neural Regeneration Research. 11, 1, p. 144-149 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Vascular regeneration in ischemic hindlimb by adeno-associated virus expressing conditionally silenced vascular endothelial growth factor

Boden, J., Lassance-Soares, R. M., Wang, H., Wei, Y., Spiga, M. G., Adi, J., Layman, H., Yu, H., Vazquez-Padron, R. I., Andreopoulos, F. & Webster, K. A., Jun 1 2016, In : Journal of the American Heart Association. 5, 6, e001815.

Research output: Contribution to journalArticle

18 Scopus citations

Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer

Thakkar, A., Wang, B., Picon-Ruiz, M., Buchwald, P. & Ince, T. A., May 1 2016, In : Breast cancer research and treatment. 157, 1, p. 77-90 14 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

Ruan, K., Zhu, Y., Li, C., Brazill, J. M. & Zhai, R. G., Nov 30 2015, In : Nature Communications. 6, 10057.

Research output: Contribution to journalArticle

21 Scopus citations

A Novel Method of Determining the Functional Effects of a Minor Genetic Modification of a Protein

Nagwekar, J., Duggal, D., Midde, K., Rich, R., Liang, J., Kazmierczak, K., Huang, W., Fudala, R., Gryczynski, I., Gryczynski, Z., Szczesna-Cordary, D. & Borejdo, J., Nov 18 2015, In : Frontiers in Cardiovascular Medicine. 2, 35.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase

Zhang, F., Patel, D. M., Colavita, K., Rodionova, I., Buckley, B., Scott, D. A., Kumar, A., Shabalina, S. A., Saha, S., Chernov, M., Osterman, A. L. & Kashina, A., Jul 15 2015, In : Nature Communications. 6, 8517.

Research output: Contribution to journalArticle

19 Scopus citations

Atg27 tyrosine sorting motif is important for its trafficking and Atg9 localization

Segarra, V. A., Boettner, D. R. & Lemmon, S., Apr 1 2015, In : Traffic. 16, 4, p. 365-378 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

BioAssay Research Database (BARD): Chemical biology and probe-development enabled by structured metadata and result types

Howe, E. A., De Souza, A., Lahr, D. L., Chatwin, S., Montgomery, P., Alexander, B. R., Nguyen, D. T., Cruz, Y., Stonich, D. A., Walzer, G., Rose, J. T., Picard, S. C., Liu, Z., Rose, J. N., Xiang, X., Asiedu, J., Durkin, D., Levine, J., Yang, J. J., Schürer, S. C. & 10 others, Braisted, J. C., Southall, N., Southern, M. R., Chung, T. D. Y., Brudz, S., Tanega, C., Schreiber, S. L., Bittker, J. A., Guha, R. & Clemons, P. A., Jan 28 2015, In : Nucleic acids research. 43, D1, p. D1163-D1170

Research output: Contribution to journalArticle

15 Scopus citations

Biphasic decline of β-cell function with age in euglycemic nonobese diabetic mice parallels diabetes onset

Cechin, S. R., Lopez-Ocejo, O., Karpinsky-Semper, D. & Buchwald, P., Aug 1 2015, In : IUBMB Life. 67, 8, p. 634-644 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Bnip3 binds and activates p300: Possible role in cardiac transcription and myocyte morphology

Thompson, J. W., Wei, J., Appau, K., Wang, H., Yu, H., Spiga, M. G., Graham, R. M. & Webster, K. A., Aug 28 2015, In : PloS one. 10, 8, e0136847.

Research output: Contribution to journalArticle

8 Scopus citations

BNIP3 promotes calcium and calpain-dependent cell death

Graham, R. M., Thompson, J. W. & Webster, K. A., Dec 1 2015, In : Life Sciences. 142, p. 26-35 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Bone marrow-derived c-kit+ cells attenuate neonatal hyperoxia-induced lung injury

Ramachandran, S., Suguihara, C., Drummond, S., Chatzistergos, K., Klim, J., Torres, E., Huang, J., Hehre, D., Rodrigues, C. D., McNiece, I. K., Hare, J. & Young, K., Jan 1 2015, In : Cell Transplantation. 24, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
18 Scopus citations

Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells

Peschansky, V. J., Pastori, C., Zeier, Z., Motti, D., Wentzel, K., Velmeshev, D., Magistri, M., Bixby, J. L., Lemmon, V. P., Silva, J. P. & Wahlestedt, C., 2015, In : Frontiers in Genetics. 6, Aug, 263.

Research output: Contribution to journalArticle

15 Scopus citations