Molecular and Cellular Pharmacology

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2008

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

Wen, Y., Pinto, J. R., Gomes, A. V., Xu, Y., Wang, Y., Wang, Y., Potter, J. D. & Kerrick, W. G. L., Jul 18 2008, In : Journal of Biological Chemistry. 283, 29, p. 20484-20494 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Functional deficits in nNOSμ-deficient skeletal muscle: Myopathy in nNOS knockout mice

Percival, J. M., Anderson, K. N. E., Gregorevic, P., Chamberlain, J. S. & Froehner, S. C., Oct 13 2008, In : PloS one. 3, 10, e3387.

Research output: Contribution to journalArticle

67 Scopus citations

Glucocorticoid receptor binding: A biphasic dependence on molecular size as revealed by the bilinear LinBiExp model

Buchwald, P., Feb 1 2008, In : Steroids. 73, 2, p. 193-208 16 p.

Research output: Contribution to journalArticle

31 Scopus citations

High-throughput screening for human galactokinase inhibitors

Wierenga, K. J., Lai, K., Buchwald, P. & Tang, M., Aug 2008, In : Journal of Biomolecular Screening. 13, 5, p. 415-423 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

High tolerance for ionizable residues in the hydrophobic interior of proteins

Isom, D. G., Cannon, B. R., Castañeda, C. A., Robinson, A. & García-Moreno E., B., Nov 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 46, p. 17784-17788 5 p.

Research output: Contribution to journalArticle

106 Scopus citations

Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening

Schürer, S. C., Brown, S. J., Gonzalez-Cabrera, P. J., Schaeffer, M. T., Chapman, J., Jo, E., Chase, P., Spicer, T., Hodder, P. & Rosen, H., Aug 15 2008, In : ACS Chemical Biology. 3, 8, p. 486-498 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer

Lyons, L. S., Rao, S., Balkan, W., Faysal, J., Maiorino, C. A. & Burnstein, K. L., Mar 2008, In : Molecular Endocrinology. 22, 3, p. 597-608 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

Landstrom, A. P., Parvatiyar, M. S., Pinto, J. R., Marquardt, M. L., Bos, J. M., Tester, D. J., Ommen, S. R., Potter, J. D. & Ackerman, M. J., Aug 2008, In : Journal of Molecular and Cellular Cardiology. 45, 2, p. 281-288 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

MsrA protects cardiac myocytes against hypoxia/reoxygenation induced cell death

Prentice, H. M., Moench, I. A., Rickaway, Z. T., Dougherty, C. J., Webster, K. A. & Weissbach, H., Feb 15 2008, In : Biochemical and biophysical research communications. 366, 3, p. 775-778 4 p.

Research output: Contribution to journalArticle

45 Scopus citations

Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice

Baudenbacher, F., Schober, T., Pinto, J. R., Sidorov, V. Y., Hilliard, F., Solaro, R. J., Potter, J. D. & Knollmann, B. C., Dec 1 2008, In : Journal of Clinical Investigation. 118, 12, p. 3893-3903 11 p.

Research output: Contribution to journalArticle

160 Scopus citations

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

Zhai, R. G., Zhang, F., Hiesinger, P. R., Cao, Y., Haueter, C. M. & Bellen, H. J., Apr 17 2008, In : Nature. 452, 7189, p. 887-891 5 p.

Research output: Contribution to journalArticle

143 Scopus citations

Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats

Wu, W. M., Huang, F., Lee, Y., Buchwald, P. & Bodor, N., Mar 1 2008, In : Journal of Pharmacy and Pharmacology. 60, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gβ5 complexes in brain

Grabowska, D., Jayaraman, M., Kaltenbronn, K. M., Sandiford, S. L., Wang, Q., Jenkins, S., Slepak, V. Z., Smith, Y. & Blumer, K. J., Feb 19 2008, In : Neuroscience. 151, 4, p. 969-982 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Proteomics in Trypanosoma cruzi- Localization of novel proteins to various organelles

Ferella, M., Nilsson, D., Darban, H., Rodrigues, C., Bontempi, E. J., Docampo, R. & Andersson, B., Jul 1 2008, In : Proteomics. 8, 13, p. 2735-2749 15 p.

Research output: Contribution to journalArticle

52 Scopus citations

Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300

Wei, J. Q., Shehadeh, L. A., Mitrani, J. M., Pessanha, M., Slepak, T. I., Webster, K. A. & Bishopric, N. H., Aug 26 2008, In : Circulation. 118, 9, p. 934-946 13 p.

Research output: Contribution to journalArticle

79 Scopus citations

Retrometabolic drug design: Principles and recent developments

Bodor, N. & Buchwald, P., Aug 1 2008, In : Pure and Applied Chemistry. 80, 8, p. 1669-1682 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Robust hypoxia-selective regulation of a retinal pigment epithelium-specific adeno-associated virus vector

Dougherty, C. J., Smith, G. W., Dorey, C. K., Prentice, H. M., Webster, K. A. & Blanks, J. C., Mar 7 2008, In : Molecular vision. 14, p. 471-480 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle

Kato, H., Matsunaga, F., Miyazaki, S., Yin, L., D'Urso, G., Tanaka, K. & Murakami, Y., Apr 15 2008, In : Cell Cycle. 7, 8, p. 1083-1094 12 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Soft corticosteroids for local immunosuppression: Exploring the possibility for the use of loteprednol etabonate for islet transplantation

Bocca, N., Pileggi, A., Molano, R. D., Marzorati, S., Wu, W., Bodor, N., Ricordi, C. & Buchwald, P., Mar 1 2008, In : Pharmazie. 63, 3, p. 226-232 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Stereoisomers of N-substituted soft anticholinergics and their zwitterionic metabolite based on glycopyrrolate - Syntheses and pharmacological evaluations

Wu, W. M., Wu, J., Mori, N., Buchwald, P. & Bodor, N., Mar 1 2008, In : Pharmazie. 63, 3, p. 200-209 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Troponin and cardiomyopathy

Chang, A. N., Parvatiyar, M. S. & Potter, J. D., Apr 25 2008, In : Biochemical and biophysical research communications. 369, 1, p. 74-81 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Zinc potentiates neuronal nicotinic receptors by increasing burst duration

Hsiao, B., Mihalak, K. B., Magleby, K. L. & Luetje, C. W., Feb 1 2008, In : Journal of neurophysiology. 99, 2, p. 999-1007 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2007

A general bilinear model to describe growth or decline time profiles

Buchwald, P., Jan 1 2007, In : Mathematical Biosciences. 205, 1, p. 108-136 29 p.

Research output: Contribution to journalArticle

28 Scopus citations

A honey bee odorant receptor for the queen substance 9-oxo-2-decenoic acid

Wanner, K. W., Nichols, A. S., Walden, K. K. O., Brockmann, A., Luetje, C. W. & Robertson, H. M., Sep 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 36, p. 14383-14388 6 p.

Research output: Contribution to journalArticle

134 Scopus citations

Arrestin Mobilizes Signaling Proteins to the Cytoskeleton and Redirects their Activity

Hanson, S. M., Cleghorn, W. M., Francis, D. J., Vishnivetskiy, S. A., Raman, D., Song, X., Nair, K. S., Slepak, V. Z., Klug, C. S. & Gurevich, V. V., Apr 27 2007, In : Journal of molecular biology. 368, 2, p. 375-387 13 p.

Research output: Contribution to journalArticle

88 Scopus citations

Coping with cyclic oxygen availability: Evolutionary aspects

Flück, M., Webster, K. A., Graham, J., Giomi, F., Gerlach, F. & Schmitz, A., Oct 1 2007, In : Integrative and comparative biology. 47, 4, p. 524-531 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development

Wang, Y., Szczesna-Cordary, D., Craig, R., Diaz-Perez, Z., Guzman, G., Miller, T. & Potter, J. D., Jul 2007, In : FASEB Journal. 21, 9, p. 2205-2214 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

From critters to cancers: Bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

Hoogewijs, D., Terwilliger, N. B., Webster, K. A., Powell-Coffman, J. A., Tokishita, S., Yamagata, H., Hankeln, T., Burmester, T., Rytknen, K. T., Nikinmaa, M., Abele, D., Heise, K., Lucassen, M., Fandrey, J., Maxwell, P. H., Phlman, S. & Gorr, T. A., Oct 2007, In : Integrative and comparative biology. 47, 4, p. 552-577 26 p.

Research output: Contribution to journalArticle

22 Scopus citations

Genetic elucidation of human hyperosmia to isovaleric acid

Menashe, I., Abaffy, T., Hasin, Y., Goshen, S., Yahalom, V., Luetje, C. W. & Lancet, D., Nov 2007, In : PLoS biology. 5, 11, p. 2462-2468 7 p.

Research output: Contribution to journalArticle

134 Scopus citations

Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy

Gomez, L. A., De Las Pozas, A., Reiner, T., Burnstein, K. & Perez-Stable, C., May 1 2007, In : Molecular cancer therapeutics. 6, 5, p. 1534-1543 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Intramolecular interaction between the DEP domain of RGS7 and the Gβ5 subunit

Narayanan, V., Sandiford, S. L., Wang, Q., Keren-Raifman, T., Levay, K. & Slepak, V. Z., Jun 12 2007, In : Biochemistry. 46, 23, p. 6859-6870 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model

Slepak, T. I., Tang, M., Slepak, V. Z. & Lai, K., Sep 1 2007, In : Molecular Genetics and Metabolism. 92, 1-2, p. 78-87 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Jun kinase delays caspase-9 activation by interaction with the apoptosome

Tran, T. H., Andreka, P., Rodrigues, C. O., Webster, K. A. & Bishopric, N. H., Jul 13 2007, In : Journal of Biological Chemistry. 282, 28, p. 20340-20350 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene

Bianco, S. D. C., Peng, J. B., Takanaga, H., Suzuki, Y., Crescenzi, A., Kos, C. H., Zhuang, L., Freeman, M. R., Gouveia, C. H. A., Wu, J., Luo, H., Mauro, T., Brown, E. M. & Hediger, M. A., Feb 2007, In : Journal of Bone and Mineral Research. 22, 2, p. 274-285 12 p.

Research output: Contribution to journalArticle

203 Scopus citations

Myocyte deficiency as a target in the treatment of cardiomyopathy

Rodrigues, C. O., Shehadeh, L. A., Webster, K. A. & Bishopric, N. H., Sep 1 2007, In : Progress in Pediatric Cardiology. 23, 1-2, p. 49-59 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients

Szczesna-Cordary, D., Jones, M., Moore, J. R., Watt, J., Kerrick, W. G. L., Xu, Y., Wang, Y., Wagg, C. & Lopaschuk, G. D., Dec 1 2007, In : FASEB Journal. 21, 14, p. 3974-3985 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Novel, cell-penetrating molecular transporters with flexible backbones and permanently charged side-chains

Bodor, N., Tóth-Sarudy, É., Holm, T., Pallagi, I., Vass, E., Buchwald, P. & Langel, Ü., Aug 1 2007, In : Journal of Pharmacy and Pharmacology. 59, 8, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Parvalbumin isoforms differentially accelerate cardiac myocyte relaxation kinetics in an animal model of diastolic dysfunction

Rodenbaugh, D. W., Wang, W., Davis, J., Edwards, T., Potter, J. D. & Metzger, J. M., Sep 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 3, p. H1705-H1713

Research output: Contribution to journalArticle

16 Scopus citations

PKC-α and TAK-1 are intermediates in the activation of c-Jun NH 2-terminal kinase by hypoxia-reoxygenation

Frazier, D. P., Wilson, A., Dougherty, C. J., Li, H., Bishopric, N. H. & Webster, K. A., Apr 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 4, p. H1675-H1684

Research output: Contribution to journalArticle

26 Scopus citations

Regulation of Bnip3 death pathways by calcium, phosphorylation, and hypoxia-reoxygenation

Graham, R. M., Thompson, J. W., Wei, J., Bishopric, N. H. & Webster, K. A., Sep 1 2007, In : Antioxidants and Redox Signaling. 9, 9, p. 1309-1315 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p

Das, M., Wiley, D. J., Medina, S., Vincent, H. A., Larrea, M., Oriolo, A. & Verde, F., Jun 2007, In : Molecular biology of the cell. 18, 6, p. 2090-2101 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins

Rosenzweig, D. H., Saidas Nair, K., Wei, J., Wang, Q., Garwin, G., Saari, J. C., Chen, C. K., Smrcka, A. V., Swaroop, A., Lem, J., Hurley, J. B. & Slepak, V. Z., May 16 2007, In : Journal of Neuroscience. 27, 20, p. 5484-5494 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression

Levay, K. & Slepak, V. Z., Sep 4 2007, In : Journal of Clinical Investigation. 117, 9, p. 2672-2683 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model

Layman, H., Spiga, M. G., Brooks, T., Pham, S., Webster, K. A. & Andreopoulos, F. M., Jun 2007, In : Biomaterials. 28, 16, p. 2646-2654 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

The molecular basis for ligand specificity in a mouse olfactory receptor: A network of functionally important residues

Abaffy, T., Malhotra, A. & Luetje, C. W., Jan 12 2007, In : Journal of Biological Chemistry. 282, 2, p. 1216-1224 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation

Da-Silva, W. S., Harney, J. W., Kim, B. W., Li, J., Bianco, S. D. C., Crescenzi, A., Christoffolete, M. A., Huang, S. A. & Bianco, A. C., Mar 1 2007, In : Diabetes. 56, 3, p. 767-776 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

Triadins modulate intracellular Ca2+ homeostasis but are not essential for excitation-contraction coupling in skeletal muscle

Shen, X., Franzini-Armstrong, C., Lopez, J. R., Jones, L. R., Kobayashi, Y. M., Wang, Y., Kerrick, W. G. L., Caswell, A. H., Potter, J. D., Miller, T., Allen, P. D. & Perez, C. F., Dec 28 2007, In : Journal of Biological Chemistry. 282, 52, p. 37864-37874 11 p.

Research output: Contribution to journalArticle

55 Scopus citations
2006

96-Well electroporation method for transfection of mammalian central neurons

Buchser, W. J., Pardinas, J. R., Shi, Y., Bixby, J. L. & Lemmon, V. P., Nov 2006, In : BioTechniques. 41, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Acidosis regulates the stability, hydrophobicity, and activity of the BH3-only protein Bnip3

Frazier, D. P., Wilson, A., Graham, R. M., Thompson, J. W., Bishopric, N. H. & Webster, K. A., Sep 1 2006, In : Antioxidants and Redox Signaling. 8, 9-10, p. 1625-1634 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Activity-Independent Prespecification of Synaptic Partners in the Visual Map of Drosophila

Hiesinger, P. R., Zhai, R. G., Zhou, Y., Koh, T. W., Mehta, S. Q., Schulze, K. L., Cao, Y., Verstreken, P., Clandinin, T. R., Fischbach, K. F., Meinertzhagen, I. A. & Bellen, H. J., Sep 19 2006, In : Current Biology. 16, 18, p. 1835-1843 9 p.

Research output: Contribution to journalArticle

69 Scopus citations