Molecular and Cellular Pharmacology

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2017
6 Scopus citations

Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice

Wang, L., Kazmierczak, K., Yuan, C. C., Yadav, S., Kawai, M. & Szczesna-Cordary, D., Jun 1 2017, In : FEBS Journal. 284, 12, p. 1897-1913 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Comprehensive metabolomics study to assess longitudinal biochemical changes and potential early biomarkers in nonobese diabetic mice that progress to diabetes

Buchwald, P., Tamayo-Garcia, A., Ramamoorthy, S., Garcia-Contreras, M., Mendez, A. J. & Ricordi, C., Oct 6 2017, In : Journal of Proteome Research. 16, 10, p. 3873-3890 18 p.

Research output: Contribution to journalArticle

4 Scopus citations

Defining disease, diagnosis, and translational medicine within a homeostatic perturbation paradigm: The National Institutes of Health undiagnosed diseases program experience

Gall, T., Valkanas, E., Bello, C., Markello, T., Adams, C., Bone, W. P., Brandt, A. J., Brazill, J. M., Carmichael, L., Davids, M., Davis, J., Diaz-Perez, Z., Draper, D., Elson, J., Flynn, E. D., Godfrey, R., Groden, C., Hsieh, C. K., Fischer, R., Golas, G. A. & 31 others, Guzman, J., Huang, Y., Kane, M. S., Lee, E., Li, C., Links, A. E., Maduro, V., Malicdan, M. C. V., Malik, F. S., Nehrebecky, M., Park, J., Pemberton, P., Schaffer, K., Simeonov, D., Sincan, M., Smedley, D., Valivullah, Z., Wahl, C., Washington, N., Wolfe, L. A., Xu, K., Zhu, Y., Gahl, W. A., Tifft, C. J., Toro, C., Adams, D. R., He, M., Robinson, P. N., Haendel, M. A., Zhai, R. G. & Boerkoel, C. F., Jan 1 2017, In : Frontiers in Medicine. 4, MAY, 62.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop

Jagodnik, K. M., Koplev, S., Jenkins, S. L., Ohno-Machado, L., Paten, B., Schuerer, S. C., Dumontier, M., Verborgh, R., Bui, A., Ping, P., McKenna, N. J., Madduri, R., Pillai, A. & Ma'ayan, A., Jul 1 2017, In : Journal of Biomedical Informatics. 71, p. 49-57 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Drug target ontology to classify and integrate drug discovery data

Lin, Y., Mehta, S., Küçük-McGinty, H., Turner, J. P., Vidovic, D., Forlin, M., Koleti, A., Nguyen, D. T., Jensen, L. J., Guha, R., Mathias, S. L., Ursu, O., Stathias, V., Duan, J., Nabizadeh, N., Chung, C., Mader, C., Visser, U. E., Yang, J. J., Bologa, C. G. & 2 others, Oprea, T. I. & Schuerer, S. C., Nov 9 2017, In : Journal of Biomedical Semantics. 8, 1, 50.

Research output: Contribution to journalArticle

8 Scopus citations

Enhanced cardioprotection by human endometrium mesenchymal stem cells driven by exosomal MicroRNA-21

Wang, K., Jiang, Z., Webster, K. A., Chen, J., Hu, H., Zhou, Y., Zhao, J., Wang, L., Wang, Y., Zhong, Z., Ni, C., Li, Q., Xiang, C., Zhang, L., Wu, R., Zhu, W., Yu, H., Hu, X. & Wang, JA., Jan 1 2017, In : Stem cells translational medicine. 6, 1, p. 209-222 14 p.

Research output: Contribution to journalArticle

65 Scopus citations

From flamingo dance to (desirable) drug discovery: A nature-inspired approach

Sánchez-Rodríguez, A., Pérez-Castillo, Y., Schuerer, S. C., Nicolotti, O., Mangiatordi, G. F., Borges, F., Cordeiro, M. N. D. S., Tejera, E., Medina-Franco, J. L. & Cruz-Monteagudo, M., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

6 Scopus citations

Functional and nonfunctional forms of CquiOR91, an odorant selectivity subunit of Culex quinquefasciatus

Hughes, D. T., Pelletier, J., Rahman, S., Chen, S., Leal, W. S. & Luetje, C. W., May 1 2017, In : Chemical Senses. 42, 4, p. 333-341 9 p., bjx011.

Research output: Contribution to journalArticle

1 Scopus citations

Functional characterizations of rare UBA1 variants in X-linked Spinal Muscular Atrophy

Baumbach-Reardon, L., Balak, C. D., Hunter, J. M., Ahearn, M. E., Wiley, D. & D'urso, G., 2017, In : F1000Research. 6, 1636.

Research output: Contribution to journalArticle

3 Scopus citations

Glucose-stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets

Buchwald, P., Tamayo-Garcia, A., Manzoli, V., Tomei, A. & Stabler, C. L., 2017, (Accepted/In press) In : Biotechnology and Bioengineering.

Research output: Contribution to journalArticle

17 Scopus citations
10 Scopus citations

Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice

Yuan, C. C., Kazmierczak, K., Liang, J., Takeuchi, R., Irving, T. C., Gomes, A. V., Wang, Y., Burghardt, T. P. & Szczesna-Cordary, D., Aug 1 2017, In : Cardiovascular Research. 113, 10, p. 1124-1136 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential

Bellio, M. A., Pinto, M. T., Florea, V., Barrios, P. A., Taylor, C. N., Brown, A. B., Lamondin, C., Hare, J., Schulman, I. H. & Rodrigues, C. D., Dec 1 2017, In : Scientific Reports. 7, 1, 9702.

Research output: Contribution to journalArticle

3 Scopus citations

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

Allen, B. K., Mehta, S., Ember, S. W. J., Zhu, J. Y., Schönbrunn, E., Ayad, N. & Schuerer, S. C., Jan 1 2017, In : ACS Omega. 2, 8, p. 4760-4771 12 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Identification of miRNAs involved in DRG neurite outgrowth and their putative targets

Motti, D., Lerch, J. K., Danzi, M. C., Gans, J. H., Kuo, F., Slepak, T. I., Bixby, J. & Lemmon, V., 2017, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit

Kepchia, D., Moliver, S., Chohan, K., Phillips, C. & Luetje, C. W., May 1 2017, In : PLoS One. 12, 5, e0177454.

Research output: Contribution to journalArticle

4 Scopus citations
4 Scopus citations

Loss of c-Kit function impairs arteriogenesis in a mouse model of hindlimb ischemia

Hernandez, D. R., Artiles, A., Duque, J. C., Martinez, L., Pinto, M. T., Webster, K. A., Velazquez, O. C., Vazquez-Padron, R. I. & Soares, R., Jan 1 2017, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

1 Scopus citations

Mammalian odorant receptor tuning breadth persists across distinct odorant panels

Kepchia, D., Sherman, B., Haddad, R. & Luetje, C. W., Sep 1 2017, In : PLoS One. 12, 9, e0185329.

Research output: Contribution to journalArticle

1 Scopus citations

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets

Garcia-Contreras, M., Tamayo-Garcia, A., Pappan, K. L., Michelotti, G. A., Stabler, C. L., Ricordi, C. & Buchwald, P., Jun 2 2017, In : Journal of Proteome Research. 16, 6, p. 2294-2306 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mutant cycle analysis identifies a ligand interaction site in an odorant receptor of the malaria vector Anopheles gambiae

Rahman, S. & Luetje, C. W., Jan 1 2017, In : Journal of Biological Chemistry. 292, 46, p. 18916-18923 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

Zhu, J., Lu, K., Zhang, N., Zhao, Y., Ma, Q., Shen, J., Lin, Y., Xiang, P., Tang, Y., Hu, X., Chen, J., Zhu, W., Webster, K. A., Wang, J. & Yu, H., Nov 14 2017, (Accepted/In press) In : Artificial Cells, Nanomedicine and Biotechnology. p. 1-12 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms

Moon, Y., Balke, J. E., Madorma, D., Siegel, M. P., Knowels, G., Brouckaert, P., Buys, E. S., Marcinek, D. J. & Percival, J., Jun 10 2017, In : Antioxidants and Redox Signaling. 26, 17, p. 966-985 20 p.

Research output: Contribution to journalArticle

11 Scopus citations

Ontological representation, integration, and analysis of LINCS cell line cells and their cellular responses

Ong, E., Xie, J., Ni, Z., Liu, Q., Sarntivijai, S., Lin, Y., Cooper, D., Terryn, R., Stathias, V., Chung, C., Schuerer, S. C. & He, Y., Dec 21 2017, In : BMC Bioinformatics. 18, 556.

Research output: Contribution to journalArticle

5 Scopus citations

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Gao, H., Danzi, M. C., Choi, C. S., Taherian, M., Dalby-Hansen, C., Ellman, D. G., Madsen, P. M., Bixby, J., Lemmon, V., Lambertsen, K. L. & Brambilla, R., Jan 3 2017, In : Cell Reports. 18, 1, p. 198-212 15 p.

Research output: Contribution to journalArticle

41 Scopus citations

Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease

Wang, W., LeBlanc, M. E., Chen, X., Chen, P., Ji, Y., Brewer, M., Tian, H., Spring, S. R., Webster, K. A. & Li, W., Apr 26 2017, (Accepted/In press) In : Angiogenesis. p. 1-14 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pharos: Collating protein information to shed light on the druggable genome

Nguyen, D. T., Mathias, S., Bologa, C., Brunak, S., Fernandez, N., Gaulton, A., Hersey, A., Holmes, J., Jensen, L. J., Karlsson, A., Liu, G., Ma'ayan, A., Mandava, G., Mani, S., Mehta, S., Overington, J., Patel, J., Rouillard, A. D., Schuerer, S. C., Sheils, T. & 10 others, Simeonov, A., Sklar, L. A., Southall, N., Ursu, O., Vidovic, D., Waller, A., Yang, J., Jadhav, A., Oprea, T. I. & Guha, R., Jan 1 2017, In : Nucleic Acids Research. 45, D1, p. D995-D1002

Research output: Contribution to journalArticle

50 Scopus citations
5 Scopus citations

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

Lenguito, G., Chaimov, D., Weitz, J. R., Rodriguez Diaz, R., Rawal, S. A. K., Tamayo-Garcia, A., Caicedo-Vierkant, D. A., Stabler, C. L., Buchwald, P. & Agarwal, A., 2017, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 17, 5, p. 772-781 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting

Luo, J., Attard, G., Balk, S. P., Bevan, C., Burnstein, K. L., Cato, L., Cherkasov, A., De Bono, J. S., Dong, Y., Gao, A. C., Gleave, M., Heemers, H., Kanayama, M., Kittler, R., Lang, J. M., Lee, R. J., Logothetis, C. J., Matusik, R., Plymate, S., Sawyers, C. L. & 7 others, Selth, L. A., Soule, H., Tilley, W., Weigel, N. L., Zoubeidi, A., Dehm, S. M. & Raj, G. V., Jan 1 2017, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

36 Scopus citations

Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction

Chen, J., Song, Y., Bojadzic, D., Tamayo-Garcia, A., Landin, A. M., Blomberg, B. B. & Buchwald, P., Nov 9 2017, In : Journal of Medicinal Chemistry. 60, 21, p. 8906-8922 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome

Li, C., Brazill, J. M., Liu, S., Bello, C., Zhu, Y., Morimoto, M., Cascio, L., Pauly, R., Diaz-Perez, Z., Malicdan, M. C. V., Wang, H., Boccuto, L., Schwartz, C. E., Gahl, W. A., Boerkoel, C. F. & Zhai, R. G., Dec 1 2017, In : Nature Communications. 8, 1, 1257.

Research output: Contribution to journalArticle

15 Scopus citations

Stability and function of a putative microtubule-organizing center in the human parasite Toxoplasma gondii

Leung, J. M., He, Y., Zhang, F., Hwang, Y. C., Nagayasu, E., Liu, J., Murray, J. M. & Hu, K., May 15 2017, In : Molecular Biology of the Cell. 28, 10, p. 1361-1378 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Stress increases peripheral axon growth and regeneration through glucocorticoid receptor-dependent transcriptional programs

Lerch, J. K., Alexander, J. K., Madalena, K. M., Motti, D., Quach, T., Dhamija, A., Zha, A., Gensel, J. C., Marketon, J. W., Lemmon, V., Bixby, J. & Popovich, P. G., Jul 1 2017, In : eNeuro. 4, 4, e0246-17.2017.

Research output: Contribution to journalArticle

5 Scopus citations

Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia

Reiter, J., Drummond, S., Sammour, I., Huang, J., Florea, V., Dornas, P., Hare, J., Rodrigues, C. D. & Young, K., Jul 12 2017, In : Respiratory Research. 18, 1, 137.

Research output: Contribution to journalArticle

15 Scopus citations

Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues

Ondachi, P. W., Castro, A. H., Sherman, B., Luetje, C. W., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Jan 18 2017, In : ACS Chemical Neuroscience. 8, 1, p. 115-127 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Systemic QSAR and phenotypic virtual screening: Chasing butterflies in drug discovery

Cruz-Monteagudo, M., Schuerer, S. C., Tejera, E., Pérez-Castillo, Y., Medina-Franco, J. L., Sánchez-Rodríguez, A. & Borges, F., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

12 Scopus citations

Targeting AR variant–coactivator interactions to exploit prostate cancer vulnerabilities

Magani, F., Peacock, S. O., Rice, M. A., Martinez, M. J., Greene, A. M., Magani, P. S., Lyles, R., Weitz, J. R. & Burnstein, K. L., Nov 1 2017, In : Molecular Cancer Research. 15, 11, p. 1469-1480 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Teaching an old drug new tricks: Agonism, antagonism, and biased signaling of pilocarpine through M3 muscarinic acetylcholine receptor

Pronin, A. N., Wang, Q. & Slepak, V. Z., Nov 1 2017, In : Molecular Pharmacology. 92, 5, p. 601-612 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

The mTOR substrate S6 kinase 1 (S6K1) is a negative regulator of axon regeneration and a potential drug target for central nervous system injury

Al-Ali, H., Ding, Y., Slepak, T., Wu, W., Sun, Y., Martinez, Y., Xu, X. M., Lemmon, V. & Bixby, J., Jul 26 2017, In : Journal of Neuroscience. 37, 30, p. 7079-7095 17 p.

Research output: Contribution to journalArticle

26 Scopus citations

Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer

Samaranayake, G. J., Troccoli, C. I., Huynh, M., Lyles, R. D. Z., Kage, K., Win, A., Lakshmanan, V., Kwon, D., Ban, Y., Chen, X., Zarco, E. R., Jorda, M., Burnstein, K. L. & Rai, P., Dec 1 2017, In : Nature Communications. 8, 1, 1204.

Research output: Contribution to journalArticle

8 Scopus citations

TIN-X: target importance and novelty explorer

Cannon, D. C., Yang, J. J., Mathias, S. L., Ursu, O., Mani, S., Waller, A., Schuerer, S. C., Jensen, L. J., Sklar, L. A., Bologa, C. G. & Oprea, T. I., Aug 15 2017, In : Bioinformatics (Oxford, England). 33, 16, p. 2601-2603 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging

Ruetenik, A. L., Ocampo, A., Ruan, K., Zhu, Y., Li, C., Zhai, R. G. & Barrientos, A., Aug 1 2016, In : Microbial Cell. 3, 8, p. 338-351 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Auxilin facilitates membrane traffic in the early secretory pathway

Ding, J., Segarra, V. A., Chen, S., Cai, H., Lemmon, S. & Ferro-Novick, S., Jan 1 2016, In : Molecular Biology of the Cell. 27, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Building concordant ontologies for drug discovery

Küçük-McGinty, H., Mehta, S., Lin, Y., Nabizadeh, N., Stathias, V., Vidovic, D., Koleti, A., Mader, C., Duan, J., Visser, U. E. & Schuerer, S. C., 2016, In : CEUR Workshop Proceedings. 1747

Research output: Contribution to journalArticle

Cell length growth patterns in fission yeast reveal a novel size control mechanism operating in late G2 phase

Horváth, A., Rácz-Mónus, A., Buchwald, P. & Sveiczer, Á., Sep 1 2016, In : Biology of the Cell. 108, 9, p. 259-277 19 p.

Research output: Contribution to journalArticle

5 Scopus citations

Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain

Boettner, D. R., Segarra, V. A., Moorthy, B. T., de León, N., Creagh, J., Collette, J. R., Malhotra, A. & Lemmon, S., Jul 1 2016, In : Traffic. 17, 7, p. 754-768 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Dose-escalation study of octanoic acid in patients with essential tremor

Voller, B., Lines, E., McCrossin, G., Tinaz, S., Lungu, C., Grimes, G., Starling, J., Potti, G., Buchwald, P., Haubenberger, D. & Hallett, M., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Edelfosine promotes apoptosis in androgen-deprived prostate tumors by increasing atf3 and inhibiting androgen receptor activity

Udayakumar, T., Stoyanova, R., Shareef, M. M., Mu, Z., Philip, S., Burnstein, K. L. & Pollack, A., Jun 1 2016, In : Molecular Cancer Therapeutics. 15, 6, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

5 Scopus citations