Molecular and Cellular Pharmacology

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2018

Publisher Correction: Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Hervera, A., de Virgiliis, F., Palmisano, I., Zhou, L., Tantardini, E., Kong, G., Hutson, T., Danzi, M. C., Perry, R. B. T., Santos, C. X. C., Kapustin, A. N., Fleck, R. A., Del Río, J. A., Carroll, T., Lemmon, V., Bixby, J., Shah, A. M., Fainzilber, M. & Di Giovanni, S., Mar 8 2018, (Accepted/In press) In : Nature Cell Biology. 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Quantitative cell biology of neurodegeneration in drosophila through unbiased analysis of fluorescently tagged proteins using imageJ

Brazill, J. M., Zhu, Y., Li, C. & Zhai, R. G., Aug 3 2018, In : Journal of Visualized Experiments. 2018, 138, e58041.

Research output: Contribution to journalArticle

2 Scopus citations

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Hervera, A., De Virgiliis, F., Palmisano, I., Zhou, L., Tantardini, E., Kong, G., Hutson, T., Danzi, M. C., Perry, R. B. T., Santos, C. X. C., Kapustin, A. N., Fleck, R. A., Del Río, J. A., Carroll, T., Lemmon, V., Bixby, J., Shah, A. M., Fainzilber, M. & Di Giovanni, S., Mar 1 2018, In : Nature Cell Biology. 20, 3, p. 307-319 13 p.

Research output: Contribution to journalArticle

43 Scopus citations

Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth

Donda, K., Zambrano, R., Moon, Y., Percival, J., Vaidya, R., Dapaah-Siakwan, F., Luo, S., Duncan, M. R., Bao, Y., Wang, L., Qin, L., Benny, M., Young, K. & Wu, S., Jul 1 2018, In : PLoS One. 13, 7, e0199927.

Research output: Contribution to journalArticle

5 Scopus citations

Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting

Luo, J., Attard, G., Balk, S. P., Bevan, C., Burnstein, K., Cato, L., Cherkasov, A., De Bono, J. S., Dong, Y., Gao, A. C., Gleave, M., Heemers, H., Kanayama, M., Kittler, R., Lang, J. M., Lee, R. J., Logothetis, C. J., Matusik, R., Plymate, S., Sawyers, C. L. & 7 others, Selth, L. A., Soule, H., Tilley, W., Weigel, N. L., Zoubeidi, A., Dehm, S. M. & Raj, G. V., May 2018, In : European urology. 73, 5, p. 715-723 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice

Yuan, C. C., Kazmierczak, K., Liang, J., Zhou, Z., Yadav, S., Gomes, A. V., Irving, T. C. & Szczesna-Cordary, D., Mar 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 10, p. E2338-E2347

Research output: Contribution to journalArticle

7 Scopus citations

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency

Al-Ali, H., Debevec, G., Santos, R. G., Houghten, R. A., Davis, J. C., Nefzi, A., Lemmon, V. P., Bixby, J. L. & Giulianotti, M. A., Oct 11 2018, In : ACS Medicinal Chemistry Letters. 9, 10, p. 1057-1062 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Single cardiac ventricular myosins are autonomous motors

Wang, Y., Yuan, C. C., Kazmierczak, K., Szczesna-Cordary, D. & Burghardt, T. P., Jan 1 2018, In : Open Biology. 4, 8, 170240.

Research output: Contribution to journalArticle

8 Scopus citations

Sustainable data and metadata management at the BD2K-LINCS Data coordination and integration center

Stathias, V., Koleti, A., Vidovic, D., Cooper, D. J., Jagodnik, K. M., Terryn, R., Forlin, M., Chung, C., Torre, D., Ayad, N., Medvedovic, M., Ma'Ayan, A., Pillai, A. & Schuerer, S. C., Jun 19 2018, In : Scientific data. 5, 180117.

Research output: Contribution to journalArticle

9 Scopus citations

The effect of Jun dimerization on neurite outgrowth and motif binding

Danzi, M. C., Mehta, S. T., Dulla, K., Zunino, G., Cooper, D. J., Bixby, J. L. & Lemmon, V. P., Oct 2018, In : Molecular and Cellular Neuroscience. 92, p. 114-127 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Amino acid metabolites that regulate G protein signaling during osmotic stress

Shellhammer, J. P., Morin-Kensicki, E., Matson, J. P., Yin, G., Isom, D. G., Campbell, S. L., Mohney, R. P. & Dohlman, H. G., May 2017, In : PLoS genetics. 13, 5, e1006829.

Research output: Contribution to journalArticle

9 Scopus citations

A Reliable Mouse Model of Hind limb Gangrene

Parikh, P. P., Castilla, D., Soares, R., Shao, H., Regueiro, M., Li, Y., Vazquez-Padron, R. I., Webster, K. A., Liu, Z-J. & Velazquez, O. C., Jan 1 2017, (Accepted/In press) In : Annals of Vascular Surgery.

Research output: Contribution to journalArticle

1 Scopus citations
7 Scopus citations

Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice

Wang, L., Kazmierczak, K., Yuan, C. C., Yadav, S., Kawai, M. & Szczesna-Cordary, D., Jun 1 2017, In : FEBS Journal. 284, 12, p. 1897-1913 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Comprehensive metabolomics study to assess longitudinal biochemical changes and potential early biomarkers in nonobese diabetic mice that progress to diabetes

Buchwald, P., Tamayo-Garcia, A., Ramamoorthy, S., Garcia-Contreras, M., Mendez, A. J. & Ricordi, C., Oct 6 2017, In : Journal of Proteome Research. 16, 10, p. 3873-3890 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Defining disease, diagnosis, and translational medicine within a homeostatic perturbation paradigm: The National Institutes of Health undiagnosed diseases program experience

Gall, T., Valkanas, E., Bello, C., Markello, T., Adams, C., Bone, W. P., Brandt, A. J., Brazill, J. M., Carmichael, L., Davids, M., Davis, J., Diaz-Perez, Z., Draper, D., Elson, J., Flynn, E. D., Godfrey, R., Groden, C., Hsieh, C. K., Fischer, R., Golas, G. A. & 31 others, Guzman, J., Huang, Y., Kane, M. S., Lee, E., Li, C., Links, A. E., Maduro, V., Malicdan, M. C. V., Malik, F. S., Nehrebecky, M., Park, J., Pemberton, P., Schaffer, K., Simeonov, D., Sincan, M., Smedley, D., Valivullah, Z., Wahl, C., Washington, N., Wolfe, L. A., Xu, K., Zhu, Y., Gahl, W. A., Tifft, C. J., Toro, C., Adams, D. R., He, M., Robinson, P. N., Haendel, M. A., Zhai, R. G. & Boerkoel, C. F., Jan 1 2017, In : Frontiers in Medicine. 4, MAY, 62.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop

Jagodnik, K. M., Koplev, S., Jenkins, S. L., Ohno-Machado, L., Paten, B., Schurer, S. C., Dumontier, M., Verborgh, R., Bui, A., Ping, P., McKenna, N. J., Madduri, R., Pillai, A. & Ma'ayan, A., Jul 2017, In : Journal of biomedical informatics. 71, p. 49-57 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Drug target ontology to classify and integrate drug discovery data

Lin, Y., Mehta, S., Küçük-McGinty, H., Turner, J. P., Vidovic, D., Forlin, M., Koleti, A., Nguyen, D. T., Jensen, L. J., Guha, R., Mathias, S. L., Ursu, O., Stathias, V., Duan, J., Nabizadeh, N., Chung, C., Mader, C., Visser, U., Yang, J. J., Bologa, C. G. & 2 others, Oprea, T. I. & Schürer, S. C., Nov 9 2017, In : Journal of Biomedical Semantics. 8, 1, 50.

Research output: Contribution to journalArticle

10 Scopus citations

Enhanced cardioprotection by human endometrium mesenchymal stem cells driven by exosomal MicroRNA-21

Wang, K., Jiang, Z., Webster, K. A., Chen, J., Hu, H., Zhou, Y., Zhao, J., Wang, L., Wang, Y., Zhong, Z., Ni, C., Li, Q., Xiang, C., Zhang, L., Wu, R., Zhu, W., Yu, H., Hu, X. & Wang, JA., Jan 2017, In : Stem Cells Translational Medicine. 6, 1, p. 209-222 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

From flamingo dance to (desirable) drug discovery: A nature-inspired approach

Sánchez-Rodríguez, A., Pérez-Castillo, Y., Schuerer, S. C., Nicolotti, O., Mangiatordi, G. F., Borges, F., Cordeiro, M. N. D. S., Tejera, E., Medina-Franco, J. L. & Cruz-Monteagudo, M., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

6 Scopus citations

Functional and nonfunctional forms of CquiOR91, an odorant selectivity subunit of Culex quinquefasciatus

Hughes, D. T., Pelletier, J., Rahman, S., Chen, S., Leal, W. S. & Luetje, C. W., May 1 2017, In : Chemical Senses. 42, 4, p. 333-341 9 p., bjx011.

Research output: Contribution to journalArticle

2 Scopus citations

Functional characterizations of rare UBA1 variants in X-linked Spinal Muscular Atrophy

Baumbach-Reardon, L., Balak, C. D., Hunter, J. M., Ahearn, M. E., Wiley, D. & D'urso, G., 2017, In : F1000Research. 6, 1636.

Research output: Contribution to journalArticle

5 Scopus citations

Glucose-stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets

Buchwald, P., Tamayo-Garcia, A., Manzoli, V., Tomei, A. & Stabler, C. L., 2017, (Accepted/In press) In : Biotechnology and Bioengineering.

Research output: Contribution to journalArticle

19 Scopus citations
11 Scopus citations

Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice

Yuan, C. C., Kazmierczak, K., Liang, J., Takeuchi, R., Irving, T. C., Gomes, A. V., Wang, Y., Burghardt, T. P. & Szczesna-Cordary, D., Aug 1 2017, In : Cardiovascular Research. 113, 10, p. 1124-1136 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential

Bellio, M. A., Pinto, M. T., Florea, V., Barrios, P. A., Taylor, C. N., Brown, A. B., Lamondin, C., Hare, J., Schulman, I. H. & Rodrigues, C. D., Dec 1 2017, In : Scientific Reports. 7, 1, 9702.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

Allen, B. K., Mehta, S., Ember, S. W. J., Zhu, J. Y., Schönbrunn, E., Ayad, N. & Schuerer, S. C., Jan 1 2017, In : ACS Omega. 2, 8, p. 4760-4771 12 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit

Kepchia, D., Moliver, S., Chohan, K., Phillips, C. & Luetje, C. W., May 1 2017, In : PLoS One. 12, 5, e0177454.

Research output: Contribution to journalArticle

4 Scopus citations
5 Scopus citations

Loss of c-Kit function impairs arteriogenesis in a mouse model of hindlimb ischemia

Hernandez, D. R., Artiles, A., Duque, J. C., Martinez, L., Pinto, M. T., Webster, K. A., Velazquez, O. C., Vazquez-Padron, R. I. & Soares, R., Jan 1 2017, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

1 Scopus citations

Mammalian odorant receptor tuning breadth persists across distinct odorant panels

Kepchia, D., Sherman, B., Haddad, R. & Luetje, C. W., Sep 1 2017, In : PLoS One. 12, 9, e0185329.

Research output: Contribution to journalArticle

1 Scopus citations

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets

Garcia-Contreras, M., Tamayo-Garcia, A., Pappan, K. L., Michelotti, G. A., Stabler, C. L., Ricordi, C. & Buchwald, P., Jun 2 2017, In : Journal of Proteome Research. 16, 6, p. 2294-2306 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mutant cycle analysis identifies a ligand interaction site in an odorant receptor of the malaria vector Anopheles gambiae

Rahman, S. & Luetje, C. W., Jan 1 2017, In : Journal of Biological Chemistry. 292, 46, p. 18916-18923 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms

Moon, Y., Balke, J. E., Madorma, D., Siegel, M. P., Knowels, G., Brouckaert, P., Buys, E. S., Marcinek, D. J. & Percival, J., Jun 10 2017, In : Antioxidants and Redox Signaling. 26, 17, p. 966-985 20 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ontological representation, integration, and analysis of LINCS cell line cells and their cellular responses

Ong, E., Xie, J., Ni, Z., Liu, Q., Sarntivijai, S., Lin, Y., Cooper, D., Terryn, R., Stathias, V., Chung, C., Schuerer, S. C. & He, Y., Dec 21 2017, In : BMC Bioinformatics. 18, 556.

Research output: Contribution to journalArticle

6 Scopus citations

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Gao, H., Danzi, M. C., Choi, C. S., Taherian, M., Dalby-Hansen, C., Ellman, D. G., Madsen, P. M., Bixby, J., Lemmon, V., Lambertsen, K. L. & Brambilla, R., Jan 3 2017, In : Cell Reports. 18, 1, p. 198-212 15 p.

Research output: Contribution to journalArticle

44 Scopus citations

Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease

Wang, W., LeBlanc, M. E., Chen, X., Chen, P., Ji, Y., Brewer, M., Tian, H., Spring, S. R., Webster, K. A. & Li, W., Apr 26 2017, (Accepted/In press) In : Angiogenesis. p. 1-14 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pharos: Collating protein information to shed light on the druggable genome

Nguyen, D. T., Mathias, S., Bologa, C., Brunak, S., Fernandez, N., Gaulton, A., Hersey, A., Holmes, J., Jensen, L. J., Karlsson, A., Liu, G., Ma'ayan, A., Mandava, G., Mani, S., Mehta, S., Overington, J., Patel, J., Rouillard, A. D., Schürer, S., Sheils, T. & 10 others, Simeonov, A., Sklar, L. A., Southall, N., Ursu, O., Vidovic, D., Waller, A., Yang, J., Jadhav, A., Oprea, T. I. & Guha, R., Jan 1 2017, In : Nucleic acids research. 45, D1, p. D995-D1002

Research output: Contribution to journalArticle

55 Scopus citations
7 Scopus citations

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

Lenguito, G., Chaimov, D., Weitz, J. R., Rodriguez Diaz, R., Rawal, S. A. K., Tamayo-Garcia, A., Caicedo-Vierkant, D. A., Stabler, C. L., Buchwald, P. & Agarwal, A., 2017, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 17, 5, p. 772-781 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction

Chen, J., Song, Y., Bojadzic, D., Tamayo-Garcia, A., Landin, A. M., Blomberg, B. B. & Buchwald, P., Nov 9 2017, In : Journal of Medicinal Chemistry. 60, 21, p. 8906-8922 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome

Li, C., Brazill, J. M., Liu, S., Bello, C., Zhu, Y., Morimoto, M., Cascio, L., Pauly, R., Diaz-Perez, Z., Malicdan, M. C. V., Wang, H., Boccuto, L., Schwartz, C. E., Gahl, W. A., Boerkoel, C. F. & Zhai, R. G., Dec 1 2017, In : Nature Communications. 8, 1, 1257.

Research output: Contribution to journalArticle

17 Scopus citations

Stability and function of a putative microtubule-organizing center in the human parasite Toxoplasma gondii

Leung, J. M., He, Y., Zhang, F., Hwang, Y. C., Nagayasu, E., Liu, J., Murray, J. M. & Hu, K., May 15 2017, In : Molecular biology of the cell. 28, 10, p. 1361-1378 18 p.

Research output: Contribution to journalArticle

8 Scopus citations

Stress increases peripheral axon growth and regeneration through glucocorticoid receptor-dependent transcriptional programs

Lerch, J. K., Alexander, J. K., Madalena, K. M., Motti, D., Quach, T., Dhamija, A., Zha, A., Gensel, J. C., Marketon, J. W., Lemmon, V. P., Bixby, J. L. & Popovich, P. G., Jul 1 2017, In : eNeuro. 4, 4, e0246-17.2017.

Research output: Contribution to journalArticle

8 Scopus citations

Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia

Reiter, J., Drummond, S., Sammour, I., Huang, J., Florea, V., Dornas, P., Hare, J. M., Rodrigues, C. O. & Young, K. C., Jul 12 2017, In : Respiratory research. 18, 1, 137.

Research output: Contribution to journalArticle

16 Scopus citations

Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues

Ondachi, P. W., Castro, A. H., Sherman, B., Luetje, C. W., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Jan 18 2017, In : ACS Chemical Neuroscience. 8, 1, p. 115-127 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting AR variant–coactivator interactions to exploit prostate cancer vulnerabilities

Magani, F., Peacock, S. O., Rice, M. A., Martinez, M. J., Greene, A. M., Magani, P. S., Lyles, R., Weitz, J. R. & Burnstein, K. L., Nov 1 2017, In : Molecular Cancer Research. 15, 11, p. 1469-1480 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Teaching an old drug new tricks: Agonism, antagonism, and biased signaling of pilocarpine through M3 muscarinic acetylcholine receptor

Pronin, A. N., Wang, Q. & Slepak, V. Z., Nov 1 2017, In : Molecular Pharmacology. 92, 5, p. 601-612 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

The mTOR substrate S6 kinase 1 (S6K1) is a negative regulator of axon regeneration and a potential drug target for central nervous system injury

Al-Ali, H., Ding, Y., Slepak, T., Wu, W., Sun, Y., Martinez, Y., Xu, X. M., Lemmon, V. & Bixby, J., Jul 26 2017, In : Journal of Neuroscience. 37, 30, p. 7079-7095 17 p.

Research output: Contribution to journalArticle

27 Scopus citations

Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer

Samaranayake, G. J., Troccoli, C. I., Huynh, M., Lyles, R. D. Z., Kage, K., Win, A., Lakshmanan, V., Kwon, D., Ban, Y., Chen, X., Zarco, E. R., Jorda, M., Burnstein, K. L. & Rai, P., Dec 1 2017, In : Nature Communications. 8, 1, 1204.

Research output: Contribution to journalArticle

12 Scopus citations