Molecular and Cellular Pharmacology

Research Output 1974 2019

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263 Citations (Scopus)

[22] Preparation of troponin and its subnits

Potter, J. D., Dec 1 1982, In : Methods in Enzymology. 85, C, p. 241-263 23 p.

Research output: Contribution to journalArticle

Troponin
Muscle Proteins
Ion Exchange Chromatography
Ether
Polyacrylamide Gel Electrophoresis
89 Citations (Scopus)

25-Hydroxyvitamin D-1α-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transfer

Whitlatch, L. W., Young, M. V., Schwartz, G. G., Flanagan, J. N., Burnstein, K. L., Lokeshwar, B. L., Rich, E. S., Holick, M. F. & Chen, T. C., Aug 23 2002, In : Journal of Steroid Biochemistry and Molecular Biology. 81, 2, p. 135-140 6 p.

Research output: Contribution to journalArticle

Gene transfer
Mixed Function Oxygenases
Prostatic Neoplasms
Cells
Genes
7 Citations (Scopus)

5-HT-stimulated arachidonic acid release from labeled phosphatidylinositol in blowfly salivary glands.

Litosch, I., Saito, Y. & Fain, J. N., Nov 1 1982, In : The American journal of physiology. 243, 5

Research output: Contribution to journalArticle

Phosphatidylinositols
Salivary Glands
Arachidonic Acid
Serotonin
Diglycerides
25 Citations (Scopus)

96-Well electroporation method for transfection of mammalian central neurons

Buchser, W. J., Pardinas, J. R., Shi, Y., Bixby, J. & Lemmon, V., Nov 1 2006, In : BioTechniques. 41, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

Electroporation
Neurons
Transfection
Plasmids
Poisons
90 Citations (Scopus)

Abnormal Contractile Function in Transgenic Mice Expressing a Familial Hypertrophic Cardiomyopathy-linked Troponin T (I79N) Mutation

Miller, T., Szczesna-Cordary, D., Housmans, P. R., Zhao, J., De Freitas, F., Gomes, A. V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W. G. & Potter, J. D., Feb 9 2001, In : Journal of Biological Chemistry. 276, 6, p. 3743-3755 13 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Troponin T
Transgenic Mice
Adenosine Triphosphatases
Troponin C
24 Citations (Scopus)

A broadly tuned mouse odorant receptor that detects nitrotoluenes

Li, J., Haddad, R., Chen, S., Santos, V. & Luetje, C. W., Jun 1 2012, In : Journal of Neurochemistry. 121, 6, p. 881-890 10 p.

Research output: Contribution to journalArticle

Odorant Receptors
Trinitrotoluene
Tuning
Mammals
Odors
16 Citations (Scopus)

Absence of androgen-mediated transcriptional effects in osteoblastic cells despite presence of androgen receptors

Czerwiec, F. S., Liaw, J. J., Liu, S. B., Perez-Stable, C., Grumbles, R., Howard, G., Roos, B. A. & Burnstein, K. L., Jul 1 1997, In : Bone. 21, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Osteoblasts
Bone and Bones
Cell Line
14 Citations (Scopus)

A case report-volatile metabolomic signature of malignant melanoma using matching skin as a control

Abaffy, T., Moller, M., Riemer, D. D., Milikowski, C. & Defazio, R. A., Dec 1 2011, In : Journal of Cancer Science and Therapy. 3, 6, p. 140-144 5 p.

Research output: Contribution to journalArticle

Metabolomics
Melanoma
Skin
Biomarkers
Skin Neoplasms
17 Citations (Scopus)

A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates

Johnstone, A. L., Reierson, G. W., Smith, R. P., Goldberg, J. L., Lemmon, V. & Bixby, J., Jun 1 2012, In : Molecular and Cellular Neuroscience. 50, 2, p. 125-135 11 p.

Research output: Contribution to journalArticle

Neurites
Antipsychotic Agents
Central Nervous System
Neurons
Growth
28 Citations (Scopus)

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis

Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schuerer, S. C., Wennerberg, K., Reynolds, R., Besra, G. S. & Dobos, K. M., Jun 1 2013, In : Molecular and Cellular Proteomics. 12, 6, p. 1644-1660 17 p.

Research output: Contribution to journalArticle

Proteome
Mycobacterium tuberculosis
Proteomics
Adenosine Triphosphate
Enzyme Inhibitors
45 Citations (Scopus)

A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration

Usher, L. C., Johnstone, A., Ertürk, A., Hu, Y., Strikis, D., Wanner, I. B., Moorman, S., Lee, J. W., Min, J., Ha, H. H., Duan, Y., Hoffman, S., Goldberg, J. L., Bradke, F., Chang, Y. T., Lemmon, V. & Bixby, J., Mar 31 2010, In : Journal of Neuroscience. 30, 13, p. 4693-4706 14 p.

Research output: Contribution to journalArticle

Neuroglia
Regeneration
Axons
Myelin Sheath
Microtubules
28 Citations (Scopus)

Acidosis regulates the stability, hydrophobicity, and activity of the BH3-only protein Bnip3

Frazier, D. P., Wilson, A., Graham, R. M., Thompson, J. W., Bishopric, N. & Webster, K. A., Sep 1 2006, In : Antioxidants and Redox Signaling. 8, 9-10, p. 1625-1634 10 p.

Research output: Contribution to journalArticle

Hydrophobicity
Acidosis
Hydrophobic and Hydrophilic Interactions
Monomers
Oligomers
25 Citations (Scopus)

A Combined Ligand- and Structure-Based Virtual Screening Protocol Identifies Submicromolar PPARγPartial Agonists

Vidović, D., Busby, S. A., Griffin, P. R. & Schuerer, S. C., Jan 3 2011, In : ChemMedChem. 6, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Screening
Ligands
Small Molecule Libraries
Lead compounds
148 Citations (Scopus)

Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress

Dougherty, C. J., Kubasiak, L. A., Prentice, H., Andreka, P., Bishopric, N. & Webster, K. A., Mar 15 2002, In : Biochemical Journal. 362, 3, p. 561-571 11 p.

Research output: Contribution to journalArticle

Oxidative stress
JNK Mitogen-Activated Protein Kinases
Cardiac Myocytes
Oxidative Stress
Phosphotransferases
34 Citations (Scopus)

Activation of growth hormone releasing hormone (GHRH) receptor stimulates cardiac reverse remodeling after myocardial infarction (MI)

Takeuchi, R., Takeuchi, L. M., Rick, F. G., Dulce, R., Treuer, A. V., Florea, V., Rodrigues, C. D., Paulino, E. C., Hatzistergos, K. E., Selem, S. M., Gonzalez, D. R., Block, N. L., Schally, A. V. & Hare, J., Jan 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 2, p. 559-563 5 p.

Research output: Contribution to journalArticle

Growth Hormone-Releasing Hormone
Myocardial Infarction
somatotropin releasing hormone receptor
Stem Cells
Hemodynamics
13 Citations (Scopus)

Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation

Yin, L., Locovei, A. M. & D'urso, G., Oct 1 2008, In : Molecular Biology of the Cell. 19, 10, p. 4374-4382 9 p.

Research output: Contribution to journalArticle

S Phase Cell Cycle Checkpoints
DNA Replication
DNA Damage
Schizosaccharomyces
Phenotype
52 Citations (Scopus)

Activity-dependent modulation of rod photoreceptor cyclic nucleotide- gated channels mediated by phosphorylation of a specific tyrosine residue

Molokanova, E., Maddox, F., Luetje, C. W. & Kramer, R. H., Jun 15 1999, In : Journal of Neuroscience. 19, 12, p. 4786-4795 10 p.

Research output: Contribution to journalArticle

Cyclic Nucleotide-Gated Cation Channels
Retinal Rod Photoreceptor Cells
Tyrosine
Phosphorylation
Light Signal Transduction
4 Citations (Scopus)
Biological Assay
High-Throughput Screening Assays
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
Isoenzymes
36 Citations (Scopus)

Adenovirus E1A inhibits cardiac myocyte-specific gene expression through its amino terminus

Bishopric, N., Zeng, G. Q., Sato, B. & Webster, K. A., Aug 15 1997, In : Journal of Biological Chemistry. 272, 33, p. 20584-20594 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Adenoviridae
Gene expression
Actins
Gene Expression
43 Citations (Scopus)

Adenylyl cyclase expression and modulation of cAMP in rat taste cells

Abaffy, T., Trubey, K. R. & Chaudhari, N., Jun 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 6 53-6

Research output: Contribution to journalArticle

Adenylyl Cyclases
Rats
Modulation
Glutamic Acid
Proteins
24 Citations (Scopus)

A determinant of odorant specificity is located at the extracellular loop 2-transmembrane domain 4 interface of an Anopheles gambiae odorant receptor subunit

Hughes, D. T., Wang, G., Zwiebel, L. J. & Luetje, C. W., Nov 1 2014, In : Chemical Senses. 39, 9, p. 761-769 9 p.

Research output: Contribution to journalArticle

Odorant Receptors
Anopheles gambiae
Mutation
Alanine
Propiophenones
2 Citations (Scopus)

A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells

Qadir, M. M. F., Álvarez-Cubela, S., Belle, K., Sapir, T., Messaggio, F., Johnson, K. B., Umland, O., Hardin, D., Klein, D., Pérez-Álvarez, I., Sadiq, F., Alcázar, O., Inverardi, L. A., Ricordi, C., Buchwald, P., Fraker, C. A., Pastori, R. L. & Domínguez-Bendala, J., Mar 5 2019, In : Stem Cell Reports. 12, 3, p. 611-623 13 p.

Research output: Contribution to journalArticle

Open Access
Stem cells
Carcinogenesis
Insulin
Prodrugs
Cell death
26 Citations (Scopus)

A general bilinear model to describe growth or decline time profiles

Buchwald, P., Jan 1 2007, In : Mathematical Biosciences. 205, 1, p. 108-136 29 p.

Research output: Contribution to journalArticle

Bilinear Model
Linear Models
Cellular Spheroids
Agricultural Crops
Schizosaccharomyces
2 Citations (Scopus)

A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe

Locovei, A. M., Yin, L. & D'urso, G., Aug 27 2010, In : Cell Division. 5, 20.

Research output: Contribution to journalArticle

Schizosaccharomyces
DNA Replication
DNA
Cells
DNA Damage
98 Citations (Scopus)

Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells

Wilson, A., Shehadeh, L., Yu, H. & Webster, K. A., Apr 7 2010, In : BMC Genomics. 11, 1, 229.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Molecular Biology
Stem Cells
Cell Aging
Bone Marrow
16 Citations (Scopus)

A glycolytic pathway to apoptosis of hypoxic cardiac myocytes: Molecular pathways of increased acid production

Webster, K. A., Discher, D. J., Hernandez, O. M., Yamashita, K. & Bishopric, N., Dec 1 2000, In : Advances in Experimental Medicine and Biology. 475, p. 161-175 15 p.

Research output: Contribution to journalArticle

Alpha Subunit Hypoxia-Inducible Factor 1
Cardiovascular Models
Plant DNA
Hypoxia-Inducible Factor 1
Cell Hypoxia
22 Citations (Scopus)
Growth Hormone-Releasing Hormone
Stem Cells
Hormones
Swine
MAP Kinase Signaling System
143 Citations (Scopus)

Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction

Ruegg, M. A. & Bixby, J., Jan 1 1998, In : Trends in Neurosciences. 21, 1, p. 22-27 6 p.

Research output: Contribution to journalArticle

Agrin
Neuromuscular Junction
Synapses
Vertebrates
Learning
125 Citations (Scopus)

A honey bee odorant receptor for the queen substance 9-oxo-2-decenoic acid

Wanner, K. W., Nichols, A. S., Walden, K. K. O., Brockmann, A., Luetje, C. W. & Robertson, H. M., Sep 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 36, p. 14383-14388 6 p.

Research output: Contribution to journalArticle

Odorant Receptors
Honey
Bees
Pheromones
Sex Attractants
25 Citations (Scopus)

Aktion in the Nucleus

Webster, K. A., Apr 16 2004, In : Circulation Research. 94, 7, p. 856-859 4 p.

Research output: Contribution to journalArticle

Cell Compartmentation
Proto-Oncogene Proteins
Biological Models
Proto-Oncogene Proteins c-akt
Protein-Serine-Threonine Kinases
177 Citations (Scopus)

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress

Ghosh, R., Wang, L., Wang, E. S., Perera, B. G. K., Igbaria, A., Morita, S., Prado, K., Thamsen, M., Caswell, D., Macias, H., Weiberth, K. F., Gliedt, M. J., Alavi, M. V., Hari, S. B., Mitra, A. K., Bhhatarai, B., Schuerer, S. C., Snapp, E. L., Gould, D. B., German, M. S. & 4 others, Backes, B. J., Maly, D. J., Oakes, S. A. & Papa, F. R., Jul 31 2014, In : Cell. 158, 3, p. 534-548 15 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Ribonucleases
Oligomerization
Cell Survival
Cells
56 Citations (Scopus)
Insulin
Secretion
Glucose
Islets of Langerhans
Oxygen
1 Citation (Scopus)

Alterations of tumor microenvironment by nitric oxide impedes castration-resistant prostate cancer growth

Arora, H., Panara, K., Kuchakulla, M., Kulandavelu, S., Burnstein, K. L., Schally, A. V., Hare, J. & Ramasamy, R., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. 11298-11303 6 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Castration
Prostatic Neoplasms
Nitric Oxide
Growth
113 Citations (Scopus)

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

Szczesna-Cordary, D., Zhang, R., Zhao, J., Jones, M., Guzman, G. & Potter, J. D., Jan 7 2000, In : Journal of Biological Chemistry. 275, 1, p. 624-630 7 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Troponin T
Myosins
Muscle Contraction
Muscle
18 Citations (Scopus)

Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

Ruan, K., Zhu, Y., Li, C., Brazill, J. M. & Zhai, R. G., Nov 30 2015, In : Nature Communications. 6, 10057.

Research output: Contribution to journalArticle

Drosophila
splicing
Alternative Splicing
neurons
Nicotinamide-Nucleotide Adenylyltransferase
9 Citations (Scopus)

Amino acid metabolites that regulate G protein signaling during osmotic stress

Shellhammer, J. P., Morin-Kensicki, E., Matson, J. P., Yin, G., Isom, D. G., Campbell, S. L., Mohney, R. P. & Dohlman, H. G., May 1 2017, In : PLoS Genetics. 13, 5, e1006829.

Research output: Contribution to journalArticle

Osmoregulation
Branched Chain Amino Acids
Osmotic Pressure
osmotic stress
G-proteins
14 Citations (Scopus)

A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice

Tapanes-Castillo, A., Weaver, E. J., Smith, R. P., Kamei, Y., Caspary, T., Hamilton-Nelson, K. L., Slifer, S. H., Martin, E. R., Bixby, J. & Lemmon, V., Feb 1 2010, In : Neurogenetics. 11, 1, p. 53-71 19 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecule L1
Chromosomes, Human, Pair 5
Hydrocephalus
Mutation
Quantitative Trait Loci
Molecular Sequence Data
Engine mountings
Troponin C
Amino Acid Sequence Homology
Troponin
28 Citations (Scopus)

A Myc-slug (Snail 2)/Twist regulatory circuit directs vascular development

Rodrigues, C. D., Nerlick, S. T., White, E. L., Cleveland, J. L. & King, M. L. L., Jun 1 2008, In : Development. 135, 11, p. 1903-1911 9 p.

Research output: Contribution to journalArticle

Gastropoda
Blood Vessels
Mesoderm
Edema
Hemorrhage
55 Citations (Scopus)

Androgen and glucocorticoid regulation of androgen receptor cDNA expression

Burnstein, K. L., Maiorino, C. A., Dai, J. L. & Cameron, D. J., Dec 29 1995, In : Molecular and Cellular Endocrinology. 115, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Glucocorticoids
Androgens
Complementary DNA
Messenger RNA
70 Citations (Scopus)

Androgenic up-regulation of androgen receptor cDNA expression in androgen-independent prostate cancer cells

Le Dai, J., Maiorino, C. A., Gkonos, P. J. & Burnstein, K. L., Sep 1 1996, In : Steroids. 61, 9, p. 531-539 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Prostatic Neoplasms
Up-Regulation
Complementary DNA
53 Citations (Scopus)

Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase

Shen, R., Sumitomo, M., Dai, J., Harris, A., Kaminetzky, D., Gao, M., Burnstein, K. L. & Nanus, D. M., Dec 1 2000, In : Endocrinology. 141, 5, p. 1699-1704 6 p.

Research output: Contribution to journalArticle

Neprilysin
Androgen Receptors
Androgens
Prostatic Neoplasms
Growth
21 Citations (Scopus)
Androgens
Hormones
Plating
Cells
Reporter Genes
15 Citations (Scopus)

An essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in ApoE-/- mice

Cesar, L., Suarez, S. V., Adi, J., Adi, N., Vazquez-Padron, R. I., Yu, H., Ma, Q., Goldschmidt-Clermont, P., Agatston, A., Kurlansky, P. & Webster, K. A., Feb 28 2011, In : PLoS One. 6, 2, e17263.

Research output: Contribution to journalArticle

Apolipoproteins E
hyperlipidemia
Nutrition
Dyslipidemias
atherosclerosis
100 Citations (Scopus)

A new in vitro model of the glial scar inhibits axon growth

Wanner, I. B., Deik, A., Torres, M., Rosendahl, A., Neary, J. T., Lemmon, V. & Bixby, J., Dec 1 2008, In : GLIA. 56, 15, p. 1691-1709 19 p.

Research output: Contribution to journalArticle

Neuroglia
Cicatrix
Axons
Nervous System Trauma
Astrocytes
12 Citations (Scopus)

A New Luciferase Reporter Gene Assay for the Detection of Androgenic and Antiandrogenic Effects Based on a Human Prostate Specific Antigen Promoter and PC3/AR Human Prostate Cancer Cells

Kizu, R., Otsuki, N., Kishida, Y., Toriba, A., Mizokami, A., Burnstein, K. L., Klinge, C. M. & Hayakawa, K., Jan 1 2004, In : Analytical Sciences. 20, 1, p. 55-59 5 p.

Research output: Contribution to journalArticle

Luciferases
Aryl Hydrocarbon Receptors
Assays
Genes
Cells
58 Citations (Scopus)

Angiogenesis is confined to the transient period of VEGF expression that follows adenoviral gene delivery to ischemic muscle

Gounis, M. J., Spiga, M. G., Graham, R. M., Wilson, A., Haliko, S., Lieber, B. B., Wakhloo, A. K. & Webster, K. A., May 1 2005, In : Gene Therapy. 12, 9, p. 762-771 10 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Muscles
Adenoviridae
Genes
Endothelial Cells
75 Citations (Scopus)

An odorant receptor from the Southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants

Pelletier, J., Hughes, D. T., Luetje, C. W. & Leal, W. S., Sep 10 2010, In : PLoS One. 5, 4, e10090.

Research output: Contribution to journalArticle

oviposition attractants
Odorant Receptors
Oviposition
Culex
Culex quinquefasciatus
38 Citations (Scopus)

A non-invasive method for in vivo skin volatile compounds sampling

Jiang, R., Cudjoe, E., Bojko, B., Abaffy, T. & Pawliszyn, J., Dec 4 2013, In : Analytica Chimica Acta. 804, p. 111-119 9 p.

Research output: Contribution to journalArticle

skin
Skin
Sampling
sampling
Membranes
18 Citations (Scopus)

An Open-Label, Single-Dose, Crossover Study of the Pharmacokinetics and Metabolism of Two Oral Formulations of 1-Octanol in Patients with Essential Tremor

Nahab, F. B., Wittevrongel, L., Ippolito, D., Toro, C., Grimes, G. J., Starling, J., Potti, G., Haubenberger, D., Bowen, D., Buchwald, P., Dong, C., Kalowitz, D. & Hallett, M., Oct 1 2011, In : Neurotherapeutics. 8, 4, p. 753-762 10 p.

Research output: Contribution to journalArticle

1-Octanol
Essential Tremor
Tremor
Cross-Over Studies
Pharmacokinetics