Molecular and Cellular Pharmacology

Research Output

Filter
Article

Intramolecular interaction between the DEP domain of RGS7 and the Gβ5 subunit

Narayanan, V., Sandiford, S. L., Wang, Q., Keren-Raifman, T., Levay, K. & Slepak, V. Z., Jun 12 2007, In : Biochemistry. 46, 23, p. 6859-6870 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

In Vitro and in Vivo Neuronal Nicotinic Receptor Properties of (+)- and (-)-Pyrido[3,4]homotropane [(+)- and (-)-PHT]: (+)-PHT is a Potent and Selective Full Agonist at α6β2 Containing Neuronal Nicotinic Acetylcholine Receptors

Carroll, F. I., Navarro, H. A., Mascarella, S. W., Castro, A. H., Luetje, C. W., Wageman, C. R., Marks, M. J., Jackson, A. & Damaj, M. I., Jun 17 2015, In : ACS Chemical Neuroscience. 6, 6, p. 920-926 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

In vitro models of axon regeneration

Al-Ali, H., Beckerman, S., Bixby, J. & Lemmon, V., Dec 4 2015, (Accepted/In press) In : Experimental Neurology.

Research output: Contribution to journalArticle

16 Scopus citations

In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain

Muthu, P., Liang, J., Schmidt, W., Moore, J. R. & Szczesna-Cordary, D., Jul 15 2014, In : Archives of Biochemistry and Biophysics. 552-553, p. 29-39 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

In vivo 17β-estradiol treatment contributes to podocyte actin stabilization in female db/db mice

Catanuto, P., Fornoni, A., Pereira-Simon, S., Wu, F., Burnstein, K. L., Xia, X., Conti, F., Lenzi, A. & Elliot, S., Dec 1 2012, In : Endocrinology. 153, 12, p. 5888-5895 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

Martins, A. S., Parvatiyar, M. S., Feng, H. Z., Bos, J. M., Gonzalez-Martinez, D., Vukmirovic, M., Turna, R. S., Sanchez-Gonzalez, M. A., Badger, C. D., Zorio, D. A. R., Singh, R. K., Wang, Y., Jin, J. P., Ackerman, M. J. & Pinto, J. R., Oct 1 2015, In : Circulation: Cardiovascular Genetics. 8, 5, p. 653-664 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast

Newpher, T. M., Smith, R. P., Lemmon, V. & Lemmon, S., Jul 1 2005, In : Developmental Cell. 9, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

139 Scopus citations

In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice

Abdulreda, M. H., Molano, R. D., Faleo, G., Lopez-Cabezas, M., Shishido, A., Ulissi, U., Fotino, C., Hernandez, L. F., Tschiggfrie, A., Aldrich, V. R., Tamayo-Garcia, A., Bayer, A. L., Ricordi, C., Caicedo-Vierkant, D. A., Buchwald, P., Pileggi, A. & Berggren, P. O., Jan 1 2019, In : Diabetologia.

Research output: Contribution to journalArticle

1 Scopus citations

In vivo upregulation of nitric oxide synthases in healthy rats

Wu, H., Jin, Y., Arias, J., Bassuk, J., Uryash, A., Kurlansky, P., Webster, K. A. & Adams, J. A., Aug 1 2009, In : Nitric Oxide - Biology and Chemistry. 21, 1, p. 63-68 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model

Slepak, T. I., Tang, M., Slepak, V. Z. & Lai, K., Sep 1 2007, In : Molecular Genetics and Metabolism. 92, 1-2, p. 78-87 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Irreversible aggregation of protein synthesis machinery after focal brain ischemia

Zhang, F., Liu, C. L. & Hu, B. R., Jul 1 2006, In : Journal of Neurochemistry. 98, 1, p. 102-112 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2

Cadete, V. J. J., Sawicka, J., Jaswal, J. S., Lopaschuk, G. D., Schulz, R., Szczesna-Cordary, D. & Sawicki, G., Jul 1 2012, In : FEBS Journal. 279, 13, p. 2444-2454 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction

Polewicz, D., Cadete, V. J. J., Doroszko, A., Hunter, B. E., Sawicka, J., Szczesna-Cordary, D., Light, P. E. & Sawicki, G., May 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 5, p. 1136-1147 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Isoform diversity and its importance for axon regeneration

Lerch, J. K., Bixby, J. & Lemmon, V., Aug 1 2012, In : Neuropathology. 32, 4, p. 420-431 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq

Lerch, J. K., Kuo, F., Motti, D., Morris, R., Bixby, J. & Lemmon, V., Jan 17 2012, In : PLoS One. 7, 1, e30417.

Research output: Contribution to journalArticle

33 Scopus citations

Is there a universal rule for cellular growth? - Problems in studying and interpreting this phenomenon

Sveiczer, Á., Horváth, A. & Buchwald, P., Jan 1 2014, In : FEMS Yeast Research. 14, 5, p. 679-682 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Jun kinase delays caspase-9 activation by interaction with the apoptosome

Tran, T. H., Andreka, P., Rodrigues, C. D., Webster, K. A. & Bishopric, N., Jul 13 2007, In : Journal of Biological Chemistry. 282, 28, p. 20340-20350 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Kidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria

Rangel, E. B., Gomes, S. A., Takeuchi, R., Saltzman, R. G., Wei, C., Ruiz, P., Reiser, J. & Hare, J., Dec 1 2018, In : Scientific Reports. 8, 1, 14723.

Research output: Contribution to journalArticle

4 Scopus citations

Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology

Buchser, W. J., Slepak, T. I., Gutierrez-Arenas, O., Bixby, J. & Lemmon, V., Aug 6 2010, In : Molecular Systems Biology. 6, 391.

Research output: Contribution to journalArticle

45 Scopus citations

Kinome-wide activity modeling from diverse public high-quality data sets

Schuerer, S. C. & Muskal, S. M., Jan 28 2013, In : Journal of Chemical Information and Modeling. 53, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

KISS1R intracellular trafficking and degradation: Effect of the Arg386Pro disease-associated mutation

Bianco, S. D. C., Vandepas, L., Correa-Medina, M., Gereben, B., Mukherjee, A., Kuohung, W., Carroll, R., Teles, M. G., Latronico, A. C. & Kaiser, U. B., Apr 1 2011, In : Endocrinology. 152, 4, p. 1616-1626 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

KLF family members regulate intrinsic axon regeneration ability

Moore, D. L., Blackmore, M. G., Hu, Y., Kaestner, K. H., Bixby, J., Lemmon, V. & Goldberg, J. L., Oct 9 2009, In : Science. 326, 5950, p. 298-301 4 p.

Research output: Contribution to journalArticle

384 Scopus citations
11 Scopus citations

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract

Blackmore, M. G., Wang, Z., Lerch, J. K., Motti, D., Zhang, Y. P., Shields, C. B., Lee, J., Goldberg, J. L., Lemmon, V. & Bixby, J., May 8 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7517-7522 6 p.

Research output: Contribution to journalArticle

136 Scopus citations

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

Allen, B. K., Mehta, S., Ember, S. W. J., Schonbrunn, E., Ayad, N. & Schuerer, S. C., Nov 24 2015, In : Scientific Reports. 5, 16924.

Research output: Contribution to journalArticle

28 Scopus citations
43 Scopus citations

Large-scale purification of Na,K-ATPase and its protein subunits from lamb kidney medulla.

Lane, L. K., Potter, J. D. & Collins, J. H., Jan 1 1979, In : Preparative Biochemistry. 9, 2, p. 157-170 14 p.

Research output: Contribution to journalArticle

62 Scopus citations

Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning

Hu, X., Wu, R., Jiang, Z., Wang, L., Chen, P., Zhang, L., Yang, L., Wu, Y., Chen, H., Chen, H., Xu, Y., Zhou, Y., Huang, X., Webster, K. A., Yu, H. & Wang, J., Jan 1 2014, In : Stem Cells. 32, 10, p. 2702-2713 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Lessons from yeast for clathrin-mediated endocytosis

Boettner, D. R., Chi, R. J. & Lemmon, S., Jan 1 2012, In : Nature Cell Biology. 14, 1, p. 2-10 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer

Lyons, L. S., Rao, S., Balkan, W. E., Faysal, J., Maiorino, C. A. & Burnstein, K. L., Mar 1 2008, In : Molecular Endocrinology. 22, 3, p. 597-608 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Ligands and signaling through receptor-type tyrosine phosphatases

Bixby, J., Sep 12 2001, In : IUBMB Life. 51, 3, p. 157-163 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions

Nair, K. S., Hanson, S. M., Mendez, A., Gurevich, E. V., Kennedy, M. J., Shestopalov, V. I., Vishnivetskiy, S. A., Chen, J., Hurley, J. B., Gurevich, V. V. & Slepak, V. Z., May 19 2005, In : Neuron. 46, 4, p. 555-567 13 p.

Research output: Contribution to journalArticle

143 Scopus citations

Light-mediated activation of Rac-1 in photoreceptor outer segments

Balasubramanian, N. & Slepak, V. Z., Aug 5 2003, In : Current Biology. 13, 15, p. 1306-1310 5 p.

Research output: Contribution to journalArticle

30 Scopus citations
4 Scopus citations

Localization of the sites for Ca2+-binding proteins on G protein- coupled receptor kinases

Levay, K., Satpaev, D. K., Pronin, A. N., Benovic, J. L. & Slepak, V. Z., Sep 29 1998, In : Biochemistry. 37, 39, p. 13650-13659 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Loss of c-Kit function impairs arteriogenesis in a mouse model of hindlimb ischemia

Hernandez, D. R., Artiles, A., Duque, J. C., Martinez, L., Pinto, M. T., Webster, K. A., Velazquez, O. C., Vazquez-Padron, R. I. & Soares, R., Jan 1 2017, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

1 Scopus citations

Loss of nNOS inhibits compensatory muscle hypertrophy and exacerbates inflammation and eccentric contraction-induced damage in mdx mice

Froehner, S. C., Reed, S. M., Anderson, K. N., Huang, P. L. & Percival, J., Jan 15 2015, In : Human Molecular Genetics. 24, 2, p. 492-505 14 p., ddu469.

Research output: Contribution to journalArticle

16 Scopus citations
48 Scopus citations

Mammalian odorant receptor tuning breadth persists across distinct odorant panels

Kepchia, D., Sherman, B., Haddad, R. & Luetje, C. W., Sep 1 2017, In : PLoS One. 12, 9, e0185329.

Research output: Contribution to journalArticle

1 Scopus citations

Mapping of ligand binding sites of neuronal nicotinic acetylcholine receptors using chimeric α subunits

Luetje, C. W., Piattoni, M. & Patrick, J., Sep 1 1993, In : Molecular Pharmacology. 44, 3, p. 657-666 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene

Bianco, S. D. C., Peng, J. B., Takanaga, H., Suzuki, Y., Crescenzi, A., Kos, C. H., Zhuang, L., Freeman, M. R., Gouveia, C. H. A., Wu, J., Luo, H., Mauro, T., Brown, E. M. & Hediger, M. A., Feb 1 2007, In : Journal of Bone and Mineral Research. 22, 2, p. 274-285 12 p.

Research output: Contribution to journalArticle

193 Scopus citations

Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: Interaction-restricted diffusion

Slepak, V. Z. & Hurley, J. B., Dec 1 2008, In : IUBMB Life. 60, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Metabolic properties of phosphonate esters

Somogyi, G., Buchwald, P. & Bodor, N., May 1 2004, In : Pharmazie. 59, 5, p. 378-381 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets

Garcia-Contreras, M., Tamayo-Garcia, A., Pappan, K. L., Michelotti, G. A., Stabler, C. L., Ricordi, C. & Buchwald, P., Jun 2 2017, In : Journal of Proteome Research. 16, 6, p. 2294-2306 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Metadata standard and data exchange specifications to describe, model, and integrate complex and diverse high-throughput screening data from the library of integrated network-based cellular signatures (LINCS)

Vempati, U. D., Chung, C., Mader, C., Koleti, A., Datar, N., Vidović, D., Wrobel, D., Erickson, S., Muhlich, J. L., Berriz, G., Benes, C. H., Subramanian, A., Pillai, A., Shamu, C. E. & Schuerer, S. C., Jan 1 2014, In : Journal of Biomolecular Screening. 19, 5, p. 803-816 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Methionine sulfoxide reductase A (MsrA) protects cultured mouse embryonic stem cells from H2O2-mediated oxidative stress

Zhang, C., Jia, P., Jia, Y., Weissbach, H., Webster, K. A., Huang, X., Lemanski, S. L., Achary, M. & Lemanski, L. F., Sep 1 2010, In : Journal of Cellular Biochemistry. 111, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mice with Targeted Disruption of the Dio2 Gene Have Cold-Induced Overexpression of the Uncoupling Protein 1 Gene but Fail to Increase Brown Adipose Tissue Lipogenesis and Adaptive Thermogenesis

Christoffolete, M. A., Linardi, C. C. G., De Jesus, L., Ebina, K. N., Carvalho, S. D., Ribeiro, M. O., Rabelo, R., Curcio, C., Martins, L., Kimura, E. T. & Bianco, A. C., Mar 1 2004, In : Diabetes. 53, 3, p. 577-584 8 p.

Research output: Contribution to journalArticle

136 Scopus citations

Microbial life in the Lake Medee, the largest deep-sea salt-saturated formation

Yakimov, M. M., La Cono, V., Slepak, V. Z., La Spada, G., Arcadi, E., Messina, E., Borghini, M., Monticelli, L. S., Rojo, D., Barbas, C., Golyshina, O. V., Ferrer, M., Golyshin, P. N. & Giuliano, L., Dec 19 2013, In : Scientific Reports. 3, 3554.

Research output: Contribution to journalArticle

49 Scopus citations

MicroRNA-20a constrains p300-driven myocardial angiogenic transcription by direct targeting of p300

Shehadeh, L., Sharma, S., Pessanha, M., Wei, J., Liu, J., Yuan, H., Rodrigues, C. D., Scherr, M., Tsinoremas, N. & Bishopric, N., Nov 13 2013, In : PLoS One. 8, 11, e79133.

Research output: Contribution to journalArticle

9 Scopus citations

MicroRNAs: A new piece in the paediatric cardiovascular disease puzzle

Omran, A., Elimam, D., Webster, K. A., Shehadeh, L. & Yin, F., Oct 1 2013, In : Cardiology in the Young. 23, 5, p. 642-655 14 p.

Research output: Contribution to journalArticle

18 Scopus citations