Molecular and Cellular Pharmacology

Research Output

Filter
Article

High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding

Faridi, M. H., Maiguel, D., Brown, B. T., Suyama, E., Barth, C. J., Hedrick, M., Vasile, S., Sergienko, E., Schuerer, S. C. & Gupta, V., Mar 26 2010, In : Biochemical and Biophysical Research Communications. 394, 1, p. 194-199 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

High-throughput screening for human galactokinase inhibitors

Wierenga, K. J., Lai, K., Buchwald, P. & Tang, M., Aug 1 2008, In : Journal of Biomolecular Screening. 13, 5, p. 415-423 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue

Carvalho, S. D., Negrao, N. & Bianco, A. C., Jan 1 1993, In : American Journal of Physiology - Endocrinology and Metabolism. 264, 6 27-6

Research output: Contribution to journalArticle

28 Scopus citations

Hormone resistance: It's SMRT to fight repression

Burnstein, K. L. & Luetje, C. W., Apr 1 2004, In : Endocrinology. 145, 4, p. 1525-1526 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

Almaca, J., Molina, J., Menegaz, D., Pronin, A. N., Tamayo, A., Slepak, V. Z., Berggren, P. O. & Caicedo-Vierkant, D. A., Dec 20 2016, In : Cell Reports. 17, 12, p. 3281-3291 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms

Jiang, Z., Hu, X., Yu, H., Xu, Y., Wang, L., Chen, H., Chen, H., Wu, R., Zhang, Z., Xiang, C., Webster, K. A. & Wang, J. A., Oct 1 2013, In : Journal of Cellular and Molecular Medicine. 17, 10, p. 1247-1260 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Hyperactivated Stat3 boosts axon regeneration in the CNS

Mehta, S. T., Luo, X., Park, K., Bixby, J. & Lemmon, V., Jun 1 2016, In : Experimental Neurology. 280, p. 115-120 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice

Yuan, C. C., Kazmierczak, K., Liang, J., Takeuchi, R., Irving, T. C., Gomes, A. V., Wang, Y., Burghardt, T. P. & Szczesna-Cordary, D., Aug 1 2017, In : Cardiovascular Research. 113, 10, p. 1124-1136 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice

Huang, W., Liang, J., Kazmierczak, K., Muthu, P., Duggal, D., Farman, G. P., Sorensen, L., Pozios, I., Abraham, T. P., Moore, J. R., Borejdo, J. & Szczesna-Cordary, D., Jan 1 2014, In : Journal of Molecular and Cellular Cardiology. 74, p. 318-329 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Hypoxia: Life on the edge

Webster, K. A., Sep 1 2007, In : Antioxidants and Redox Signaling. 9, 9, p. 1303-1307 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes

Laderoute, K. R. & Webster, K. A., Mar 8 1997, In : Circulation Research. 80, 3, p. 336-344 9 p.

Research output: Contribution to journalArticle

156 Scopus citations

Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53

Webster, K. A., Discher, D. J., Kaiser, S., Hernandez, O., Sato, B. & Bishopric, N., Aug 1 1999, In : Journal of Clinical Investigation. 104, 3, p. 239-252 14 p.

Research output: Contribution to journalArticle

200 Scopus citations

Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3

Kubasiak, L. A., Hernandez, O. M., Bishopric, N. & Webster, K. A., Oct 1 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 20, p. 12825-12830 6 p.

Research output: Contribution to journalArticle

346 Scopus citations

Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand

Hu, J., Discher, D. J., Bishopric, N. & Webster, K. A., Apr 28 1998, In : Biochemical and Biophysical Research Communications. 245, 3, p. 894-899 6 p.

Research output: Contribution to journalArticle

226 Scopus citations

Hypoxia regulates β-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element

Discher, D. J., Bishopric, N., Wu, X., Peterson, C. A. & Webster, K. A., Oct 2 1998, In : Journal of Biological Chemistry. 273, 40, p. 26087-26093 7 p.

Research output: Contribution to journalArticle

142 Scopus citations

Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential

Bellio, M. A., Pinto, M. T., Florea, V., Barrios, P. A., Taylor, C. N., Brown, A. B., Lamondin, C., Hare, J., Schulman, I. H. & Rodrigues, C. D., Dec 1 2017, In : Scientific Reports. 7, 1, 9702.

Research output: Contribution to journalArticle

3 Scopus citations

Identification and cloning of two putative subunits of DNA polymerase epsilon in fussion yeast

Spiga, M. G. & D'urso, G., Nov 9 2004, In : Nucleic Acids Research. 32, 16, p. 4945-4953 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of an alternatively spliced avian member of the synaptophysin gene family

Bixby, J., Jan 1 1992, In : Molecular Brain Research. 13, 4, p. 339-348 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Identification of an oncogenic network with prognostic and therapeutic value in prostate cancer

Magani, F., Bray, E. R., Martinez, M. J., Zhao, N., Copello, V. A., Heidman, L., Peacock, S. O., Wiley, D. J., D'urso, G. & Burnstein, K. L., Aug 1 2018, In : Molecular Systems Biology. 14, 8, e8202.

Research output: Contribution to journalArticle

3 Scopus citations

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

Allen, B. K., Mehta, S., Ember, S. W. J., Zhu, J. Y., Schönbrunn, E., Ayad, N. & Schuerer, S. C., Jan 1 2017, In : ACS Omega. 2, 8, p. 4760-4771 12 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Identification of a truncated form of methionine sulfoxide reductase a expressed in mouse embryonic stem cells

Jia, P., Zhang, C., Jia, Y., Webster, K. A., Huang, X., Kochegarov, A. A., Lemanski, S. L. & Lemanski, L. F., Jun 24 2011, In : Journal of Biomedical Science. 18, 1, 46.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of miRNAs involved in DRG neurite outgrowth and their putative targets

Motti, D., Lerch, J. K., Danzi, M. C., Gans, J. H., Kuo, F., Slepak, T. I., Bixby, J. & Lemmon, V., 2017, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit

Chen, S. & Luetje, C. W., May 8 2012, In : PLoS One. 7, 5, e36784.

Research output: Contribution to journalArticle

42 Scopus citations

Identification of novel agonists of the integrin CD11b/CD18

Faridi, M. H., Maiguel, D., Barth, C. J., Stoub, D., Day, R., Schuerer, S. C. & Gupta, V., Dec 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 24, p. 6902-6906 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors

Everhart, D., Reiller, E., Mirzoian, A., McIntosh, J. M., Malhotra, A. & Luetje, C. W., Aug 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 2, p. 664-670 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening

Bialkowska, A. B., Crisp, M., Bannister, T., He, Y., Chowdhury, S., Schuerer, S. C., Chase, P., Spicer, T., Madoux, F., Tian, C., Hodder, P., Zaharevitz, D. & Yang, V. W., Nov 2011, In : Molecular Cancer Therapeutics. 10, 11, p. 2043-2051 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Identification of suppressor of Clathrin deficiency-1 (SCD1) and its connection to Clathrin-mediated endocytosis in Saccharomyces cerevisiae

Moorthy, B. T., Sharma, A., Boettner, D. R., Wilson, T. E. & Lemmon, S., Mar 1 2019, In : G3: Genes, Genomes, Genetics. 9, 3, p. 867-877 11 p.

Research output: Contribution to journalArticle

Open Access

Identification of the Gβ5-RGS7 protein complex in the retina

Cabrera, J. L., De Freitas, F., Satpaev, D. K. & Slepak, V. Z., Aug 28 1998, In : Biochemical and Biophysical Research Communications. 249, 3, p. 898-902 5 p.

Research output: Contribution to journalArticle

107 Scopus citations

Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics

Farman, G. P., Muthu, P., Kazmierczak, K., Szczesna-Cordary, D. & Moore, J. R., Dec 15 2014, In : Journal of applied physiology (Bethesda, Md. : 1985). 117, 12, p. 1471-1477 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Impaired CXCR4 expression and cell engraftment of bone marrow-derived cells from aged atherogenic mice

Xu, Q., Wang, JA., He, J., Zhou, M., Adi, J., Webster, K. A. & Yu, H., Nov 1 2011, In : Atherosclerosis. 219, 1, p. 92-99 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
Open Access
1 Scopus citations

Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy

Gomez, L. A., De Las Pozas, A., Reiner, T., Burnstein, K. L. & Perez-Stable, C., May 1 2007, In : Molecular Cancer Therapeutics. 6, 5, p. 1534-1543 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Inflammasome activation induces pyroptosis in the retina exposed to ocular hypertension injury

Pronin, A., Pham, D., An, W., Dvoriantchikova, G., Reshetnikova, G., Qiao, J., Kozhekbaeva, Z., Reiser, A. E., Slepak, V. Z. & Shestopalov, V. I., Feb 12 2019, In : Frontiers in Molecular Neuroscience. 12, 36.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Influence of diet on visceral adipose remodeling in NONcNZO10 mice with polygenic susceptibility for type 2 diabetes

Adi, N. C., Adi, J. N., Cesar, L., Agatston, A. S., Kurlansky, P. & Webster, K. A., Oct 1 2012, In : Obesity. 20, 10, p. 2142-2146 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Influence of the N-acetylation polymorphism on the metabolism of talampanel: An investigation in fasted and fed subjects genotyped for NAT2 variants

Buchwald, P., Juhász, A., Bell, C., Pátfalusi, M., Kovács, P., Hochhaus, G., Howes, J. & Bodor, N., Feb 1 2006, In : Pharmazie. 61, 2, p. 125-134 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Inhibition of androgen receptor transcriptional activity as a novel mechanism of action of arsenic

Rosenblatt, A. E. & Burnstein, K. L., Mar 1 2009, In : Molecular Endocrinology. 23, 3, p. 412-421 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit

Kepchia, D., Moliver, S., Chohan, K., Phillips, C. & Luetje, C. W., May 1 2017, In : PLoS One. 12, 5, e0177454.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids

Vang, T., Xie, Y., Liu, W. H., Vidović, D., Liu, Y., Wu, S., Smith, D. H., Rinderspacher, A., Chung, C., Gong, G., Mustelin, T., Landry, D. W., Rickert, R. C., Schuerer, S. C., Deng, S. X. & Tautz, L., Jan 27 2011, In : Journal of Medicinal Chemistry. 54, 2, p. 562-571 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis

Leri, A., Fiordaliso, F., Setoguchi, M., Limana, F., Bishopric, N., Kajstura, J., Webster, K. A. & Anversa, P., Dec 1 2000, In : American Journal of Pathology. 157, 3, p. 843-857 15 p.

Research output: Contribution to journalArticle

61 Scopus citations

Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer

Rosenblatt, A. E., Garcia, M. I., Lyons, L., Xie, Y., Maiorino, C., Désiré, L., Slingerland, J. M. & Burnstein, K. L., Apr 1 2011, In : Endocrine-Related Cancer. 18, 2, p. 207-219 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis

Graham, R. M., Thompson, J. W. & Webster, K. A., Jan 1 2014, In : Oncotarget. 5, 5, p. 1162-1173 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Inhibition of tyrosine phosphorylation potentiates substrate-induced neurite growth

Bixby, J. & Jhabvala, P., Aug 10 1992, In : Journal of Neurobiology. 23, 5, p. 468-480 13 p.

Research output: Contribution to journalArticle

76 Scopus citations

Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing

Kumar, A., Birnbaum, M. D., Moorthy, B. T., Singh, J., Palovcak, A., Patel, D. M. & Zhang, F., Jul 24 2019, In : BMC genomics. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Instability of a multiple copy enhancer in plasmid vectors: Practical considerations

Discher, D. J., Bishopric, N., Hernandez, O. M. & Webster, K. A., Jun 24 1999, In : BioTechniques. 26, 6, p. 1026-1030 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Interaction of rhodopsin kinase with recoverin and calmodulin

Satpaev, D. K., Levay, K. & Slepak, V. Z., Dec 1 1998, In : FASEB Journal. 12, 8

Research output: Contribution to journalArticle

International union of pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: Glucocorticoid, mineralocorticoid, progesterone, and androgen receptors

Lu, N. Z., Wardell, S. E., Burnstein, K. L., Defranco, D., Fuller, P. J., Giguere, V., Hochberg, R. B., Mckay, L., Renoir, J. M., Weigel, N. L., Wilson, E. M., Mcdonnell, D. P. & Cidlowski, J. A., Dec 1 2006, In : Pharmacological Reviews. 58, 4, p. 782-797 16 p.

Research output: Contribution to journalArticle

225 Scopus citations

Intracellular mechanisms of axon growth induction by CAMs and integrins: Some unresolved issues

Bixby, J. & Bookman, R. J., Dec 1 1996, In : Perspectives on Developmental Neurobiology. 4, 2-3, p. 147-156 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormone-inducible receptor messenger RNA down-regulation through multiple mechanisms

Burnstein, K. L., Jewell, C. M., Sar, M. & Cidlowski, J. A., Dec 1 1994, In : Molecular Endocrinology. 8, 12, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

87 Scopus citations