Molecular and Cellular Pharmacology

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Formalization, Annotation and Analysis of Diverse Drug and Probe Screening Assay Datasets Using the BioAssay Ontology (BAO)

Vempati, U. D., Przydzial, M. J., Chung, C., Abeyruwan, S., Mir, A., Sakurai, K., Visser, U. E., Lemmon, V. & Schuerer, S. C., Nov 14 2012, In : PLoS One. 7, 11, e49198.

Research output: Contribution to journalArticle

37 Scopus citations

From critters to cancers: Bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

Hoogewijs, D., Terwilliger, N. B., Webster, K. A., Powell-Coffman, J. A., Tokishita, S., Yamagata, H., Hankeln, T., Burmester, T., Rytknen, K. T., Nikinmaa, M., Abele, D., Heise, K., Lucassen, M., Fandrey, J., Maxwell, P. H., Phlman, S. & Gorr, T. A., Oct 1 2007, In : Integrative and Comparative Biology. 47, 4, p. 552-577 26 p.

Research output: Contribution to journalArticle

19 Scopus citations

From flamingo dance to (desirable) drug discovery: A nature-inspired approach

Sánchez-Rodríguez, A., Pérez-Castillo, Y., Schuerer, S. C., Nicolotti, O., Mangiatordi, G. F., Borges, F., Cordeiro, M. N. D. S., Tejera, E., Medina-Franco, J. L. & Cruz-Monteagudo, M., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

6 Scopus citations

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

Križaj, D., Ryskamp, D. A., Tian, N., Tezel, G., Mitchell, C. H., Slepak, V. Z. & Shestopalov, V. I., Feb 1 2014, In : Current Eye Research. 39, 2, p. 105-119 15 p.

Research output: Contribution to journalArticle

75 Scopus citations

Fully automated islet cell counter (ICC) for the assessment of islet mass, purity, and size distribution by digital image analysis

Buchwald, P., Bernal, A., Echeverri, F., Tamayo-Garcia, A., Linetsky, E. & Ricordi, C., 2016, In : Cell Transplantation. 25, 10, p. 1747-1761 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Functional analysis of a mammalian odorant receptor subfamily

Abaffy, T., Matsunami, H. & Luetje, C. W., Jun 1 2006, In : Journal of Neurochemistry. 97, 5, p. 1506-1518 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

Functional and nonfunctional forms of CquiOR91, an odorant selectivity subunit of Culex quinquefasciatus

Hughes, D. T., Pelletier, J., Rahman, S., Chen, S., Leal, W. S. & Luetje, C. W., May 1 2017, In : Chemical Senses. 42, 4, p. 333-341 9 p., bjx011.

Research output: Contribution to journalArticle

1 Scopus citations

Functional assay of mammalian and insect olfactory receptors using Xenopus oocytes.

Luetje, C. W., Nichols, A. S., Castro, A. & Sherman, B. L., Oct 4 2013, In : Methods in molecular biology (Clifton, N.J.). 1003, p. 187-202 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Functional characterizations of rare UBA1 variants in X-linked Spinal Muscular Atrophy

Baumbach-Reardon, L., Balak, C. D., Hunter, J. M., Ahearn, M. E., Wiley, D. & D'urso, G., 2017, In : F1000Research. 6, 1636.

Research output: Contribution to journalArticle

3 Scopus citations

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

Wen, Y., Pinto, J. R., Gomes, A. V., Xu, Y., Wang, Y., Wang, Y., Potter, J. D. & Kerrick, W. G., Jul 18 2008, In : Journal of Biological Chemistry. 283, 29, p. 20484-20494 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Functional Effects of a Restrictive-Cardiomyopathy-Linked Cardiac Troponin I Mutation (R145W) in Transgenic Mice

Wen, Y., Xu, Y., Wang, Y., Pinto, J. R., Potter, J. D. & Kerrick, W. G., Oct 9 2009, In : Journal of Molecular Biology. 392, 5, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons

Maddox, F. N., Valeyev, A. Y., Poth, K., Holohean, A. M., Wood, P., Davidoff, R. A., Hackman, J. C. & Luetje, C. W., Apr 19 2004, In : Developmental Brain Research. 149, 2, p. 143-151 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

GADD45γ: A new vitamin D-regulated gene that is antiproliferative in prostate cancer cells

Flores, O. & Burnstein, K. L., Oct 1 2010, In : Endocrinology. 151, 10, p. 4654-4664 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Gene and cell therapy for heart disease

Graham, R. M., Bishopric, N. & Webster, K. A., Aug 1 2002, In : IUBMB Life. 54, 2, p. 59-66 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain

Huang, W., Kazmierczak, K., Zhou, Z., Aguiar-Pulido, V., Narasimhan, G. & Szczesna-Cordary, D., Nov 1 2015, (Accepted/In press) In : Archives of Biochemistry and Biophysics.

Research output: Contribution to journalArticle

5 Scopus citations

General linearized biexponential model for QSAR data showing bilinear-type distribution

Buchwald, P., Nov 1 2005, In : Journal of Pharmaceutical Sciences. 94, 11, p. 2355-2379 25 p.

Research output: Contribution to journalArticle

27 Scopus citations

Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy

Wang, Y., Pinto, J. R., Solis, R. S., Dweck, D., Liang, J., Diaz-Perez, Z., Ge, Y., Walker, J. W. & Potter, J. D., Jan 13 2012, In : Journal of Biological Chemistry. 287, 3, p. 2156-2167 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury

Dvoriantchikova, G., Ivanov, D. V., Barakat, D., Grinberg, A., Wen, R., Slepak, V. Z. & Shestopalov, V. I., Feb 23 2012, In : PLoS One. 7, 2, e31991.

Research output: Contribution to journalArticle

70 Scopus citations

Genetic elucidation of human hyperosmia to isovaleric acid.

Menashe, I., Abaffy, T., Hasin, Y., Goshen, S., Yahalom, V., Luetje, C. W. & Lancet, D., Oct 30 2007, In : PLoS Biology. 5, 11

Research output: Contribution to journalArticle

131 Scopus citations

Gene transfer and models of gene therapy for the myocardium

Yvonne Alexander, M., Webster, K. A., McDonald, P. H. & Prentice, H. M., Sep 28 1999, In : Clinical and Experimental Pharmacology and Physiology. 26, 9, p. 661-668 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Genomic and proteomic profiles of heart disease

Prentice, H. & Webster, K. A., Oct 1 2004, In : Trends in Cardiovascular Medicine. 14, 7, p. 282-288 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin

Lu, X., Kazmierczak, K., Jiang, X., Jones, M., Watt, J., Helfman, D. M., Moore, J. R., Szczesna-Cordary, D. & Lossos, I., Jun 1 2011, In : FEBS Journal. 278, 11, p. 1922-1931 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Getting in Touch with the Clathrin Terminal Domain

Lemmon, S. & Traub, L. M., Apr 1 2012, In : Traffic. 13, 4, p. 511-519 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Getting past the asterisk: The subunit composition of presynaptic nicotinic receptors that modulate striatal dopamine release

Luetje, C. W., Jun 1 2004, In : Molecular Pharmacology. 65, 6, p. 1333-1335 3 p.

Research output: Contribution to journalArticle

33 Scopus citations

Global Deletion of Trp53 Reverts Ovarian Tumor Phenotype of the Germ Cell–Deficient White Spotting Variant (Wv) Mice

Cai, K. Q., Wang, Y., Smith, E. R., Smedberg, J. L., Yang, D. H., Yang, W. L. & Xu, X., Jan 1 2015, In : Neoplasia. 17, 1, p. 89-100 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors

Cornacchia, F., Fornoni, A., Plati, A. R., Thomas, A., Wang, Y., Inverardi, L. A., Striker, L. J. & Striker, G. E., Dec 29 2001, In : Journal of Clinical Investigation. 108, 11, p. 1649-1656 8 p.

Research output: Contribution to journalArticle

109 Scopus citations

Glucocorticoid receptor binding: A biphasic dependence on molecular size as revealed by the bilinear LinBiExp model

Buchwald, P., Feb 1 2008, In : Steroids. 73, 2, p. 193-208 16 p.

Research output: Contribution to journalArticle

31 Scopus citations

Glucose-stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets

Buchwald, P., Tamayo-Garcia, A., Manzoli, V., Tomei, A. & Stabler, C. L., 2017, (Accepted/In press) In : Biotechnology and Bioengineering.

Research output: Contribution to journalArticle

17 Scopus citations

Glycosaminoglycan-dependent and -independent inhibition of neurite outgrowth by agrin

Baerwald-De La Torre, K., Winzen, U., Halfter, W. & Bixby, J., Jul 1 2004, In : Journal of Neurochemistry. 90, 1, p. 50-61 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Glycosylation within the Cystein loop and six residues near conserved Cys192/Cys193 are determinants of neuronal bungarotoxin sensitivity on the neuronal nicotinic receptor α3 subunit

Luetje, C. W., Maddox, F. N. & Harvey, S. C., Jun 1 1998, In : Molecular Pharmacology. 53, 6, p. 1112-1119 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1

Chan, Y. M., Broder-Fingert, S., Paraschos, S., Lapatto, R., Au, M., Hughes, V., Bianco, S. D. C., Min, L., Plummer, L., Cerrato, F., De Guillebon, A., Wu, I. H., Wahab, F., Dwyer, A., Kirsch, S., Quinton, R., Cheetham, T., Ozata, M., Ten, S., Chanoine, J. P. & 8 others, Pitteloud, N., Martin, K. A., Schiffmann, R., Van Der Kamp, H. J., Nader, S., Hall, J. E., Kaiser, U. B. & Seminara, S. B., Nov 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 11

Research output: Contribution to journalArticle

41 Scopus citations

GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1

Chan, Y. M., Broder-Fingert, S., Parachos, S., Lapatto, R., Au, M., Hughes, V., Bianco, S. D. C., Min, L., Plummer, L., Cerrato, F., De Guillebon, A., Wu, I. H., Wahab, F., Dwyer, A., Kirsch, S., Quinton, R., Cheetham, T., Ozata, M., Ten, S., Chanoine, J. P. & 8 others, Pitteloud, N., Martin, K. A., Schiffmann, R., Van Der Kamp, H. J., Nader, S., Hall, J. E., Kaiser, U. B. & Seminara, S. B., Sep 1 2012, In : Obstetrical and Gynecological Survey. 67, 9, p. 546-547 2 p.

Research output: Contribution to journalArticle

GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework.

Przydzial, M. J., Bhhatarai, B., Koleti, A., Vempati, U. & Schuerer, S. C., Dec 15 2013, In : Bioinformatics (Oxford, England). 29, 24, p. 3211-3219 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Growth cone steering by receptor tyrosine phosphatase δ defines a distinct class of guidance cue

Sun, Q. L., Wang, J., Bookman, R. J. & Bixby, J., Dec 1 2000, In : Molecular and Cellular Neuroscience. 16, 5, p. 686-695 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Growth hormone-releasing hormone agonists reduce myocardial infarct scar in swine With subacute ischemic cardiomyopathy

Bagno, L. L., Takeuchi, R., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., Wang, B., Premer, C., Balkan, W. E., Rodriguez, J., Valdes, D., Rosado, M., Block, N. L., Goldstein, P., Morales, A. R., Cai, R. Z., Sha, W., Schally, A. V. & Hare, J., 2015, In : Journal of the American Heart Association. 4, 4, e001464.

Research output: Contribution to journalArticle

12 Scopus citations

GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

Penas, C., Mishra, J. K., Wood, S. D., Schuerer, S. C., Roush, W. R. & Ayad, N., Feb 1 2015, In : Cell Cycle. 14, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

GSK3 involvement in amylin signaling in isolated rat soleus muscle

Abaffy, T. & Cooper, G. J. S., Dec 1 2004, In : Peptides. 25, 12, p. 2119-2125 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
10 Scopus citations
82 Scopus citations

Gβ5-RGS7 inhibits Gαq-mediated signaling via a direct protein-protein interaction

Witherow, D. S., Tovey, S. C., Wang, Q., Willars, G. B. & Slepak, V. Z., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 21307-21313 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex

Karpinsky-Semper, D., Tayou, J., Levay, K., Schuchardt, B. J., Bhat, V., Volmar, C. H., Farooq, A. & Slepak, V. Z., Feb 3 2015, In : Biochemistry. 54, 4, p. 1077-1088 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis

Hu, X., Zhang, L., Jin, J., Zhu, W., Xu, Y., Wu, Y., Wang, Y., Chen, H., Webster, K. A., Chen, H., Yu, H. & Wang, J., Jun 1 2015, In : Stem Cells. 33, 6, p. 1850-1862 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hepatocyte growth factor and vitamin D cooperatively inhibit androgen-unresponsive prostate cancer cell lines

Qadan, L. R., Perez-Stable, C., Schwall, R. H., Burnstein, K. L., Ostenson, R. C., Howard, G. & Roos, B. A., Dec 1 2000, In : Endocrinology. 141, 7, p. 2567-2573 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Hepatoma-derived growth factor-related protein-3 is a novel angiogenic factor

LeBlanc, M. E., Wang, W., Caberoy, N. B., Chen, X., Guo, F., Alvarado, G., Shen, C., Wang, F., Wang, H., Chen, R., Liu, Z-J., Webster, K. A. & Li, W., May 21 2015, In : PLoS One. 10, 5, e0127904.

Research output: Contribution to journalArticle

10 Scopus citations

Heterogeneity in SDF-1 expression defines the vasculogenic potential of adult cardiac progenitor cells

Rodrigues, C. D., Shehadeh, L., Hoosien, M., Otero, V., Chopra, I., Tsinoremas, N. & Bishopric, N., Aug 24 2011, In : PLoS One. 6, 8, e24013.

Research output: Contribution to journalArticle

11 Scopus citations

Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia

Poth, K., Nutter, T. J., Cuevas, J., Parker, M. J., Adams, D. J. & Luetje, C. W., Jan 20 1997, In : Journal of Neuroscience. 17, 2, p. 586-596 11 p.

Research output: Contribution to journalArticle

89 Scopus citations

High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries

Nelersa, C. M., Barreras, H., Runko, E., Ricard, J., Shi, Y., Glass, S. J., Bixby, J., Lemmon, V. & Liebl, D. J., Jul 1 2012, In : Journal of Biomolecular Screening. 17, 6, p. 785-795 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

High content screening of cortical neurons identifies novel regulators of axon growth

Blackmore, M. G., Moore, D. L., Smith, R. P., Goldberg, J. L., Bixby, J. & Lemmon, V., May 1 2010, In : Molecular and Cellular Neuroscience. 44, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

74 Scopus citations

High quality, small molecule-activity datasets for kinase research [version 1; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

5 Scopus citations

High quality, small molecule-activity datasets for kinase research [version 2; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

1 Scopus citations