Molecular and Cellular Pharmacology

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2020

A Collagen Based Cryogel Bioscaffold that Generates Oxygen for Islet Transplantation

Razavi, M., Primavera, R., Kevadiya, B. D., Wang, J., Buchwald, P. & Thakor, A. S., Apr 1 2020, In : Advanced Functional Materials. 30, 15, 1902463.

Research output: Contribution to journalArticle

Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes

Inherited Neuropathy Consortium, May 1 2020, In : Nature genetics. 52, 5, p. 473-481 9 p.

Research output: Contribution to journalArticle

CRISPR-addressable yeast strains with applications in human G protein-coupled receptor profiling and synthetic biology

Rowe, J. B., Taghon, G. J., Kapolka, N. J., Morgan, W. M. & Isom, D. G., Jun 12 2020, In : The Journal of biological chemistry. 295, 24, p. 8262-8271 10 p.

Research output: Contribution to journalArticle

Open Access

Dcyfir: A high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery

Kapolka, N. J., Taghon, G. J., Rowe, J. B., Morgan, W. M., Enten, J. F., Lambert, N. A. & Isom, D. G., Jun 9 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 23, p. 13117-13126 10 p.

Research output: Contribution to journalArticle

Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library

Gibbons, G. S., Chakraborty, A., Grigsby, S. M., Umeano, A. C., Liao, C., Moukha-Chafiq, O., Pathak, V., Mathew, B., Lee, Y. T., Dou, Y., Schürer, S. C., Reynolds, R. C., Snowden, T. S. & Nikolovska-Coleska, Z., Mar 1 2020, In : European Journal of Medicinal Chemistry. 189, 112023.

Research output: Contribution to journalArticle

LINCS Data Portal 2.0: next generation access point for perturbation-response signatures

Stathias, V., Turner, J., Koleti, A., Vidovic, D., Cooper, D., Fazel-Najafabadi, M., Pilarczyk, M., Terryn, R., Chung, C., Umeano, A., Clarke, D. J. B., Lachmann, A., Evangelista, J. E., Ma'ayan, A., Medvedovic, M. & Schürer, S. C., Jan 8 2020, In : Nucleic acids research. 48, D1, p. D431-D439

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Longitudinal proteomics analysis in the immediate microenvironment of islet allografts during progression of rejection

Alcazar, O., Hernandez, L. F., Nakayasu, E. S., Piehowski, P. D., Ansong, C., Abdulreda, M. H. & Buchwald, P., Jul 15 2020, In : Journal of Proteomics. 223, 103826.

Research output: Contribution to journalArticle

Nicotinamide mononucleotide adenylyl transferase uses its NAD+ substrate-binding site to chaperone phosphorylated TAU

Ma, X., Zhu, Y., Lu, J., Xie, J., Li, C., Shin, W. S., Qiang, J., Liu, J., Dou, S., Xiao, Y., Wang, C., Jia, C., Long, H., Yang, J., Fang, Y., Jiang, L., Zhang, Y., Zhang, S., Zhai, R. G., Liu, C. & 1 others, Li, D., Apr 2020, In : eLife. 9, e51859.

Research output: Contribution to journalArticle

Open Access

The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- And extracellular signal-stimulated insulin secretion

Wang, Q., Henry, T. A. N., Pronin, A. N., Jang, G. F., Lubaczeuski, C., Crabb, J. W., Bernal-Mizrachi, E. & Slepak, V. Z., May 22 2020, In : Journal of Biological Chemistry. 295, 21, p. 7213-7223 11 p.

Research output: Contribution to journalArticle

Open Access
2019

A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells

Qadir, M. M. F., Álvarez-Cubela, S., Belle, K., Sapir, T., Messaggio, F., Johnson, K. B., Umland, O., Hardin, D., Klein, D., Pérez-Álvarez, I., Sadiq, F., Alcázar, O., Inverardi, L. A., Ricordi, C., Buchwald, P., Fraker, C. A., Pastori, R. L. & Domínguez-Bendala, J., Mar 5 2019, In : Stem Cell Reports. 12, 3, p. 611-623 13 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
Open Access
2 Scopus citations

Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer

Zhao, N., Peacock, S. O., Lo, C. H., Heidman, L. M., Rice, M. A., Fahrenholtz, C. D., Greene, A. M., Magani, F., Copello, V. A., Martinez, M. J., Zhang, Y., Daaka, Y., Lynch, C. C. & Burnstein, K. L., Jan 1 2019, In : Science Translational Medicine. 11, 498, eaaw4636.

Research output: Contribution to journalArticle

2 Scopus citations

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Hutson, T. H., Kathe, C., Palmisano, I., Bartholdi, K., Hervera, A., De Virgiliis, F., McLachlan, E., Zhou, L., Kong, G., Barraud, Q., Danzi, M. C., Medrano-Fernandez, A., Lopez-Atalaya, J. P., Boutillier, A. L., Sinha, S. H., Singh, A. K., Chaturbedy, P., Moon, L. D. F., Kundu, T. K., Bixby, J. L. & 4 others, Lemmon, V. P., Barco, A., Courtine, G. & Giovanni, S. D., Apr 10 2019, In : Science Translational Medicine. 11, 487, eaaw2064.

Research output: Contribution to journalArticle

14 Scopus citations
Open Access
3 Scopus citations

Conserved NDR/LATS kinase controls RAS GTPase activity to regulate cell growth and chronological lifespan

Chen, C., Pino, M. R., Haller, P. R. & Verde, F., Sep 15 2019, In : Molecular biology of the cell. 30, 20, p. 2598-2616 19 p.

Research output: Contribution to journalArticle

Open Access

DrugCentral 2018: An update

Ursu, O., Holmes, J., Bologa, C. G., Yang, J. J., Mathias, S. L., Stathias, V., Nguyen, D. T., Schürer, S. & Oprea, T., Jan 8 2019, In : Nucleic acids research. 47, D1, p. D963-D970

Research output: Contribution to journalArticle

16 Scopus citations

Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss

Li, C., Bademci, G., Subasioglu, A., Diaz-Horta, O., Zhu, Y., Liu, J., Mitchell, T. G., Abad, C., Seyhan, S., Duman, D., Cengiz, F. B., Tokgoz-Yilmaz, S., Blanton, S. H., Farooq, A., Walz, K., Grace Zhai, R. & Tekin, M., Jan 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1347-1352 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Efficient proximal gradient algorithm for inference of differential gene networks

Wang, C., Gao, F., Giannakis, G. B., D'Urso, G. & Cai, X., May 2 2019, In : BMC Bioinformatics. 20, 1, 224.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Feasibility of localized metabolomics in the study of pancreatic islets and diabetes

Alcazar, O., Hernandez, L. F., Tschiggfrie, A., Muehlbauer, M. J., Bain, J. R., Buchwald, P. & Abdulreda, M. H., Oct 2019, In : Metabolites. 9, 10, 207.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Identification of suppressor of Clathrin deficiency-1 (SCD1) and its connection to Clathrin-mediated endocytosis in Saccharomyces cerevisiae

Moorthy, B. T., Sharma, A., Boettner, D. R., Wilson, T. E. & Lemmon, S. K., Mar 1 2019, In : G3: Genes, Genomes, Genetics. 9, 3, p. 867-877 11 p.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Scopus citations

Inflammasome activation induces pyroptosis in the retina exposed to ocular hypertension injury

Pronin, A., Pham, D., An, W., Dvoriantchikova, G., Reshetnikova, G., Qiao, J., Kozhekbaeva, Z., Reiser, A. E., Slepak, V. Z. & Shestopalov, V. I., Feb 12 2019, In : Frontiers in Molecular Neuroscience. 12, 36.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing

Kumar, A., Birnbaum, M. D., Moorthy, B. T., Singh, J., Palovcak, A., Patel, D. M. & Zhang, F., Jul 24 2019, In : BMC genomics. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice

Abdulreda, M. H., Molano, R., Faleo, G., Lopez-Cabezas, M., Shishido, A., Ulissi, U., Fotino, C., Hernandez, L. F., Tschiggfrie, A., Aldrich, V. R., Tamayo-Garcia, A., Bayer, A. S., Ricordi, C., Caicedo, A., Buchwald, P., Pileggi, A. & Berggren, P-O. Y., Jul 1 2019, In : Diabetologia. 62, 7, p. 1237-1250 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

MicroRNA-25 protects smooth muscle cells against corticosterone-induced apoptosis

Zhang, B., Zhang, G., Wei, T., Yang, Z., Tan, W., Mo, Z., Liu, J., Li, D., Wei, Y., Zhang, L., Webster, K. A. & Wei, J., 2019, In : Oxidative Medicine and Cellular Longevity. 2019, 2691514.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Novel Curcumin inspired bis-chalcone promotes endoplasmic reticulum stress and glioblastoma neurosphere cell death

Sansalone, L., Veliz, E. A., Myrthil, N. G., Stathias, V., Walters, W., Torrens, I. I., Schürer, S. C., Vanni, S., Leblanc, R. M. & Graham, R. M., Mar 2019, In : Cancers. 11, 3, 357.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

OSCI: Standardized stem cell ontology representation and use cases for stem cell investigation

He, Y., Duncan, W. D., Cooper, D. J., Hansen, J., Iyengar, R., Ong, E., Walker, K., Tibi, O., Smith, S., Serra, L. M., Zheng, J., Sarntivijai, S., Schuerer, S. C., O'shea, K. S. & Diehl, A. D., Apr 25 2019, In : BMC Bioinformatics. 20, 180.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Progenitor/Stem Cell Delivery by Suprarenal Aorta Route in Acute Kidney Injury

Rangel, É. B., Gomes, S. A., Kanashiro-Takeuchi, R. & Hare, J. M., Nov 1 2019, In : Cell Transplantation. 28, 11, p. 1390-1403 14 p.

Research output: Contribution to journalArticle

Open Access

Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis

Birnbaum, M. D., Zhao, N., Moorthy, B. T., Patel, D. M., Kryvenko, O. N., Heidman, L., Kumar, A., Morgan, W. M., Ban, Y., Reis, I. M., Chen, X., Gonzalgo, M. L., Jorda, M., Burnstein, K. L. & Zhang, F., Feb 7 2019, In : Oncogene. 38, 6, p. 838-851 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain

Kazmierczak, K., Liang, J., Yuan, C. C., Yadav, S., Sitbon, Y. H., Walz, K., Ma, W., Irving, T. C., Cheah, J. X., Gomes, A. V. & Szczesna-Cordary, D., Mar 1 2019, In : FASEB Journal. 33, 3, p. 3152-3166 15 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy

Parvatiyar, M. S., Brownstein, A. J., Kanashiro-Takeuchi, R. M., Collado, J. R., Dieseldorff Jones, K. M., Gopal, J., Hammond, K. G., Marshall, J. L., Ferrel, A., Beedle, A. M., Chamberlain, J. S., Pinto, J. R. & Crosbie, R. H., Jun 6 2019, In : JCI Insight. 4, 11, e123855.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM

Yadav, S., Yuan, C. C., Kazmierczak, K., Liang, J., Huang, W., Takeuchi, L. M., Kanashiro-Takeuchi, R. M. & Szczesna-Cordary, D., Jul 1 2019, In : Journal of Molecular Medicine. 97, 7, p. 1033-1047 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit

Kepchia, D., Xu, P., Terryn, R., Castro, A., Schürer, S. C., Leal, W. S. & Luetje, C. W., Dec 1 2019, In : Scientific reports. 9, 1, 4055.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Alterations of tumor microenvironment by nitric oxide impedes castration-resistant prostate cancer growth

Arora, H., Panara, K., Kuchakulla, M., Kulandavelu, S., Burnstein, K. L., Schally, A. V., Hare, J. & Ramasamy, R., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. 11298-11303 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency

Birnbaum, M. D., Nemzow, L., Kumar, A., Gong, F. & Zhang, F., Jan 1 2018, (Accepted/In press) In : Cell Chemical Biology.

Research output: Contribution to journalArticle

A testosterone metabolite 19-hydroxyandrostenedione induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olfactory receptor

Abaffy, T., Bain, J. R., Muehlbauer, M. J., Spasojevic, I., Lodha, S., Bruguera, E., O'Neal, S. K., Kim, S. Y. & Matsunami, H., May 28 2018, In : Frontiers in Oncology. 8, MAY, 162.

Research output: Contribution to journalArticle

4 Scopus citations

Can Chromatin Accessibility be Exploited for Axon Regeneration?

Danzi, M. C., O’Neill, N., Bixby, J. & Lemmon, V., Jan 1 2018, (Accepted/In press) In : Developmental Neurobiology.

Research output: Contribution to journalArticle

2 Scopus citations

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

9 Scopus citations

Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast

Isom, D. G., Page, S. C., Collins, L. B., Kapolka, N. J., Taghon, G. J. & Dohlman, H. G., Feb 16 2018, In : Journal of Biological Chemistry. 293, 7, p. 2318-2329 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: Integrated access to diverse large-scale cellular perturbation response data

Koleti, A., Terryn, R., Stathias, V., Chung, C., Cooper, D. J., Turner, J. P., VidoviÄ ‡, D., Forlin, M., Kelley, T. T., D'Urso, A., Allen, B. K., Torre, D., Jagodnik, K. M., Wang, L., Jenkins, S. L., Mader, C., Niu, W., Fazel, M., Mahi, N., Pilarczyk, M. & 9 others, Clark, N., Shamsaei, B., Meller, J., Vasiliauskas, J., Reichard, J., Medvedovic, M., Ma'Ayan, A., Pillai, A. & Schürer, S. C., Jan 1 2018, In : Nucleic acids research. 46, D1, p. D558-D566

Research output: Contribution to journalArticle

35 Scopus citations

Design, synthesis, and evaluation of novel immunomodulatory small molecules targeting the CD40–CD154 costimulatory protein-protein interaction

Bojadzic, D., Chen, J., Alcazar, O. & Buchwald, P., 2018, In : Molecules. 23, 5, 1153.

Research output: Contribution to journalArticle

3 Scopus citations

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schürer, S. C. & Ayad, N. G., Dec 1 2018, In : Nature Communications. 9, 1, 5315.

Research output: Contribution to journalArticle

10 Scopus citations

Endothelial cells from different anatomical origin have distinct responses during SNAIL/TGF-β2-mediated endothelial-mesenchymal transition

Pinto, M. T., Melo, F. U. F., Malta, T. M., Rodrigues, E. S., Plaça, J. R., Silva, W. A., Panepucci, R. A., Covas, D. T., Rodrigues, C. D. O. & Kashima, S., Jan 1 2018, In : American Journal of Translational Research. 10, 12, p. 4065-4081 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Far away from the lamppost

Oprea, T. I., Jan, L., Johnson, G. L., Roth, B. L., Ma’ayan, A., Schürer, S., Shoichet, B. K., Sklar, L. A. & McManus, M. T., Dec 2018, In : PLoS biology. 16, 12, e3000067.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of an oncogenic network with prognostic and therapeutic value in prostate cancer

Magani, F., Bray, E. R., Martinez, M. J., Zhao, N., Copello, V. A., Heidman, L., Peacock, S. O., Wiley, D. J., D'Urso, G. & Burnstein, K. L., Aug 2018, In : Molecular Systems Biology. 14, 8, e8202.

Research output: Contribution to journalArticle

6 Scopus citations

Kidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria

Rangel, E. B., Gomes, S. A., Takeuchi, R., Saltzman, R. G., Wei, C., Ruiz, P., Reiser, J. & Hare, J., Dec 1 2018, In : Scientific Reports. 8, 1, 14723.

Research output: Contribution to journalArticle

6 Scopus citations

Mutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2

Lassuthova, P., Rebelo, A. P., Ravenscroft, G., Lamont, P. J., Davis, M. R., Manganelli, F., Feely, S. M., Bacon, C., Brožková, D. Š., Haberlova, J., Mazanec, R., Tao, F., Saghira, C., Abreu, L., Courel, S., Powell, E., Buglo, E., Bis, D. M., Baxter, M. F., Ong, R. W. & 14 others, Marns, L., Lee, Y. C., Bai, Y., Isom, D. G., Barro-Soria, R., Chung, K. W., Scherer, S. S., Larsson, H. P., Laing, N. G., Choi, B. O., Seeman, P., Shy, M. E., Santoro, L. & Zuchner, S., Mar 1 2018, In : American journal of human genetics. 102, 3, p. 505-514 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

Zhu, J., Lu, K., Zhang, N., Zhao, Y., Ma, Q., Shen, J., Lin, Y., Xiang, P., Tang, Y., Hu, X., Chen, J., Zhu, W., Webster, K. A., Wang, J. & Yu, H., Nov 17 2018, In : Artificial Cells, Nanomedicine and Biotechnology. 46, 8, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy

Brazill, J. M., Cruz, B., Zhu, Y. & Zhai, R. G., Jun 2018, In : DMM Disease Models and Mechanisms. 11, 6, dmm.032938.

Research output: Contribution to journalArticle

6 Scopus citations