Molecular and Cellular Pharmacology

Research Output

2010

Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation

Zhang, F., Saha, S., Shabalina, S. A. & Kashina, A., Sep 17 2010, In : Science. 329, 5998, p. 1534-1537 4 p.

Research output: Contribution to journalArticle

119 Scopus citations

Differential volatile signatures from skin, naevi and melanoma: A novel approach to detect a pathological process

Abaffy, T., Duncan, R., Riemer, D. D., Tietje, O., Elgart, G., Milikowski, C. & Anthony Defazio, R., Nov 18 2010, In : PloS one. 5, 11, e13813.

Research output: Contribution to journalArticle

45 Scopus citations

Discovery of potent and selective urea-based ROCK inhibitors and their effects on intraocular pressure in rats

Yin, Y., Cameron, M. D., Lin, L., Khan, S., Schröter, T., Grant, W., Pocas, J., Chen, Y. T., Schürer, S., Pachori, A., Lograsso, P. & Feng, Y., Aug 27 2010, In : ACS Medicinal Chemistry Letters. 1, 4, p. 175-179 5 p.

Research output: Contribution to journalArticle

33 Scopus citations
14 Scopus citations

Explicit targeting of transformed cells by VSV in ovarian epithelial tumor-bearing Wv mouse models

Capo-chichi, C. D., Yeasky, T. M., Heiber, J. F., Wang, Y., Barber, G. N. & Xu, X. X., Feb 1 2010, In : Gynecologic oncology. 116, 2, p. 269-275 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Expression of PTPRO in the interneurons of adult mouse olfactory bulb

Kotani, T., Murata, Y., Ohnishi, H., Mori, M., Kusakari, S., Saito, Y., Okazawa, H., Bixby, J. L. & Matozaki, T., Jan 15 2010, In : Journal of Comparative Neurology. 518, 2, p. 119-136 18 p.

Research output: Contribution to journalArticle

8 Scopus citations

Expression of the Argonaute protein PiwiL2 and piRNAs in adult mouse mesenchymal stem cells

Wu, Q., Ma, Q., Shehadeh, L. A., Wilson, A., Xia, L., Yu, H. & Webster, K. A., Jun 11 2010, In : Biochemical and biophysical research communications. 396, 4, p. 915-920 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-β isoform specific and required for adaptive thermogenesis

Ribeiro, M. O., Bianco, S. D. C., Kaneshige, M., Schultz, J. J., Cheng, S. Y., Bianco, A. C. & Brent, G. A., Jan 1 2010, In : Endocrinology. 151, 1, p. 432-440 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

Familial hypertrophic cardiomyopathy can be characterized by a specific pattern of orientation fluctuations of actin molecules

Borejdo, J., Szczesna-Cordary, D., Muthu, P. & Calander, N., Jun 29 2010, In : Biochemistry. 49, 25, p. 5269-5277 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Feasibility of localized immunosuppression: 2. PLA microspheres for the sustained local delivery of a soft immunosuppressant

Pinto, E., Zhang, B., Song, S., Bodor, N., Buchwald, P. & Hochhaus, G., Jun 1 2010, In : Pharmazie. 65, 6, p. 429-435 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Feasibility of localized immunosuppression: 1. Exploratory studies with glucocorticoids in a biohybrid device designed for cell transplantation

Buchwald, P., Bocca, N., Marzorati, S., Hochhaus, G., Bodor, N., Stabler, C., Kenyon, N. S., Inverardi, L., Molano, R. D., Ricordi, C. & Pileggi, A., Jun 1 2010, In : Pharmazie. 65, 6, p. 421-428 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

GADD45γ: A new vitamin D-regulated gene that is antiproliferative in prostate cancer cells

Flores, O. & Burnstein, K. L., Oct 1 2010, In : Endocrinology. 151, 10, p. 4654-4664 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

High content screening of cortical neurons identifies novel regulators of axon growth

Blackmore, M. G., Moore, D. L., Smith, R. P., Goldberg, J. L., Bixby, J. L. & Lemmon, V. P., May 1 2010, In : Molecular and Cellular Neuroscience. 44, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding

Faridi, M. H., Maiguel, D., Brown, B. T., Suyama, E., Barth, C. J., Hedrick, M., Vasile, S., Sergienko, E., Schürer, S. & Gupta, V., Mar 26 2010, In : Biochemical and biophysical research communications. 394, 1, p. 194-199 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Institutional open access funds: Now is the time

Eckman, C. D. & Weil, B. T., May 1 2010, In : PLoS biology. 8, 5

Research output: Contribution to journalArticle

12 Scopus citations

Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology

Buchser, W. J., Slepak, T. I., Gutierrez-Arenas, O., Bixby, J. L. & Lemmon, V. P., Aug 6 2010, In : Molecular Systems Biology. 6, 391.

Research output: Contribution to journalArticle

45 Scopus citations

Methionine sulfoxide reductase A (MsrA) protects cultured mouse embryonic stem cells from H2O2-mediated oxidative stress

Zhang, C., Jia, P., Jia, Y., Weissbach, H., Webster, K. A., Huang, X., Lemanski, S. L., Achary, M. & Lemanski, L. F., Sep 1 2010, In : Journal of cellular biochemistry. 111, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Microtubule-Dependent Spatial Organization of Mitochondria in Fission Yeast

Das, M., Chiron, S. & Verde, F., Aug 20 2010, C ed. Unknown Publisher. 19 p. (Methods in Cell Biology; vol. 97, no. C)

Research output: Book/ReportBook

2 Scopus citations

Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gβ5-RGS7

Sandiford, S. L., Wang, Q., Levay, K., Buchwald, P. & Slepak, V. Z., Jun 22 2010, In : Biochemistry. 49, 24, p. 4998-5006 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function?

Willott, R. H., Gomes, A. V., Chang, A. N., Parvatiyar, M. S., Pinto, J. R. & Potter, J. D., May 1 2010, In : Journal of Molecular and Cellular Cardiology. 48, 5, p. 882-892 11 p.

Research output: Contribution to journalReview article

137 Scopus citations

Mutations of the KISS1 gene in disorders of puberty

Silveira, L. G., Noel, S. D., Silveira-Neto, A. P., Abreu, A. P., Brito, V. N., Santos, M. G., Bianco, S. D. C., Kuohung, W., Xu, S., Gryngarten, M., Escobar, M. E., Arnhold, I. J. P., Mendonca, B. B., Kaiser, U. B. & Latronico, A. C., May 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2276-2280 5 p.

Research output: Contribution to journalArticle

184 Scopus citations

Neonatal asphyxia induces the nitration of cardiac myosin light chain 2 that is associated with cardiac systolic dysfunction

Doroszko, A., Polewicz, D., Cadete, V. J. J., Sawicka, J., Jones, M., Szczesna-Cordary, D., Cheung, P. Y. & Sawicki, G., Dec 1 2010, In : Shock. 34, 6, p. 592-600 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Novel role of Egr-1 in nicotine-related neointimal formation

Vazquez-Padron, R. I., Mateu, D., Rodriguez-Menocal, L., Wei, Y., Webster, K. A. & Pham, S. M., Nov 1 2010, In : Cardiovascular Research. 88, 2, p. 296-303 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition

Flores, O., Wang, Z., Knudsen, K. E. & Burnstein, K. L., Mar 1 2010, In : Endocrinology. 151, 3, p. 896-908 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Odorant receptor from the Southern House mosquito narrowly tuned to the oviposition attractant skatole

Hughes, D. T., Pelletier, J., Luetje, C. W. & Leal, W. S., Jul 12 2010, In : Journal of Chemical Ecology. 36, 8, p. 797-800 4 p.

Research output: Contribution to journalArticle

51 Scopus citations
10 Scopus citations

Pharmacokinetics and Δ1-cortienic acid excretion after intravenous administration of prednisolone and loteprednol etabonate in rats

Wu, W. M., Tang, Y., Buchwald, P. & Bodor, N., Jun 1 2010, In : Pharmazie. 65, 6, p. 412-416 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C

Parvatiyar, M. S., Pinto, J. R., Liang, J. & Potter, J. D., Sep 3 2010, In : Journal of Biological Chemistry. 285, 36, p. 27785-27797 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Prontolearn: Unsupervised lexico-semantic ontology generation using probabilistic methods

Abeyruwan, S., Visser, U., Lemmon, V. & Schürer, S., Dec 1 2010, In : CEUR Workshop Proceedings. 654, p. 25-36 12 p.

Research output: Contribution to journalConference article

2 Scopus citations

Recent advances in retrometabolic drug design (RMDD) and development

Bodor, N. & Buchwald, P., Jun 1 2010, In : Pharmazie. 65, 6, p. 395-403 9 p.

Research output: Contribution to journalReview article

10 Scopus citations

Sex pheromone receptor specificity in the european corn borer moth, Ostrinia nubilalis

Wanner, K. W., Nichols, A. S., Allen, J. E., Bunger, P. L., Garczynski, S. F., Linn, C. E., Robertson, H. M. & Luetje, C. W., Jan 13 2010, In : PloS one. 5, 1, e8685.

Research output: Contribution to journalArticle

104 Scopus citations

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

Adamo, C. M., Dai, D. F., Percival, J. M., Minami, E., Willis, M. S., Patrucco, E., Froehner, S. C. & Beavo, J. A., Nov 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 44, p. 19079-19083 5 p.

Research output: Contribution to journalArticle

119 Scopus citations

Single molecule kinetics in the familial hypertrophic cardiomyopathy D166V mutant mouse heart

Muthu, P., Mettikolla, P., Calander, N., Luchowski, R., Gryczynski, I., Gryczynski, Z., Szczesna-Cordary, D. & Borejdo, J., May 1 2010, In : Journal of Molecular and Cellular Cardiology. 48, 5, p. 989-998 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
67 Scopus citations

Tetrahydroisoquinoline derivatives as highly selective and potent rho kinase inhibitors

Fang, X., Yin, Y., Chen, Y. T., Yao, L., Wang, B., Cameron, M. D., Lin, L., Khan, S., Ruiz, C., Schröter, T., Grant, W., Weiser, A., Pocas, J., Pachori, A., Schürer, S., Lograsso, P. & Feng, Y., Aug 12 2010, In : Journal of Medicinal Chemistry. 53, 15, p. 5727-5737 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
26 Scopus citations

Therapeutic angiogenesis for coronary artery disease: Clinical trials of proteins, plasmids, adenovirus and stem cells

Webster, K. A., Dec 1 2010, Stem Cell and Regenerative Medicine. Bentham Science Publishers Ltd., p. 65-74 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Transmembrane segment 3 of Drosophila melanogaster odorant receptor subunit 85b contributes to ligand-receptor interactions

Nichols, A. S. & Luetje, C. W., Apr 16 2010, In : Journal of Biological Chemistry. 285, 16, p. 11854-11862 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
13 Scopus citations

β-N-methylamino-L-alanine induces neurological deficits and shortened life span in drosophila

Zhou, X., Escala, W., Papapetropoulos, S. & Grace Zhai, R., Nov 1 2010, In : Toxins. 2, 11, p. 2663-2679 17 p.

Research output: Contribution to journalArticle

16 Scopus citations
2009

A functional and structural study of tropon in C mutations related to hypertrophic cardiomyopathy

Pinto, J. R., Parvatiyar, M. S., Jones, M. A., Liang, J., Ackerman, M. J. & Potter, J. D., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19090-19100 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

A novel CXCR4 antagonist derived from human SDF-1β enhances angiogenesis in ischaemic mice

Tan, Y., Li, Y., Xiao, J., Shao, H., Ding, C., Arteel, G. E., Webster, K. A., Yan, J., Yu, H., Cai, L. & Li, X., Jun 1 2009, In : Cardiovascular Research. 82, 3, p. 513-521 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

Yin, Y., Lin, L., Ruiz, C., Cameron, M. D., Pocas, J., Grant, W., Schröter, T., Chen, W., Duckett, D., Schürer, S., LoGrasso, P. & Feng, Y., Dec 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 23, p. 6686-6690 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

BMAA neurotoxicity in Drosophila

Zhou, X., Escala, W., Papapetropoulos, S., Bradley, W. G. & Zhai, R. G., Dec 1 2009, In : Amyotrophic Lateral Sclerosis. 10, SUPPL. 2, p. 61-66 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Chapter 2 Human Diseases Associated with GPR54 Mutations

Gurgel Teles, M., Gontijo Silveira, L. F., Bianco, S. & Claudia Latronico, A., Dec 1 2009, In : Progress in Molecular Biology and Translational Science. 88, C, p. 33-56 24 p.

Research output: Contribution to journalReview article

Chapter 6 Structure, Function, and Localization of Gβ5-RGS Complexes

Slepak, V. Z., Dec 1 2009, In : Progress in Molecular Biology and Translational Science. 86, C, p. 157-203 47 p.

Research output: Contribution to journalReview article

20 Scopus citations

Clathrin functions in the absence of the terminal domain binding site for adaptor-associated clathrin-box motifs

Collette, J. R., Chi, R. J., Boettner, D. R., Fernandez-Golbano, I. M., Plemel, R., Merz, A. J., Geli, M. I., Traub, L. M. & Lemmon, S. K., Jul 15 2009, In : Molecular biology of the cell. 20, 14, p. 3401-3413 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Clinical and functional Characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy

Hershberger, R. E., Pinto, J. R., Parks, S. B., Kushner, J. D., Li, D., Ludwigsen, S., Cowan, J., Morales, A., Parvatiyar, M. S. & Potter, J. D., Aug 1 2009, In : Circulation: Cardiovascular Genetics. 2, 4, p. 306-313 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice

Abraham, T. P., Jones, M., Kazmierczak, K., Liang, H. Y., Pinheiro, A. C., Wagg, C. S., Lopaschuk, G. D. & Szczesna-Cordary, D., Apr 1 2009, In : Cardiovascular Research. 82, 1, p. 84-92 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC

Hower, A. E., Beltran, P. J. & Bixby, J. L., Sep 1 2009, In : Journal of neurochemistry. 110, 5, p. 1635-1647 13 p.

Research output: Contribution to journalArticle

21 Scopus citations