Molecular and Cellular Pharmacology

Research Output

Article

G protein-mediated inhibition of phospholipase C activity in a solubilized membrane preparation

Litosch, I., Sulkholutskaya, I. & Weng, C., Jan 1 1993, In : Journal of Biological Chemistry. 268, 12, p. 8692-8697 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
21 Scopus citations

G-protein βγ subunits antagonize protein kinase C-dependent phosphorylation and inhibition of phospholipase C-β1

Litosch, I., Sep 15 1997, In : Biochemical Journal. 326, 3, p. 701-707 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Growth cone steering by receptor tyrosine phosphatase δ defines a distinct class of guidance cue

Sun, Q. L., Wang, J., Bookman, R. J. & Bixby, J. L., Jan 1 2000, In : Molecular and Cellular Neuroscience. 16, 5, p. 686-695 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Growth hormone-releasing hormone agonists reduce myocardial infarct scar in swine With subacute ischemic cardiomyopathy

Bagno, L. L., Takeuchi, R., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., Wang, B., Premer, C., Balkan, W. E., Rodriguez, J., Valdes, D., Rosado, M., Block, N. L., Goldstein, P., Morales, A. R., Cai, R. Z., Sha, W., Schally, A. V. & Hare, J., 2015, In : Journal of the American Heart Association. 4, 4, e001464.

Research output: Contribution to journalArticle

12 Scopus citations

GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

Penas, C., Mishra, J. K., Wood, S. D., Schuerer, S. C., Roush, W. R. & Ayad, N., Feb 1 2015, In : Cell Cycle. 14, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

GSK3 involvement in amylin signaling in isolated rat soleus muscle

Abaffy, T. & Cooper, G. J. S., Dec 1 2004, In : Peptides. 25, 12, p. 2119-2125 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
11 Scopus citations

Guanine nucleotide and NaF stimulation of phospholipase C activity in rat cerebral-cortical membranes. Studies on substrate specificity

Litosch, I., Jan 1 1987, In : Biochemical Journal. 244, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

61 Scopus citations

Guanine nucleotides mediate stimulatory and inhibitory effects on cerebral-cortical membrane phospholipase C activity

Litosch, I., Jan 1 1989, In : Biochemical Journal. 261, 1, p. 245-251 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
82 Scopus citations

Gβ5-RGS7 inhibits Gαq-mediated signaling via a direct protein-protein interaction

Witherow, D. S., Tovey, S. C., Wang, Q., Willars, G. B. & Slepak, V. Z., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 21307-21313 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex

Karpinsky-Semper, D., Tayou, J., Levay, K., Schuchardt, B. J., Bhat, V., Volmar, C. H., Farooq, A. & Slepak, V. Z., Feb 3 2015, In : Biochemistry. 54, 4, p. 1077-1088 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis

Hu, X., Zhang, L., Jin, J., Zhu, W., Xu, Y., Wu, Y., Wang, Y., Chen, H., Webster, K. A., Chen, H., Yu, H. & Wang, J., Jun 1 2015, In : Stem Cells. 33, 6, p. 1850-1862 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hepatocyte growth factor and vitamin D cooperatively inhibit androgen-unresponsive prostate cancer cell lines

Qadan, L. R., Perez-Stable, C. M., Schwall, R. H., Burnstein, K. L., Ostenson, R. C., Howard, G. A. & Roos, B. A., Jan 1 2000, In : Endocrinology. 141, 7, p. 2567-2573 7 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Hepatoma-derived growth factor-related protein-3 is a novel angiogenic factor

LeBlanc, M. E., Wang, W., Caberoy, N. B., Chen, X., Guo, F., Alvarado, G., Shen, C., Wang, F., Wang, H., Chen, R., Liu, Z-J., Webster, K. A. & Li, W., May 21 2015, In : PLoS One. 10, 5, e0127904.

Research output: Contribution to journalArticle

11 Scopus citations

Heterogeneity in SDF-1 expression defines the vasculogenic potential of adult cardiac progenitor cells

Rodrigues, C. O., Shehadeh, L. A., Hoosien, M., Otero, V., Chopra, I., Tsinoremas, N. F. & Bishopric, N. H., Aug 24 2011, In : PloS one. 6, 8, e24013.

Research output: Contribution to journalArticle

11 Scopus citations

Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia

Poth, K., Nutter, T. J., Cuevas, J., Parker, M. J., Adams, D. J. & Luetje, C. W., Jan 20 1997, In : Journal of Neuroscience. 17, 2, p. 586-596 11 p.

Research output: Contribution to journalArticle

89 Scopus citations

High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries

Nelersa, C. M., Barreras, H., Runko, E., Ricard, J., Shi, Y., Glass, S. J., Bixby, J. L., Lemmon, V. P. & Liebl, D. J., Jul 1 2012, In : Journal of Biomolecular Screening. 17, 6, p. 785-795 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

High content screening of cortical neurons identifies novel regulators of axon growth

Blackmore, M. G., Moore, D. L., Smith, R. P., Goldberg, J. L., Bixby, J. L. & Lemmon, V. P., May 1 2010, In : Molecular and Cellular Neuroscience. 44, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

High quality, small molecule-activity datasets for kinase research [version 1; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

High quality, small molecule-activity datasets for kinase research [version 2; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

3 Scopus citations

High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding

Faridi, M. H., Maiguel, D., Brown, B. T., Suyama, E., Barth, C. J., Hedrick, M., Vasile, S., Sergienko, E., Schürer, S. & Gupta, V., Mar 26 2010, In : Biochemical and biophysical research communications. 394, 1, p. 194-199 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

High-throughput screening for human galactokinase inhibitors

Wierenga, K. J., Lai, K., Buchwald, P. & Tang, M., Aug 1 2008, In : Journal of Biomolecular Screening. 13, 5, p. 415-423 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Hormonal Activation of Phosphoinositide Breakdown in the Presence of Guanine Nucleotides Using a Cell-Free System from Blowfly Salivary Glands

Fain, J. N. & Litosch, I., Jan 1987, In : Methods in enzymology. 141, C, p. 255-261 7 p.

Research output: Contribution to journalArticle

Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue

Carvalho, S. D., Negrao, N. & Bianco, A. C., Jan 1 1993, In : American Journal of Physiology - Endocrinology and Metabolism. 264, 6 27-6, p. E874-E881

Research output: Contribution to journalArticle

28 Scopus citations

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

Almaca, J., Molina, J., Menegaz, D., Pronin, A. N., Tamayo, A., Slepak, V. Z., Berggren, P. O. & Caicedo-Vierkant, D. A., Dec 20 2016, In : Cell Reports. 17, 12, p. 3281-3291 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms

Jiang, Z., Hu, X., Yu, H., Xu, Y., Wang, L., Chen, H., Chen, H., Wu, R., Zhang, Z., Xiang, C., Webster, K. A. & Wang, J. A., Oct 1 2013, In : Journal of Cellular and Molecular Medicine. 17, 10, p. 1247-1260 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Hydrophobic interaction between the monomer of mitochondrial malate dehydrogenase and phospholipid membranes.

Webster, K. A., Freeman, K. B. & Ohki, S., Jan 15 1980, In : The Biochemical journal. 186, 1, p. 227-233 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hyperactivated Stat3 boosts axon regeneration in the CNS

Mehta, S. T., Luo, X., Park, K. K., Bixby, J. L. & Lemmon, V. P., Jun 1 2016, In : Experimental neurology. 280, p. 115-120 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice

Yuan, C. C., Kazmierczak, K., Liang, J., Takeuchi, R., Irving, T. C., Gomes, A. V., Wang, Y., Burghardt, T. P. & Szczesna-Cordary, D., Aug 1 2017, In : Cardiovascular Research. 113, 10, p. 1124-1136 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice

Huang, W., Liang, J., Kazmierczak, K., Muthu, P., Duggal, D., Farman, G. P., Sorensen, L., Pozios, I., Abraham, T. P., Moore, J. R., Borejdo, J. & Szczesna-Cordary, D., Sep 2014, In : Journal of Molecular and Cellular Cardiology. 74, p. 318-329 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
156 Scopus citations

Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes

Laderoute, K. R. & Webster, K. A., Jan 1 1997, In : Circulation research. 80, 3, p. 336-344 9 p.

Research output: Contribution to journalArticle

156 Scopus citations

Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53

Webster, K. A., Discher, D. J., Kaiser, S., Hernandez, O., Sato, B. & Bishopric, N. H., Aug 1 1999, In : Journal of Clinical Investigation. 104, 3, p. 239-252 14 p.

Research output: Contribution to journalArticle

202 Scopus citations

Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3

Kubasiak, L. A., Hernandez, O. M., Bishopric, N. H. & Webster, K. A., Oct 1 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 20, p. 12825-12830 6 p.

Research output: Contribution to journalArticle

351 Scopus citations

Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand

Hu, J., Discher, D. J., Bishopric, N. H. & Webster, K. A., Apr 28 1998, In : Biochemical and biophysical research communications. 245, 3, p. 894-899 6 p.

Research output: Contribution to journalArticle

226 Scopus citations

Hypoxia regulates β-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element

Discher, D. J., Bishopric, N. H., Wu, X., Peterson, C. A. & Webster, K. A., Oct 2 1998, In : Journal of Biological Chemistry. 273, 40, p. 26087-26093 7 p.

Research output: Contribution to journalArticle

142 Scopus citations

Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential

Bellio, M. A., Pinto, M. T., Florea, V., Barrios, P. A., Taylor, C. N., Brown, A. B., Lamondin, C., Hare, J., Schulman, I. H. & Rodrigues, C. D., Dec 1 2017, In : Scientific Reports. 7, 1, 9702.

Research output: Contribution to journalArticle

4 Scopus citations

Identification and cloning of two putative subunits of DNA polymerase epsilon in fussion yeast

Spiga, M. G. & D'Urso, G., Nov 9 2004, In : Nucleic acids research. 32, 16, p. 4945-4953 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of an alternatively spliced avian member of the synaptophysin gene family

Bixby, J. L., May 1992, In : Molecular Brain Research. 13, 4, p. 339-348 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Identification of an oncogenic network with prognostic and therapeutic value in prostate cancer

Magani, F., Bray, E. R., Martinez, M. J., Zhao, N., Copello, V. A., Heidman, L., Peacock, S. O., Wiley, D. J., D'Urso, G. & Burnstein, K. L., Aug 2018, In : Molecular Systems Biology. 14, 8, e8202.

Research output: Contribution to journalArticle

6 Scopus citations

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

Allen, B. K., Mehta, S., Ember, S. W. J., Zhu, J. Y., Schönbrunn, E., Ayad, N. & Schuerer, S. C., Jan 1 2017, In : ACS Omega. 2, 8, p. 4760-4771 12 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Identification of a truncated form of methionine sulfoxide reductase a expressed in mouse embryonic stem cells

Jia, P., Zhang, C., Jia, Y., Webster, K. A., Huang, X., Kochegarov, A. A., Lemanski, S. L. & Lemanski, L. F., Jun 24 2011, In : Journal of Biomedical Science. 18, 1, 46.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library

Gibbons, G. S., Chakraborty, A., Grigsby, S. M., Umeano, A. C., Liao, C., Moukha-Chafiq, O., Pathak, V., Mathew, B., Lee, Y. T., Dou, Y., Schürer, S. C., Reynolds, R. C., Snowden, T. S. & Nikolovska-Coleska, Z., Mar 1 2020, In : European Journal of Medicinal Chemistry. 189, 112023.

Research output: Contribution to journalArticle

Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit

Chen, S. & Luetje, C. W., May 8 2012, In : PloS one. 7, 5, e36784.

Research output: Contribution to journalArticle

42 Scopus citations

Identification of novel agonists of the integrin CD11b/CD18

Faridi, M. H., Maiguel, D., Barth, C. J., Stoub, D., Day, R., Schürer, S. & Gupta, V., Dec 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 24, p. 6902-6906 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes

Seufferheld, M., Vieira, M. C. F., Ruiz, F. A., Rodrigues, C. O., Moreno, S. N. J. & Docampo, R., Aug 8 2003, In : Journal of Biological Chemistry. 278, 32, p. 29971-29978 8 p.

Research output: Contribution to journalArticle

115 Scopus citations

Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors

Everhart, D., Reiller, E., Mirzoian, A., McIntosh, J. M., Malhotra, A. & Luetje, C. W., Aug 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 2, p. 664-670 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening

Bialkowska, A. B., Crisp, M., Bannister, T., He, Y., Chowdhury, S., Schur̈er, S., Chase, P., Spicer, T., Madoux, F., Tian, C., Hodder, P., Zaharevitz, D. & Yang, V. W., Nov 1 2011, In : Molecular cancer therapeutics. 10, 11, p. 2043-2051 9 p.

Research output: Contribution to journalArticle

32 Scopus citations