Molecular and Cellular Pharmacology

Research Output

Familial Hypertrophic Cardiomyopathy Mutations in the Regulatory Light Chains of Myosin Affect their Structure, Ca2+ Binding, and Phosphorylation

Szczesna, D., Ghosh, D., Li, Q., Gomes, A. V., Guzman, G., Arana, C., Zhi, G., Stull, J. T. & Potter, J. D., Mar 9 2001, In : Journal of Biological Chemistry. 276, 10, p. 7086-7092 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Fanconi anemia complementation group A (FANCA) protein has intrinsic affinity for nucleic acids with preference for single-stranded forms

Yuan, F., Qian, L., Zhao, X., Liu, J. Y., Song, L., D'Urso, G., Jain, C. & Zhang, Y., Feb 10 2012, In : Journal of Biological Chemistry. 287, 7, p. 4800-4807 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Far away from the lamppost

Oprea, T. I., Jan, L., Johnson, G. L., Roth, B. L., Ma’ayan, A., Schuerer, S. C., Shoichet, B. K., Sklar, L. A. & McManus, M. T., Dec 1 2018, In : PLoS Biology. 16, 12, e3000067.

Research output: Contribution to journalArticle

4 Scopus citations

Fast and accurate semantic annotation of bioassays exploiting a hybrid of machine learning and user confirmation

Clark, A. M., Bunin, B. A., Litterman, N. K., Schuerer, S. C. & Visser, U. E., 2014, In : PeerJ. 2014, 1, e524.

Research output: Contribution to journalArticle

13 Scopus citations

Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development

Wang, Y., Szczesna-Cordary, D., Craig, R., Diaz-Perez, Z., Guzman, G., Miller, T. & Potter, J. D., Jul 2007, In : FASEB Journal. 21, 9, p. 2205-2214 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Fast skeletal muscle skinned fibers and myofibrils reconstituted with N-terminal fluorescent analogues of troponin C

Zot, H. G., Guth, K. & Potter, J. D., Dec 1 1986, In : Journal of Biological Chemistry. 261, 34, p. 15883-15890 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Feasibility of localized immunosuppression: 2. PLA microspheres for the sustained local delivery of a soft immunosuppressant

Pinto, E., Zhang, B., Song, S., Bodor, N., Buchwald, P. & Hochhaus, G., Jun 1 2010, In : Pharmazie. 65, 6, p. 429-435 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Feasibility of localized immunosuppression: 1. Exploratory studies with glucocorticoids in a biohybrid device designed for cell transplantation

Buchwald, P., Bocca, N., Marzorati, S., Hochhaus, G., Bodor, N., Stabler, C., Kenyon, N. S., Inverardi, L., Molano, R. D., Ricordi, C. & Pileggi, A., Jun 1 2010, In : Pharmazie. 65, 6, p. 421-428 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Feasibility of localized immunosuppression: 3. Preliminary evaluation of organosilicone constructs designed for sustained drug release in a cell transplant environment using dexamethasone

Song, Y., Margolles-Clark, E., Fraker, C. A., Weaver, J. D., Ricordi, C., Pileggi, A., Stabler, C. L. & Buchwald, P., Jun 21 2012, In : Pharmazie. 67, 5, p. 394-399 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Feasibility of localized metabolomics in the study of pancreatic islets and diabetes

Alcazar, O., Hernandez, L. F., Tschiggfrie, A., Muehlbauer, M. J., Bain, J. R., Buchwald, P. & Abdulreda, M. H., Oct 2019, In : Metabolites. 9, 10, 207.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
76 Scopus citations

Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: A clinical, genetic, and functional approach

Pinto, J. R., Yang, S. W., Hitz, M. P., Parvatiyar, M. S., Jones, M. A., Liang, J., Kokta, V., Talajic, M., Tremblay, N., Jaeggi, M., Andelfinger, G. & Potter, J. D., Jun 10 2011, In : Journal of Biological Chemistry. 286, 23, p. 20901-20912 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Fibroblast growth factor receptor signaling in Xenopus retinal axon extension

Lom, B., Höpker, V., McFarlane, S., Bixby, J. L. & Holt, C. E., Dec 1 1998, In : Journal of Neurobiology. 37, 4, p. 633-641 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis

Kanai, M., Kume, K., Miyahara, K., Sakai, K., Nakamura, K., Leonhard, K., Wiley, D. J., Verde, F., Toda, T. & Hirata, D., Sep 1 2005, In : EMBO Journal. 24, 17, p. 3012-3025 14 p.

Research output: Contribution to journalArticle

55 Scopus citations
172 Scopus citations

Fluorescence changes from single striated muscle fibres injected with labelled troponin C (TnCDANZ)

Griffiths, P. J., Potter, J. D., Coles, B., Strang, P. & Ashley, C. C., Oct 15 1984, In : FEBS letters. 176, 1, p. 144-150 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Fluorescence lifetime of actin in the familial hypertrophic cardiomyopathy transgenic heart

Mettikolla, P., Luchowski, R., Gryczynski, I., Gryczynski, Z., Szczesna-Cordary, D. & Borejdo, J., Feb 17 2009, In : Biochemistry. 48, 6, p. 1264-1271 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Fluorescence studies of the interaction of calmodulin with myosin light chain kinase

Johnson, J. D., Holroyde, M. J., Crouch, T. H., Solaro, R. J. & Potter, J. D., Dec 1 1981, In : Journal of Biological Chemistry. 256, 23, p. 12194-12198 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca2+-dependent events in vitro and in situ

Putkey, J. A., Liu, W., Lin, X., Ahmed, S., Zhang, M., Potter, J. D. & Kerrick, W. G. L., Jan 28 1997, In : Biochemistry. 36, 4, p. 970-978 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Follicle depletion provides a permissive environment for ovarian carcinogenesis

Wang, Y., Cai, K. Q., Smith, E. R., Yeasky, T. M., Moore, R., Ganjei-Azar, P., Klein-Szanto, A. J., Godwin, A. K., Hamilton, T. C. & Xua, X. X., Jan 1 2016, In : Molecular and cellular biology. 36, 18, p. 2418-2430 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Formalization, Annotation and Analysis of Diverse Drug and Probe Screening Assay Datasets Using the BioAssay Ontology (BAO)

Vempati, U. D., Przydzial, M. J., Chung, C., Abeyruwan, S., Mir, A., Sakurai, K., Visser, U., Lemmon, V. P. & Schürer, S. C., Nov 14 2012, In : PloS one. 7, 11, e49198.

Research output: Contribution to journalArticle

37 Scopus citations

Forskolin an an activator of cyclic AMP accumulation and lipolysis in rat adipocytes

Litosch, I., Hudson, T. H., Mills, I. & Fain, J. N., Oct 5 1982, In : Molecular Pharmacology. 22, 1, p. 109-115 7 p.

Research output: Contribution to journalArticle

107 Scopus citations

Forskolin as an activator of cyclic AMP accumulation and secretion in blowfly salivary glands

Litosch, I., Saito, Y. & Fain, J. N., Jan 1 1982, In : Biochemical Journal. 204, 1, p. 147-151 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

From critters to cancers: Bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

Hoogewijs, D., Terwilliger, N. B., Webster, K. A., Powell-Coffman, J. A., Tokishita, S., Yamagata, H., Hankeln, T., Burmester, T., Rytknen, K. T., Nikinmaa, M., Abele, D., Heise, K., Lucassen, M., Fandrey, J., Maxwell, P. H., Phlman, S. & Gorr, T. A., Oct 1 2007, In : Integrative and comparative biology. 47, 4, p. 552-577 26 p.

Research output: Contribution to journalArticle

20 Scopus citations

From flamingo dance to (desirable) drug discovery: A nature-inspired approach

Sánchez-Rodríguez, A., Pérez-Castillo, Y., Schuerer, S. C., Nicolotti, O., Mangiatordi, G. F., Borges, F., Cordeiro, M. N. D. S., Tejera, E., Medina-Franco, J. L. & Cruz-Monteagudo, M., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

6 Scopus citations

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

Križaj, D., Ryskamp, D. A., Tian, N., Tezel, G., Mitchell, C. H., Slepak, V. Z. & Shestopalov, V. I., Feb 1 2014, In : Current Eye Research. 39, 2, p. 105-119 15 p.

Research output: Contribution to journalReview article

77 Scopus citations

Fully automated islet cell counter (ICC) for the assessment of islet mass, purity, and size distribution by digital image analysis

Buchwald, P., Bernal, A., Echeverri, F., Tamayo-Garcia, A., Linetsky, E. & Ricordi, C., 2016, In : Cell Transplantation. 25, 10, p. 1747-1761 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Functional analysis of a dominant negative mutant of Gαi2

Slepak, V. Z., Katz, A. & Simon, M. I., Feb 24 1995, In : Journal of Biological Chemistry. 270, 8, p. 4037-4041 5 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Functional analysis of a mammalian odorant receptor subfamily

Abaffy, T., Matsunami, H. & Luetje, C. W., Jun 1 2006, In : Journal of neurochemistry. 97, 5, p. 1506-1518 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy

Lang, R., Gomes, A. V., Zhao, J., Housmans, P. R., Miller, T. & Potter, J. D., Apr 5 2002, In : Journal of Biological Chemistry. 277, 14, p. 11670-11678 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

Functional and nonfunctional forms of CquiOR91, an odorant selectivity subunit of Culex quinquefasciatus

Hughes, D. T., Pelletier, J., Rahman, S., Chen, S., Leal, W. S. & Luetje, C. W., May 1 2017, In : Chemical Senses. 42, 4, p. 333-341 9 p., bjx011.

Research output: Contribution to journalArticle

2 Scopus citations

Functional assay of mammalian and insect olfactory receptors using Xenopus oocytes.

Luetje, C. W., Nichols, A. S., Castro, A. & Sherman, B. L., Oct 4 2013, In : Methods in molecular biology (Clifton, N.J.). 1003, p. 187-202 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Functional characterization of the two isoforms of troponin C from the arthropod Balanus nubilus

Ashley, C. C., Lea, T. J., Hoar, P. E., Kerrick, W. G. L., Strang, P. F. & Potter, J. D., Dec 1 1991, In : Journal of Muscle Research and Cell Motility. 12, 6, p. 532-542 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy

Pinto, J. R., Siegfried, J. D., Parvatiyar, M. S., Li, D., Norton, N., Jones, M. A., Liang, J., Potter, J. D. & Hershberger, R. E., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34404-34412 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Functional characterizations of rare UBA1 variants in X-linked Spinal Muscular Atrophy

Baumbach-Reardon, L., Balak, C. D., Hunter, J. M., Ahearn, M. E., Wiley, D. & D'urso, G., 2017, In : F1000Research. 6, 1636.

Research output: Contribution to journalArticle

5 Scopus citations

Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in α-tropomyosin

Chang, A. N., Harada, K., Ackerman, M. J. & Potter, J. D., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 34343-34349 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

Wen, Y., Pinto, J. R., Gomes, A. V., Xu, Y., Wang, Y., Wang, Y., Potter, J. D. & Kerrick, W. G. L., Jul 18 2008, In : Journal of Biological Chemistry. 283, 29, p. 20484-20494 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Functional diversity of neuronal nicotinic acetylcholine receptors

Patrick, J., Séquéla, P., Vernino, S., Amador, M., Luetje, C. & Dani, J. A., Jan 1 1993, In : Progress in brain research. 98, C, p. 113-120 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Functional Effects of a Restrictive-Cardiomyopathy-Linked Cardiac Troponin I Mutation (R145W) in Transgenic Mice

Wen, Y., Xu, Y., Wang, Y., Pinto, J. R., Potter, J. D. & Kerrick, W. G. L., Oct 9 2009, In : Journal of molecular biology. 392, 5, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Fusigenic liposome-mediated DNA transfer into cardiac myocytes

Ellison, K. E., Bishopric, N. H., Webster, K. A., Morishita, R., Gibbons, G. H., Kaneda, Y., Sato, B. & Dzau, V. J., Jul 1996, In : Journal of Molecular and Cellular Cardiology. 28, 7, p. 1385-1399 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons

Maddox, F. N., Valeyev, A. Y., Poth, K., Holohean, A. M., Wood, P. M., Davidoff, R. A., Hackman, J. C. & Luetje, C. W., Apr 19 2004, In : Developmental Brain Research. 149, 2, p. 143-151 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

GADD45γ: A new vitamin D-regulated gene that is antiproliferative in prostate cancer cells

Flores, O. & Burnstein, K. L., Oct 1 2010, In : Endocrinology. 151, 10, p. 4654-4664 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Gene and cell therapy for heart disease

Graham, R. M., Bishopric, N. H. & Webster, K. A., Aug 1 2002, In : IUBMB life. 54, 2, p. 59-66 8 p.

Research output: Contribution to journalReview article

13 Scopus citations

Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain

Huang, W., Kazmierczak, K., Zhou, Z., Aguiar-Pulido, V., Narasimhan, G. & Szczesna-Cordary, D., Nov 1 2015, (Accepted/In press) In : Archives of Biochemistry and Biophysics.

Research output: Contribution to journalArticle

5 Scopus citations

General linearized biexponential model for QSAR data showing bilinear-type distribution

Buchwald, P., Nov 2005, In : Journal of Pharmaceutical Sciences. 94, 11, p. 2355-2379 25 p.

Research output: Contribution to journalArticle

27 Scopus citations

Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy

Wang, Y., Pinto, J. R., Solis, R. S., Dweck, D., Liang, J., Diaz-Perez, Z., Ge, Y., Walker, J. W. & Potter, J. D., Jan 13 2012, In : Journal of Biological Chemistry. 287, 3, p. 2156-2167 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury

Dvoriantchikova, G., Ivanov, D., Barakat, D., Grinberg, A., Wen, R., Slepak, V. Z. & Shestopalov, V. I., Feb 23 2012, In : PloS one. 7, 2, e31991.

Research output: Contribution to journalArticle

72 Scopus citations

Genetically modifying transcription factors to promote CNS axon regeneration

Mehta, S. T., Bixby, J. & Lemmon, V., May 1 2017, In : Neural Regeneration Research. 12, 5, p. 737-738 2 p.

Research output: Contribution to journalComment/debate

Genetic elucidation of human hyperosmia to isovaleric acid

Menashe, I., Abaffy, T., Hasin, Y., Goshen, S., Yahalom, V., Luetje, C. W. & Lancet, D., Nov 1 2007, In : PLoS biology. 5, 11, p. 2462-2468 7 p.

Research output: Contribution to journalArticle

132 Scopus citations

Gene transfer and models of gene therapy for the myocardium

Yvonne Alexander, M., Webster, K. A., McDonald, P. H. & Prentice, H. M., Sep 28 1999, In : Clinical and Experimental Pharmacology and Physiology. 26, 9, p. 661-668 8 p.

Research output: Contribution to journalReview article

19 Scopus citations