Molecular and Cellular Pharmacology

Research Output

2011

Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging

Shehadeh, L. A., Webster, K. A., Hare, J. M. & Vazquez-Padron, R. I., Oct 7 2011, In : PloS one. 6, 10, e25855.

Research output: Contribution to journalArticle

23 Scopus citations

Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation

Wang, Y., Smedberg, J. L., Cai, K. Q., Capo-Chichi, D. C. & Xu, X. X., Mar 1 2011, In : Developmental Dynamics. 240, 3, p. 566-576 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Effects of Combination of Proliferative Agents and Erythropoietin on Left Ventricular Remodeling Post-Myocardial Infarction

Kanashiro-Takeuchi, R. M., Takeuchi, L. M., Hatzistergos, K., Quevedo, H., Selem, S. M., Treuer, A. V., Premer, C., Balkan, W., Margitich, I., Song, Y., Hu, Q. & Hare, J. M., Jun 1 2011, In : Clinical and Translational Science. 4, 3, p. 168-174 7 p.

Research output: Contribution to journalReview article

2 Scopus citations

Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: A clinical, genetic, and functional approach

Pinto, J. R., Yang, S. W., Hitz, M. P., Parvatiyar, M. S., Jones, M. A., Liang, J., Kokta, V., Talajic, M., Tremblay, N., Jaeggi, M., Andelfinger, G. & Potter, J. D., Jun 10 2011, In : Journal of Biological Chemistry. 286, 23, p. 20901-20912 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy

Pinto, J. R., Siegfried, J. D., Parvatiyar, M. S., Li, D., Norton, N., Jones, M. A., Liang, J., Potter, J. D. & Hershberger, R. E., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34404-34412 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin

Lu, X., Kazmierczak, K., Jiang, X., Jones, M., Watt, J., Helfman, D. M., Moore, J. R., Szczesna-Cordary, D. & Lossos, I. S., Jun 1 2011, In : FEBS Journal. 278, 11, p. 1922-1931 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1

Chan, Y. M., Broder-Fingert, S., Paraschos, S., Lapatto, R., Au, M., Hughes, V., Bianco, S. D. C., Min, L., Plummer, L., Cerrato, F., De Guillebon, A., Wu, I. H., Wahab, F., Dwyer, A., Kirsch, S., Quinton, R., Cheetham, T., Ozata, M., Ten, S., Chanoine, J. P. & 8 others, Pitteloud, N., Martin, K. A., Schiffmann, R., Van Der Kamp, H. J., Nader, S., Hall, J. E., Kaiser, U. B. & Seminara, S. B., Nov 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 11, p. E1771-E1781

Research output: Contribution to journalArticle

42 Scopus citations

Heterogeneity in SDF-1 expression defines the vasculogenic potential of adult cardiac progenitor cells

Rodrigues, C. O., Shehadeh, L. A., Hoosien, M., Otero, V., Chopra, I., Tsinoremas, N. F. & Bishopric, N. H., Aug 24 2011, In : PloS one. 6, 8, e24013.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of a truncated form of methionine sulfoxide reductase a expressed in mouse embryonic stem cells

Jia, P., Zhang, C., Jia, Y., Webster, K. A., Huang, X., Kochegarov, A. A., Lemanski, S. L. & Lemanski, L. F., Jun 24 2011, In : Journal of Biomedical Science. 18, 1, 46.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening

Bialkowska, A. B., Crisp, M., Bannister, T., He, Y., Chowdhury, S., Schur̈er, S., Chase, P., Spicer, T., Madoux, F., Tian, C., Hodder, P., Zaharevitz, D. & Yang, V. W., Nov 1 2011, In : Molecular cancer therapeutics. 10, 11, p. 2043-2051 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Impaired CXCR4 expression and cell engraftment of bone marrow-derived cells from aged atherogenic mice

Xu, Q., Wang, JA., He, J., Zhou, M., Adi, J., Webster, K. A. & Yu, H., Nov 1 2011, In : Atherosclerosis. 219, 1, p. 92-99 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids

Vang, T., Xie, Y., Liu, W. H., Vidović, D., Liu, Y., Wu, S., Smith, D. H., Rinderspacher, A., Chung, C., Gong, G., Mustelin, T., Landry, D. W., Rickert, R. C., Schürer, S. C., Deng, S. X. & Tautz, L., Jan 27 2011, In : Journal of Medicinal Chemistry. 54, 2, p. 562-571 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer

Rosenblatt, A. E., Garcia, M. I., Lyons, L., Xie, Y., Maiorino, C., Désiré, L., Slingerland, J. & Burnstein, K. L., Apr 1 2011, In : Endocrine-Related Cancer. 18, 2, p. 207-219 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
13 Scopus citations

Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction

Polewicz, D., Cadete, V. J. J., Doroszko, A., Hunter, B. E., Sawicka, J., Szczesna-Cordary, D., Light, P. E. & Sawicki, G., May 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 5, p. 1136-1147 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

KISS1R intracellular trafficking and degradation: Effect of the Arg386Pro disease-associated mutation

Bianco, S. D. C., Vandepas, L., Correa-Medina, M., Gereben, B., Mukherjee, A., Kuohung, W., Carroll, R., Teles, M. G., Latronico, A. C. & Kaiser, U. B., Apr 1 2011, In : Endocrinology. 152, 4, p. 1616-1626 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury

Hellal, F., Hurtado, A., Ruschel, J., Flynn, K. C., Laskowski, C. J., Umlauf, M., Kapitein, L. C., Strikis, D., Lemmon, V., Bixby, J., Hoogenraad, C. C. & Bradke, F., Feb 18 2011, In : Science. 331, 6019, p. 928-931 4 p.

Research output: Contribution to journalArticle

341 Scopus citations

Mutagenesis and analysis of genetic mutations in the GC-rich KISS1 receptor sequence identified in humans with reproductive disorders

da Silva, L. M., Vandepas, L. & Bianco, S. D. C., Sep 2011, In : Journal of Visualized Experiments. 55, e2897.

Research output: Contribution to journalArticle

3 Scopus citations

Mutagenesis and analysis of genetic mutations in the GC-rich KISS1 receptor sequence identified in humans with reproductive disorders.

Madeira da Silva, L., Vandepas, L. & Bianco, S. D. C., Dec 1 2011, In : Journal of visualized experiments : JoVE. 55

Research output: Contribution to journalArticle

Myosin cross-bridges do not form precise rigor bonds in hypertrophic heart muscle carrying troponin t mutations

Midde, K., Dumka, V., Pinto, J. R., Muthu, P., Marandos, P., Gryczynski, I., Gryczynski, Z., Potter, J. D. & Borejdo, J., Sep 1 2011, In : Journal of Molecular and Cellular Cardiology. 51, 3, p. 409-418 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1α pathway

Ali, Y. O., McCormack, R., Darrand, A. & Zhai, R. G., May 27 2011, In : Journal of Biological Chemistry. 286, 21, p. 19089-19099 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Nmnat exerts neuroprotective effects in dendrites and axons

Wen, Y., Parrish, J. Z., He, R., Zhai, R. G. & Kim, M. D., Sep 1 2011, In : Molecular and Cellular Neuroscience. 48, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
35 Scopus citations

Quantification of the islet product: Presentation of a standardized current good manufacturing practices compliant system with minimal variability

Friberg, A. S., Brandhorst, H., Buchwald, P., Goto, M., Ricordi, C., Brandhorst, D. & Korsgren, O., Mar 27 2011, In : Transplantation. 91, 6, p. 677-683 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy

Litosch, I., Nov 18 2011, In : Biochemical and biophysical research communications. 415, 2, p. 215-219 5 p.

Research output: Contribution to journalShort survey

3 Scopus citations

Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease

Maiguel, D., Faridi, M. H., Wei, C., Kuwano, Y., Balla, K. M., Hernandez, D., Barth, C. J., Lugo, G., Donnelly, M., Nayer, A., Moita, L. F., Schürer, S., Traver, D., Ruiz, P., Vazquez-Padron, R. I., Ley, K., Reiser, J. & Gupta, V., Sep 6 2011, In : Science Signaling. 4, 189

Research output: Contribution to journalArticle

54 Scopus citations

Strong cross-bridges potentiate the Ca2+ affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: A fast kinetic approach

Pinto, J. R., Reynaldo, D. P., Parvatiyar, M. S., Dweck, D., Liang, J., Jones, M. A., Sorenson, M. M. & Potter, J. D., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1005-1013 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction

Muthu, P., Wang, L., Yuan, C. C., Kazmierczak, K., Huang, W., Hernandez, O. M., Kawai, M., Irving, T. C. & Szczesna-Cordary, D., Dec 1 2011, In : FASEB Journal. 25, 12, p. 4394-4405 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Subunit contributions to insect olfactory receptor function: Channel block and odorant recognition

Nichols, A. S., Chen, S. & Luetje, C. W., Nov 1 2011, In : Chemical senses. 36, 9, p. 781-790 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Suppression of TH 17 differentiation and autoimmunity by a synthetic ROR ligand

Solt, L. A., Kumar, N., Nuhant, P., Wang, Y., Lauer, J. L., Liu, J., Istrate, M. A., Kamenecka, T. M., Roush, W. R., Vidović, D., Schürer, S. C., Xu, J., Wagoner, G., Drew, P. D., Griffin, P. R. & Burris, T. P., Apr 28 2011, In : Nature. 472, 7344, p. 491-494 4 p.

Research output: Contribution to journalArticle

313 Scopus citations

Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice

Wang, Q., Levay, K., Chanturiya, T., Dvoriantchikova, G., Anderson, K. L., Bianco, S. D. C., Ueta, C. B., Molano, R. D., Pileggi, A., Gurevich, E. V., Gavrilova, O. & Slepak, V. Z., Nov 1 2011, In : FASEB Journal. 25, 11, p. 3949-3957 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

The food colorant erythrosine is a promiscuous protein-protein interaction inhibitor

Ganesan, L., Margolles-Clark, E., Song, Y. & Buchwald, P., Mar 15 2011, In : Biochemical Pharmacology. 81, 6, p. 810-818 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

The location of olfactory receptors within olfactory epithelium is independent of odorant volatility and solubility

Abaffy, T. & DeFazio, A. R., May 10 2011, In : BMC Research Notes. 4, 137.

Research output: Contribution to journalArticle

4 Scopus citations

Transcriptional profiling of intrinsic PNS factors in the postnatal mouse

Smith, R. P., Lerch-Haner, J. K., Pardinas, J. R., Buchser, W. J., Bixby, J. L. & Lemmon, V. P., Jan 1 2011, In : Molecular and Cellular Neuroscience. 46, 1, p. 32-44 13 p.

Research output: Contribution to journalArticle

39 Scopus citations
2010

A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration

Usher, L. C., Johnstone, A., Ertürk, A., Hu, Y., Strikis, D., Wanner, I. B., Moorman, S., Lee, J. W., Min, J., Ha, H. H., Duan, Y., Hoffman, S., Goldberg, J. L., Bradke, F., Chang, Y. T., Lemmon, V. P. & Bixby, J. L., Mar 31 2010, In : Journal of Neuroscience. 30, 13, p. 4693-4706 14 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding

Dweck, D., Reynaldo, D. P., Pinto, J. R. & Potter, J. D., Jun 4 2010, In : Journal of Biological Chemistry. 285, 23, p. 17371-17379 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe

Locovei, A. M., Yin, L. & D'Urso, G., Aug 27 2010, In : Cell Division. 5, 20.

Research output: Contribution to journalArticle

2 Scopus citations

Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells

Wilson, A., Shehadeh, L. A., Yu, H. & Webster, K. A., Apr 7 2010, In : BMC genomics. 11, 1, 229.

Research output: Contribution to journalArticle

101 Scopus citations

A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice

Tapanes-Castillo, A., Weaver, E. J., Smith, R. P., Kamei, Y., Caspary, T., Hamilton-Nelson, K. L., Slifer, S. H., Martin, E. R., Bixby, J. L. & Lemmon, V. P., Feb 1 2010, In : Neurogenetics. 11, 1, p. 53-71 19 p.

Research output: Contribution to journalArticle

14 Scopus citations

An odorant receptor from the Southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants

Pelletier, J., Hughes, D. T., Luetje, C. W. & Leal, W. S., Sep 10 2010, In : PloS one. 5, 4, e10090.

Research output: Contribution to journalArticle

76 Scopus citations

A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism

Teles, M. G., Trarbach, E. B., Noel, S. D., Guerra, G., Jorge, A., Beneduzzi, D., Bianco, S. D., Mukherjee, A., Baptista, M. T., Costa, E. M., De Castro, M., Mendonça, B. B., Kaiser, U. B. & Latronico, A. C., Jul 1 2010, In : European Journal of Endocrinology. 163, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

A novel mouse model of in-stent restenosis

Rodriguez-Menocal, L., Wei, Y., Pham, S. M., St-Pierre, M., Li, S., Webster, K., Goldschmidt-Clermont, P. & Vazquez-Padron, R. I., Apr 1 2010, In : Atherosclerosis. 209, 2, p. 359-366 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Arginylation regulates intracellular actin polymer level by modulating actin properties and binding of capping and severing proteins

Saha, S., Mundia, M. M., Zhang, F., Demers, R. W., Korobova, F., Svitkina, T., Perieteanu, A. A., Dawson, J. F. & Kashina, A., Apr 15 2010, In : Molecular biology of the cell. 21, 8, p. 1350-1361 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites

GrÖtsch, H., Giblin, J. P., Idrissi, F. Z., Fernández-Golbano, I. M., Collette, J. R., Newpher, T. M., Robles, V., Lemmon, S. K. & Geli, M. I., Sep 1 2010, In : EMBO Journal. 29, 17, p. 2899-2914 16 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cardiac troponin mutations and restrictive cardiomyopathy

Potter, J. D., Parvatiyar, M. S., Pinto, J. R. & Dweck, D., Jul 19 2010, In : Journal of Biomedicine and Biotechnology. 2010, 350706.

Research output: Contribution to journalReview article

35 Scopus citations

Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry

Greenberg, M. J., Kazmierczak, K., Szczesna-Cordary, D. & Moore, J. R., Oct 5 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 40, p. 17403-17408 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction

Kanashiro-Takeuchi, R. M., Tziomalos, K., Takeuchi, L. M., Treuer, A. V., Lamirault, G., Dulce, R., Hurtado, M., Song, Y., Block, N. L., Rick, F., Klukovits, A., Hu, Q., Varga, J. L., Schally, A. V. & Hare, J. M., Feb 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2604-2609 6 p.

Research output: Contribution to journalArticle

71 Scopus citations

Choice of immunosuppression influences cytomegalovirus DNAemia in cynomolgus monkey (Macaca fascicularis) islet allograft recipients

Han, D., Berman, D. M., Willman, M., Buchwald, P., Rothen, D., Kenyon, N. M. & Kenyon, N. S., Dec 1 2010, In : Cell Transplantation. 19, 12, p. 1547-1561 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy

Li, Y., Charles, P. Y. J., Nan, C., Pinto, J. R., Wang, Y., Liang, J., Wu, G., Tian, J., Feng, H. Z., Potter, J. D., Jin, J. P. & Huang, X., Sep 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 3, p. 402-411 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Dealing with misfolded proteins: Examining the neuroprotective role of molecular chaperones in neurodegeneration

Ali, Y. O., Kitay, B. M. & Zhai, R. G., Oct 1 2010, In : Molecules. 15, 10, p. 6859-6887 29 p.

Research output: Contribution to journalReview article

30 Scopus citations