Molecular and Cellular Pharmacology

Research Output

2012

Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq

Lerch, J. K., Kuo, F., Motti, D., Morris, R., Bixby, J. L. & Lemmon, V. P., Jan 17 2012, In : PloS one. 7, 1, e30417.

Research output: Contribution to journalArticle

33 Scopus citations

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract

Blackmore, M. G., Wang, Z., Lerch, J. K., Motti, D., Zhang, Y. P., Shields, C. B., Lee, J. K., Goldberg, J. L., Lemmon, V. P. & Bixby, J. L., May 8 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7517-7522 6 p.

Research output: Contribution to journalArticle

140 Scopus citations

Lessons from yeast for clathrin-mediated endocytosis

Boettner, D. R., Chi, R. J. & Lemmon, S. K., Jan 1 2012, In : Nature Cell Biology. 14, 1, p. 2-10 9 p.

Research output: Contribution to journalReview article

77 Scopus citations

MicroRNAs and neuronal development

Motti, D., Bixby, J. L. & Lemmon, V. P., Dec 1 2012, In : Seminars in Fetal and Neonatal Medicine. 17, 6, p. 347-352 6 p.

Research output: Contribution to journalReview article

22 Scopus citations

Mitochondrial membrane permeabilization and cell death during myocardial infarction: Roles of calcium and reactive oxygen species

Webster, K. A., Nov 1 2012, In : Future Cardiology. 8, 6, p. 863-884 22 p.

Research output: Contribution to journalReview article

162 Scopus citations

Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice

Kazmierczak, K., Muthu, P., Huang, W., Jones, M., Wang, Y. & Szczesna-Cordary, D., Feb 15 2012, In : Biochemical Journal. 442, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
5 Scopus citations

Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism

Jo, S., Kalló, I., Bardóczi, Z., e Drigo, R. A., Zeöld, A., Liposits, Z., Oliva, A., Lemmon, V. P., Bixby, J. L., Gereben, B. & Bianco, A. C., Jun 20 2012, In : Journal of Neuroscience. 32, 25, p. 8491-8500 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy

Ali, Y. O., Ruan, K. & Zhai, R. G., Jan 1 2012, In : Human molecular genetics. 21, 2, p. 237-250 14 p., ddr449.

Research output: Contribution to journalArticle

64 Scopus citations

Novel kinase inhibitors by reshuffling ligand functionalities across the human kinome

Vidović, D., Muskal, S. M. & Schürer, S. C., Dec 21 2012, In : Journal of Chemical Information and Modeling. 52, 12, p. 3107-3115 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Novel selective allosteric and bitopic ligands for the S1P3 receptor

Jo, E., Bhhatarai, B., Repetto, E., Guerrero, M., Riley, S., Brown, S. J., Kohno, Y., Roberts, E., Schürer, S. C. & Rosen, H., Dec 21 2012, In : ACS Chemical Biology. 7, 12, p. 1975-1983 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth

Das, M., Drake, T., Wiley, D. J., Buchwald, P., Vavylonis, D. & Verde, F., Jul 13 2012, In : Science. 337, 6091, p. 239-243 5 p.

Research output: Contribution to journalArticle

85 Scopus citations

Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates

Buchser, W. J., Smith, R. P., Pardinas, J. R., Haddox, C. L., Hutson, T., Moon, L., Hoffman, S. R., Bixby, J. L. & Lemmon, V. P., Jun 6 2012, In : PloS one. 7, 6, e38101.

Research output: Contribution to journalArticle

16 Scopus citations

Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle

Chopra, I., Li, H. F., Wang, H. & Webster, K. A., Mar 1 2012, In : Diabetologia. 55, 3, p. 783-794 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini

Ouyang, H., Ali, Y. O., Ravichandran, M., Dong, A., Qiu, W., MacKenzie, F., Dhe-Paganon, S., Arrowsmith, C. H. & Zhai, R. G., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2317-2327 11 p.

Research output: Contribution to journalArticle

114 Scopus citations

RegIIA: An α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs

Franco, A., Kompella, S. N., Akondi, K. B., Melaun, C., Daly, N. L., Luetje, C. W., Alewood, P. F., Craik, D. J., Adams, D. J. & Marí, F., Feb 1 2012, In : Biochemical Pharmacology. 83, 3, p. 419-426 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis

Chi, R. J., Torres, O. T., Segarra, V. A., Lansley, T., Chang, J. S., Newpher, T. M. & Lemmon, S. K., Dec 1 2012, In : Journal of Cell Science. 125, 20, p. 4728-4739 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Sequencing and characterizing odorant receptors of the cerambycid beetle Megacyllene caryae

Mitchell, R. F., Hughes, D. T., Luetje, C. W., Millar, J. G., Soriano-Agatón, F., Hanks, L. M. & Robertson, H. M., Jul 1 2012, In : Insect Biochemistry and Molecular Biology. 42, 7, p. 499-505 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Single molecule detection approach to muscle study: kinetics of a single cross-bridge during contraction of muscle.

Borejdo, J., Szczesna-Cordary, D., Muthu, P., Metticolla, P., Luchowski, R., Gryczynski, Z. & Gryczynski, I., Sep 11 2012, In : Methods in molecular biology (Clifton, N.J.). 875, p. 311-334 24 p.

Research output: Contribution to journalArticle

6 Scopus citations

Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells

Liapis, E., Sandiford, S., Wang, Q., Gaidosh, G., Motti, D., Levay, K. & Slepak, V. Z., Aug 1 2012, In : Journal of neurochemistry. 122, 3, p. 568-581 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2′-fluoro-3′-(substituted phenyl)deschloroepibatidine analogues of 2′-fluoro-3′-(4- nitrophenyl)deschloroepibatidine

Ondachi, P., Castro, A., Luetje, C. W., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Jul 26 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6512-6522 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

The effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse hearts

Muthu, P., Kazmierczak, K., Jones, M. & Szczesna-Cordary, D., Dec 1 2012, In : Journal of Cellular and Molecular Medicine. 16, 4, p. 911-919 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation

Pinto, J. R., Gomes, A. V., Jones, M. A., Liang, J., Nguyen, S., Miller, T., Parvatiyar, M. S. & Potter, J. D., Oct 26 2012, In : Journal of Biological Chemistry. 287, 44, p. 37362-37370 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

The microRNA -23b/-27b Cluster Suppresses the Metastatic Phenotype of Castration-Resistant Prostate Cancer Cells

Ishteiwy, R. A., Ward, T. M., Dykxhoorn, D. M. & Burnstein, K. L., Dec 29 2012, In : PloS one. 7, 12, e52106.

Research output: Contribution to journalArticle

66 Scopus citations

Vav3 enhances androgen receptor splice variant activity and is critical for castration-resistant prostate cancer growth and survival

Peacock, S. O., Fahrenholtz, C. D. & Burnstein, K. L., Dec 1 2012, In : Molecular Endocrinology. 26, 12, p. 1967-1979 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Whole-mount imaging of the mouse hindlimb vasculature using the lipophilic carbocyanine dye DiI

Boden, J., Wei, J., McNamara, G., Layman, H., Abdulreda, M. H., Andreopoulos, F. M. & Webster, K. A., Jul 1 2012, In : BioTechniques. 53, 1

Research output: Contribution to journalArticle

5 Scopus citations

Will periodic intravenous injections of conditioned bone marrow cells effectively reduce atherosclerosis?

Song, X., Ma, Q., Liu, X., Seo, P., Herderick, E., Webster, K., Goldschmidt-Clermont, P. J. & Seo, D., Jan 1 2012, In : Antioxidants and Redox Signaling. 16, 1, p. 85-91 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schürer, S. C., Nomura, D. K., Rosen, H., Fu, G. C. & Cravatt, B. F., Apr 26 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 6811-6816 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

A case report-volatile metabolomic signature of malignant melanoma using matching skin as a control

Abaffy, T., Möller, M., Riemer, D. D., Milikowski, C. & Defazio, R. A., Dec 1 2011, In : Journal of Cancer Science and Therapy. 3, 6, p. 140-144 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

A Combined Ligand- and Structure-Based Virtual Screening Protocol Identifies Submicromolar PPARγPartial Agonists

Vidović, D., Busby, S. A., Griffin, P. R. & Schürer, S. C., Jan 3 2011, In : ChemMedChem. 6, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
59 Scopus citations

An essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in ApoE-/- mice

Cesar, L., Suarez, S. V., Adi, J., Adi, N., Vazquez-Padron, R., Yu, H., Ma, Q., Goldschmidt-Clermont, P. J., Agatston, A., Kurlansky, P. & Webster, K. A., Feb 28 2011, In : PloS one. 6, 2, e17263.

Research output: Contribution to journalArticle

16 Scopus citations

An Open-Label, Single-Dose, Crossover Study of the Pharmacokinetics and Metabolism of Two Oral Formulations of 1-Octanol in Patients with Essential Tremor

Nahab, F. B., Wittevrongel, L., Ippolito, D., Toro, C., Grimes, G. J., Starling, J., Potti, G., Haubenberger, D., Bowen, D., Buchwald, P., Dong, C., Kalowitz, D. & Hallett, M., Oct 1 2011, In : Neurotherapeutics. 8, 4, p. 753-762 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Anoxia, acidosis, and intergenic interactions selectively regulate methionine sulfoxide reductase transcriptions in mouse embryonic stem cells

Zhang, C., Jia, P., Jia, Y., Li, Y., Webster, K. A., Huang, X., Achary, M., Lemanski, S. L. & Lemanski, L. F., Jan 1 2011, In : Journal of cellular biochemistry. 112, 1, p. 98-106 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Choi, J. H., Banks, A. S., Kamenecka, T. M., Busby, S. A., Chalmers, M. J., Kumar, N., Kuruvilla, D. S., Shin, Y., He, Y., Bruning, J. B., Marciano, D. P., Cameron, M. D., Laznik, D., Jurczak, M. J., Schürer, S. C., Vidović, D., Shulman, G. I., Spiegelman, B. M. & Griffin, P. R., Sep 22 2011, In : Nature. 477, 7365, p. 477-481 5 p.

Research output: Contribution to journalArticle

334 Scopus citations

A Protocol for Characterizing the Impact of Collateral Flow after Distal Middle Cerebral Artery Occlusion

DeFazio, R. A., Levy, S., Morales, C. L., Levy, R. V., Lin, H. W., Abaffy, T., Dave, K. R., Watson, B. D., Perez-Pinzon, M. A. & Ohanna, V., Mar 1 2011, In : Translational stroke research. 2, 1, p. 112-127 16 p.

Research output: Contribution to journalArticle

18 Scopus citations

Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration

Ali, Y. O., Escala, W., Ruan, K. & Zhai, R. G., Mar 2011, In : Journal of Visualized Experiments. 49, e2504.

Research output: Contribution to journalArticle

82 Scopus citations

BioAssay Ontology (BAO): A semantic description of bioassays and high-throughput screening results

Visser, U., Abeyruwan, S., Vempati, U., Smith, R. P., Lemmon, V. & Schürer, S. C., Jun 24 2011, In : BMC Bioinformatics. 12, 257.

Research output: Contribution to journalArticle

75 Scopus citations

BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets

Schürer, S. C., Vempati, U., Smith, R., Southern, M. & Lemmon, V., Apr 1 2011, In : Journal of Biomolecular Screening. 16, 4, p. 415-426 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Bioassay ontology to describe high-throughput screening assays and their results

Vempati, U., Visser, U., Abeyruwan, S., Sakurai, K., Przydzial, M., Chung, C., Smith, R., Koleti, A., Mader, C., Lemmon, V. & Schürer, S., Dec 1 2011, In : CEUR Workshop Proceedings. 833, p. 209-216 8 p.

Research output: Contribution to journalConference article

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins

Goldsmith, B. R., Mitala, J. J., Josue, J., Castro, A., Lerner, M. B., Bayburt, T. H., Khamis, S. M., Jones, R. A., Brand, J. G., Sligar, S. G., Luetje, C. W., Gelperin, A., Rhodes, P. A., Discher, B. M. & Johnson, A. T. C., Jul 26 2011, In : ACS Nano. 5, 7, p. 5408-5416 9 p.

Research output: Contribution to journalArticle

115 Scopus citations

Cell line ontology: Redesigning the cell line knowledgebase to aid integrative translational informatics

Sarntivijai, S., Xiang, Z., Meehan, T. F., Diehl, A. D., Vempati, U., Schurer, S., Pang, C., Malone, J., Parkinson, H., Athey, B. D. & He, Y., Dec 1 2011, In : CEUR Workshop Proceedings. 833, p. 25-32 8 p.

Research output: Contribution to journalConference article

11 Scopus citations

Challenges in small screening laboratories: Implementing an on-demand laboratory information management system

Lemmon, V. P., Jia, Y., Shi, Y., Holbrook, S. D., Bixby, J. L. & Buchser, W., Nov 1 2011, In : Combinatorial Chemistry and High Throughput Screening. 14, 9, p. 742-748 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

C-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction

Wei, J., Wang, W., Chopra, I., Li, H. F., Dougherty, C. J., Adi, J., Adi, N., Wang, H. & Webster, K. A., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 13995-14006 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin

Boettner, D. R., Friesen, H., Andrews, B. & Lemmon, S. K., Oct 1 2011, In : Molecular biology of the cell. 22, 19, p. 3699-3714 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Computational modeling of substrate specificity and catalysis of the β-secretase (BACE1) enzyme

Barman, A., Schürer, S. & Prabhakar, R., May 24 2011, In : Biochemistry. 50, 20, p. 4337-4349 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Cross-bridge kinetics in myofibrils containing familial hypertrophic cardiomyopathy R58Q mutation in the regulatory light chain of myosin

Mettikolla, P., Calander, N., Luchowski, R., Gryczynski, I., Gryczynski, Z., Zhao, J., Szczesna-Cordary, D. & Borejdo, J., Sep 7 2011, In : Journal of theoretical biology. 284, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Current and Future Challenges for Collaborative Computational Technologies for the Life Sciences

Williams, A. J., Arnold, R. J. G., Neylon, C., Spencer, R. W., Schürer, S. & Ekins, S., May 3 2011, Collaborative Computational Technologies for Biomedical Research. John Wiley and Sons, p. 491-518 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Defective CXCR4 expression in aged bone marrow cells impairs vascular regeneration

Shao, H., Xu, Q., Wu, Q., Ma, Q., Salgueiro, L., Wang, JA., Eton, D., Webster, K. A. & Yu, H., Oct 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 10, p. 2046-2056 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Chowdhury, S., Sessions, E. H., Pocas, J. R., Grant, W., Schröter, T., Lin, L., Ruiz, C., Cameron, M. D., Schürer, S., Lograsso, P., Bannister, T. D. & Feng, Y., Dec 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 23, p. 7107-7112 6 p.

Research output: Contribution to journalArticle

31 Scopus citations