Molecular and Cellular Pharmacology

Research Output

2013

NMNATs, evolutionarily conserved neuronal maintenance factors

Ali, Y. O., Li-Kroeger, D., Bellen, H. J., Zhai, R. G. & Lu, H. C., Nov 1 2013, In : Trends in Neurosciences. 36, 11, p. 632-640 9 p.

Research output: Contribution to journalReview article

36 Scopus citations

Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance

Wang, W., Barnabei, M. S., Asp, M. L., Heinis, F. I., Arden, E., Davis, J., Braunlin, E., Li, Q., Davis, J. P., Potter, J. D. & Metzger, J. M., Mar 1 2013, In : Nature medicine. 19, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
17 Scopus citations

Octanoic acid in alcohol-responsive essential tremor: A randomized controlled study

Haubenberger, D., McCrossin, G., Lungu, C., Considine, E., Toro, C., Nahab, F. B., Auh, S., Buchwald, P., Grimes, G. J., Starling, J., Potti, G., Scheider, L., Kalowitz, D., Bowen, D., Carnie, A. & Hallett, M., Mar 5 2013, In : Neurology. 80, 10, p. 933-940 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Partaking of Archaea to biogeochemical cycling in oxygen-deficient zones of meromictic saline Lake Faro (Messina, Italy)

La Cono, V., La Spada, G., Arcadi, E., Placenti, F., Smedile, F., Ruggeri, G., Michaud, L., Raffa, C., De Domenico, E., Sprovieri, M., Mazzola, S., Genovese, L., Giuliano, L., Slepak, V. Z. & Yakimov, M. M., Jun 1 2013, In : Environmental Microbiology. 15, 6, p. 1717-1733 17 p.

Research output: Contribution to journalArticle

20 Scopus citations

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration

Kuboyama, T., Luo, X., Park, K., Blackmore, M. G., Tojima, T., Tohda, C., Bixby, J. L., Lemmon, V. P. & Kamiguchi, H., Oct 1 2013, In : Experimental neurology. 248, p. 157-169 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Phenylthiophenecarboxamide antagonists of the olfactory receptor co-receptor subunit from a mosquito

Chen, S. & Luetje, C. W., Dec 17 2013, In : PloS one. 8, 12, e84575.

Research output: Contribution to journalArticle

14 Scopus citations

PrOntoLearn: Unsupervised lexico-semantic ontology generation using probabilistic methods

Abeyruwan, S., Visser, U., Lemmon, V. & Schürer, S., Jan 30 2013, Uncertainty Reasoning for the Semantic Web II - International Workshops, URSW 2008-2010 Held at ISWC and UniDL 2010 Held at FLoC, Revised Selected Papers. p. 217-236 20 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 7123 LNAI).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and ret signaling

Gatto, G., Dudanova, I., Suetterlin, P., Davies, A. M., Drescher, U., Bixby, J. L. & Klein, R., Mar 25 2013, In : Annals of internal medicine. 158, 6, p. 5399-5410 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Receptors: Chemical courtship in mice

Luetje, C. W., Mar 1 2013, In : Nature Chemical Biology. 9, 3, p. 140-141 2 p.

Research output: Contribution to journalArticle

Regulation of phospholipase C-β1 GTPase-activating protein (GAP) function and relationship to Gq efficacy

Litosch, I., Nov 1 2013, In : IUBMB life. 65, 11, p. 936-940 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Role of Cdc42 dynamics in the control of fission yeast cell polarization

Das, M. & Verde, F., Dec 1 2013, In : Biochemical Society transactions. 41, 6, p. 1745-1749 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Signaling mechanisms of Vav3, a guanine nucleotide exchange factor and androgen receptor coactivator, in physiology and prostate cancer progression

Lyons, L. S. & Burnstein, K. L., Jan 1 2013, Prostate Cancer: Biochemistry, Molecular Biology and Genetics. Springer New York, p. 187-205 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Silent, generic and plant kairomone sensitive odorant receptors from the Southern house mosquito

Xu, P., Choo, Y. M., Pelletier, J., Sujimoto, F. R., Hughes, D. T., Zhu, F., Atungulu, E., Cornel, A. J., Luetje, C. W. & Leal, W. S., Sep 1 2013, In : Journal of Insect Physiology. 59, 9, p. 961-966 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells

Gomes, S. A., Rangel, E. B., Premer, C., Dulce, R. A., Cao, Y., Florea, V., Balkan, W., Rodrigues, C. O., Schally, A. V. & Hare, J. M., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8, p. 2834-2839 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Stem cell factor improves lung recovery in rats following neonatal hyperoxia-induced lung injury

Miranda, L. F., Rodrigues, C. O., Ramachandran, S., Torres, E., Huang, J., Klim, J., Hehre, D., McNiece, I., Hare, J. M., Suguihara, C. Y. & Young, K. C., Dec 1 2013, In : Pediatric Research. 74, 6, p. 682-688 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes

Shi, H., Chen, L., Wang, H., Zhu, S., Dong, C., Webster, K. A. & Wei, J., Jan 11 2013, In : Biochemical and biophysical research communications. 430, 2, p. 827-832 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
17 Scopus citations

The promiscuous protein binding ability of erythrosine B studied by metachromasy (metachromasia)

Ganesan, L. & Buchwald, P., Apr 1 2013, In : Journal of Molecular Recognition. 26, 4, p. 181-189 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The role of autophagy in Nmnat-mediated protection against hypoxia-induced dendrite degeneration

Wen, Y., Zhai, R. G. & Kim, M. D., Jan 1 2013, In : Molecular and Cellular Neuroscience. 52, p. 140-151 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

A broadly tuned mouse odorant receptor that detects nitrotoluenes

Li, J., Haddad, R., Chen, S., Santos, V. & Luetje, C. W., Jun 1 2012, In : Journal of neurochemistry. 121, 6, p. 881-890 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates

Johnstone, A. L., Reierson, G. W., Smith, R. P., Goldberg, J. L., Lemmon, V. P. & Bixby, J. L., Jun 1 2012, In : Molecular and Cellular Neuroscience. 50, 2, p. 125-135 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Activation of growth hormone releasing hormone (GHRH) receptor stimulates cardiac reverse remodeling after myocardial infarction (MI)

Kanashiro-Takeuchi, R. M., Takeuchi, L. M., Rick, F. G., Dulce, R., Treuer, A. V., Florea, V., Rodrigues, C. O., Paulino, E. C., Hatzistergos, K. E., Selem, S. M., Gonzalez, D. R., Block, N. L., Schally, A. V. & Hare, J. M., Jan 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 2, p. 559-563 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation

Parvatiyar, M. S., Landstrom, A. P., Figueiredo-Freitas, C., Potter, J. D., Ackerman, M. J. & Pinto, J. R., Sep 14 2012, In : Journal of Biological Chemistry. 287, 38, p. 31845-31855 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer

Rao, S., Lyons, L. S., Fahrenholtz, C. D., Wu, F., Farooq, A., Balkan, W. & Burnstein, K. L., Feb 1 2012, In : Oncogene. 31, 6, p. 716-727 12 p.

Research output: Contribution to journalArticle

34 Scopus citations
24 Scopus citations

Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion

Zhang, F., Saha, S. & Kashina, A., Jun 11 2012, In : Journal of Cell Biology. 197, 6, p. 819-836 18 p.

Research output: Contribution to journalArticle

37 Scopus citations

A sirtuin link between metabolism and heart disease

Webster, K. A., Nov 1 2012, In : Nature medicine. 18, 11, p. 1617-1619 3 p.

Research output: Contribution to journalShort survey

10 Scopus citations

Cardiomyopathies: Classification, clinical characterization, and functional phenotypes

Szczesna-Cordary, D., Morimoto, S., Gomes, A. V. & Moore, J. R., Dec 26 2012, In : Biochemistry Research International. 870942.

Research output: Contribution to journalEditorial

3 Scopus citations

Compound profiling with high-content screening methodology

Mayer, T. & Schuerer, S. C., Jan 1 2012, Chemical Genomics. Cambridge University Press, p. 215-224 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Conserved rules govern genetic interaction degree across species

Koch, E. N., Costanzo, M., Bellay, J., Deshpande, R., Chatfield-Reed, K., Chua, G., D'Urso, G., Andrews, B. J., Boone, C. & Myers, C. L., Jul 2 2012, In : Genome biology. 13, 7, R57.

Research output: Contribution to journalArticle

29 Scopus citations

CREB-activity and NMNAT2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

Ljungberg, M. C., Ali, Y. O., Zhu, J., Wu, C. S., Oka, K., Zhai, R. G. & Lu, H. C., Jan 1 2012, In : Human molecular genetics. 21, 2, p. 251-267 17 p., ddr492.

Research output: Contribution to journalArticle

65 Scopus citations

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Wang, L., Perera, B. G. K., Hari, S. B., Bhhatarai, B., Backes, B. J., Seeliger, M. A., Schürer, S. C., Oakes, S. A., Papa, F. R. & Maly, D. J., Dec 1 2012, In : Nature Chemical Biology. 8, 12, p. 982-989 8 p.

Research output: Contribution to journalArticle

107 Scopus citations

DNase activation by hypoxia-acidosis parallels but is independent of programmed cell death

Thompson, J. W., Graham, R. M. & Webster, K. A., Sep 17 2012, In : Life Sciences. 91, 7-8, p. 223-229 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology

Slepak, T. I., Salay, L. D., Lemmon, V. P. & Bixby, J. L., Jul 1 2012, In : Cytoskeleton. 69, 7, p. 514-527 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Evidence for Multiple Phototransduction Pathways in a Reef-Building Coral

Mason, B., Schmale, M., Gibbs, P., Miller, M. W., Wang, Q., Levay, K., Shestopalov, V. & Slepak, V. Z., Dec 5 2012, In : PloS one. 7, 12, e50371.

Research output: Contribution to journalArticle

24 Scopus citations

Exploratory computational assessment of possible binding modes for small molecule inhibitors of the CD40-CD154 co-stimulatory interaction

Ganesan, L., Vidović, D., Schürer, S. C. & Buchwald, P., Jun 21 2012, In : Pharmazie. 67, 5, p. 374-379 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fanconi anemia complementation group A (FANCA) protein has intrinsic affinity for nucleic acids with preference for single-stranded forms

Yuan, F., Qian, L., Zhao, X., Liu, J. Y., Song, L., D'Urso, G., Jain, C. & Zhang, Y., Feb 10 2012, In : Journal of Biological Chemistry. 287, 7, p. 4800-4807 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Feasibility of localized immunosuppression: 3. Preliminary evaluation of organosilicone constructs designed for sustained drug release in a cell transplant environment using dexamethasone

Song, Y., Margolles-Clark, E., Fraker, C. A., Weaver, J. D., Ricordi, C., Pileggi, A., Stabler, C. L. & Buchwald, P., Jun 21 2012, In : Pharmazie. 67, 5, p. 394-399 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Formalization, Annotation and Analysis of Diverse Drug and Probe Screening Assay Datasets Using the BioAssay Ontology (BAO)

Vempati, U. D., Przydzial, M. J., Chung, C., Abeyruwan, S., Mir, A., Sakurai, K., Visser, U., Lemmon, V. P. & Schürer, S. C., Nov 14 2012, In : PloS one. 7, 11, e49198.

Research output: Contribution to journalArticle

37 Scopus citations

Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy

Wang, Y., Pinto, J. R., Solis, R. S., Dweck, D., Liang, J., Diaz-Perez, Z., Ge, Y., Walker, J. W. & Potter, J. D., Jan 13 2012, In : Journal of Biological Chemistry. 287, 3, p. 2156-2167 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury

Dvoriantchikova, G., Ivanov, D., Barakat, D., Grinberg, A., Wen, R., Slepak, V. Z. & Shestopalov, V. I., Feb 23 2012, In : PloS one. 7, 2, e31991.

Research output: Contribution to journalArticle

72 Scopus citations

Getting in Touch with the Clathrin Terminal Domain

Lemmon, S. K. & Traub, L. M., Apr 1 2012, In : Traffic. 13, 4, p. 511-519 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1

Chan, Y. M., Broder-Fingert, S., Parachos, S., Lapatto, R., Au, M., Hughes, V., Bianco, S. D. C., Min, L., Plummer, L., Cerrato, F., De Guillebon, A., Wu, I. H., Wahab, F., Dwyer, A., Kirsch, S., Quinton, R., Cheetham, T., Ozata, M., Ten, S., Chanoine, J. P. & 8 others, Pitteloud, N., Martin, K. A., Schiffmann, R., Van Der Kamp, H. J., Nader, S., Hall, J. E., Kaiser, U. B. & Seminara, S. B., Sep 1 2012, In : Obstetrical and Gynecological Survey. 67, 9, p. 546-547 2 p.

Research output: Contribution to journalComment/debate

High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries

Nelersa, C. M., Barreras, H., Runko, E., Ricard, J., Shi, Y., Glass, S. J., Bixby, J. L., Lemmon, V. P. & Liebl, D. J., Jul 1 2012, In : Journal of Biomolecular Screening. 17, 6, p. 785-795 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit

Chen, S. & Luetje, C. W., May 8 2012, In : PloS one. 7, 5, e36784.

Research output: Contribution to journalArticle

42 Scopus citations

Influence of diet on visceral adipose remodeling in NONcNZO10 mice with polygenic susceptibility for type 2 diabetes

Adi, N. C., Adi, J. N., Cesar, L., Agatston, A. S., Kurlansky, P. & Webster, K. A., Oct 1 2012, In : Obesity. 20, 10, p. 2142-2146 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

In vivo 17β-estradiol treatment contributes to podocyte actin stabilization in female db/db mice

Catanuto, P., Fornoni, A., Pereira-Simon, S., Wu, F., Burnstein, K. L., Xia, X., Conti, F., Lenzi, A. & Elliot, S., Dec 1 2012, In : Endocrinology. 153, 12, p. 5888-5895 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2

Cadete, V. J. J., Sawicka, J., Jaswal, J. S., Lopaschuk, G. D., Schulz, R., Szczesna-Cordary, D. & Sawicki, G., Jul 1 2012, In : FEBS Journal. 279, 13, p. 2444-2454 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Isoform diversity and its importance for axon regeneration

Lerch, J. K., Bixby, J. L. & Lemmon, V. P., Aug 1 2012, In : Neuropathology. 32, 4, p. 420-431 12 p.

Research output: Contribution to journalArticle

4 Scopus citations