Molecular and Cellular Pharmacology

Research Output

Article

Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice

Abraham, T. P., Jones, M., Kazmierczak, K., Liang, H. Y., Pinheiro, A. C., Wagg, C. S., Lopaschuk, G. D. & Szczesna-Cordary, D., Apr 1 2009, In : Cardiovascular Research. 82, 1, p. 84-92 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Differences in the glucocorticoid to the progesterone receptor selectivity of inhaled glucocorticoids

Issar, M., Sahasranaman, S., Buchwald, P. & Hochhaus, G., Mar 1 2006, In : European Respiratory Journal. 27, 3, p. 511-516 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Different Functional Properties of Troponin T Mutants that Cause Dilated Cardiomyopathy

Venkatraman, G., Harada, K., Gomes, A. V., Kerrick, W. G. L. & Potter, J. D., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 41670-41676 7 p.

Research output: Contribution to journalArticle

54 Scopus citations
13 Scopus citations

Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation

Zhang, F., Saha, S., Shabalina, S. A. & Kashina, A., Sep 17 2010, In : Science. 329, 5998, p. 1534-1537 4 p.

Research output: Contribution to journalArticle

121 Scopus citations

Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts - Role of myofilament Ca2+ sensitivity increase

Sirenko, S. G., Potter, J. D. & Knollmann, B. C., Aug 1 2006, In : Journal of Physiology. 575, 1, p. 201-213 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Differential effects of the Gβ5-RGS7 complex on muscarinic M3 receptor-induced Ca2+ influx and release

Karpinsky-Semper, D., Volmar, C. H., Brothers, S. P. & Slepak, V. Z., May 2014, In : Molecular Pharmacology. 85, 5, p. 758-768 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Differential inhibition by α-conotoxin-MII of the nicotinic stimulation of [3H] dopamine release from rat striatal synaptosomes and slices

Kaiser, S. A., Soliakov, L., Harvey, S. C., Luetje, C. W. & Wonnacott, S., Mar 1 1998, In : Journal of neurochemistry. 70, 3, p. 1069-1076 8 p.

Research output: Contribution to journalArticle

139 Scopus citations

Differential regulation of synaptic vesicle protein genes by target and synaptic activity

Plunkett, J. A., Baccus, S. A. & Bixby, J. L., Aug 1 1998, In : Journal of Neuroscience. 18, 15, p. 5832-5838 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Differential roles for disulfide bonds in the structural integrity and biological activity of κ-bungarotoxin, a neuronal nicotinic acetylcholine receptor antagonist

Grant, G. A., Luetje, C. W., Summers, R. & Xu, X. L., Sep 1 1998, In : Biochemistry. 37, 35, p. 12166-12171 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Differential tissue expression and developmental regulation of guanine nucleotide binding regulatory proteins and their messenger RNAs in rat heart

Luetje, C. W., Tietje, K. M., Christian, J. L. & Nathanson, N. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 26, p. 13357-13365 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Differential volatile signatures from skin, naevi and melanoma: A novel approach to detect a pathological process

Abaffy, T., Duncan, R., Riemer, D. D., Tietje, O., Elgart, G., Milikowski, C. & Anthony Defazio, R., Nov 18 2010, In : PloS one. 5, 11, e13813.

Research output: Contribution to journalArticle

46 Scopus citations

Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy

Westermann, D., Knollmann, B. C., Steendijk, P., Rutschow, S., Riad, A., Pauschinger, M., Potter, J. D., Schultheiss, H. P. & Tschöpe, C., Mar 1 2006, In : European Journal of Heart Failure. 8, 2, p. 115-121 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC

Hower, A. E., Beltran, P. J. & Bixby, J. L., Sep 1 2009, In : Journal of neurochemistry. 110, 5, p. 1635-1647 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Direct, differential-equation-based in-vitro-in-vivo correlation (IVIVC) method

Buchwald, P., Apr 1 2003, In : Journal of Pharmacy and Pharmacology. 55, 4, p. 495-504 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors

Nair, K. S., Hanson, S. M., Kennedy, M. J., Hurley, J. B., Gurevich, V. V. & Slepak, V. Z., Sep 24 2004, In : Journal of Biological Chemistry. 279, 39, p. 41240-41248 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Chowdhury, S., Sessions, E. H., Pocas, J. R., Grant, W., Schröter, T., Lin, L., Ruiz, C., Cameron, M. D., Schürer, S., Lograsso, P., Bannister, T. D. & Feng, Y., Dec 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 23, p. 7107-7112 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation

Bavan, S., Sherman, B., Luetje, C. W. & Abaffy, T., Mar 17 2014, In : PloS one. 9, 3, e92064.

Research output: Contribution to journalArticle

21 Scopus citations

Discovery of potent and selective urea-based ROCK inhibitors and their effects on intraocular pressure in rats

Yin, Y., Cameron, M. D., Lin, L., Khan, S., Schröter, T., Grant, W., Pocas, J., Chen, Y. T., Schürer, S., Pachori, A., Lograsso, P. & Feng, Y., Aug 27 2010, In : ACS Medicinal Chemistry Letters. 1, 4, p. 175-179 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy

Kazmierczak, K., Paulino, E. C., Huang, W., Muthu, P., Liang, J., Yuan, C. C., Rojas, A. I., Hare, J. M. & Szczesna-Cordary, D., May 8 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 4, p. H575-H589

Research output: Contribution to journalArticle

21 Scopus citations

Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype

Vidović, D., Xie, Y., Rinderspacher, A., Deng, S. X., Landry, D. W., Chung, C., Smith, D. H., Tautz, L. & Schürer, S. C., Sep 1 2011, In : Journal of Computer-Aided Molecular Design. 25, 9, p. 873-883 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices

Tomaselli, K. J., Reichardt, L. E. & Bixby, J. L., Dec 1 1986, In : Journal of Cell Biology. 103, 6, p. 2659-2672 14 p.

Research output: Contribution to journalArticle

Open Access
168 Scopus citations

Distinct neurite outgrowth signaling pathways converge on ERK activation

Perron, J. C. & Bixby, J. L., May 1999, In : Molecular and Cellular Neurosciences. 13, 5, p. 362-378 17 p.

Research output: Contribution to journalArticle

146 Scopus citations

Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis

Tournebize, R., Andersen, S. S. L., Verde, F., Dorée, M., Karsenti, E. & Hyman, A. A., Sep 15 1997, In : EMBO Journal. 16, 18, p. 5537-5549 13 p.

Research output: Contribution to journalArticle

154 Scopus citations

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Wang, L., Perera, B. G. K., Hari, S. B., Bhhatarai, B., Backes, B. J., Seeliger, M. A., Schürer, S. C., Oakes, S. A., Papa, F. R. & Maly, D. J., Dec 1 2012, In : Nature Chemical Biology. 8, 12, p. 982-989 8 p.

Research output: Contribution to journalArticle

107 Scopus citations
14 Scopus citations

Diversity of axonal growth-promoting receptors and regulation of their function

Bixby, J. L., Feb 1992, In : Current Opinion in Neurobiology. 2, 1, p. 66-69 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Diversity of bacteria at healthy human conjunctiva

Dong, Q., Brulc, J. M., Iovieno, A., Bates, B., Garoutte, A., Miller, D., Revanna, K. V., Gao, X., Antonopoulos, D. A., Slepak, V. Z. & Shestopalov, V. I., Jul 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5408-5413 6 p.

Research output: Contribution to journalArticle

134 Scopus citations

DNase activation by hypoxia-acidosis parallels but is independent of programmed cell death

Thompson, J. W., Graham, R. M. & Webster, K. A., Sep 17 2012, In : Life Sciences. 91, 7-8, p. 223-229 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dose-escalation study of octanoic acid in patients with essential tremor

Voller, B., Lines, E., McCrossin, G., Tinaz, S., Lungu, C., Grimes, G., Starling, J., Potti, G., Buchwald, P., Haubenberger, D. & Hallett, M., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schürer, S. C. & Ayad, N. G., Dec 1 2018, In : Nature Communications. 9, 1, 5315.

Research output: Contribution to journalArticle

10 Scopus citations

DrugCentral 2018: an update

Ursu, O., Holmes, J., Bologa, C. G., Yang, J. J., Mathias, S. L., Stathias, V., Nguyen, D. T., Schuerer, S. C. & Oprea, T., Jan 8 2019, In : Nucleic Acids Research. 47, D1, p. D963-D970

Research output: Contribution to journalArticle

16 Scopus citations

Drug target ontology to classify and integrate drug discovery data

Lin, Y., Mehta, S., Küçük-McGinty, H., Turner, J. P., Vidovic, D., Forlin, M., Koleti, A., Nguyen, D. T., Jensen, L. J., Guha, R., Mathias, S. L., Ursu, O., Stathias, V., Duan, J., Nabizadeh, N., Chung, C., Mader, C., Visser, U., Yang, J. J., Bologa, C. G. & 2 others, Oprea, T. I. & Schürer, S. C., Nov 9 2017, In : Journal of Biomedical Semantics. 8, 1, 50.

Research output: Contribution to journalArticle

10 Scopus citations

Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging

Shehadeh, L. A., Webster, K. A., Hare, J. M. & Vazquez-Padron, R. I., Oct 7 2011, In : PloS one. 6, 10, e25855.

Research output: Contribution to journalArticle

24 Scopus citations

Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology

Slepak, T. I., Salay, L. D., Lemmon, V. P. & Bixby, J. L., Jul 1 2012, In : Cytoskeleton. 69, 7, p. 514-527 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss

Li, C., Bademci, G., Subasioglu, A., Diaz-Horta, O., Zhu, Y., Liu, J., Mitchell, T. G., Abad, C., Seyhan, S., Duman, D., Cengiz, F. B., Tokgoz-Yilmaz, S., Blanton, S. H., Farooq, A., Walz, K., Zhai, R. G. & Tekin, M., Jan 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1347-1352 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

E22K mutation of RLC that causes familial hypertrophic cardiomyopathy in heterozygous mouse myocardium: Effect on cross-bridge kinetics

Dumka, D., Talent, J., Akopova, I., Guzman, G., Szczesna-Cordary, D. & Borejdo, J., Nov 24 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 5, p. H2098-H2106

Research output: Contribution to journalArticle

9 Scopus citations

Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation

Wang, Y., Smedberg, J. L., Cai, K. Q., Capo-Chichi, D. C. & Xu, X. X., Mar 1 2011, In : Developmental Dynamics. 240, 3, p. 566-576 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Edelfosine promotes apoptosis in androgen-deprived prostate tumors by increasing atf3 and inhibiting androgen receptor activity

Udayakumar, T., Stoyanova, R., Shareef, M. M., Mu, Z., Philip, S., Burnstein, K. L. & Pollack, A., Jun 1 2016, In : Molecular Cancer Therapeutics. 15, 6, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
14 Scopus citations

Effect of a myosin regulatory light chain mutation K104E on actin-myosin interactions

Duggal, D., Nagwekar, J., Rich, R., Huang, W., Midde, K., Fudala, R., Das, H., Gryczynski, I., Szczesna-Cordary, D. & Borejdo, J., May 15 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 10, p. H1248-H1257

Research output: Contribution to journalArticle

4 Scopus citations

Effect of Ca2+ binding on troponin C. Changes in spin label mobility, extrinsic fluorescence, and sulfhydryl reactivity

Potter, J. D., Seidel, J. C. & Leavis, P., Jan 1 1976, In : Journal of Biological Chemistry. 251, 23, p. 7551-7556 6 p.

Research output: Contribution to journalArticle

67 Scopus citations
181 Scopus citations

Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells

Solovyeva, V. V., Kolobynina, K. G., Gomzikova, M. O., Tazetdinova, L. G., Zhuravleva, M. N., Slepak, V. Z. & Rizvanov, A. A., Dec 1 2015, In : Genes and Cells. 10, 4, p. 90-93 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effect of thyroid status on α- and β-catecholamine responsiveness of hamster adipocytes

Garćia-Sáinz, J. A., Litosch, I., Hoffman, B. B., Lefkowitz, R. J. & Fain, J. N., Dec 18 1981, In : BBA - General Subjects. 678, 3, p. 334-341 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity

Carvalho, S. D., Bianco, A. C. & Silva, J. E., Jan 1 1996, In : Endocrinology. 137, 12, p. 5519-5529 11 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Effects of isoproterenol on twitch contraction of wild type and phospholamban-deficient murine ventricular myocardium

Pan, B. S., Hannon, J. D., Wiedmann, R., Potter, J. D., Kranias, E. G., Shen, Y. T., Johnson, R. G. & Housmans, P. R., Jan 1999, In : Journal of Molecular and Cellular Cardiology. 31, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effects of mutations in the central helix of troponin C on its biological activity

Sheng, Z., Francois, J. M., Hitchcock-DeGregori, S. E. & Potter, J. D., Oct 22 1991, In : Journal of Biological Chemistry. 266, 9, p. 5711-5715 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine

Avalos, M., Parker, M. J., Maddox, F. N., Ivy Carroll, F. & Luetje, C. W., Sep 1 2002, In : Journal of Pharmacology and Experimental Therapeutics. 302, 3, p. 1246-1252 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells

Cechin, S. R. & Buchwald, P., Jul 2014, In : Steroids. 85, p. 36-43 8 p.

Research output: Contribution to journalArticle

9 Scopus citations