Molecular and Cellular Pharmacology

Research Output

2014

Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics

Farman, G. P., Muthu, P., Kazmierczak, K., Szczesna-Cordary, D. & Moore, J. R., Dec 15 2014, In : Journal of applied physiology (Bethesda, Md. : 1985). 117, 12, p. 1471-1477 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis

Graham, R. M., Thompson, J. W. & Webster, K. A., 2014, In : Oncotarget. 5, 5, p. 1162-1173 12 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain

Muthu, P., Liang, J., Schmidt, W., Moore, J. R. & Szczesna-Cordary, D., Jul 15 2014, In : Archives of Biochemistry and Biophysics. 552-553, p. 29-39 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Is there a universal rule for cellular growth? - Problems in studying and interpreting this phenomenon

Sveiczer, Á., Horváth, A. & Buchwald, P., Aug 2014, In : FEMS Yeast Research. 14, 5, p. 679-682 4 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
43 Scopus citations

Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning

Hu, X., Wu, R., Jiang, Z., Wang, L., Chen, P., Zhang, L., Yang, L., Wu, Y., Chen, H., Chen, H., Xu, Y., Zhou, Y., Huang, X., Webster, K. A., Yu, H. & Wang, J., Jan 1 2014, In : Stem Cells. 32, 10, p. 2702-2713 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Low magnification confocal microscopy of tumor angiogenesis

McNamara, G., Yanai, A., Khankaldyyan, V., Laug, W. E., Boden, J., Webster, K. A., Li, Y. & Wen, R., 2014, Methods in Molecular Biology. Humana Press Inc., Vol. 1075. p. 149-175 27 p. (Methods in Molecular Biology; vol. 1075).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Metadata standard and data exchange specifications to describe, model, and integrate complex and diverse high-throughput screening data from the library of integrated network-based cellular signatures (LINCS)

Vempati, U. D., Chung, C., Mader, C., Koleti, A., Datar, N., Vidović, D., Wrobel, D., Erickson, S., Muhlich, J. L., Berriz, G., Benes, C. H., Subramanian, A., Pillai, A., Shamu, C. E. & Schürer, S. C., Jun 2014, In : Journal of Biomolecular Screening. 19, 5, p. 803-816 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Minimum information about a spinal cord injury experiment: A proposed reporting standard for spinal cord injury experiments

Lemmon, V. P., Ferguson, A. R., Popovich, P. G., Xu, X. M., Snow, D. M., Igarashi, M., Beattie, C. E. & Bixby, J. L., Aug 1 2014, In : Journal of neurotrauma. 31, 15, p. 1354-1361 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Molecular pathways of pannexin1-mediated neurotoxicity

Shestopalov, V. I. & Slepak, V. Z., Jan 1 2014, In : Frontiers in Physiology. 5 FEB, Article 23.

Research output: Contribution to journalReview article

27 Scopus citations

Preclinical efficacy of growth hormone-releasing hormone antagonists for androgen-dependent and castration-resistant human prostate cancer

Fahrenholtz, C. D., Rick, F. G., Garcia, M. I., Zarandi, M., Cai, R. Z., Block, N. L., Schally, A. V. & Burnstein, K. L., Jan 21 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1084-1089 6 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Regulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcin

Levay, K. & Slepak, V. Z., Jun 2014, In : Journal of Cell Science. 127, 11, p. 2448-2459 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Remodeling of the heart in hypertrophy in animal model swith myosin essential light chain mutations

Kazmierczak, K., Yuan, C. C., Liang, J., Huang, W., Rojasand, A. I. & Szczesna-Cordary, D., Sep 22 2014, In : Frontiers in Physiology. 5, 353.

Research output: Contribution to journalArticle

8 Scopus citations

Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells

Hu, X., Wu, R., Shehadeh, L. A., Zhou, Q., Jiang, C., Huang, X., Zhang, L., Gao, F., Liu, X., Yu, H., Webster, K. A. & Wang, J., Apr 23 2014, In : BMC genomics. 15, 1, 303.

Research output: Contribution to journalArticle

25 Scopus citations

Small-molecule modulators of the OX40OX40 ligand co-stimulatory proteinprotein interaction

Song, Y., Margolles-Clark, E., Bayer, A. & Buchwald, P., Nov 2014, In : British Journal of Pharmacology. 171, 21, p. 4955-4969 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2′-fluoro-3′-(substituted pyridinyl)-7- deschloroepibatidine analogues

Ondachi, P. W., Castro, A. H., Bartkowiak, J. M., Luetje, C. W., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Feb 13 2014, In : Journal of Medicinal Chemistry. 57, 3, p. 836-848 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities

Cai, R., Schally, A. V., Cui, T., Szalontay, L., Halmos, G., Sha, W., Kovacs, M., Jaszberenyi, M., He, J., Rick, F. G., Popovics, P., Kanashiro-Takeuchi, R., Hare, J. M., Block, N. L. & Zarandi, M., Feb 1 2014, In : Peptides. 52, p. 104-112 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Trace amines inhibit insect odorant receptor function through antagonism of the co-receptor subunit

Luetje, C. W. & Chen, S., Apr 3 2014, In : F1000Research. 3

Research output: Contribution to journalArticle

16 Scopus citations

VAV3 mediates resistance to breast cancer endocrine therapy

Aguilar, H., Urruticoechea, A., Halonen, P., Kiyotani, K., Mushiroda, T., Barril, X., Serra-Musach, J., Islam, A., Caizzi, L., Di Croce, L., Nevedomskaya, E., Zwart, W., Bostner, J., Karlsson, E., Pérez Tenorio, G., Fornander, T., Sgroi, D. C., Garcia-Mata, R., Jansen, M. P. H. M., García, N. & 25 others, Bonifaci, N., Climent, F., Soler, M. T., Rodríguez-Vida, A., Gil, M., Brunet, J., Martrat, G., Gómez-Baldó, L., Extremera, A. I., Figueras, A., Balart, J., Clarke, R., Burnstein, K. L., Carlson, K. E., Katzenellenbogen, J. A., Vizoso, M., Esteller, M., Villanueva, A., Rodríguez-Peña, A. B., Bustelo, X. R., Nakamura, Y., Zembutsu, H., Stål, O., Beijersbergen, R. L. & Pujana, M. A., May 28 2014, In : Breast Cancer Research. 16, 3, R53.

Research output: Contribution to journalArticle

17 Scopus citations

Yeast Augmented Network Analysis (YANA): A new systems approach to identify therapeutic targets for human genetic diseases

D'Urso, G., Wiley, D. J., Juan, I., Le, H., Cai, X., Baumbach, L. & Beattie, C., Jun 2 2014, In : F1000Research. 3, 4188.1.

Research output: Contribution to journalArticle

5 Scopus citations
2013

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis

Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schürer, S., Wennerberg, K., Reynolds, R., Besra, G. S. & Dobos, K. M., Jun 1 2013, In : Molecular and Cellular Proteomics. 12, 6, p. 1644-1660 17 p.

Research output: Contribution to journalArticle

28 Scopus citations

A non-invasive method for in vivo skin volatile compounds sampling

Jiang, R., Cudjoe, E., Bojko, B., Abaffy, T. & Pawliszyn, J., Dec 4 2013, In : Analytica Chimica Acta. 804, p. 111-119 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

A sphingosine 1-phosphate receptor 2 selective allosteric agonist

Satsu, H., Schaeffer, M. T., Guerrero, M., Saldana, A., Eberhart, C., Hodder, P., Cayanan, C., Schürer, S., Bhhatarai, B., Roberts, E., Rosen, H. & Brown, S. J., Sep 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5373-5382 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec4 to endomembranes

Mukherjee, D., Sen, A., Boettner, D. R., Fairn, G. D., Schlam, D., Valentin, F. J. B., McCaffery, J. M., Hazbun, T., Staiger, C. J., Grinstein, S., Lemmon, S. K. & Aguilar, R. C., Oct 18 2013, In : Journal of Cell Science. 126, 20, p. 4560-4571 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice

Hong, E. G., Kim, B. W., Jung, D. Y., Kim, J. H., Yu, T., Da Silva, W. S., Friedline, R. H., Bianco, S. D., Seslar, S. P., Wakimoto, H., Berul, C. I., Russell, K. S., Lee, K. W., Larsen, P. R., Bianco, A. C. & Kim, J. K., Oct 1 2013, In : Endocrinology. 154, 10, p. 3937-3946 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cell length growth in fission yeast: An analysis of its bilinear character and the nature of its rate change transition

Horváth, A., Rácz-Mónus, A., Buchwald, P. & Sveiczer, Á., Nov 1 2013, In : FEMS Yeast Research. 13, 7, p. 635-649 15 p.

Research output: Contribution to journalArticle

12 Scopus citations
18 Scopus citations
29 Scopus citations

C-kit+ cells isolated from developing kidneys are a novel population of stem cells with regenerative potential

Rangel, E. B., Gomes, S. A., Dulce, R. A., Premer, C., Rodrigues, C. O., Kanashiro-Takeuchi, R. M., Oskouei, B., Carvalho, D. A., Ruiz, P., Reiser, J. & Hare, J. M., Aug 1 2013, In : Stem Cells. 31, 8, p. 1644-1656 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

c-Myc Is Essential to Prevent Endothelial Pro-Inflammatory Senescent Phenotype

Florea, V., Bhagavatula, N., Simovic, G., Macedo, F. Y., Fock, R. A. & Rodrigues, C. O., Sep 6 2013, In : PloS one. 8, 9, e73146.

Research output: Contribution to journalArticle

14 Scopus citations

Comparative analysis of volatile metabolomics signals from melanoma and benign skin: A pilot study

Abaffy, T., Möller, M. G., Riemer, D. D., Milikowski, C. & DeFazio, R. A., Oct 1 2013, In : Metabolomics. 9, 5, p. 998-1008 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of duchenne muscular dystrophy are not alleviated by PDE5 inhibition

Percival, J. M., Siegel, M. P., Knowels, G. & Marcinek, D. J., Jan 1 2013, In : Human molecular genetics. 22, 1, p. 153-167 15 p., dds415.

Research output: Contribution to journalArticle

64 Scopus citations

Deletion of 1-43 amino acids in cardiac myosin essential light chain blunts length dependency of ca2+ sensitivity and cross-bridge detachment kinetics

Michael, J. J., Gollapudi, S. K., Ford, S. J., Kazmierczak, K., Szczesna-Cordary, D. & Chandra, M., Jan 15 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 2, p. H253-H259

Research output: Contribution to journalArticle

16 Scopus citations

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties

Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schürer, S., Chen, W., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., Duckett, D. R., Cleveland, J. L. & Roush, W. R., Aug 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 15, p. 4374-4380 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy

Kazmierczak, K., Paulino, E. C., Huang, W., Muthu, P., Liang, J., Yuan, C. C., Rojas, A. I., Hare, J. M. & Szczesna-Cordary, D., May 8 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 4, p. H575-H589

Research output: Contribution to journalArticle

21 Scopus citations
14 Scopus citations

Functional assay of mammalian and insect olfactory receptors using Xenopus oocytes.

Luetje, C. W., Nichols, A. S., Castro, A. & Sherman, B. L., Oct 4 2013, In : Methods in molecular biology (Clifton, N.J.). 1003, p. 187-202 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

GPCR ontology: Development and application of a G protein-coupled receptor pharmacology knowledge framework

Przydzial, M. J., Bhhatarai, B., Koleti, A., Vempati, U., Schürer, S. C. & Wren, J., Dec 15 2013, In : Bioinformatics. 29, 24, p. 3211-3219 9 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

G protein co-signaling and challenges for translational research

Litosch, I., Mar 1 2013, In : Translational Neuroscience. 4, 1, p. 66-73 8 p.

Research output: Contribution to journalReview article

3 Scopus citations

Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms

Jiang, Z., Hu, X., Yu, H., Xu, Y., Wang, L., Chen, H., Chen, H., Wu, R., Zhang, Z., Xiang, C., Webster, K. A. & Wang, J. A., Oct 1 2013, In : Journal of Cellular and Molecular Medicine. 17, 10, p. 1247-1260 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Kinome-wide activity modeling from diverse public high-quality data sets

Schürer, S. C. & Muskal, S. M., Jan 28 2013, In : Journal of Chemical Information and Modeling. 53, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Microbial life in the Lake Medee, the largest deep-sea salt-saturated formation

Yakimov, M. M., La Cono, V., Slepak, V. Z., La Spada, G., Arcadi, E., Messina, E., Borghini, M., Monticelli, L. S., Rojo, D., Barbas, C., Golyshina, O. V., Ferrer, M., Golyshin, P. N. & Giuliano, L., Dec 19 2013, In : Scientific reports. 3, 3554.

Research output: Contribution to journalArticle

51 Scopus citations

MicroRNA-20a constrains p300-driven myocardial angiogenic transcription by direct targeting of p300

Shehadeh, L. A., Sharma, S., Pessanha, M., Wei, J. Q., Liu, J., Yuan, H., Rodrigues, C. O., Scherr, M., Tsinoremas, N. F. & Bishopric, N. H., Nov 13 2013, In : PloS one. 8, 11, e79133.

Research output: Contribution to journalArticle

9 Scopus citations

MicroRNAs: A new piece in the paediatric cardiovascular disease puzzle

Omran, A., Elimam, D., Webster, K. A., Shehadeh, L. A. & Yin, F., Oct 1 2013, In : Cardiology in the young. 23, 5, p. 642-655 14 p.

Research output: Contribution to journalReview article

18 Scopus citations
34 Scopus citations

Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice

Siegel, M. P., Kruse, S. E., Percival, J. M., Goh, J., White, C. C., Hopkins, H. C., Kavanagh, T. J., Szeto, H. H., Rabinovitch, P. S. & Marcinek, D. J., Oct 1 2013, In : Aging Cell. 12, 5, p. 763-771 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

Molecular biology of the kisspeptin receptor: Signaling, function, and mutations

Bianco, S. D. C. & Kaiser, U. B., Dec 1 2013, Advances in Experimental Medicine and Biology. Vol. 784. p. 133-158 26 p. (Advances in Experimental Medicine and Biology; vol. 784).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot

Zang, S., Ali, Y. O., Ruan, K. & Zhai, R. G., Jan 1 2013, In : EMBO Reports. 14, 1, p. 87-94 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling

Zhou, M. S., Chadipiralla, K., Mendez, A. J., Jaimes, E. A., Silverstein, R. L., Webster, K. & Raij, L., May 8 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 4, p. H563-H574

Research output: Contribution to journalArticle

32 Scopus citations

NMNATs, evolutionarily conserved neuronal maintenance factors

Ali, Y. O., Li-Kroeger, D., Bellen, H. J., Zhai, R. G. & Lu, H. C., Nov 1 2013, In : Trends in Neurosciences. 36, 11, p. 632-640 9 p.

Research output: Contribution to journalReview article

34 Scopus citations