Molecular and Cellular Pharmacology

Research Output

2015

Hepatoma-derived growth factor-related protein-3 is a novel angiogenic factor

LeBlanc, M. E., Wang, W., Caberoy, N. B., Chen, X., Guo, F., Alvarado, G., Shen, C., Wang, F., Wang, H., Chen, R., Liu, Z-J., Webster, K. A. & Li, W., May 21 2015, In : PLoS One. 10, 5, e0127904.

Research output: Contribution to journalArticle

11 Scopus citations

High-Content Screening Applied to Nervous System Injury: Advantages, Challenges, and Proof of Principle

Lemmon, V. & Bixby, J., Feb 6 2015, Neural Regeneration. Elsevier Inc., p. 411-419 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

In Vitro and in Vivo Neuronal Nicotinic Receptor Properties of (+)- and (-)-Pyrido[3,4]homotropane [(+)- and (-)-PHT]: (+)-PHT is a Potent and Selective Full Agonist at α6β2 Containing Neuronal Nicotinic Acetylcholine Receptors

Carroll, F. I., Navarro, H. A., Mascarella, S. W., Castro, A. H., Luetje, C. W., Wageman, C. R., Marks, M. J., Jackson, A. & Damaj, M. I., Jun 17 2015, In : ACS Chemical Neuroscience. 6, 6, p. 920-926 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

In vitro models of axon regeneration

Al-Ali, H., Beckerman, S., Bixby, J. & Lemmon, V., Dec 4 2015, (Accepted/In press) In : Experimental Neurology.

Research output: Contribution to journalArticle

16 Scopus citations

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

Martins, A. S., Parvatiyar, M. S., Feng, H. Z., Bos, J. M., Gonzalez-Martinez, D., Vukmirovic, M., Turna, R. S., Sanchez-Gonzalez, M. A., Badger, C. D., Zorio, D. A. R., Singh, R. K., Wang, Y., Jin, J. P., Ackerman, M. J. & Pinto, J. R., Oct 1 2015, In : Circulation: Cardiovascular Genetics. 8, 5, p. 653-664 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

Allen, B. K., Mehta, S., Ember, S. W. J., Schonbrunn, E., Ayad, N. & Schuerer, S. C., Nov 24 2015, In : Scientific Reports. 5, 16924.

Research output: Contribution to journalArticle

29 Scopus citations

Loss of nNOS inhibits compensatory muscle hypertrophy and exacerbates inflammation and eccentric contraction-induced damage in mdx mice

Froehner, S. C., Reed, S. M., Anderson, K. N., Huang, P. L. & Percival, J. M., Jan 15 2015, In : Human molecular genetics. 24, 2, p. 492-505 14 p., ddu469.

Research output: Contribution to journalArticle

16 Scopus citations

Molecular mechanism of muscle contraction: New perspectives and ideas

Matusovsky, O. S., Mayans, O. & Szczesna-Cordary, D., 2015, In : BioMed Research International. 2015, 694345.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations

Huang, W. & Szczesna-Cordary, D., Dec 1 2015, In : Journal of Muscle Research and Cell Motility. 36, 6, p. 433-445 13 p.

Research output: Contribution to journalReview article

15 Scopus citations

Myosin regulatory light chain phosphorylation enhances cardiac β-myosin in vitro motility under load

Karabina, A., Kazmierczak, K., Szczesna-Cordary, D. & Moore, J. R., Jul 6 2015, In : Archives of Biochemistry and Biophysics. 580, p. 14-21 8 p., 7007.

Research output: Contribution to journalArticle

16 Scopus citations

New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor

Kanashiro-Takeuchi, R. M., Szalontay, L., Schally, A. V., Takeuchi, L. M., Popovics, P., Jaszberenyi, M., Vidaurre, I., Zarandi, M., Cai, R. Z., Block, N. L., Hare, J. M. & Rick, F. G., Jan 1 2015, In : Oncotarget. 6, 12, p. 9728-9739 12 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Noribogaine is a G-protein biased κ-opioid receptor agonist

Maillet, E. L., Milon, N., Heghinian, M. D., Fishback, J., Schuerer, S. C., Garamszegi, N. & Mash, D. C., Dec 1 2015, In : Neuropharmacology. 99, p. 675-688 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Novel familial dilated cardiomyopathy mutation in MYL2 affects the structure and function of myosin regulatory light chain

Huang, W., Liang, J., Yuan, C. C., Kazmierczak, K., Zhou, Z., Morales, A., McBride, K. L., Fitzgerald-Butt, S. M., Hershberger, R. E. & Szczesna-Cordary, D., Jun 1 2015, In : FEBS Journal. 282, 12, p. 2379-2393 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Phenotypic Assays to Identify Agents That Induce Reactive Gliosis: A Counter-Screen to Prioritize Compounds for Preclinical Animal Studies

Beckerman, S. R., Jimenez, J. E., Shi, Y., Al-Ali, H., Bixby, J. & Lemmon, V., Sep 1 2015, In : Assay and Drug Development Technologies. 13, 7, p. 377-388 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis

Das, M., Nuñeza, I., Rodriguez, M., Wiley, D. J., Rodriguez, J., Sarkeshik, A., Yates, J. R., Buchwald, P. & Verde, F., Oct 1 2015, In : Molecular biology of the cell. 26, 19, p. 3520-3534 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains

Gomes, A. V., Kazmierczak, K., Cheah, J. X., Gilda, J. E., Yuan, C. C., Zhou, Z. & Szczesna-Cordary, D., Dec 1 2015, In : Journal of Muscle Research and Cell Motility. 36, 6, p. 447-461 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Proton-dependent glutamine uptake by aphid bacteriocyte amino acid transporter ApGLNT1

Price, D. R. G., Wilson, A. & Luetje, C. W., Jul 11 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 10, p. 2085-2091 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets to Promote Axon Growth

Al-Ali, H., Lee, D. H., Danzi, M. C., Nassif, H., Gautam, P., Wennerberg, K., Zuercher, B., Drewry, D. H., Lee, J., Lemmon, V. & Bixby, J., Aug 21 2015, In : ACS Chemical Biology. 10, 8, p. 1939-1951 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Receptive range analysis of a mouse odorant receptor subfamily

Li, J., Haddad, R., Santos, V., Bavan, S. & Luetje, C. W., Jul 1 2015, In : Journal of Neurochemistry. 134, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Screening of cell cycle fusion proteins to identify kinase signaling networks

Trojanowsky, M., Vidovic, D., Simanski, S., Penas, C., Schuerer, S. C. & Ayad, N., Apr 15 2015, In : Cell Cycle. 14, 8, p. 1274-1281 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

Abdul-Hay, S. O., Bannister, T. D., Wang, H., Cameron, M. D., Caulfield, T. R., Masson, A., Bertrand, J., Howard, E. A., McGuire, M. P., Crisafulli, U., Rosenberry, T. R., Topper, C. L., Thompson, C. R., Schuerer, S. C., Madoux, F., Hodder, P. & Leissring, M. A., Dec 18 2015, In : ACS Chemical Biology. 10, 12, p. 2716-2724 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

S-Nitrosoglutathione Reductase Deficiency Enhances the Proliferative Expansion of Adult Heart Progenitors and Myocytes Post Myocardial Infarction

Hatzistergos, K. E., Paulino, E. C., Dulce, R. A., Takeuchi, L. M., Bellio, M. A., Kulandavelu, S., Cao, Y., Balkan, W. E., Takeuchi, R. & Hare, J., Jul 15 2015, In : Journal of the American Heart Association. 4, 7

Research output: Contribution to journalArticle

25 Scopus citations

Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3′-(substituted pyridinyl)-deschloroepibatidine analogs

Ondachi, P. W., Ye, Z., Castro, A. H., Luetje, C. W., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., May 22 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5693-5701 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

Ruschel, J., Hellal, F., Flynn, K. C., Dupraz, S., Elliott, D. A., Tedeschi, A., Bates, M., Sliwinski, C., Brook, G., Dobrindt, K., Peitz, M., Brüstle, O., Norenberg, M. D., Blesch, A., Weidner, N., Bunge, M. B., Bixby, J. & Bradke, F., Apr 17 2015, In : Science. 348, 6232, p. 347-352 6 p.

Research output: Contribution to journalArticle

197 Scopus citations
3 Scopus citations

The role of EF-hand Ca2+/Mg2+-binding tescalcin protein in cell proliferation and differentiation

Kolobynina, K. G., Solovyeva, V. V., Slepak, V. Z. & Rizvanov, A. A., 2015, In : Genes and Cells. 10, 1, p. 28-34 7 p.

Research output: Contribution to journalReview article

1 Scopus citations

TNF superfamily protein-protein interactions: Feasibility of small-molecule modulation

Song, Y. & Buchwald, P., Jan 1 2015, In : Current Drug Targets. 16, 4, p. 393-408 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

Using the BioAssay Ontology for analyzing high-throughput screening data

Zander Balderud, L., Murray, D., Larsson, N., Vempati, U., Schuerer, S. C., Bjäreland, M. & Engkvist, O., Mar 25 2015, In : Journal of Biomolecular Screening. 20, 3, p. 402-415 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014
4 Scopus citations

A determinant of odorant specificity is located at the extracellular loop 2-transmembrane domain 4 interface of an Anopheles gambiae odorant receptor subunit

Hughes, D. T., Wang, G., Zwiebel, L. J. & Luetje, C. W., Nov 1 2014, In : Chemical Senses. 39, 9, p. 761-769 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
22 Scopus citations

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress

Ghosh, R., Wang, L., Wang, E. S., Perera, B. G. K., Igbaria, A., Morita, S., Prado, K., Thamsen, M., Caswell, D., Macias, H., Weiberth, K. F., Gliedt, M. J., Alavi, M. V., Hari, S. B., Mitra, A. K., Bhhatarai, B., Schürer, S. C., Snapp, E. L., Gould, D. B., German, M. S. & 4 others, Backes, B. J., Maly, D. J., Oakes, S. A. & Papa, F. R., Jul 31 2014, In : Cell. 158, 3, p. 534-548 15 p.

Research output: Contribution to journalArticle

189 Scopus citations

A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells

Fahrenholtz, C. D., Greene, A. M., Beltran, P. J. & Burnstein, K. L., Jan 1 2014, In : Oncotarget. 5, 19, p. 9007-9021 15 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

An overview of the challenges in designing, integrating, and delivering BARD: A public chemical-biology resource and query portal for multiple organizations, locations, and disciplines

De Souza, A., Bittker, J. A., Lahr, D. L., Brudz, S., Chatwin, S., Oprea, T. I., Waller, A., Yang, J. J., Southall, N., Guha, R., Schürer, S. C., Vempati, U. D., Southern, M. R., Dawson, E. S., Clemons, P. A. & Chung, T. D. Y., Jun 2014, In : Journal of Biomolecular Screening. 19, 5, p. 614-627 14 p.

Research output: Contribution to journalReview article

19 Scopus citations

Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts

Price, D. R. G., Feng, H., Baker, J. D., Bavan, S., Luetje, C. W. & Wilson, A. C. C., Jan 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 1, p. 320-325 6 p.

Research output: Contribution to journalArticle

64 Scopus citations

Bilinear model for the size-dependency of the CYP3A4 inhibitory activity of structurally diverse compounds

Buchwald, P. & Yamashita, F., Jan 1 2014, In : Molecular Informatics. 33, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Casein kinase 1-dependent wee1 protein degradation

Penas, L., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., Chauhan, R., Barnaby, O., Schurer, S., Hodder, P., Steen, J., Roush, W. R. & Ayad, N. G., Jul 4 2014, In : Journal of Biological Chemistry. 289, 27, p. 18893-18903 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

CJun promotes CNS axon growth

Lerch, J. K., Martínez-Ondaro, Y. R., Bixby, J. L. & Lemmon, V. P., Mar 1 2014, In : Molecular and Cellular Neuroscience. 59, p. 97-105 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

CLO: The cell line ontology

Sarntivijai, S., Lin, Y., Xiang, Z., Meehan, T. F., Diehl, A. D., Vempati, U. D., Schürer, S. C., Pang, C., Malone, J., Parkinson, H., Liu, Y., Takatsuki, T., Saijo, K., Masuya, H., Nakamura, Y., Brush, M. H., Haendel, M. A., Zheng, J., Stoeckert, C. J., Peters, B. & 5 others, Mungall, C. J., Carey, T. E., States, D. J., Athey, B. D. & He, Y., Aug 13 2014, In : Journal of Biomedical Semantics. 5, 1, 37.

Research output: Contribution to journalArticle

46 Scopus citations

Coactivator MYST1 regulates nuclear factor-κB and androgen receptor functions during proliferation of prostate cancer cells

Jaganathan, A., Chaurasia, P., Xiao, G. Q., Philizaire, M., Lv, X., Yao, S., Burnstein, K. L., Liu, D. P., Levine, A. C. & Mujtaba, S., Jun 2014, In : Molecular Endocrinology. 28, 6, p. 872-885 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Development of a mouse model of menopausal ovarian cancer

Smith, E. R., Wang, Y. & Xu, X. X., Jan 1 2014, In : Frontiers in Oncology. 4 MAR, Article 36.

Research output: Contribution to journalReview article

10 Scopus citations

Differential effects of the Gβ5-RGS7 complex on muscarinic M3 receptor-induced Ca2+ influx and release

Karpinsky-Semper, D., Volmar, C. H., Brothers, S. P. & Slepak, V. Z., May 2014, In : Molecular Pharmacology. 85, 5, p. 758-768 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation

Bavan, S., Sherman, B., Luetje, C. W. & Abaffy, T., Mar 17 2014, In : PloS one. 9, 3, e92064.

Research output: Contribution to journalArticle

21 Scopus citations

Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells

Cechin, S. R. & Buchwald, P., Jul 2014, In : Steroids. 85, p. 36-43 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Evolving BioAssay Ontology (BAO): Modularization, integration and applications

Abeyruwan, S., Vempati, U. D., Küçük-McGinty, H., Visser, U. E., Koleti, A., Mir, A., Sakurai, K., Chung, C., Bittker, J. A., Clemons, P. A., Brudz, S., Siripala, A., Morales, A. J., Romacker, M., Twomey, D., Bureeva, S., Lemmon, V. & Schuerer, S. C., 2014, In : Journal of Biomedical Semantics. 5, S5.

Research output: Contribution to journalArticle

45 Scopus citations

Expression of olfactory signaling genes in the eye

Pronin, A., Levay, K., Velmeshev, D., Faghihi, M., Shestopalov, V. I. & Slepak, V. Z., Apr 30 2014, In : PloS one. 9, 4, e96435.

Research output: Contribution to journalArticle

22 Scopus citations

Facilitating transparency in spinal cord injury studies using data standards and ontologies

Lemmon, V. P., Abeyruwan, S., Visser, U. & Bixby, J. L., Jan 2014, In : Neural Regeneration Research. 9, 1, p. 6-7 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Fast and accurate semantic annotation of bioassays exploiting a hybrid of machine learning and user confirmation

Clark, A. M., Bunin, B. A., Litterman, N. K., Schuerer, S. C. & Visser, U. E., 2014, In : PeerJ. 2014, 1, e524.

Research output: Contribution to journalArticle

13 Scopus citations

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

Križaj, D., Ryskamp, D. A., Tian, N., Tezel, G., Mitchell, C. H., Slepak, V. Z. & Shestopalov, V. I., Feb 1 2014, In : Current Eye Research. 39, 2, p. 105-119 15 p.

Research output: Contribution to journalReview article

77 Scopus citations

Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice

Huang, W., Liang, J., Kazmierczak, K., Muthu, P., Duggal, D., Farman, G. P., Sorensen, L., Pozios, I., Abraham, T. P., Moore, J. R., Borejdo, J. & Szczesna-Cordary, D., Sep 2014, In : Journal of Molecular and Cellular Cardiology. 74, p. 318-329 12 p.

Research output: Contribution to journalArticle

18 Scopus citations