Molecular and Cellular Pharmacology

Research Output

2016

Synthesis, Nicotinic Acetylcholine Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(carbamoylpyridinyl)deschloroepibatidine Analogues

Ondachi, P. W., Castro, A. H., Luetje, C. W., Wageman, C. R., Marks, M. J., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Jul 20 2016, In : ACS Chemical Neuroscience. 7, 7, p. 1004-1012 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

The Cell Line Ontology integration and analysis of the knowledge of LINCS cell lines

Ong, E., Xie, J., Ni, Z., Liu, Q., Lin, Y., Stathias, V., Chung, C., Schuerer, S. C. & He, Y., 2016, In : CEUR Workshop Proceedings. 1747

Research output: Contribution to journalArticle

The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related

Rice, M. A., Ishteiwy, R. A., Magani, F., Udayakumar, T., Reiner, T., Yates, T. J., Miller, P., Perez-Stable, C., Rai, P., Verdun, R. E., Dykxhoorn, D. M. & Burnstein, K. L., Feb 22 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

20 Scopus citations

The regulatory role of hepatoma-derived growth factor as an angiogenic factor in the eye

LeBlanc, M. E., Wang, W., Chen, X., Ji, Y., Shakya, A., Shen, C., Zhang, C., Gonzalez, V., Brewer, M., Ma, J. X., Wen, R., Zhang, F. & Li, W., Apr 23 2016, In : Molecular Vision. 22, p. 374-386 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Treatment with analgesics after mouse sciatic nerve injury does not alter expression of wound healingassociated genes

Danzi, M. C., Motti, D., Avison, D., Bixby, J. & Lemmon, V., Jan 1 2016, In : Neural Regeneration Research. 11, 1, p. 144-149 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Vascular regeneration in ischemic hindlimb by adeno-associated virus expressing conditionally silenced vascular endothelial growth factor

Boden, J., Soares, R., Wang, H., Wei, Y., Spiga, M. G., Adi, J., Layman, H., Yu, H., Vazquez-Padron, R. I., Andreopoulos, F. M. & Webster, K. A., Jun 1 2016, In : Journal of the American Heart Association. 5, 6, e001815.

Research output: Contribution to journalArticle

18 Scopus citations
26 Scopus citations
2015

Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

Ruan, K., Zhu, Y., Li, C., Brazill, J. M. & Zhai, R. G., Nov 30 2015, In : Nature Communications. 6, 10057.

Research output: Contribution to journalArticle

18 Scopus citations

Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase

Zhang, F., Patel, D. M., Colavita, K., Rodionova, I., Buckley, B., Scott, D. A., Kumar, A., Shabalina, S. A., Saha, S., Chernov, M., Osterman, A. L. & Kashina, A., Jul 15 2015, In : Nature Communications. 6, 8517.

Research output: Contribution to journalArticle

18 Scopus citations

Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers

Rai, R., Zhang, F., Colavita, K., Leu, N. A., Kurosaka, S., Kumar, A., Birnbaum, M. D., Győrffy, B., Dong, D. W., Shtutman, M. & Kashina, A., Dec 21 2015, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

9 Scopus citations

Atg27 tyrosine sorting motif is important for its trafficking and Atg9 localization

Segarra, V. A., Boettner, D. R. & Lemmon, S., Apr 1 2015, In : Traffic. 16, 4, p. 365-378 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Bnip3 binds and activates p300: Possible role in cardiac transcription and myocyte morphology

Thompson, J. W., Wei, J., Appau, K., Wang, H., Yu, H., Spiga, M. G., Graham, R. M. & Webster, K. A., Aug 28 2015, In : PLoS One. 10, 8, e0136847.

Research output: Contribution to journalArticle

7 Scopus citations

BNIP3 promotes calcium and calpain-dependent cell death

Graham, R. M., Thompson, J. W. & Webster, K. A., Dec 1 2015, In : Life Sciences. 142, p. 26-35 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Bone marrow-derived c-kit+ cells attenuate neonatal hyperoxia-induced lung injury

Ramachandran, S., Suguihara, C., Drummond, S., Chatzistergos, K., Klim, J., Torres, E., Huang, J., Hehre, D., Rodrigues, C. D., McNiece, I. K., Hare, J. & Young, K., Jan 1 2015, In : Cell Transplantation. 24, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells

Peschansky, V. J., Pastori, C., Zeier, Z. R., Motti, D., Wentzel, K., Velmeshev, D., Magistri, M., Bixby, J., Lemmon, V., Silva, J. P. & Wahlestedt, C. R., 2015, In : Frontiers in Genetics. 6, Aug, 263.

Research output: Contribution to journalArticle

14 Scopus citations

CKit+ cardiac progenitors of neural crest origin

Hatzistergos, K. E., Takeuchi, L. M., Saur, D., Seidler, B., Dymecki, S. M., Mai, J. J., White, I. A., Balkan, W. E., Takeuchi, R., Schally, A. V. & Hare, J., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. 13051-13056 6 p.

Research output: Contribution to journalArticle

55 Scopus citations
1 Scopus citations

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice

Yuan, C. C., Muthu, P., Kazmierczak, K., Liang, J., Huang, W., Irving, T. C., Takeuchi, R., Hare, J. & Szczesna-Cordary, D., Jul 28 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 30, p. E4138-E4146

Research output: Contribution to journalArticle

36 Scopus citations
11 Scopus citations

Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells

Solovyeva, V. V., Kolobynina, K. G., Gomzikova, M. O., Tazetdinova, L. G., Zhuravleva, M. N., Slepak, V. Z. & Rizvanov, A. A., Dec 1 2015, In : Genes and Cells. 10, 4, p. 90-93 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Elemental sulfur and acetate can support life of a novel strictly anaerobic haloarchaeon

Sorokin, D. Y., Kublanov, I. V., Gavrilov, S. N., Rojo, D., Roman, P., Golyshin, P. N., Slepak, V. Z., Smedile, F., Ferrer, M., Messina, E., la Cono, V. & Yakimov, M. M., May 15 2015, (Accepted/In press) In : ISME Journal.

Research output: Contribution to journalArticle

29 Scopus citations

Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 351-363 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
16 Scopus citations

Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain

Huang, W., Kazmierczak, K., Zhou, Z., Aguiar-Pulido, V., Narasimhan, G. & Szczesna-Cordary, D., Nov 1 2015, (Accepted/In press) In : Archives of Biochemistry and Biophysics.

Research output: Contribution to journalArticle

5 Scopus citations

Global Deletion of Trp53 Reverts Ovarian Tumor Phenotype of the Germ Cell–Deficient White Spotting Variant (Wv) Mice

Cai, K. Q., Wang, Y., Smith, E. R., Smedberg, J. L., Yang, D. H., Yang, W. L. & Xu, X., Jan 1 2015, In : Neoplasia. 17, 1, p. 89-100 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Growth hormone-releasing hormone agonists reduce myocardial infarct scar in swine With subacute ischemic cardiomyopathy

Bagno, L. L., Takeuchi, R., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., Wang, B., Premer, C., Balkan, W. E., Rodriguez, J., Valdes, D., Rosado, M., Block, N. L., Goldstein, P., Morales, A. R., Cai, R. Z., Sha, W., Schally, A. V. & Hare, J., 2015, In : Journal of the American Heart Association. 4, 4, e001464.

Research output: Contribution to journalArticle

12 Scopus citations

GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

Penas, C., Mishra, J. K., Wood, S. D., Schuerer, S. C., Roush, W. R. & Ayad, N., Feb 1 2015, In : Cell Cycle. 14, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex

Karpinsky-Semper, D., Tayou, J., Levay, K., Schuchardt, B. J., Bhat, V., Volmar, C. H., Farooq, A. & Slepak, V. Z., Feb 3 2015, In : Biochemistry. 54, 4, p. 1077-1088 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis

Hu, X., Zhang, L., Jin, J., Zhu, W., Xu, Y., Wu, Y., Wang, Y., Chen, H., Webster, K. A., Chen, H., Yu, H. & Wang, J., Jun 1 2015, In : Stem Cells. 33, 6, p. 1850-1862 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hepatoma-derived growth factor-related protein-3 is a novel angiogenic factor

LeBlanc, M. E., Wang, W., Caberoy, N. B., Chen, X., Guo, F., Alvarado, G., Shen, C., Wang, F., Wang, H., Chen, R., Liu, Z-J., Webster, K. A. & Li, W., May 21 2015, In : PLoS One. 10, 5, e0127904.

Research output: Contribution to journalArticle

10 Scopus citations

High-Content Screening Applied to Nervous System Injury: Advantages, Challenges, and Proof of Principle

Lemmon, V. & Bixby, J., Feb 6 2015, Neural Regeneration. Elsevier Inc., p. 411-419 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

In vitro models of axon regeneration

Al-Ali, H., Beckerman, S., Bixby, J. & Lemmon, V., Dec 4 2015, (Accepted/In press) In : Experimental Neurology.

Research output: Contribution to journalArticle

16 Scopus citations

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

Martins, A. S., Parvatiyar, M. S., Feng, H. Z., Bos, J. M., Gonzalez-Martinez, D., Vukmirovic, M., Turna, R. S., Sanchez-Gonzalez, M. A., Badger, C. D., Zorio, D. A. R., Singh, R. K., Wang, Y., Jin, J. P., Ackerman, M. J. & Pinto, J. R., Oct 1 2015, In : Circulation: Cardiovascular Genetics. 8, 5, p. 653-664 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

Allen, B. K., Mehta, S., Ember, S. W. J., Schonbrunn, E., Ayad, N. & Schuerer, S. C., Nov 24 2015, In : Scientific Reports. 5, 16924.

Research output: Contribution to journalArticle

28 Scopus citations

Loss of nNOS inhibits compensatory muscle hypertrophy and exacerbates inflammation and eccentric contraction-induced damage in mdx mice

Froehner, S. C., Reed, S. M., Anderson, K. N., Huang, P. L. & Percival, J., Jan 15 2015, In : Human Molecular Genetics. 24, 2, p. 492-505 14 p., ddu469.

Research output: Contribution to journalArticle

16 Scopus citations
2 Scopus citations
15 Scopus citations
16 Scopus citations

New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor

Takeuchi, R., Szalontay, L., Schally, A. V., Takeuchi, L. M., Popovics, P., Jaszberenyi, M., Vidaurre, I., Zarandi, M., Cai, R. Z., Block, N. L., Hare, J. & Rick, F. G., 2015, In : Oncotarget. 6, 12, p. 9728-9739 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Noribogaine is a G-protein biased κ-opioid receptor agonist

Maillet, E. L., Milon, N., Heghinian, M. D., Fishback, J., Schuerer, S. C., Garamszegi, N. & Mash, D. C., Dec 1 2015, In : Neuropharmacology. 99, p. 675-688 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Novel familial dilated cardiomyopathy mutation in MYL2 affects the structure and function of myosin regulatory light chain

Huang, W., Liang, J., Yuan, C. C., Kazmierczak, K., Zhou, Z., Morales, A., McBride, K. L., Fitzgerald-Butt, S. M., Hershberger, R. E. & Szczesna-Cordary, D., Jun 1 2015, In : FEBS Journal. 282, 12, p. 2379-2393 15 p.

Research output: Contribution to journalArticle

16 Scopus citations
4 Scopus citations

Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis

Das, M., Nuñeza, I., Rodriguez, M., Wiley, D. J., Rodriguez, J., Sarkeshik, A., Yates, J. R., Buchwald, P. & Verde, F., Oct 1 2015, In : Molecular Biology of the Cell. 26, 19, p. 3520-3534 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains

Gomes, A. V., Kazmierczak, K., Cheah, J. X., Gilda, J. E., Yuan, C. C., Zhou, Z. & Szczesna-Cordary, D., Dec 14 2015, (Accepted/In press) In : Journal of Muscle Research and Cell Motility. p. 1-15 15 p.

Research output: Contribution to journalArticle

5 Scopus citations