Molecular and Cellular Pharmacology

Research Output

Article

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Choi, J. H., Banks, A. S., Kamenecka, T. M., Busby, S. A., Chalmers, M. J., Kumar, N., Kuruvilla, D. S., Shin, Y., He, Y., Bruning, J. B., Marciano, D. P., Cameron, M. D., Laznik, D., Jurczak, M. J., Schürer, S. C., Vidović, D., Shulman, G. I., Spiegelman, B. M. & Griffin, P. R., Sep 22 2011, In : Nature. 477, 7365, p. 477-481 5 p.

Research output: Contribution to journalArticle

330 Scopus citations
213 Scopus citations

Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts

Price, D. R. G., Feng, H., Baker, J. D., Bavan, S., Luetje, C. W. & Wilson, A. C. C., Jan 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 1, p. 320-325 6 p.

Research output: Contribution to journalArticle

64 Scopus citations
16 Scopus citations

Appointing a proxy under the best of circumstances.

White, P. D., Dec 1 1992, In : Utah law review. 1992, 3, p. 849-860 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

A Protocol for Characterizing the Impact of Collateral Flow after Distal Middle Cerebral Artery Occlusion

DeFazio, R. A., Levy, S., Morales, C. L., Levy, R. V., Lin, H. W., Abaffy, T., Dave, K. R., Watson, B. D., Perez-Pinzon, M. A. & Ohanna, V., Mar 1 2011, In : Translational stroke research. 2, 1, p. 112-127 16 p.

Research output: Contribution to journalArticle

18 Scopus citations

A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency

Birnbaum, M. D., Nemzow, L., Kumar, A., Gong, F. & Zhang, F., Jan 1 2018, (Accepted/In press) In : Cell Chemical Biology.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A Reliable Mouse Model of Hind limb Gangrene

Parikh, P. P., Castilla, D., Soares, R., Shao, H., Regueiro, M., Li, Y., Vazquez-Padron, R. I., Webster, K. A., Liu, Z-J. & Velazquez, O. C., Jan 1 2017, (Accepted/In press) In : Annals of Vascular Surgery.

Research output: Contribution to journalArticle

1 Scopus citations

Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer

Zhao, N., Peacock, S. O., Lo, C. H., Heidman, L. M., Rice, M. A., Fahrenholtz, C. D., Greene, A. M., Magani, F., Copello, V. A., Martinez, M. J., Zhang, Y., Daaka, Y., Lynch, C. C. & Burnstein, K. L., Jan 1 2019, In : Science Translational Medicine. 11, 498, eaaw4636.

Research output: Contribution to journalArticle

2 Scopus citations

Arginylation-dependent neural crest cell migration is essential for mouse development

Kurosaka, S., Leu, N. A., Zhang, F., Bunte, R., Saha, S., Wang, J., Guo, C., He, W. & Kashina, A., Mar 1 2010, In : PLoS genetics. 6, 3, e1000878.

Research output: Contribution to journalArticle

42 Scopus citations

Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion

Zhang, F., Saha, S. & Kashina, A., Jun 11 2012, In : Journal of Cell Biology. 197, 6, p. 819-836 18 p.

Research output: Contribution to journalArticle

36 Scopus citations

Arginylation regulates intracellular actin polymer level by modulating actin properties and binding of capping and severing proteins

Saha, S., Mundia, M. M., Zhang, F., Demers, R. W., Korobova, F., Svitkina, T., Perieteanu, A. A., Dawson, J. F. & Kashina, A., Apr 15 2010, In : Molecular biology of the cell. 21, 8, p. 1350-1361 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase

Zhang, F., Patel, D. M., Colavita, K., Rodionova, I., Buckley, B., Scott, D. A., Kumar, A., Shabalina, S. A., Saha, S., Chernov, M., Osterman, A. L. & Kashina, A., Jul 15 2015, In : Nature Communications. 6, 8517.

Research output: Contribution to journalArticle

18 Scopus citations

Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo

Wang, J., Han, X., Saha, S., Xu, T., Rai, R., Zhang, F., Wolf, Y. I., Wolfson, A., Yates, J. R. & Kashina, A., Jan 28 2011, In : Chemistry and Biology. 18, 1, p. 121-130 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers

Rai, R., Zhang, F., Colavita, K., Leu, N. A., Kurosaka, S., Kumar, A., Birnbaum, M. D., Győrffy, B., Dong, D. W., Shtutman, M. & Kashina, A., Dec 21 2015, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

9 Scopus citations

A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells

Kizu, R., Okamura, K., Toriba, A., Kakishima, H., Mizokami, A., Burnstein, K. L. & Hayakawa, K., Jun 1 2003, In : Archives of Toxicology. 77, 6, p. 335-343 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

A routine electrocardiogram should not be used to determine the size of myocardial infarction in the rat

Bonilha, A. M. M., Saraiva, R. M., Kanashiro, R. M., Portes, L. A., Antonio, E. L. & Tucci, P. J. F., Apr 2005, In : Brazilian Journal of Medical and Biological Research. 38, 4, p. 615-619 5 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Arrestin Mobilizes Signaling Proteins to the Cytoskeleton and Redirects their Activity

Hanson, S. M., Cleghorn, W. M., Francis, D. J., Vishnivetskiy, S. A., Raman, D., Song, X., Nair, K. S., Slepak, V. Z., Klug, C. S. & Gurevich, V. V., Apr 27 2007, In : Journal of molecular biology. 368, 2, p. 375-387 13 p.

Research output: Contribution to journalArticle

83 Scopus citations

A simple, predictive, structure-based skin permeability model

Buchwald, P. & Bodor, N., Aug 29 2001, In : Journal of Pharmacy and Pharmacology. 53, 8, p. 1087-1098 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Aspectos estruturais e funcionais do coração de ratos com e sem infarto do miocárdio. Experiência inicial com ecocardiografia doppler

Moisés, V. A., Ferreira, R. L., Nozawa, E., Kanashiro, R. M., Campos, O., De Andrade, J. L., Carvalho, A. C. C. & Tucci, P. J. F., Dec 1 2000, In : Arquivos Brasileiros de Cardiologia. 75, 2, p. 125-130 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

A sphingosine 1-phosphate receptor 2 selective allosteric agonist

Satsu, H., Schaeffer, M. T., Guerrero, M., Saldana, A., Eberhart, C., Hodder, P., Cayanan, C., Schürer, S., Bhhatarai, B., Roberts, E., Rosen, H. & Brown, S. J., Sep 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5373-5382 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration

Ali, Y. O., Escala, W., Ruan, K. & Zhai, R. G., Mar 2011, In : Journal of Visualized Experiments. 49, e2504.

Research output: Contribution to journalArticle

77 Scopus citations

Assembling the presynaptic active zone: A characterization of an active zone precursor vesicle

Zhai, R. G., Vardinon-Friedman, H., Cases-Langhoff, C., Becker, B., Gundelfinger, E. D., Ziv, N. E. & Garner, C. C., Jan 1 2001, In : Neuron. 29, 1, p. 131-143 13 p.

Research output: Contribution to journalArticle

324 Scopus citations

Assignment of an oligomycin-resistance locus to human chromosome 10

Webster, K. A., Oliver, N. A. & Wallace, D. C., Mar 1 1982, In : Somatic Cell Genetics. 8, 2, p. 223-244 22 p.

Research output: Contribution to journalArticle

12 Scopus citations
22 Scopus citations
123 Scopus citations

Atg27 tyrosine sorting motif is important for its trafficking and Atg9 localization

Segarra, V. A., Boettner, D. R. & Lemmon, S., Apr 1 2015, In : Traffic. 16, 4, p. 365-378 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
6 Scopus citations

A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin

Pinto, J. R., Parvatiyar, M. S., Jones, M. A., Liang, J. & Potter, J. D., Jan 25 2008, In : Journal of Biological Chemistry. 283, 4, p. 2156-2166 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Attempts of ranking in a series of synthetic nonpsychotropic cannabinoids

Pop, E. & Buchwald, P., Jan 1 2001, In : SAR and QSAR in environmental research. 12, 1-2, p. 113-127 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging

Ruetenik, A. L., Ocampo, A., Ruan, K., Zhu, Y., Li, C., Zhai, R. G. & Barrientos, A., Aug 1 2016, In : Microbial Cell. 3, 8, p. 338-351 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Autophosphorylation and ADP regulate the Ca2+-dependent interaction of recoverin with rhodopsin kinase

Satpaev, D. K., Chen, C. K., Scotti, A., Simon, M. I., Hurley, J. B. & Slepak, V. Z., Jul 14 1998, In : Biochemistry. 37, 28, p. 10256-10262 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Autoregulation of glucocorticoid receptor gene expression

Burnstein, K. L., Bellingham, D. L., Jewell, C. M., Powell-Oliver, F. E. & Cidlowski, J. A., Feb 1991, In : Steroids. 56, 2, p. 52-58 7 p.

Research output: Contribution to journalArticle

137 Scopus citations

Auxilin facilitates membrane traffic in the early secretory pathway

Ding, J., Segarra, V. A., Chen, S., Cai, H., Lemmon, S. & Ferro-Novick, S., Jan 1 2016, In : Molecular Biology of the Cell. 27, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

A vacuolar-type H+-pyrophosphatase governs maintenance of functional acidocalcisomes and growth of the insect and mammalian forms of Trypanosoma brucei

Lemercier, G., Dutoya, S., Luo, S., Ruiz, F. A., Rodrigues, C. O., Baltz, T., Docampo, R. & Bakalara, N., Oct 4 2002, In : Journal of Biological Chemistry. 277, 40, p. 37369-37376 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

A versatile synthesis of substituted tetrahydropyridines

Schurer, S. C. & Blechert, S., Mar 5 1999, In : Tetrahedron Letters. 40, 10, p. 1877-1880 4 p.

Research output: Contribution to journalArticle

62 Scopus citations

Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec4 to endomembranes

Mukherjee, D., Sen, A., Boettner, D. R., Fairn, G. D., Schlam, D., Valentin, F. J. B., McCaffery, J. M., Hazbun, T., Staiger, C. J., Grinstein, S., Lemmon, S. K. & Aguilar, R. C., Oct 18 2013, In : Journal of Cell Science. 126, 20, p. 4560-4571 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

Sessions, E. H., Yin, Y., Bannister, T. D., Weiser, A., Griffin, E., Pocas, J., Cameron, M. D., Ruiz, C., Lin, L., Schürer, S. C., Schröter, T., LoGrasso, P. & Feng, Y., Dec 15 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 24, p. 6390-6393 4 p.

Research output: Contribution to journalArticle

62 Scopus citations

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

Yin, Y., Lin, L., Ruiz, C., Cameron, M. D., Pocas, J., Grant, W., Schröter, T., Chen, W., Duckett, D., Schürer, S., LoGrasso, P. & Feng, Y., Dec 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 23, p. 6686-6690 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Bilinear model for the size-dependency of the CYP3A4 inhibitory activity of structurally diverse compounds

Buchwald, P. & Yamashita, F., Jan 1 2014, In : Molecular Informatics. 33, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Binding of phosphorylated and dephosphorylated heavy meromyosin to F-actin

Szczçsna, D., Sobieszek, A. & Ka̧kol, I., Jan 5 1987, In : FEBS letters. 210, 2, p. 177-180 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Binding of the Ca2+ antagonist, 2-butyl-3-dimethylamino-5,6-methylenedioxyindene (butyl-MDI), to calmodulin (CAM)

Piascik, M. T., Johnson, C. L., Potter, J. D. & Rahwan, R. G., Jan 1 1981, In : Federation Proceedings. 40, 6, 1 p.

Research output: Contribution to journalArticle

5 Scopus citations

BioAssay Ontology (BAO): A semantic description of bioassays and high-throughput screening results

Visser, U., Abeyruwan, S., Vempati, U., Smith, R. P., Lemmon, V. & Schürer, S. C., Jun 24 2011, In : BMC Bioinformatics. 12, 257.

Research output: Contribution to journalArticle

72 Scopus citations

BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets

Schürer, S. C., Vempati, U., Smith, R., Southern, M. & Lemmon, V., Apr 1 2011, In : Journal of Biomolecular Screening. 16, 4, p. 415-426 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

BioAssay Research Database (BARD): Chemical biology and probe-development enabled by structured metadata and result types

Howe, E. A., De Souza, A., Lahr, D. L., Chatwin, S., Montgomery, P., Alexander, B. R., Nguyen, D. T., Cruz, Y., Stonich, D. A., Walzer, G., Rose, J. T., Picard, S. C., Liu, Z., Rose, J. N., Xiang, X., Asiedu, J., Durkin, D., Levine, J., Yang, J. J., Schuerer, S. C. & 10 others, Braisted, J. C., Southall, N., Southern, M. R., Chung, T. D. Y., Brudz, S., Tanega, C., Schreiber, S. L., Bittker, J. A., Guha, R. & Clemons, P. A., Jan 28 2015, In : Nucleic Acids Research. 43, D1, p. D1163-D1170

Research output: Contribution to journalArticle

13 Scopus citations

Biochemical and immunological studies on the regulation of cardiac and neuronal muscarinic acetylcholine receptor number and function

Subers, E. M., Liles, W. C., Luetje, C. W. & Nathanson, N. M., Jan 1 1987, In : Trends in Pharmacological Sciences. 8, SUPPL., p. 25-28 4 p.

Research output: Contribution to journalArticle

Biological cross reactivity of rat testis phosphodiesterase activator protein and rabbit skeletal muscle troponin C

Dedman, J. R., Potter, J. D. & Means, A. R., Jan 1 1977, In : Journal of Biological Chemistry. 252, 7, p. 2437-2440 4 p.

Research output: Contribution to journalArticle

85 Scopus citations

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins

Goldsmith, B. R., Mitala, J. J., Josue, J., Castro, A., Lerner, M. B., Bayburt, T. H., Khamis, S. M., Jones, R. A., Brand, J. G., Sligar, S. G., Luetje, C. W., Gelperin, A., Rhodes, P. A., Discher, B. M. & Johnson, A. T. C., Jul 26 2011, In : ACS Nano. 5, 7, p. 5408-5416 9 p.

Research output: Contribution to journalArticle

112 Scopus citations