Molecular and Cellular Pharmacology

Research Output

2017

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Gao, H., Danzi, M. C., Choi, C. S., Taherian, M., Dalby-Hansen, C., Ellman, D. G., Madsen, P. M., Bixby, J., Lemmon, V., Lambertsen, K. L. & Brambilla, R., Jan 3 2017, In : Cell Reports. 18, 1, p. 198-212 15 p.

Research output: Contribution to journalArticle

41 Scopus citations

Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease

Wang, W., LeBlanc, M. E., Chen, X., Chen, P., Ji, Y., Brewer, M., Tian, H., Spring, S. R., Webster, K. A. & Li, W., Apr 26 2017, (Accepted/In press) In : Angiogenesis. p. 1-14 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pharos: Collating protein information to shed light on the druggable genome

Nguyen, D. T., Mathias, S., Bologa, C., Brunak, S., Fernandez, N., Gaulton, A., Hersey, A., Holmes, J., Jensen, L. J., Karlsson, A., Liu, G., Ma'ayan, A., Mandava, G., Mani, S., Mehta, S., Overington, J., Patel, J., Rouillard, A. D., Schuerer, S. C., Sheils, T. & 10 others, Simeonov, A., Sklar, L. A., Southall, N., Ursu, O., Vidovic, D., Waller, A., Yang, J., Jadhav, A., Oprea, T. I. & Guha, R., Jan 1 2017, In : Nucleic Acids Research. 45, D1, p. D995-D1002

Research output: Contribution to journalArticle

50 Scopus citations

Pseudophosphorylation of cardiac myosin regulatory light chain: a promising new tool for treatment of cardiomyopathy

Yadav, S. & Szczesna-Cordary, D., Feb 1 2017, In : Biophysical Reviews. 9, 1, p. 57-64 8 p.

Research output: Contribution to journalReview article

4 Scopus citations
5 Scopus citations

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

Lenguito, G., Chaimov, D., Weitz, J. R., Rodriguez Diaz, R., Rawal, S. A. K., Tamayo-Garcia, A., Caicedo-Vierkant, D. A., Stabler, C. L., Buchwald, P. & Agarwal, A., 2017, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 17, 5, p. 772-781 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting

Luo, J., Attard, G., Balk, S. P., Bevan, C., Burnstein, K. L., Cato, L., Cherkasov, A., De Bono, J. S., Dong, Y., Gao, A. C., Gleave, M., Heemers, H., Kanayama, M., Kittler, R., Lang, J. M., Lee, R. J., Logothetis, C. J., Matusik, R., Plymate, S., Sawyers, C. L. & 7 others, Selth, L. A., Soule, H., Tilley, W., Weigel, N. L., Zoubeidi, A., Dehm, S. M. & Raj, G. V., Jan 1 2017, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

36 Scopus citations

Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction

Chen, J., Song, Y., Bojadzic, D., Tamayo-Garcia, A., Landin, A. M., Blomberg, B. B. & Buchwald, P., Nov 9 2017, In : Journal of Medicinal Chemistry. 60, 21, p. 8906-8922 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome

Li, C., Brazill, J. M., Liu, S., Bello, C., Zhu, Y., Morimoto, M., Cascio, L., Pauly, R., Diaz-Perez, Z., Malicdan, M. C. V., Wang, H., Boccuto, L., Schwartz, C. E., Gahl, W. A., Boerkoel, C. F. & Zhai, R. G., Dec 1 2017, In : Nature Communications. 8, 1, 1257.

Research output: Contribution to journalArticle

15 Scopus citations

Stability and function of a putative microtubule-organizing center in the human parasite Toxoplasma gondii

Leung, J. M., He, Y., Zhang, F., Hwang, Y. C., Nagayasu, E., Liu, J., Murray, J. M. & Hu, K., May 15 2017, In : Molecular Biology of the Cell. 28, 10, p. 1361-1378 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Stress increases peripheral axon growth and regeneration through glucocorticoid receptor-dependent transcriptional programs

Lerch, J. K., Alexander, J. K., Madalena, K. M., Motti, D., Quach, T., Dhamija, A., Zha, A., Gensel, J. C., Marketon, J. W., Lemmon, V., Bixby, J. & Popovich, P. G., Jul 1 2017, In : eNeuro. 4, 4, e0246-17.2017.

Research output: Contribution to journalArticle

5 Scopus citations

Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia

Reiter, J., Drummond, S., Sammour, I., Huang, J., Florea, V., Dornas, P., Hare, J., Rodrigues, C. D. & Young, K., Jul 12 2017, In : Respiratory Research. 18, 1, 137.

Research output: Contribution to journalArticle

15 Scopus citations

Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues

Ondachi, P. W., Castro, A. H., Sherman, B., Luetje, C. W., Damaj, M. I., Mascarella, S. W., Navarro, H. A. & Carroll, F. I., Jan 18 2017, In : ACS Chemical Neuroscience. 8, 1, p. 115-127 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Systemic QSAR and phenotypic virtual screening: Chasing butterflies in drug discovery

Cruz-Monteagudo, M., Schuerer, S. C., Tejera, E., Pérez-Castillo, Y., Medina-Franco, J. L., Sánchez-Rodríguez, A. & Borges, F., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

12 Scopus citations

Targeting AR variant–coactivator interactions to exploit prostate cancer vulnerabilities

Magani, F., Peacock, S. O., Rice, M. A., Martinez, M. J., Greene, A. M., Magani, P. S., Lyles, R., Weitz, J. R. & Burnstein, K. L., Nov 1 2017, In : Molecular Cancer Research. 15, 11, p. 1469-1480 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Teaching an old drug new tricks: Agonism, antagonism, and biased signaling of pilocarpine through M3 muscarinic acetylcholine receptor

Pronin, A. N., Wang, Q. & Slepak, V. Z., Nov 1 2017, In : Molecular Pharmacology. 92, 5, p. 601-612 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

The mTOR substrate S6 kinase 1 (S6K1) is a negative regulator of axon regeneration and a potential drug target for central nervous system injury

Al-Ali, H., Ding, Y., Slepak, T., Wu, W., Sun, Y., Martinez, Y., Xu, X. M., Lemmon, V. & Bixby, J., Jul 26 2017, In : Journal of Neuroscience. 37, 30, p. 7079-7095 17 p.

Research output: Contribution to journalArticle

26 Scopus citations

The ontology reference model for visual selectivity analysis in drug-target interactions

Cheng, Q., Lopez, F. A., Duran, C., Camarillo, C., Oprea, T. I. & Schuerer, S. C., Dec 15 2017, Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017. Institute of Electrical and Electronics Engineers Inc., Vol. 2017-January. p. 2091-2097 7 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer

Samaranayake, G. J., Troccoli, C. I., Huynh, M., Lyles, R. D. Z., Kage, K., Win, A., Lakshmanan, V., Kwon, D., Ban, Y., Chen, X., Zarco, E. R., Jorda, M., Burnstein, K. L. & Rai, P., Dec 1 2017, In : Nature Communications. 8, 1, 1204.

Research output: Contribution to journalArticle

8 Scopus citations

TIN-X: target importance and novelty explorer

Cannon, D. C., Yang, J. J., Mathias, S. L., Ursu, O., Mani, S., Waller, A., Schuerer, S. C., Jensen, L. J., Sklar, L. A., Bologa, C. G. & Oprea, T. I., Aug 15 2017, In : Bioinformatics (Oxford, England). 33, 16, p. 2601-2603 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging

Ruetenik, A. L., Ocampo, A., Ruan, K., Zhu, Y., Li, C., Zhai, R. G. & Barrientos, A., Aug 1 2016, In : Microbial Cell. 3, 8, p. 338-351 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Auxilin facilitates membrane traffic in the early secretory pathway

Ding, J., Segarra, V. A., Chen, S., Cai, H., Lemmon, S. & Ferro-Novick, S., Jan 1 2016, In : Molecular Biology of the Cell. 27, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
7 Scopus citations

Building concordant ontologies for drug discovery

Küçük-McGinty, H., Mehta, S., Lin, Y., Nabizadeh, N., Stathias, V., Vidovic, D., Koleti, A., Mader, C., Duan, J., Visser, U. E. & Schuerer, S. C., 2016, In : CEUR Workshop Proceedings. 1747

Research output: Contribution to journalArticle

Cell length growth patterns in fission yeast reveal a novel size control mechanism operating in late G2 phase

Horváth, A., Rácz-Mónus, A., Buchwald, P. & Sveiczer, Á., Sep 1 2016, In : Biology of the Cell. 108, 9, p. 259-277 19 p.

Research output: Contribution to journalArticle

5 Scopus citations

Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain

Boettner, D. R., Segarra, V. A., Moorthy, B. T., de León, N., Creagh, J., Collette, J. R., Malhotra, A. & Lemmon, S., Jul 1 2016, In : Traffic. 17, 7, p. 754-768 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Dose-escalation study of octanoic acid in patients with essential tremor

Voller, B., Lines, E., McCrossin, G., Tinaz, S., Lungu, C., Grimes, G., Starling, J., Potti, G., Buchwald, P., Haubenberger, D. & Hallett, M., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Edelfosine promotes apoptosis in androgen-deprived prostate tumors by increasing atf3 and inhibiting androgen receptor activity

Udayakumar, T., Stoyanova, R., Shareef, M. M., Mu, Z., Philip, S., Burnstein, K. L. & Pollack, A., Jun 1 2016, In : Molecular Cancer Therapeutics. 15, 6, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation

Kolobynina, K. G., Solovyova, V. V., Levay, K., Rizvanov, A. A. & Slepak, V. Z., 2016, In : Journal of Cell Science. 129, 19, p. 3533-3540 8 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

Endothelial Mesenchymal Transition: Comparative Analysis of Different Induction Methods

Pinto, M. T., Covas, D. T., Kashima, S. & Rodrigues, C. D., Apr 27 2016, In : Biological Procedures Online. 18, 1, 40.

Research output: Contribution to journalArticle

16 Scopus citations

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System

Luo, X., Ribeiro, M., Bray, E. R., Lee, D. H., Yungher, B. J., Mehta, S. T., Thakor, K. A., Diaz, F., Lee, J., Moraes, C. T., Bixby, J., Lemmon, V. & Park, K., Apr 12 2016, In : Cell Reports. 15, 2, p. 398-410 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Exploiting kinase polypharmacology for nerve regeneration

Al-Ali, H., Bixby, J. & Lemmon, V., Jan 1 2016, In : Neural Regeneration Research. 11, 1, p. 71-72 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Follicle depletion provides a permissive environment for ovarian carcinogenesis

Wang, Y., Cai, K. Q., Smith, E. R., Yeasky, T. M., Moore, R., Ganjei-Azar, P., Klein-Szanto, A. J., Godwin, A. K., Hamilton, T. C. & Xua, X. X., Jan 1 2016, In : Molecular and Cellular Biology. 36, 18, p. 2418-2430 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fully automated islet cell counter (ICC) for the assessment of islet mass, purity, and size distribution by digital image analysis

Buchwald, P., Bernal, A., Echeverri, F., Tamayo-Garcia, A., Linetsky, E. & Ricordi, C., 2016, In : Cell Transplantation. 25, 10, p. 1747-1761 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

High quality, small molecule-activity datasets for kinase research [version 1; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

5 Scopus citations

High quality, small molecule-activity datasets for kinase research [version 2; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

1 Scopus citations

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

Almaca, J., Molina, J., Menegaz, D., Pronin, A. N., Tamayo, A., Slepak, V. Z., Berggren, P. O. & Caicedo-Vierkant, D. A., Dec 20 2016, In : Cell Reports. 17, 12, p. 3281-3291 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Hyperactivated Stat3 boosts axon regeneration in the CNS

Mehta, S. T., Luo, X., Park, K., Bixby, J. & Lemmon, V., Jun 1 2016, In : Experimental Neurology. 280, p. 115-120 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy

Hu, X., Chen, P., Wu, Y., Wang, K., Xu, Y., Chen, H., Zhang, L., Wu, R., Webster, K. A., Yu, H., Zhu, W. & Wang, J., Jul 1 2016, In : Stem Cells. 34, 7, p. 1846-1858 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
5 Scopus citations

Myosin light chain phosphorylation, novel targets to repair a broken heart?

Szczesna-Cordary, D. & De Tombe, P. P., 2016, In : Cardiovascular Research. 111, 1, p. 5-7 3 p.

Research output: Contribution to journalReview article

5 Scopus citations

N-Terminus of Cardiac Myosin Essential Light Chain Modulates Myosin Step-Size

Wang, Y., Ajtai, K., Kazmierczak, K., Szczesna-Cordary, D. & Burghardt, T. P., Jan 19 2016, In : Biochemistry. 55, 1, p. 186-198 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration

Cooper, D. J., Zunino, G., Bixby, J. & Lemmon, V., Apr 25 2016, (Accepted/In press) In : Molecular and Cellular Neuroscience.

Research output: Contribution to journalArticle

5 Scopus citations

Physiological and hypoxic oxygen concentration differentially regulates human c-kit+ cardiac stem cell proliferation and migration

Bellio, M. A., Rodrigues, C. D., Landin, A. M., Hatzistergos, K. E., Kuznetsov, J., Florea, V., Valasaki, K., Khan, A., Hare, J. & Schulman, I. H., Dec 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 6, p. H1509-H1519

Research output: Contribution to journalArticle

14 Scopus citations

Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response

Kumar, A., Birnbaum, M. D., Patel, D. M., Morgan, W. M., Singh, J., Barrientos, A. & Zhang, F., Sep 29 2016, In : Cell Death and Disease. 7, 9, e2378.

Research output: Contribution to journalArticle

8 Scopus citations

Profound Actions of an Agonist of Growth Hormone–Releasing Hormone on Angiogenic Therapy by Mesenchymal Stem Cells

Ma, Q., Xia, X., Tao, Q., Lu, K., Shen, J., Xu, Q., Hu, X., Tang, Y., Block, N. L., Webster, K. A., Schally, A. V., Wang, J. & Yu, H., Feb 11 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

14 Scopus citations

RegenBase: A knowledge base of spinal cord injury biology for translational research

Callahan, A., Abeyruwan, S. W., Al-Ali, H., Sakurai, K., Ferguson, A. R., Popovich, P. G., Shah, N. H., Visser, U. E., Bixby, J. & Lemmon, V., 2016, In : Database : the journal of biological databases and curation. 2016, baw040.

Research output: Contribution to journalArticle

5 Scopus citations

Regulator of G protein signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein

Tayou, J., Wang, Q., Jang, G. F., Pronin, A. N., Orlandi, C., Martemyanov, K. A., Crabb, J. W. & Slepak, V. Z., Apr 22 2016, In : Journal of Biological Chemistry. 291, 17, p. 9133-9147 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1

Graham, R. M., Hernandez, F., Puerta, N., De Angulo, G., Webster, K. A. & Vanni, S., Feb 5 2016, In : Experimental and Molecular Medicine. 48, 2, e210.

Research output: Contribution to journalArticle

26 Scopus citations

Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

Nuñez, I., Pino, M. R., Wiley, D. J., Das, M. E., Chen, C., Goshima, T., Kume, K., Hirata, D., Toda, T. & Verde, F., Jul 30 2016, In : eLife. 5, JULY, e14216.

Research output: Contribution to journalArticle

7 Scopus citations