Molecular and Cellular Pharmacology

Research Output

2001

Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis

Andreka, P., Zang, J., Dougherty, C., Slepak, T. I., Webster, K. A. & Bishopric, N. H., Feb 16 2001, In : Circulation research. 88, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations

Determinants of agonist binding affinity on neuronal nicotinic receptor β subunits

Parker, M. J., Harvey, S. C. & Luetje, C. W., Oct 9 2001, In : Journal of Pharmacology and Experimental Therapeutics. 299, 1, p. 385-391 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K+ channel and control regulation of RGS7 by Gβ5

Keren-Raifman, T., Bera, A. K., Zveig, D., Peleg, S., Witherow, D. S., Slepak, V. Z. & Dascal, N., Mar 9 2001, In : FEBS letters. 492, 1-2, p. 20-28 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Expression of RFG/ELE1α/ARA70 in normal and malignant prostatic epithelial cell cultures and lines: Regulation by methylation and sex steroids

Tekur, S., Lau, K. M., Long, J., Burnstein, K. & Ho, S. M., Feb 19 2001, In : Molecular Carcinogenesis. 30, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Familial Hypertrophic Cardiomyopathy Mutations in the Regulatory Light Chains of Myosin Affect their Structure, Ca2+ Binding, and Phosphorylation

Szczesna, D., Ghosh, D., Li, Q., Gomes, A. V., Guzman, G., Arana, C., Zhi, G., Stull, J. T. & Potter, J. D., Mar 9 2001, In : Journal of Biological Chemistry. 276, 10, p. 7086-7092 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors

Cornacchia, F., Fornoni, A., Plati, A. R., Thomas, A., Wang, Y., Inverardi, L., Striker, L. J. & Striker, G. E., Dec 29 2001, In : Journal of Clinical Investigation. 108, 11, p. 1649-1656 8 p.

Research output: Contribution to journalArticle

109 Scopus citations
2 Scopus citations

Invited review: Pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation

Hernandez, O. M., Housmans, P. R. & Potter, J. D., 2001, In : Journal of applied physiology. 90, 3, p. 1125-1136 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

Ligands and signaling through receptor-type tyrosine phosphatases

Bixby, J. L., Sep 12 2001, In : IUBMB life. 51, 3, p. 157-163 7 p.

Research output: Contribution to journalReview article

23 Scopus citations

Magnesium-calcium exchange with the high affinity Ca2+-Mg2+ binding sites of cardiac troponin

Harada, K., Arana, C. & Potter, J. D., Jan 1 2001, In : Journal of Molecular and Cellular Cardiology. 33, 3, p. 593-596 4 p.

Research output: Contribution to journalLetter

2 Scopus citations

Molecular mechanisms of apoptosis in the cardiac myocyte

Bishopric, N. H., Andreka, P., Slepak, T. & Webster, K. A., Apr 1 2001, In : Current Opinion in Pharmacology. 1, 2, p. 141-150 10 p.

Research output: Contribution to journalReview article

217 Scopus citations

Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, and p300/CBP

Yamashita, K., Discher, D. J., Hu, J., Bishopric, N. H. & Webster, K. A., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 12645-12653 9 p.

Research output: Contribution to journalArticle

263 Scopus citations

Oxidation of zinc finger transcription factors: Physiological consequences

Webster, K. A., Prentice, H. & Bishopric, N. H., Jan 1 2001, In : Antioxidants and Redox Signaling. 3, 4, p. 535-548 14 p.

Research output: Contribution to journalReview article

108 Scopus citations

Phosphorylation of the regulator of G protein signaling RGS9-1 by protein kinase a is a potential mechanism of light- and Ca2+-mediated regulation of G protein function in photoreceptors

Balasubramanian, N., Levay, K., Keren-Raifman, T., Faurobert, E. & Slepak, V. Z., Oct 23 2001, In : Biochemistry. 40, 42, p. 12619-12627 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
114 Scopus citations

Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1

Yamashita, K., Kajstura, J., Discher, D. J., Wasserlauf, B. J., Bishopric, N. H., Anversa, P. & Webster, K. A., Mar 30 2001, In : Circulation research. 88, 6, p. 609-614 6 p.

Research output: Contribution to journalArticle

Open Access
122 Scopus citations
87 Scopus citations

Standardization of cardiac troponin I assays: Round robin of ten candidate reference materials

Christenson, R. H., Show Hong Duh, H. D., Apple, F. S., Bodor, G. S., Bunk, D. M., Dalluge, J., Panteghini, M., Potter, J. D., Welch, M. J., Wu, A. H. B. & Kahn, S. E., 2001, In : Clinical chemistry. 47, 3, p. 431-437 7 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations
31 Scopus citations

Subunit-dependent modulation of neuronal nicotinic receptors by zinc

Hsiao, B., Dweck, D. & Luetje, C. W., Mar 15 2001, In : Journal of Neuroscience. 21, 6, p. 1848-1856 9 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

The androgen receptor (AR) amino-terminus imposes androgen-specific regulation of AR gene expression via an exonic enhancer

Grad, J. M., Lyons, L. S., Robins, D. M. & Burnstein, K. L., Jan 1 2001, In : Endocrinology. 142, 3, p. 1107-1116 10 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

The Highly Conserved Protein Methyltransferase, Skb1, Is a Mediator of Hyperosmotic Stress Response in the Fission Yeast Schizosaccharomyces pombe

Bao, S., Qyang, Y., Yang, P., Kim, H. W., Du, H., Bartholomeusz, G., Henkel, J., Pimental, R., Verde, F. & Marcus, S., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 14549-14552 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

De Jesus, L. A., Carvalho, S. D., Ribeiro, M. O., Schneider, M., Kim, S. W., Harney, J. W., Larsen, P. R. & Bianco, A. C., Dec 13 2001, In : Journal of Clinical Investigation. 108, 9, p. 1379-1385 7 p.

Research output: Contribution to journalArticle

325 Scopus citations

Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific

Ribeiro, M. O., Carvalho, S. D., Schultz, J. J., Chiellini, G., Scanlan, T. S., Bianco, A. C. & Brent, G. A., Jul 24 2001, In : Journal of Clinical Investigation. 108, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

197 Scopus citations

Type 2 iodothyronine deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis

Pachucki, J., Hopkins, J., Peeters, R., Tu, H., Carvalho, S. D., Kaulbach, H., Dale Abel, E., Wondisford, F. E., Ingwall, J. S. & Reed Larsen, P., Mar 12 2001, In : Endocrinology. 142, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

54 Scopus citations
2000

A glycolytic pathway to apoptosis of hypoxic cardiac myocytes: Molecular pathways of increased acid production

Webster, K. A., Discher, D. J., Hernandez, O. M., Yamashita, K. & Bishopric, N. H., 2000, In : Advances in experimental medicine and biology. 475, p. 161-175 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

Szczesna, D., Zhang, R., Zhao, J., Jones, M., Guzman, G. & Potter, J. D., Jan 7 2000, In : Journal of Biological Chemistry. 275, 1, p. 624-630 7 p.

Research output: Contribution to journalArticle

114 Scopus citations

Analysis of protein-protein interactions in phototransduction cascade using surface plasmon resonance

Satpaev, D. K. & Slepak, A. Z., 2000, In : Methods in enzymology. 316, p. 20-40 21 p.

Research output: Contribution to journalReview article

9 Scopus citations

Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase

Shen, R., Sumitomo, M., Dai, J., Harris, A., Kaminetzky, D., Gao, M., Burnstein, K. L. & Nanus, D. M., 2000, In : Endocrinology. 141, 5, p. 1699-1704 6 p.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations
16 Scopus citations

Chapter 8 Molecular and cellular stress pathways in ischemic heart disease: Targets for regulated gene therapy

Webster, K. A., Dec 1 2000, In : Cell and Molecular Response to Stress. 1, C, p. 99-112 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Complexes of the G protein subunit Gβ5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells

Witherow, D. S., Wang, Q., Levay, K., Cabrera, J. L., Chen, J., Willars, G. B. & Slepak, V. Z., Aug 11 2000, In : Journal of Biological Chemistry. 275, 32, p. 24872-24880 9 p.

Research output: Contribution to journalArticle

124 Scopus citations

Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat

Ribeiro, M. O., Lebrun, F. L. A. S., Christoffolete, M. A., Branco, M., Crescenzi, A., Carvalho, S. D., Negrão, N. & Bianco, A. C., 2000, In : American Journal of Physiology - Endocrinology and Metabolism. 279, 2 42-2, p. E314-E322

Research output: Contribution to journalArticle

39 Scopus citations

Extended covalent solid forms of carbon dioxide with carbon-oxygen single bonds

Bodor, N. & Buchwald, P., Mar 24 2000, In : Chemical Physics Letters. 319, 5-6, p. 645-649 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Growth cone steering by receptor tyrosine phosphatase δ defines a distinct class of guidance cue

Sun, Q. L., Wang, J., Bookman, R. J. & Bixby, J. L., Jan 1 2000, In : Molecular and Cellular Neuroscience. 16, 5, p. 686-695 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Hepatocyte growth factor and vitamin D cooperatively inhibit androgen-unresponsive prostate cancer cell lines

Qadan, L. R., Perez-Stable, C. M., Schwall, R. H., Burnstein, K. L., Ostenson, R. C., Howard, G. A. & Roos, B. A., Jan 1 2000, In : Endocrinology. 141, 7, p. 2567-2573 7 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis

Leri, A., Fiordaliso, F., Setoguchi, M., Limana, F., Bishopric, N. H., Kajstura, J., Webster, K. & Anversa, P., 2000, In : American Journal of Pathology. 157, 3, p. 843-857 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

Investigating the role of Ca2+-binding site IV in barnacle troponin C

Allhouse, L. D., Li, Q., Guzman, G., Miller, T., Lipscomb, S., Potter, J. D. & Ashley, C. C., Jan 1 2000, In : Pflugers Archiv European Journal of Physiology. 439, 5, p. 600-609 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Molecular aspects and gene therapy prospects for diastolic failure

Webster, K. A. & Bishopric, N. H., Jan 1 2000, In : Cardiology clinics. 18, 3, p. 621-635 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Presence of a Na+/H+ exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial drugs

Vercesi, A. E., Rodrigues, C. O., Catisti, R. & Docampo, R., May 12 2000, In : FEBS letters. 473, 2, p. 203-206 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes

Hernandez, O. M., Discher, D. J., Bishopric, N. H. & Webster, K. A., Jan 1 2000, In : Circulation research. 86, 2, p. 198-204 7 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

Receptor tyrosine phosphatases in axon growth and guidance

Bixby, J. L., Jul 2000, In : Neuroreport. 11, 10, p. R5-R10

Research output: Contribution to journalReview article

36 Scopus citations

Regulation of phospholipase C-β1 activity by phosphatidic acid

Litosch, I., Jul 4 2000, In : Biochemistry. 39, 26, p. 7736-7743 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Regulation of retinal neurite growth by alterations in MAPK/ERK kinase (MEK) activity

Dimitropoulou, A. & Bixby, J. L., Mar 2 2000, In : Brain Research. 858, 1, p. 205-214 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Simple model for nonassociative organic liquids and water

Buchwald, P. & Bodor, N., Nov 1 2000, In : Journal of the American Chemical Society. 122, 43, p. 10671-10679 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography

Moisés, V. A., Ferreira, R. L., Nozawa, E., Kanashiro, R. M., Campos, O. F., De Andrade, J. L., Carvalho, A. C. C. & Tucci, P. J. F., 2000, In : Arquivos Brasileiros de Cardiologia. 75, 2, p. 131-136 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Structure-fluorescence correlations in a single tryptophan mutant of carp parvalbumin: Solution structure, backbone and side-chain dynamics

Moncrieffe, M. C., Juranić, N., Kemple, M. D., Potter, J. D., Macura, S. & Prendergast, F. G., Mar 17 2000, In : Journal of molecular biology. 297, 1, p. 147-163 17 p.

Research output: Contribution to journalArticle

34 Scopus citations

The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1α,25- dihydroxyvitamin D2 as therapeutic agents for prostate cancer

Chen, T. C., Schwartz, G. G., Burnstein, K. L., Lokeshwar, B. L. & Holick, M. F., Mar 1 2000, In : Clinical Cancer Research. 6, 3, p. 901-908 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Therapeutic angiogenesis: A case for targeted, regulated gene delivery

Webster, K. A., 2000, In : Critical Reviews in Eukaryotic Gene Expression. 10, 2, p. 113-125 13 p.

Research output: Contribution to journalReview article

15 Scopus citations

The role of the CA2+ regulatory sites of skeletal troponin C in modulating muscle fibre reactivity to the CA2+ sensitizer bepridil

Kischel, P., Bastide, B., Potter, J. D. & Mounier, Y., Jan 1 2000, In : British Journal of Pharmacology. 131, 7, p. 1496-1502 7 p.

Research output: Contribution to journalArticle

11 Scopus citations