Molecular and Cellular Pharmacology

Research Output

2005

Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in α-tropomyosin

Chang, A. N., Harada, K., Ackerman, M. J. & Potter, J. D., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 34343-34349 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

General linearized biexponential model for QSAR data showing bilinear-type distribution

Buchwald, P., Nov 2005, In : Journal of Pharmaceutical Sciences. 94, 11, p. 2355-2379 25 p.

Research output: Contribution to journalArticle

27 Scopus citations

In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast

Newpher, T. M., Smith, R. P., Lemmon, V. & Lemmon, S. K., Jul 1 2005, In : Developmental Cell. 9, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

143 Scopus citations

Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions

Nair, K. S., Hanson, S. M., Mendez, A., Gurevich, E. V., Kennedy, M. J., Shestopalov, V. I., Vishnivetskiy, S. A., Chen, J., Hurley, J. B., Gurevich, V. V. & Slepak, V. Z., May 19 2005, In : Neuron. 46, 4, p. 555-567 13 p.

Research output: Contribution to journalArticle

143 Scopus citations

Listeria's right-handed helical rocket-tail trajectories: Mechanistic implications for force generation in actin-based motility

Zeile, W. L., Zhang, F., Dickinson, R. B. & Purich, D. L., Feb 1 2005, In : Cell Motility and the Cytoskeleton. 60, 2, p. 121-128 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Modest actomyosin energy conservation increases myocardial postischemic function

Blunt, B. C., Chen, Y., Potter, J. D. & Hofmann, P. A., Mar 1 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 288, 3 57-3, p. H1088-H1096

Research output: Contribution to journalArticle

6 Scopus citations

Motor neurite outgrowth is selectively inhibited by cell surface MuSK and agrin

Dimitropoulou, A. & Bixby, J. L., Feb 2005, In : Molecular and Cellular Neuroscience. 28, 2, p. 292-302 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components

Mehta, S. Q., Hiesinger, P. R., Beronja, S., Zhai, R. G., Schulze, K. L., Verstreken, P., Cao, Y., Zhou, Y., Tepass, U., Crair, M. C. & Bellen, H. J., Apr 21 2005, In : Neuron. 46, 2, p. 219-232 14 p.

Research output: Contribution to journalArticle

107 Scopus citations

Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development

Gomes, A. V., Liang, J. & Potter, J. D., Sep 2 2005, In : Journal of Biological Chemistry. 280, 35, p. 30909-30915 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

Neuronal pentraxin with chromo domain (NPCD) is a novel class of protein expressed in multiple neuronal domains

Chen, B. & Bixby, J. L., Jan 24 2005, In : Journal of Comparative Neurology. 481, 4, p. 391-402 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Ophthalmic drug design based on the metabolic activity of the eye: Soft drugs and chemical delivery systems

Bodor, N. & Buchwald, P., Dec 28 2005, In : AAPS Journal. 7, 4, 79.

Research output: Contribution to journalReview article

75 Scopus citations

Pharmacokinetic and pharmacodynamic evaluations of the zwitterionic metabolite of a new series of N-substituted soft anticholinergics

Wu, W. M., Buchwald, P., Mori, N., Ji, F., Wu, J. X. & Bodor, N., Dec 1 2005, In : Pharmaceutical Research. 22, 12, p. 2035-2044 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Prospective exploration of synthetically feasible, medicinally relevant chemical space

Schürer, S. C., Tyagi, P. & Muskal, S. M., Mar 1 2005, In : Journal of Chemical Information and Modeling. 45, 2, p. 239-248 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
10 Scopus citations

RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation

Cheng, L., Lemmon, S. & Lemmon, V., Aug 1 2005, In : Journal of neurochemistry. 94, 4, p. 1102-1110 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Receptor tyrosine phosphatases guide vertebrate motor axons during development

Stepanek, L., Stoker, A. W., Stoeckli, E. & Bixby, J. L., Apr 13 2005, In : Journal of Neuroscience. 25, 15, p. 3813-3823 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Regulation of androgen receptor levels: Implications for prostate cancer progression and therapy

Burnstein, K. L., Jul 1 2005, In : Journal of cellular biochemistry. 95, 4, p. 657-669 13 p.

Research output: Contribution to journalReview article

83 Scopus citations

Sarcomeric protein mutations in dilated cardiomyopathy

Chang, A. N. & Potter, J. D., Sep 1 2005, In : Heart Failure Reviews. 10, 3, p. 225-235 11 p.

Research output: Contribution to journalReview article

101 Scopus citations

Synthesis and pharmacological effects of new, N-substituted soft anticholinergics based on glycopyrrolate

Ji, F., Wu, W., Dai, X., Mori, N., Wu, J., Buchwald, P. & Bodor, N., Dec 1 2005, In : Journal of Pharmacy and Pharmacology. 57, 11, p. 1427-1435 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice

Szczesna-Cordary, D., Guzman, G., Zhao, J., Hernandez, O., Wei, J. & Diaz-Perez, Z., Aug 15 2005, In : Journal of Cell Science. 118, 16, p. 3675-3683 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

The miscommunicative cardiac cell: When good proteins go bad

Gomes, A. V., Venkatraman, G. & Potter, J. D., Jan 1 2005, In : Annals of the New York Academy of Sciences. 1047, p. 30-37 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors

Nair, K. S., Mendez, A., Blumer, J. B., Rosenzweig, D. H. & Slepak, V. Z., Jan 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 1, p. 383-389 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila

Hiesinger, P. R., Fayyazuddin, A., Mehta, S. Q., Rosenmund, T., Schulze, K. L., Zhai, R. G., Verstreken, P., Cao, Y., Zhou, Y., Kunz, J. & Bellen, H. J., May 20 2005, In : Cell. 121, 4, p. 607-620 14 p.

Research output: Contribution to journalArticle

222 Scopus citations

Unified pharmacogenetics-based parent-metabolite pharmacokinetic model incorporating acetylation polymorphism for talampanel in humans

Buchwald, P., Juhász, A., Bell, C., Pátfalusi, M., Howes, J. & Bodor, N., Aug 1 2005, In : Journal of Pharmacokinetics and Pharmacodynamics. 32, 3-4, p. 377-400 24 p.

Research output: Contribution to journalArticle

5 Scopus citations
2004

Aktion in the Nucleus

Webster, K. A., Apr 16 2004, In : Circulation research. 94, 7, p. 856-859 4 p.

Research output: Contribution to journalEditorial

25 Scopus citations

A New Luciferase Reporter Gene Assay for the Detection of Androgenic and Antiandrogenic Effects Based on a Human Prostate Specific Antigen Promoter and PC3/AR Human Prostate Cancer Cells

Kizu, R., Otsuki, N., Kishida, Y., Toriba, A., Mizokami, A., Burnstein, K. L., Klinge, C. M. & Hayakawa, K., Jan 2004, In : Analytical Sciences. 20, 1, p. 55-59 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

A novel RING-finger-like protein Ini1 is essential for cell cycle progression in fission yeast

Oltra, E., Verde, F., Werner, R. & D'Urso, G., Feb 29 2004, In : Journal of Cell Science. 117, 6, p. 967-974 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Antiandrogenic activity of extracts of diesel exhaust particles emitted from diesel-engine truck under different engine loads and speeds

Okamura, K., Kizu, R., Toriba, A., Murahashi, T., Mizokami, A., Burnstein, K. L., Klinge, C. M. & Hayakawa, K., Feb 15 2004, In : Toxicology. 195, 2-3, p. 243-254 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

A unique pathway of cardiac myocyte death caused by hypoxia-acidosis

Graham, R. M., Frazier, D. P., Thompson, J. W., Haliko, S., Li, H., Wasserlauf, B. J., Spiga, M. G., Bishopric, N. H. & Webster, K. A., Aug 1 2004, In : Journal of Experimental Biology. 207, 18, p. 3189-3200 12 p.

Research output: Contribution to journalReview article

136 Scopus citations

Cardiac troponin T isoforms affect the Ca2+ sensitivity of force development in the presence of slow skeletal troponin I: Insights into the role of troponin T isoforms in the fetal heart

Gomes, A. V., Venkatraman, G., Davis, J. P., Tikunova, S. B., Engel, P., Solaro, R. J. & Potter, J. D., Nov 26 2004, In : Journal of Biological Chemistry. 279, 48, p. 49579-49587 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene

Gomes, A. V. & Potter, J. D., Aug 1 2004, In : Molecular and Cellular Biochemistry. 263, 1, p. 99-114 16 p.

Research output: Contribution to journalArticle

52 Scopus citations

Chronic cardiac-specific thyrotoxicosis increases myocardial β-adrenergic responsiveness

Carvalho-Bianco, S. D., Kim, B. W., Zhang, J. X., Harney, J. W., Ribeiro, R. S., Gereben, B., Bianco, A. C., Mende, U. & Larsen, P. R., Jul 1 2004, In : Molecular Endocrinology. 18, 7, p. 1840-1849 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21CIP1 levels in androgen-independent human prostate cancer cells

Knight-Krajewski, S., Welsh, C. F., Liu, Y., Lyons, L. S., Faysal, J. M., Yang, E. S. & Burnstein, K. L., Jul 15 2004, In : Oncogene. 23, 32, p. 5513-5522 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
25 Scopus citations

Determinants of Potency on α-Conotoxin MII, a Peptide Antagonist of Neuronal Nicotinic Receptors

Everhart, D., Cartier, G. E., Malhotra, A., Gomes, A. V., McIntosh, J. M. & Luetje, C. W., Mar 16 2004, In : Biochemistry. 43, 10, p. 2732-2737 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors

Nair, K. S., Hanson, S. M., Kennedy, M. J., Hurley, J. B., Gurevich, V. V. & Slepak, V. Z., Sep 24 2004, In : Journal of Biological Chemistry. 279, 39, p. 41240-41248 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Endograft technology: A delivery vehicle for intravascular gene therapy

Eton, D., Yu, H., Wang, Y., Raines, J., Striker, G., Livingstone, A. & Baxter, T., May 2004, In : Journal of vascular surgery. 39, 5, p. 1066-1073 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
50 Scopus citations
62 Scopus citations

GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons

Maddox, F. N., Valeyev, A. Y., Poth, K., Holohean, A. M., Wood, P. M., Davidoff, R. A., Hackman, J. C. & Luetje, C. W., Apr 19 2004, In : Developmental Brain Research. 149, 2, p. 143-151 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Genomic and proteomic profiles of heart disease

Prentice, H. & Webster, K. A., Oct 2004, In : Trends in Cardiovascular Medicine. 14, 7, p. 282-288 7 p.

Research output: Contribution to journalReview article

12 Scopus citations

Getting past the asterisk: The subunit composition of presynaptic nicotinic receptors that modulate striatal dopamine release

Luetje, C. W., Jun 1 2004, In : Molecular Pharmacology. 65, 6, p. 1333-1335 3 p.

Research output: Contribution to journalReview article

33 Scopus citations

Glycosaminoglycan-dependent and -independent inhibition of neurite outgrowth by agrin

Baerwald-De La Torre, K., Winzen, U., Halfter, W. & Bixby, J. L., Jul 1 2004, In : Journal of neurochemistry. 90, 1, p. 50-61 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

GSK3 involvement in amylin signaling in isolated rat soleus muscle

Abaffy, T. & Cooper, G. J. S., Dec 1 2004, In : Peptides. 25, 12, p. 2119-2125 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hormone resistance: It's SMRT to fight repression

Burnstein, K. L. & Luetje, C. W., Apr 1 2004, In : Endocrinology. 145, 4, p. 1525-1526 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Identification and cloning of two putative subunits of DNA polymerase epsilon in fussion yeast

Spiga, M. G. & D'Urso, G., Nov 9 2004, In : Nucleic acids research. 32, 16, p. 4945-4953 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Metabolic properties of phosphonate esters

Somogyi, G., Buchwald, P. & Bodor, N., May 1 2004, In : Pharmazie. 59, 5, p. 378-381 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mice with Targeted Disruption of the Dio2 Gene Have Cold-Induced Overexpression of the Uncoupling Protein 1 Gene but Fail to Increase Brown Adipose Tissue Lipogenesis and Adaptive Thermogenesis

Christoffolete, M. A., Linardi, C. C. G., De Jesus, L., Ebina, K. N., Carvalho, S. D., Ribeiro, M. O., Rabelo, R., Curcio, C., Martins, L., Kimura, E. T. & Bianco, A. C., Mar 1 2004, In : Diabetes. 53, 3, p. 577-584 8 p.

Research output: Contribution to journalArticle

140 Scopus citations

Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation

Dougherty, C. J., Kubasiak, L. A., Frazier, D. P., Li, H., Xiong, W. C., Bishopric, N. H. & Webster, K. A., Jul 1 2004, In : FASEB Journal. 18, 10, p. 1060-1070 11 p.

Research output: Contribution to journalArticle

81 Scopus citations

Molecular and cellular aspects of troponin cardiomyopathies

Gomes, A. V. & Potter, J. D., Jan 1 2004, In : Annals of the New York Academy of Sciences. 1015, p. 214-224 11 p.

Research output: Contribution to journalArticle

84 Scopus citations