Molecular and Cellular Pharmacology

Research Output

2007

Triadins modulate intracellular Ca2+ homeostasis but are not essential for excitation-contraction coupling in skeletal muscle

Shen, X., Franzini-Armstrong, C., Lopez, J. R., Jones, L. R., Kobayashi, Y. M., Wang, Y., Kerrick, W. G. L., Caswell, A. H., Potter, J. D., Miller, T., Allen, P. D. & Perez, C. F., Dec 28 2007, In : Journal of Biological Chemistry. 282, 52, p. 37864-37874 11 p.

Research output: Contribution to journalArticle

53 Scopus citations
2006

96-Well electroporation method for transfection of mammalian central neurons

Buchser, W. J., Pardinas, J. R., Shi, Y., Bixby, J. L. & Lemmon, V. P., Nov 1 2006, In : BioTechniques. 41, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Acidosis regulates the stability, hydrophobicity, and activity of the BH3-only protein Bnip3

Frazier, D. P., Wilson, A., Graham, R. M., Thompson, J. W., Bishopric, N. H. & Webster, K. A., Sep 1 2006, In : Antioxidants and Redox Signaling. 8, 9-10, p. 1625-1634 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Activity-Independent Prespecification of Synaptic Partners in the Visual Map of Drosophila

Hiesinger, P. R., Zhai, R. G., Zhou, Y., Koh, T. W., Mehta, S. Q., Schulze, K. L., Cao, Y., Verstreken, P., Clandinin, T. R., Fischbach, K. F., Meinertzhagen, I. A. & Bellen, H. J., Sep 19 2006, In : Current Biology. 16, 18, p. 1835-1843 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Antibodies and antibody-fusion proteins as anti-angiogenic, anti-tumor agents

Calfa, C. I., Rosenblatt, J. D., Cho, H. M., Webster, K. & Shin, S. U., Jun 1 2006, In : Update on Cancer Therapeutics. 1, 2, p. 159-173 15 p.

Research output: Contribution to journalReview article

6 Scopus citations

Brain-targeted delivery of estradiol: Therapeutic potential and results obtained with a chemical delivery system approach

Bodor, N. & Buchwald, P., Sep 12 2006, In : American Journal of Drug Delivery. 4, 3, p. 161-175 15 p.

Research output: Contribution to journalReview article

8 Scopus citations

Brain-targeted delivery of peptides

Bodor, N. & Buchwald, P., Jan 1 2006, In : American Pharmaceutical Review. 9, 1, p. 100-104 5 p.

Research output: Contribution to journalReview article

2 Scopus citations

Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast

Newpher, T. M. & Lemmon, S. K., May 1 2006, In : Traffic. 7, 5, p. 574-588 15 p.

Research output: Contribution to journalArticle

47 Scopus citations

Cortical recruitment and nuclear-cytoplasmic shuttling of Scd5p, a protein phosphatase-1-targeting protein involved in actin organization and endocytosis

Chang, J. S., Henry, K., Geli, M. I. & Lemmon, S. K., Jan 1 2006, In : Molecular biology of the cell. 17, 1, p. 251-262 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Corticosteroid design for the treatment of asthma: Structural insights and the therapeutic potential of soft corticosteroids

Bodor, N. & Buchwald, P., Sep 1 2006, In : Current Pharmaceutical Design. 12, 25, p. 3241-3260 20 p.

Research output: Contribution to journalReview article

45 Scopus citations

Determinants of zinc potentiation on the α4 subunit of neuronal nicotinic receptors

Hsiao, B., Mihalak, K. B., Repicky, S. E., Everhart, D., Mederos, A. H., Malhotra, A. & Luetje, C. W., Jan 1 2006, In : Molecular Pharmacology. 69, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Determinants of α-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor β subunit

Shiembob, D. L., Roberts, R. L., Luetje, C. W. & McIntosh, J. M., Sep 19 2006, In : Biochemistry. 45, 37, p. 11200-11207 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Differences in the glucocorticoid to the progesterone receptor selectivity of inhaled glucocorticoids

Issar, M., Sahasranaman, S., Buchwald, P. & Hochhaus, G., Mar 1 2006, In : European Respiratory Journal. 27, 3, p. 511-516 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
13 Scopus citations

Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts - Role of myofilament Ca2+ sensitivity increase

Sirenko, S. G., Potter, J. D. & Knollmann, B. C., Aug 1 2006, In : Journal of Physiology. 575, 1, p. 201-213 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy

Westermann, D., Knollmann, B. C., Steendijk, P., Rutschow, S., Riad, A., Pauschinger, M., Potter, J. D., Schultheiss, H. P. & Tschöpe, C., Mar 1 2006, In : European Journal of Heart Failure. 8, 2, p. 115-121 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

E22K mutation of RLC that causes familial hypertrophic cardiomyopathy in heterozygous mouse myocardium: Effect on cross-bridge kinetics

Dumka, D., Talent, J., Akopova, I., Guzman, G., Szczesna-Cordary, D. & Borejdo, J., Nov 24 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 5, p. H2098-H2106

Research output: Contribution to journalArticle

9 Scopus citations

Functional analysis of a mammalian odorant receptor subfamily

Abaffy, T., Matsunami, H. & Luetje, C. W., Jun 1 2006, In : Journal of neurochemistry. 97, 5, p. 1506-1518 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Influence of the N-acetylation polymorphism on the metabolism of talampanel: An investigation in fasted and fed subjects genotyped for NAT2 variants

Buchwald, P., Juhász, A., Bell, C., Pátfalusi, M., Kovács, P., Hochhaus, G., Howes, J. & Bodor, N., Feb 1 2006, In : Pharmazie. 61, 2, p. 125-134 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

International union of pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: Glucocorticoid, mineralocorticoid, progesterone, and androgen receptors

Lu, N. Z., Wardell, S. E., Burnstein, K. L., Defranco, D., Fuller, P. J., Giguere, V., Hochberg, R. B., Mckay, L., Renoir, J. M., Weigel, N. L., Wilson, E. M., Mcdonnell, D. P. & Cidlowski, J. A., Dec 1 2006, In : Pharmacological Reviews. 58, 4, p. 782-797 16 p.

Research output: Contribution to journalReview article

229 Scopus citations

Irreversible aggregation of protein synthesis machinery after focal brain ischemia

Zhang, F., Liu, C. L. & Hu, B. R., Jul 1 2006, In : Journal of neurochemistry. 98, 1, p. 102-112 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Novel function of clathrin light chain in promoting endocytic vesicle formation

Newpher, T. M., Idrissi, F. Z., Geli, M. I. & Lemmon, S. K., Oct 1 2006, In : Molecular biology of the cell. 17, 10, p. 4343-4352 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Performance of two-dimensional Doppler echocardiography for the assessment of infarct size and left ventricular function in rats

Nozawa, E., Kanashiro, R. M., Murad, N., Carvalho, A. C. C., Cravo, S. L. D., Campos, O., Tucci, P. J. F. & Moises, V. A., May 1 2006, In : Brazilian Journal of Medical and Biological Research. 39, 5, p. 687-695 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Pharmacological effects of some newly developed soft anticholinergics and a receptor-binding QSAR study

Mori, N., Buchwald, P., Wu, W. M., Ji, F., Hochhaus, G. & Bodor, N., Feb 1 2006, In : Pharmazie. 61, 2, p. 148-153 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Prolonged Ca2+ and Force Transients in Myosin RLC Transgenic Mouse Fibers Expressing Malignant and Benign FHC Mutations

Wang, Y., Xu, Y., Kerrick, W. G. L., Wang, Y., Guzman, G., Diaz-Perez, Z. & Szczesna-Cordary, D., Aug 11 2006, In : Journal of molecular biology. 361, 2, p. 286-299 14 p.

Research output: Contribution to journalArticle

47 Scopus citations
11 Scopus citations

Redox stress and the contributions of BH3-only proteins to infarction

Webster, K. A., Graham, R. M., Thompson, J. W., Spiga, M. G., Frazier, D. P., Wilson, A. & Bishopric, N. H., Sep 1 2006, In : Antioxidants and Redox Signaling. 8, 9-10, p. 1667-1676 10 p.

Research output: Contribution to journalReview article

54 Scopus citations
16 Scopus citations

Structural basis for calcium-induced inhibition of rhodopsin kinase by recoverin

Ames, J. B., Levay, K., Wingard, J. N., Lusin, J. D. & Slepak, V. Z., Dec 1 2006, In : Journal of Biological Chemistry. 281, 48, p. 37237-37245 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Structural determinants for phosphatidic acid regulation of phospholipase C-β1

Ross, E. M., Mateu, D., Gomes, A. V., Arana, C., Tran, T. & Litosch, I., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33087-33094 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

The bHLH-PAS protein spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons

Kim, M. D., Lily, Y. J. & Yuh, N. J., Oct 15 2006, In : Genes and Development. 20, 20, p. 2806-2819 14 p.

Research output: Contribution to journalArticle

84 Scopus citations

The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast

Locovei, A. M., Spiga, M. G., Tanaka, K., Murakami, Y. & D'Urso, G., Nov 17 2006, In : Cell Division. 1, 27.

Research output: Contribution to journalArticle

10 Scopus citations
14 Scopus citations

Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors

Mihalak, K. B., Carroll, F. I. & Luetje, C. W., Aug 28 2006, In : Molecular Pharmacology. 70, 3, p. 801-805 5 p.

Research output: Contribution to journalArticle

424 Scopus citations
53 Scopus citations
2005

Adenoviral delivery of vegf promotes short term angiogenic effect

Gounis, M. J., Lieber, B. B., Webster, K. A., Spiga, M. G., Bishopric, N. H. & Wakhloo, A. K., Dec 1 2005, Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. p. 709-710 2 p. (Proceedings of the 2005 Summer Bioengineering Conference; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

45 Scopus citations
21 Scopus citations

Angiogenesis is confined to the transient period of VEGF expression that follows adenoviral gene delivery to ischemic muscle

Gounis, M. J., Spiga, M. G., Graham, R. M., Wilson, A., Haliko, S., Lieber, B. B., Wakhloo, A. K. & Webster, K. A., May 1 2005, In : Gene Therapy. 12, 9, p. 762-771 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

A novel substrate of receptor tyrosine phosphatase PTPRO is required for nerve growth factor-induced process outgrowth

Chen, B. & Bixby, J. L., Feb 26 2005, In : Journal of Neuroscience. 25, 4, p. 880-888 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

A routine electrocardiogram should not be used to determine the size of myocardial infarction in the rat

Bonilha, A. M. M., Saraiva, R. M., Kanashiro, R. M., Portes, L. A., Antonio, E. L. & Tucci, P. J. F., Apr 2005, In : Brazilian Journal of Medical and Biological Research. 38, 4, p. 615-619 5 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

BNip3 and signal-specific programmed death in the heart

Webster, K. A., Graham, R. M. & Bishopric, N. H., Jan 1 2005, In : Journal of Molecular and Cellular Cardiology. 38, 1, p. 35-45 11 p.

Research output: Contribution to journalReview article

76 Scopus citations

Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform

Venkatraman, G., Gomes, A. V., Kerrick, W. G. L. & Potter, J. D., May 6 2005, In : Journal of Biological Chemistry. 280, 18, p. 17584-17592 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Co-translational protein aggregation after transient cerebral ischemia

Liu, C. L., Ge, P., Zhang, F. & Hu, B. R., Sep 5 2005, In : Neuroscience. 134, 4, p. 1273-1284 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: A new intracellular target for matrix metalloproteinase-2

Sawicki, G., Leon, H., Sawicka, J., Sariahmetoglu, M., Schulze, C. J., Scott, P. G., Szczesna-Cordary, D. & Schulz, R., Jul 26 2005, In : Circulation. 112, 4, p. 544-552 9 p.

Research output: Contribution to journalArticle

206 Scopus citations

Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein

Cho, H. M., Rosenblatt, J. D., Kang, Y. S., Iruela-Arispe, M. L., Morrison, S. L., Penichet, M. L., Kwon, Y. G., Kim, T. W., Webster, K. A., Nechustan, H. & Shin, S. U., Jun 1 2005, In : Molecular cancer therapeutics. 4, 6, p. 956-967 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Expanding the range of free calcium regulation in biological solutions

Dweck, D., Reyes-Alfonso, A. & Potter, J. D., Dec 15 2005, In : Analytical Biochemistry. 347, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

58 Scopus citations

Expression of neuronal markers suggests heterogeneity of chick sympathoadrenal cells prior to invasion of the adrenal anlagen

Ernsberger, U., Esposito, L., Partimo, S., Huber, K., Franke, A., Bixby, J. L., Kalcheim, C. & Unsicker, K., Jan 1 2005, In : Cell and Tissue Research. 319, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers

Hernandez, O. M., Szczesna-Cordary, D., Knollmann, B. C., Miller, T., Bell, M., Zhao, J., Sirenko, S. G., Diaz, Z., Guzman, G., Xu, Y., Wang, Y., Kerrick, W. G. L. & Potter, J. D., Nov 4 2005, In : Journal of Biological Chemistry. 280, 44, p. 37183-37194 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis

Kanai, M., Kume, K., Miyahara, K., Sakai, K., Nakamura, K., Leonhard, K., Wiley, D. J., Verde, F., Toda, T. & Hirata, D., Sep 1 2005, In : EMBO Journal. 24, 17, p. 3012-3025 14 p.

Research output: Contribution to journalArticle

55 Scopus citations