Molecular and Cellular Pharmacology

Research Output

2008

Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer

Lyons, L. S., Rao, S., Balkan, W., Faysal, J., Maiorino, C. A. & Burnstein, K. L., Mar 1 2008, In : Molecular Endocrinology. 22, 3, p. 597-608 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: Interaction-restricted diffusion

Slepak, V. Z. & Hurley, J. B., Dec 1 2008, In : IUBMB life. 60, 1, p. 2-9 8 p.

Research output: Contribution to journalReview article

51 Scopus citations

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

Landstrom, A. P., Parvatiyar, M. S., Pinto, J. R., Marquardt, M. L., Bos, J. M., Tester, D. J., Ommen, S. R., Potter, J. D. & Ackerman, M. J., Aug 1 2008, In : Journal of Molecular and Cellular Cardiology. 45, 2, p. 281-288 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

MsrA protects cardiac myocytes against hypoxia/reoxygenation induced cell death

Prentice, H. M., Moench, I. A., Rickaway, Z. T., Dougherty, C. J., Webster, K. A. & Weissbach, H., Feb 15 2008, In : Biochemical and biophysical research communications. 366, 3, p. 775-778 4 p.

Research output: Contribution to journalArticle

45 Scopus citations

Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice

Baudenbacher, F., Schober, T., Pinto, J. R., Sidorov, V. Y., Hilliard, F., Solaro, R. J., Potter, J. D. & Knollmann, B. C., Dec 1 2008, In : Journal of Clinical Investigation. 118, 12, p. 3893-3903 11 p.

Research output: Contribution to journalArticle

158 Scopus citations

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

Zhai, R. G., Zhang, F., Hiesinger, P. R., Cao, Y., Haueter, C. M. & Bellen, H. J., Apr 17 2008, In : Nature. 452, 7189, p. 887-891 5 p.

Research output: Contribution to journalArticle

142 Scopus citations

Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats

Wu, W. M., Huang, F., Lee, Y., Buchwald, P. & Bodor, N., Mar 1 2008, In : Journal of Pharmacy and Pharmacology. 60, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gβ5 complexes in brain

Grabowska, D., Jayaraman, M., Kaltenbronn, K. M., Sandiford, S. L., Wang, Q., Jenkins, S., Slepak, V. Z., Smith, Y. & Blumer, K. J., Feb 19 2008, In : Neuroscience. 151, 4, p. 969-982 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Proteomics in Trypanosoma cruzi- Localization of novel proteins to various organelles

Ferella, M., Nilsson, D., Darban, H., Rodrigues, C., Bontempi, E. J., Docampo, R. & Andersson, B., Jul 1 2008, In : Proteomics. 8, 13, p. 2735-2749 15 p.

Research output: Contribution to journalArticle

52 Scopus citations

Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300

Wei, J. Q., Shehadeh, L. A., Mitrani, J. M., Pessanha, M., Slepak, T. I., Webster, K. A. & Bishopric, N. H., Aug 26 2008, In : Circulation. 118, 9, p. 934-946 13 p.

Research output: Contribution to journalArticle

79 Scopus citations

Retrometabolic drug design: Principles and recent developments

Bodor, N. & Buchwald, P., Aug 1 2008, In : Pure and Applied Chemistry. 80, 8, p. 1669-1682 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Robust hypoxia-selective regulation of a retinal pigment epithelium-specific adeno-associated virus vector

Dougherty, C. J., Smith, G. W., Dorey, C. K., Prentice, H. M., Webster, K. A. & Blanks, J. C., Mar 7 2008, In : Molecular vision. 14, p. 471-480 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle

Kato, H., Matsunaga, F., Miyazaki, S., Yin, L., D'Urso, G., Tanaka, K. & Murakami, Y., Apr 15 2008, In : Cell Cycle. 7, 8, p. 1083-1094 12 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Soft corticosteroids for local immunosuppression: Exploring the possibility for the use of loteprednol etabonate for islet transplantation

Bocca, N., Pileggi, A., Molano, R. D., Marzorati, S., Wu, W., Bodor, N., Ricordi, C. & Buchwald, P., Mar 1 2008, In : Pharmazie. 63, 3, p. 226-232 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Stereoisomers of N-substituted soft anticholinergics and their zwitterionic metabolite based on glycopyrrolate - Syntheses and pharmacological evaluations

Wu, W. M., Wu, J., Mori, N., Buchwald, P. & Bodor, N., Mar 1 2008, In : Pharmazie. 63, 3, p. 200-209 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Stress hyperglycemia and enhanced sensitivity to myocardial infarction

Webster, K. A., Feb 1 2008, In : Current Hypertension Reports. 10, 1, p. 78-84 7 p.

Research output: Contribution to journalReview article

17 Scopus citations

Structural studies on the chiral selector capacity of cyclodextrin derivatives.

Tokés, B., Ferencz, L., Buchwald, P., Donáth-Nagy, G., Vancea, S., Sánta, N. & Kis, E. L., Apr 24 2008, In : Journal of biochemical and biophysical methods. 70, 6, p. 1276-1282 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Thyroid-adrenergic interactions: Physiological and clinical implications

Silva, J. E. & Bianco, S. D. C., Feb 1 2008, In : Thyroid. 18, 2, p. 157-165 9 p.

Research output: Contribution to journalReview article

128 Scopus citations

Troponin and cardiomyopathy

Chang, A. N., Parvatiyar, M. S. & Potter, J. D., Apr 25 2008, In : Biochemical and biophysical research communications. 369, 1, p. 74-81 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Zinc potentiates neuronal nicotinic receptors by increasing burst duration

Hsiao, B., Mihalak, K. B., Magleby, K. L. & Luetje, C. W., Feb 1 2008, In : Journal of neurophysiology. 99, 2, p. 999-1007 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2007

A general bilinear model to describe growth or decline time profiles

Buchwald, P., Jan 1 2007, In : Mathematical Biosciences. 205, 1, p. 108-136 29 p.

Research output: Contribution to journalArticle

27 Scopus citations

A honey bee odorant receptor for the queen substance 9-oxo-2-decenoic acid

Wanner, K. W., Nichols, A. S., Walden, K. K. O., Brockmann, A., Luetje, C. W. & Robertson, H. M., Sep 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 36, p. 14383-14388 6 p.

Research output: Contribution to journalArticle

130 Scopus citations

Arrestin Mobilizes Signaling Proteins to the Cytoskeleton and Redirects their Activity

Hanson, S. M., Cleghorn, W. M., Francis, D. J., Vishnivetskiy, S. A., Raman, D., Song, X., Nair, K. S., Slepak, V. Z., Klug, C. S. & Gurevich, V. V., Apr 27 2007, In : Journal of molecular biology. 368, 2, p. 375-387 13 p.

Research output: Contribution to journalArticle

88 Scopus citations

Computer-aided retrometabolic drug design: Soft drugs

Buchwald, P., Jul 1 2007, In : Expert Opinion on Drug Discovery. 2, 7, p. 923-933 11 p.

Research output: Contribution to journalReview article

5 Scopus citations

Coping with cyclic oxygen availability: Evolutionary aspects

Flück, M., Webster, K. A., Graham, J., Giomi, F., Gerlach, F. & Schmitz, A., Oct 1 2007, In : Integrative and comparative biology. 47, 4, p. 524-531 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development

Wang, Y., Szczesna-Cordary, D., Craig, R., Diaz-Perez, Z., Guzman, G., Miller, T. & Potter, J. D., Jul 2007, In : FASEB Journal. 21, 9, p. 2205-2214 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

From critters to cancers: Bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

Hoogewijs, D., Terwilliger, N. B., Webster, K. A., Powell-Coffman, J. A., Tokishita, S., Yamagata, H., Hankeln, T., Burmester, T., Rytknen, K. T., Nikinmaa, M., Abele, D., Heise, K., Lucassen, M., Fandrey, J., Maxwell, P. H., Phlman, S. & Gorr, T. A., Oct 1 2007, In : Integrative and comparative biology. 47, 4, p. 552-577 26 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genetic elucidation of human hyperosmia to isovaleric acid

Menashe, I., Abaffy, T., Hasin, Y., Goshen, S., Yahalom, V., Luetje, C. W. & Lancet, D., Nov 1 2007, In : PLoS biology. 5, 11, p. 2462-2468 7 p.

Research output: Contribution to journalArticle

132 Scopus citations

Hypoxia: Life on the edge

Webster, K. A., Sep 1 2007, In : Antioxidants and Redox Signaling. 9, 9, p. 1303-1307 5 p.

Research output: Contribution to journalReview article

20 Scopus citations

Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy

Gomez, L. A., De Las Pozas, A., Reiner, T., Burnstein, K. & Perez-Stable, C., May 1 2007, In : Molecular cancer therapeutics. 6, 5, p. 1534-1543 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Intramolecular interaction between the DEP domain of RGS7 and the Gβ5 subunit

Narayanan, V., Sandiford, S. L., Wang, Q., Keren-Raifman, T., Levay, K. & Slepak, V. Z., Jun 12 2007, In : Biochemistry. 46, 23, p. 6859-6870 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model

Slepak, T. I., Tang, M., Slepak, V. Z. & Lai, K., Sep 1 2007, In : Molecular Genetics and Metabolism. 92, 1-2, p. 78-87 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Jun kinase delays caspase-9 activation by interaction with the apoptosome

Tran, T. H., Andreka, P., Rodrigues, C. O., Webster, K. A. & Bishopric, N. H., Jul 13 2007, In : Journal of Biological Chemistry. 282, 28, p. 20340-20350 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene

Bianco, S. D. C., Peng, J. B., Takanaga, H., Suzuki, Y., Crescenzi, A., Kos, C. H., Zhuang, L., Freeman, M. R., Gouveia, C. H. A., Wu, J., Luo, H., Mauro, T., Brown, E. M. & Hediger, M. A., Feb 1 2007, In : Journal of Bone and Mineral Research. 22, 2, p. 274-285 12 p.

Research output: Contribution to journalArticle

199 Scopus citations

Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields

Parrish, J. Z., Emoto, K., Kim, M. D. & Yuh, N. J., Aug 13 2007, In : Annual Review of Neuroscience. 30, p. 399-423 25 p.

Research output: Contribution to journalReview article

191 Scopus citations

Myocyte deficiency as a target in the treatment of cardiomyopathy

Rodrigues, C. O., Shehadeh, L. A., Webster, K. A. & Bishopric, N. H., Sep 1 2007, In : Progress in Pediatric Cardiology. 23, 1-2, p. 49-59 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Myosin essential light chain in health and disease

Hernandez, O. M., Jones, M., Guzman, G. & Szczesna-Cordary, D., Apr 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 4, p. H1643-H1654

Research output: Contribution to journalReview article

88 Scopus citations

Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients

Szczesna-Cordary, D., Jones, M., Moore, J. R., Watt, J., Kerrick, W. G. L., Xu, Y., Wang, Y., Wagg, C. & Lopaschuk, G. D., Dec 1 2007, In : FASEB Journal. 21, 14, p. 3974-3985 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Novel, cell-penetrating molecular transporters with flexible backbones and permanently charged side-chains

Bodor, N., Tóth-Sarudy, É., Holm, T., Pallagi, I., Vass, E., Buchwald, P. & Langel, Ü., Aug 1 2007, In : Journal of Pharmacy and Pharmacology. 59, 8, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Parvalbumin isoforms differentially accelerate cardiac myocyte relaxation kinetics in an animal model of diastolic dysfunction

Rodenbaugh, D. W., Wang, W., Davis, J., Edwards, T., Potter, J. D. & Metzger, J. M., Sep 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 3, p. H1705-H1713

Research output: Contribution to journalArticle

16 Scopus citations

PKC-α and TAK-1 are intermediates in the activation of c-Jun NH 2-terminal kinase by hypoxia-reoxygenation

Frazier, D. P., Wilson, A., Dougherty, C. J., Li, H., Bishopric, N. H. & Webster, K. A., Apr 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 4, p. H1675-H1684

Research output: Contribution to journalArticle

26 Scopus citations

Programmed death as a therapeutic target to reduce myocardial infarction

Webster, K. A., Sep 1 2007, In : Trends in Pharmacological Sciences. 28, 9, p. 492-499 8 p.

Research output: Contribution to journalReview article

41 Scopus citations

Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction

Saraiva, R. M., Kanashiro-Takeuchi, R. M., Antonio, E. L., Campos, O., Tucci, P. J. F. & Moisés, V. A., Nov 2007, In : Brazilian Journal of Medical and Biological Research. 40, 11, p. 1557-1565 9 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Regulation of Bnip3 death pathways by calcium, phosphorylation, and hypoxia-reoxygenation

Graham, R. M., Thompson, J. W., Wei, J., Bishopric, N. H. & Webster, K. A., Sep 1 2007, In : Antioxidants and Redox Signaling. 9, 9, p. 1309-1315 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p

Das, M., Wiley, D. J., Medina, S., Vincent, H. A., Larrea, M., Oriolo, A. & Verde, F., Jun 1 2007, In : Molecular biology of the cell. 18, 6, p. 2090-2101 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins

Rosenzweig, D. H., Saidas Nair, K., Wei, J., Wang, Q., Garwin, G., Saari, J. C., Chen, C. K., Smrcka, A. V., Swaroop, A., Lem, J., Hurley, J. B. & Slepak, V. Z., May 16 2007, In : Journal of Neuroscience. 27, 20, p. 5484-5494 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

Targeting of Neuropharmaceuticals by Chemical Delivery Systems

Bodor, N. & Buchwald, P., May 31 2007, Blood-Brain Barriers: From Ontogeny to Artificial Interfaces. Wiley-Blackwell, Vol. 1. p. 463-500 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression

Levay, K. & Slepak, V. Z., Sep 4 2007, In : Journal of Clinical Investigation. 117, 9, p. 2672-2683 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model

Layman, H., Spiga, M. G., Brooks, T., Pham, S., Webster, K. A. & Andreopoulos, F. M., Jun 1 2007, In : Biomaterials. 28, 16, p. 2646-2654 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

The molecular basis for ligand specificity in a mouse olfactory receptor: A network of functionally important residues

Abaffy, T., Malhotra, A. & Luetje, C. W., Jan 12 2007, In : Journal of Biological Chemistry. 282, 2, p. 1216-1224 9 p.

Research output: Contribution to journalArticle

78 Scopus citations