Molecular and Cellular Pharmacology

Research Output

2019

Novel Curcumin inspired bis-chalcone promotes endoplasmic reticulum stress and glioblastoma neurosphere cell death

Sansalone, L., Veliz, E. A., Myrthil, N. G., Stathias, V., Walters, W., Torrens, I. I., Schürer, S. C., Vanni, S., Leblanc, R. M. & Graham, R. M., Mar 2019, In : Cancers. 11, 3, 357.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

OSCI: Standardized stem cell ontology representation and use cases for stem cell investigation

He, Y., Duncan, W. D., Cooper, D. J., Hansen, J., Iyengar, R., Ong, E., Walker, K., Tibi, O., Smith, S., Serra, L. M., Zheng, J., Sarntivijai, S., Schürer, S., O'shea, K. S. & Diehl, A. D., Apr 25 2019, In : BMC Bioinformatics. 20, 180.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway

Yousefi, K., Irion, C. I., Takeuchi, L. M., Ding, W., Lambert, G., Eisenberg, T., Sukkar, S., Granzier, H. L., Methawasin, M., Lee, D. I., Hahn, V. S., Kass, D. A., Hatzistergos, K. E., Hare, J. M., Webster, K. A. & Shehadeh, L. A., Jun 4 2019, In : Journal of the American College of Cardiology. 73, 21, p. 2705-2718 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Parallel evaluation of two promising immunoisolation strategies for beta cell replacement: Conformal coating versus double alginate encapsulation

Toni, T. D., Stock, A. A., Safley, S. A., Weber, C., Alcazar, O., Buchwald, P. & Tomei, A., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Phosphomimetic-mediated in vitro rescue of hypertrophic cardiomyopathy linked to R58Q mutation in myosin regulatory light chain

Yadav, S., Kazmierczak, K., Liang, J., Sitbon, Y. H. & Szczesna-Cordary, D., Jan 2019, In : FEBS Journal. 286, 1, p. 151-168 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure

Hervera, A., Zhou, L., Palmisano, I., McLachlan, E., Kong, G., Hutson, T. H., Danzi, M. C., Lemmon, V. P., Bixby, J. L., Matamoros-Angles, A., Forsberg, K., De Virgiliis, F., Matheos, D. P., Kwapis, J., Wood, M. A., Puttagunta, R., del Río, J. A. & Di Giovanni, S., Jul 1 2019, In : EMBO Journal. 38, 13, e101032.

Research output: Contribution to journalArticle

8 Scopus citations

Progenitor/Stem Cell Delivery by Suprarenal Aorta Route in Acute Kidney Injury

Rangel, É. B., Gomes, S. A., Kanashiro-Takeuchi, R. & Hare, J. M., Nov 1 2019, In : Cell transplantation. 28, 11, p. 1390-1403 14 p.

Research output: Contribution to journalArticle

Open Access

Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis

Birnbaum, M. D., Zhao, N., Moorthy, B. T., Patel, D. M., Kryvenko, O. N., Heidman, L., Kumar, A., Morgan, W. M., Ban, Y., Reis, I. M., Chen, X., Gonzalgo, M. L., Jorda, M., Burnstein, K. L. & Zhang, F., Feb 7 2019, In : Oncogene. 38, 6, p. 838-851 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Research Techniques Made Simple: Molecular Docking in Dermatology - A Foray into In Silico Drug Discovery

Issa, N. T., Badiavas, E. V. & Schürer, S., Dec 2019, In : Journal of Investigative Dermatology. 139, 12, p. 2400-2408.e1

Research output: Contribution to journalShort survey

Open Access

Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence

Lukacs, M., Gilley, J., Zhu, Y., Orsomando, G., Angeletti, C., Liu, J., Yang, X., Park, J., Hopkin, R. J., Coleman, M. P., Zhai, R. G. & Stottmann, R. W., Oct 2019, In : Experimental neurology. 320, 112961.

Research output: Contribution to journalArticle

8 Scopus citations

Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain

Kazmierczak, K., Liang, J., Yuan, C. C., Yadav, S., Sitbon, Y. H., Walz, K., Ma, W., Irving, T. C., Cheah, J. X., Gomes, A. V. & Szczesna-Cordary, D., Mar 1 2019, In : FASEB Journal. 33, 3, p. 3152-3166 15 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy

Parvatiyar, M. S., Brownstein, A. J., Kanashiro-Takeuchi, R. M., Collado, J. R., Dieseldorff Jones, K. M., Gopal, J., Hammond, K. G., Marshall, J. L., Ferrel, A., Beedle, A. M., Chamberlain, J. S., Pinto, J. R. & Crosbie, R. H., Jun 6 2019, In : JCI Insight. 4, 11, e123855.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies

Zhu, Y., Liu, J., Park, J., Rai, P. & Zhai, R. G., Aug 2019, In : Pharmacology and Therapeutics. 200, p. 27-41 15 p.

Research output: Contribution to journalReview article

9 Scopus citations

Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents

Wang, X., Ren, Q. W., Liu, X. X., Yang, Y. T., Wang, B. H., Zhai, R., Qi, J. G., Tian, J. W., Wang, H. B. & Bi, Y., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 364-377 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM

Yadav, S., Yuan, C. C., Kazmierczak, K., Liang, J., Huang, W., Takeuchi, L. M., Kanashiro-Takeuchi, R. M. & Szczesna-Cordary, D., Jul 1 2019, In : Journal of Molecular Medicine. 97, 7, p. 1033-1047 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells

Bray, E. R., Yungher, B. J., Levay, K., Ribeiro, M., Dvoryanchikov, G., Ayupe, A. C., Thakor, K., Marks, V., Randolph, M., Danzi, M. C., Schmidt, T. M., Chaudhari, N., Lemmon, V. P., Hattar, S. & Park, K. K., Aug 21 2019, In : Neuron. 103, 4, p. 642-657.e7

Research output: Contribution to journalArticle

12 Scopus citations

Trading amino acids at the aphid–Buchnera symbiotic interface

Feng, H., Edwards, N., Anderson, C. M. H., Althaus, M., Duncan, R. P., Hsu, Y. C., Luetje, C. W., Price, D. R. G., Wilson, A. C. C. & Thwaites, D. T., Aug 6 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16003-16011 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit

Kepchia, D., Xu, P., Terryn, R., Castro, A., Schürer, S. C., Leal, W. S. & Luetje, C. W., Dec 1 2019, In : Scientific reports. 9, 1, 4055.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Alterations of tumor microenvironment by nitric oxide impedes castration-resistant prostate cancer growth

Arora, H., Panara, K., Kuchakulla, M., Kulandavelu, S., Burnstein, K. L., Schally, A. V., Hare, J. M. & Ramasamy, R., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. 11298-11303 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency

Birnbaum, M. D., Nemzow, L., Kumar, A., Gong, F. & Zhang, F., Aug 16 2018, In : Cell Chemical Biology. 25, 8, p. 1038-1049.e5

Research output: Contribution to journalArticle

1 Scopus citations

A testosterone metabolite 19-hydroxyandrostenedione induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olfactory receptor

Abaffy, T., Bain, J. R., Muehlbauer, M. J., Spasojevic, I., Lodha, S., Bruguera, E., O'Neal, S. K., Kim, S. Y. & Matsunami, H., May 28 2018, In : Frontiers in Oncology. 8, MAY, 162.

Research output: Contribution to journalArticle

7 Scopus citations

Can Chromatin Accessibility be Exploited for Axon Regeneration?

Danzi, M. C., O’Neill, N., Bixby, J. L. & Lemmon, V. P., Oct 2018, In : Developmental Neurobiology. 78, 10, p. 991-997 7 p.

Research output: Contribution to journalReview article

2 Scopus citations

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

9 Scopus citations

CEDAR: Semantic Web Technology to Support Open Science

Musen, M. A., Sansone, S. A., Cheung, K. H., Kleinstein, S. H., Crafts, M., Schürer, S. C. & Graybeal, J., Apr 23 2018, The Web Conference 2018 - Companion of the World Wide Web Conference, WWW 2018. Association for Computing Machinery, Inc, p. 427-428 2 p. (The Web Conference 2018 - Companion of the World Wide Web Conference, WWW 2018).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
1 Scopus citations

Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast

Isom, D. G., Page, S. C., Collins, L. B., Kapolka, N. J., Taghon, G. J. & Dohlman, H. G., Feb 16 2018, In : Journal of Biological Chemistry. 293, 7, p. 2318-2329 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: Integrated access to diverse large-scale cellular perturbation response data

Koleti, A., Terryn, R., Stathias, V., Chung, C., Cooper, D. J., Turner, J. P., VidoviÄ ‡, D., Forlin, M., Kelley, T. T., D'Urso, A., Allen, B. K., Torre, D., Jagodnik, K. M., Wang, L., Jenkins, S. L., Mader, C., Niu, W., Fazel, M., Mahi, N., Pilarczyk, M. & 9 others, Clark, N., Shamsaei, B., Meller, J., Vasiliauskas, J., Reichard, J., Medvedovic, M., Ma'Ayan, A., Pillai, A. & Schürer, S. C., Jan 1 2018, In : Nucleic acids research. 46, D1, p. D558-D566

Research output: Contribution to journalArticle

42 Scopus citations

Design, synthesis, and evaluation of novel immunomodulatory small molecules targeting the CD40–CD154 costimulatory protein-protein interaction

Bojadzic, D., Chen, J., Alcazar, O. & Buchwald, P., 2018, In : Molecules. 23, 5, 1153.

Research output: Contribution to journalArticle

3 Scopus citations

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schürer, S. C. & Ayad, N. G., Dec 1 2018, In : Nature communications. 9, 1, 5315.

Research output: Contribution to journalArticle

14 Scopus citations

Drug repositioning in glioblastoma: A pathway perspective

Tan, S. K., Jermakowicz, A., Mookhtiar, A. K., Nemeroff, C. B., Schürer, S. C. & Ayad, N. G., Mar 16 2018, In : Frontiers in Pharmacology. 9, MAR, 218.

Research output: Contribution to journalReview article

22 Scopus citations

Endothelial cells from different anatomical origin have distinct responses during SNAIL/TGF-β2-mediated endothelial-mesenchymal transition

Pinto, M. T., Melo, F. U. F., Malta, T. M., Rodrigues, E. S., Plaça, J. R., Silva, W. A., Panepucci, R. A., Covas, D. T., Rodrigues, C. D. O. & Kashima, S., 2018, In : American Journal of Translational Research. 10, 12, p. 4065-4081 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

Erratum: Unexplored therapeutic opportunities in the human genome (Nature reviews. Drug discovery (2018) 17 5 (317-332))

Oprea, T. I., Bologa, C. G., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., Gomez, S. M., Guha, R., Hersey, A., Holmes, J., Jadhav, A., Jensen, L. J., Johnson, G. L., Karlson, A., Leach, A. R., Ma'ayan, A., Malovannaya, A., Mani, S., Mathias, S. L., McManus, M. T. & 21 others, Meehan, T. F., von Mering, C., Muthas, D., Nguyen, D. T., Overington, J. P., Papadatos, G., Qin, J., Reich, C., Roth, B. L., Schürer, S. C., Simeonov, A., Sklar, L. A., Southall, N., Tomita, S., Tudose, I., Ursu, O., Vidovic, D., Waller, A., Westergaard, D., Yang, J. J. & Zahoránszky-Köhalmi, G., May 1 2018, In : Nature reviews. Drug discovery. 17, 5, p. 377 1 p.

Research output: Contribution to journalComment/debate

Open Access
10 Scopus citations

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216) (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Nov 12 2018, In : Cancer Cell. 34, 5, p. 868 1 p.

Research output: Contribution to journalComment/debate

Erratum: Publisher Correction: Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome (Nature communications (2017) 8 1 (1257))

Li, C., Brazill, J. M., Liu, S., Bello, C., Zhu, Y., Morimoto, M., Cascio, L., Pauly, R., Diaz-Perez, Z., Malicdan, M. C. V., Wang, H., Boccuto, L., Schwartz, C. E., Gahl, W. A., Boerkoel, C. F. & Zhai, R. G., Jan 18 2018, In : Nature communications. 9, 1, p. 337 1 p., 337.

Research output: Contribution to journalComment/debate

Far away from the lamppost

Oprea, T. I., Jan, L., Johnson, G. L., Roth, B. L., Ma’ayan, A., Schürer, S., Shoichet, B. K., Sklar, L. A. & McManus, M. T., Dec 2018, In : PLoS biology. 16, 12, e3000067.

Research output: Contribution to journalArticle

4 Scopus citations

Glucose-stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets

Buchwald, P., Tamayo-Garcia, A., Manzoli, V., Tomei, A. A. & Stabler, C. L., Jan 2018, In : Biotechnology and Bioengineering. 115, 1, p. 232-245 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo

Yang, Y., Guan, D., Lei, L., Lu, J., Liu, J. Q., Yang, G., Yan, C., Zhai, R., Tian, J., Bi, Y., Fu, F. & Wang, H., Feb 15 2018, In : Toxicology and Applied Pharmacology. 341, p. 98-105 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

High content screening of mammalian primary cortical neurons

Motti, D., Blackmore, M., Bixby, J. & Lemmon, V., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1683. p. 293-304 12 p. (Methods in Molecular Biology; vol. 1683).

Research output: Chapter in Book/Report/Conference proceedingChapter

Identification of an oncogenic network with prognostic and therapeutic value in prostate cancer

Magani, F., Bray, E. R., Martinez, M. J., Zhao, N., Copello, V. A., Heidman, L., Peacock, S. O., Wiley, D. J., D'Urso, G. & Burnstein, K. L., Aug 2018, In : Molecular Systems Biology. 14, 8, e8202.

Research output: Contribution to journalArticle

7 Scopus citations

Kidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria

Rangel, E. B., Gomes, S. A., Kanashiro-Takeuchi, R., Saltzman, R. G., Wei, C., Ruiz, P., Reiser, J. & Hare, J. M., Dec 1 2018, In : Scientific reports. 8, 1, 14723.

Research output: Contribution to journalArticle

6 Scopus citations

Mutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2

Lassuthova, P., Rebelo, A. P., Ravenscroft, G., Lamont, P. J., Davis, M. R., Manganelli, F., Feely, S. M., Bacon, C., Brožková, D. Š., Haberlova, J., Mazanec, R., Tao, F., Saghira, C., Abreu, L., Courel, S., Powell, E., Buglo, E., Bis, D. M., Baxter, M. F., Ong, R. W. & 14 others, Marns, L., Lee, Y. C., Bai, Y., Isom, D. G., Barro-Soria, R., Chung, K. W., Scherer, S. S., Larsson, H. P., Laing, N. G., Choi, B. O., Seeman, P., Shy, M. E., Santoro, L. & Zuchner, S., Mar 1 2018, In : American journal of human genetics. 102, 3, p. 505-514 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

Zhu, J., Lu, K., Zhang, N., Zhao, Y., Ma, Q., Shen, J., Lin, Y., Xiang, P., Tang, Y., Hu, X., Chen, J., Zhu, W., Webster, K. A., Wang, J. & Yu, H., Nov 17 2018, In : Artificial Cells, Nanomedicine and Biotechnology. 46, 8, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy

Brazill, J. M., Cruz, B., Zhu, Y. & Zhai, R. G., Jun 2018, In : DMM Disease Models and Mechanisms. 11, 6, dmm.032938.

Research output: Contribution to journalArticle

7 Scopus citations
1 Scopus citations

Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

Dvoriantchikova, G., Pronin, A., Kurtenbach, S., Toychiev, A., Chou, T. H., Yee, C. W., Prindeville, B., Tayou, J., Porciatti, V., Sagdullaev, B. T., Slepak, V. Z. & Shestopalov, V. I., Dec 1 2018, In : Scientific reports. 8, 1, 5797.

Research output: Contribution to journalArticle

4 Scopus citations
2 Scopus citations

Polypharmacology or promiscuity? Structural interactions of resveratrol with its bandwagon of targets

Saqib, U., Kelley, T. T., Panguluri, S. K., Liu, D., Savai, R., Baig, M. S. & Schürer, S. C., Oct 24 2018, In : Frontiers in Pharmacology. 9, OCT, 1201.

Research output: Contribution to journalArticle

11 Scopus citations

Publisher Correction: Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Hervera, A., de Virgiliis, F., Palmisano, I., Zhou, L., Tantardini, E., Kong, G., Hutson, T., Danzi, M. C., Perry, R. B. T., Santos, C. X. C., Kapustin, A. N., Fleck, R. A., Del Río, J. A., Carroll, T., Lemmon, V., Bixby, J., Shah, A. M., Fainzilber, M. & Di Giovanni, S., Mar 8 2018, (Accepted/In press) In : Nature Cell Biology. 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Quantitative cell biology of neurodegeneration in drosophila through unbiased analysis of fluorescently tagged proteins using imageJ

Brazill, J. M., Zhu, Y., Li, C. & Zhai, R. G., Aug 3 2018, In : Journal of Visualized Experiments. 2018, 138, e58041.

Research output: Contribution to journalArticle

3 Scopus citations

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Hervera, A., De Virgiliis, F., Palmisano, I., Zhou, L., Tantardini, E., Kong, G., Hutson, T., Danzi, M. C., Perry, R. B. T., Santos, C. X. C., Kapustin, A. N., Fleck, R. A., Del Río, J. A., Carroll, T., Lemmon, V., Bixby, J., Shah, A. M., Fainzilber, M. & Di Giovanni, S., Mar 1 2018, In : Nature Cell Biology. 20, 3, p. 307-319 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Regulation of vascular calcification by growth hormone-releasing hormone and its agonists

Shen, J., Zhang, N., Lin, Y. N., Xiang, P. P., Liu, X. B., Shan, P. F., Hu, X. Y., Zhu, W., Tang, Y. L., Webster, K. A., Cai, R., Schally, A. V., Wang, J. & Yu, H., May 2018, In : Circulation research. 122, 10, p. 1395-1408 14 p.

Research output: Contribution to journalArticle

9 Scopus citations