Molecular and Cellular Pharmacology

Research Output

2020

A Collagen Based Cryogel Bioscaffold that Generates Oxygen for Islet Transplantation

Razavi, M., Primavera, R., Kevadiya, B. D., Wang, J., Buchwald, P. & Thakor, A. S., Apr 1 2020, In : Advanced Functional Materials. 30, 15, 1902463.

Research output: Contribution to journalArticle

Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes

Inherited Neuropathy Consortium, May 1 2020, In : Nature genetics. 52, 5, p. 473-481 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

CRISPR-addressable yeast strains with applications in human G protein-coupled receptor profiling and synthetic biology

Rowe, J. B., Taghon, G. J., Kapolka, N. J., Morgan, W. M. & Isom, D. G., Jun 12 2020, In : The Journal of biological chemistry. 295, 24, p. 8262-8271 10 p.

Research output: Contribution to journalArticle

Open Access

Dcyfir: A high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery

Kapolka, N. J., Taghon, G. J., Rowe, J. B., Morgan, W. M., Enten, J. F., Lambert, N. A. & Isom, D. G., Jun 9 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 23, p. 13117-13126 10 p.

Research output: Contribution to journalArticle

Open Access

FAIR SCI Ahead: The Evolution of the Open Data Commons for Pre-Clinical Spinal Cord Injury Research

Fouad, K., Bixby, J. L., Callahan, A., Grethe, J. S., Jakeman, L. B., Lemmon, V. P., Magnuson, D. S. K., Martone, M. E., Nielson, J. L., Schwab, J. M., Taylor-Burds, C., Tetzlaff, W., Torres-Espin, A. & Ferguson, A. R., Mar 15 2020, In : Journal of neurotrauma. 37, 6, p. 831-838 8 p.

Research output: Contribution to journalReview article

3 Scopus citations

Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library

Gibbons, G. S., Chakraborty, A., Grigsby, S. M., Umeano, A. C., Liao, C., Moukha-Chafiq, O., Pathak, V., Mathew, B., Lee, Y. T., Dou, Y., Schürer, S. C., Reynolds, R. C., Snowden, T. S. & Nikolovska-Coleska, Z., Mar 1 2020, In : European Journal of Medicinal Chemistry. 189, 112023.

Research output: Contribution to journalArticle

LINCS Data Portal 2.0: next generation access point for perturbation-response signatures

Stathias, V., Turner, J., Koleti, A., Vidovic, D., Cooper, D., Fazel-Najafabadi, M., Pilarczyk, M., Terryn, R., Chung, C., Umeano, A., Clarke, D. J. B., Lachmann, A., Evangelista, J. E., Ma'ayan, A., Medvedovic, M. & Schürer, S. C., Jan 8 2020, In : Nucleic acids research. 48, D1, p. D431-D439

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Longitudinal proteomics analysis in the immediate microenvironment of islet allografts during progression of rejection

Alcazar, O., Hernandez, L. F., Nakayasu, E. S., Piehowski, P. D., Ansong, C., Abdulreda, M. H. & Buchwald, P., Jul 15 2020, In : Journal of Proteomics. 223, 103826.

Research output: Contribution to journalArticle

Machine and deep learning approaches for cancer drug repurposing

Issa, N. T., Stathias, V., Schürer, S. & Dakshanamurthy, S., Jan 1 2020, (Accepted/In press) In : Seminars in Cancer Biology.

Research output: Contribution to journalReview article

5 Scopus citations

Nicotinamide mononucleotide adenylyl transferase uses its NAD+ substrate-binding site to chaperone phosphorylated TAU

Ma, X., Zhu, Y., Lu, J., Xie, J., Li, C., Shin, W. S., Qiang, J., Liu, J., Dou, S., Xiao, Y., Wang, C., Jia, C., Long, H., Yang, J., Fang, Y., Jiang, L., Zhang, Y., Zhang, S., Zhai, R. G., Liu, C. & 1 others, Li, D., Apr 2020, In : eLife. 9, e51859.

Research output: Contribution to journalArticle

Open Access

Nuclear Osteopontin Is a Marker of Advanced Heart Failure and Cardiac Allograft Vasculopathy: Evidence From Transplant and Retransplant Hearts

Irion, C. I., Dunkley, J. C., John-Williams, K., Condor Capcha, J. M., Shehadeh, S. A., Pinto, A., Loebe, M., Webster, K. A., Brozzi, N. A. & Shehadeh, L. A., Aug 13 2020, In : Frontiers in Physiology. 11, 928.

Research output: Contribution to journalArticle

Open Access
Open Access

Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants

Batlahally, S., Franklin, A., Damianos, A., Huang, J., Chen, P., Sharma, M., Duara, J., Keerthy, D., Zambrano, R., Shehadeh, L. A., Martinez, E. C., DeFreitas, M. J., Kulandavelu, S., Abitbol, C. L., Freundlich, M., Kanashiro-Takeuchi, R. M., Schmidt, A., Benny, M., Wu, S., Mestan, K. K. & 1 others, Young, K. C., Dec 1 2020, In : Scientific reports. 10, 1, 12368.

Research output: Contribution to journalArticle

Open Access

The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- And extracellular signal-stimulated insulin secretion

Wang, Q., Henry, T. A. N., Pronin, A. N., Jang, G. F., Lubaczeuski, C., Crabb, J. W., Bernal-Mizrachi, E. & Slepak, V. Z., May 22 2020, In : Journal of Biological Chemistry. 295, 21, p. 7213-7223 11 p.

Research output: Contribution to journalArticle

Open Access
2019

A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells

Qadir, M. M. F., Álvarez-Cubela, S., Belle, K., Sapir, T., Messaggio, F., Johnson, K. B., Umland, O., Hardin, D., Klein, D., Pérez-Álvarez, I., Sadiq, F., Alcázar, O., Inverardi, L. A., Ricordi, C., Buchwald, P., Fraker, C. A., Pastori, R. L. & Domínguez-Bendala, J., Mar 5 2019, In : Stem Cell Reports. 12, 3, p. 611-623 13 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

A Gene Family-led Meta-Analysis of Drug-Target Interactions

Cheng, Q., Mehta, S. & Schuerer, S. C., Jan 21 2019, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. Schmidt, H., Griol, D., Wang, H., Baumbach, J., Zheng, H., Callejas, Z., Hu, X., Dickerson, J. & Zhang, L. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 1618-1623 6 p. 8621087. (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Allele-Specific Silencing Ameliorates Restrictive Cardiomyopathy Attributable to a Human Myosin Regulatory Light Chain Mutation

Zaleta-Rivera, K., Dainis, A., Ribeiro, A. J. S., Cordero, P., Rubio, G., Shang, C., Liu, J., Finsterbach, T., Parikh, V. N., Sutton, S., Seo, K., Sinha, N., Jain, N., Huang, Y., Hajjar, R. J., Kay, M. A., Szczesna-Cordary, D., Pruitt, B. L., Wheeler, M. T. & Ashley, E. A., Aug 27 2019, In : Circulation. 140, 9, p. 765-778 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access
5 Scopus citations

Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer

Zhao, N., Peacock, S. O., Lo, C. H., Heidman, L. M., Rice, M. A., Fahrenholtz, C. D., Greene, A. M., Magani, F., Copello, V. A., Martinez, M. J., Zhang, Y., Daaka, Y., Lynch, C. C. & Burnstein, K. L., Jan 1 2019, In : Science Translational Medicine. 11, 498, eaaw4636.

Research output: Contribution to journalArticle

2 Scopus citations

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Hutson, T. H., Kathe, C., Palmisano, I., Bartholdi, K., Hervera, A., De Virgiliis, F., McLachlan, E., Zhou, L., Kong, G., Barraud, Q., Danzi, M. C., Medrano-Fernandez, A., Lopez-Atalaya, J. P., Boutillier, A. L., Sinha, S. H., Singh, A. K., Chaturbedy, P., Moon, L. D. F., Kundu, T. K., Bixby, J. L. & 4 others, Lemmon, V. P., Barco, A., Courtine, G. & Giovanni, S. D., Apr 10 2019, In : Science Translational Medicine. 11, 487, eaaw2064.

Research output: Contribution to journalArticle

21 Scopus citations

CD40-targeting KGYY15 peptides do not efficiently block the CD40–CD40L interaction

Bojadzic, D. & Buchwald, P., Nov 1 2019, In : Diabetologia. 62, 11, p. 2158-2160 3 p.

Research output: Contribution to journalLetter

Open Access
4 Scopus citations

Conserved NDR/LATS kinase controls RAS GTPase activity to regulate cell growth and chronological lifespan

Chen, C., Pino, M. R., Haller, P. R. & Verde, F., Sep 15 2019, In : Molecular biology of the cell. 30, 20, p. 2598-2616 19 p.

Research output: Contribution to journalArticle

Open Access

Correction to: In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice (Diabetologia, (2019), 62, 7, (1237-1250), 10.1007/s00125-019-4879-0)

Abdulreda, M. H., Molano, R., Faleo, G., Lopez-Cabezas, M., Shishido, A., Ulissi, U., Fotino, C., Hernandez, L. F., Tschiggfrie, A., Aldrich, V. R., Tamayo-Garcia, A., Bayer, A. S., Ricordi, C., Caicedo, A., Buchwald, P., Pileggi, A. & Berggren, P-O. Y., Jan 1 2019, In : Diabetologia.

Research output: Contribution to journalComment/debate

1 Scopus citations

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity

Ni, J., Guo, M., Cao, Y., Lei, L., Liu, K., Wang, B., Lu, F., Zhai, R., Gao, X., Yan, C., Wang, H. & Bi, Y., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 122-131 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

DrugCentral 2018: An update

Ursu, O., Holmes, J., Bologa, C. G., Yang, J. J., Mathias, S. L., Stathias, V., Nguyen, D. T., Schürer, S. & Oprea, T., Jan 8 2019, In : Nucleic acids research. 47, D1, p. D963-D970

Research output: Contribution to journalArticle

24 Scopus citations

Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss

Li, C., Bademci, G., Subasioglu, A., Diaz-Horta, O., Zhu, Y., Liu, J., Mitchell, T. G., Abad, C., Seyhan, S., Duman, D., Cengiz, F. B., Tokgoz-Yilmaz, S., Blanton, S. H., Farooq, A., Walz, K., Grace Zhai, R. & Tekin, M., Jan 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1347-1352 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Effects of rotigotine and rotigotine extended-release microsphere therapy on myocardial ischemic injury in mice

Lv, H., Yu, F., Sha, C., Huang, Y., Lu, Y., Zhang, L., Zhai, R., Wang, T. & Fu, F., Jun 15 2019, In : European Journal of Pharmaceutical Sciences. 134, p. 1-6 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Efficient proximal gradient algorithm for inference of differential gene networks

Wang, C., Gao, F., Giannakis, G. B., D'Urso, G. & Cai, X., May 2 2019, In : BMC Bioinformatics. 20, 1, 224.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Epigenomic signatures underpin the axonal regenerative ability of dorsal root ganglia sensory neurons

Palmisano, I., Danzi, M. C., Hutson, T. H., Zhou, L., McLachlan, E., Serger, E., Shkura, K., Srivastava, P. K., Hervera, A., Neill, N. O., Liu, T., Dhrif, H., Wang, Z., Kubat, M., Wuchty, S., Merkenschlager, M., Levi, L., Elliott, E., Bixby, J. L., Lemmon, V. P. & 1 others, Di Giovanni, S., Nov 1 2019, In : Nature Neuroscience. 22, 11, p. 1913-1924 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216), (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., Jermakowicz, A. M., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D. G., Watts, J., Vega, F. & Nimer, S. D., Jan 14 2019, In : Cancer Cell. 35, 1, p. 156 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

FAIRshake: Toolkit to Evaluate the FAIRness of Research Digital Resources

Clarke, D. J. B., Wang, L., Jones, A., Wojciechowicz, M. L., Torre, D., Jagodnik, K. M., Jenkins, S. L., McQuilton, P., Flamholz, Z., Silverstein, M. C., Schilder, B. M., Robasky, K., Castillo, C., Idaszak, R., Ahalt, S. C., Williams, J., Schurer, S., Cooper, D. J., de Miranda Azevedo, R., Klenk, J. A. & 14 others, Haendel, M. A., Nedzel, J., Avillach, P., Shimoyama, M. E., Harris, R. M., Gamble, M., Poten, R., Charbonneau, A. L., Larkin, J., Brown, C. T., Bonazzi, V. R., Dumontier, M. J., Sansone, S. A. & Ma'ayan, A., Nov 27 2019, In : Cell Systems. 9, 5, p. 417-421 5 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Feasibility of localized metabolomics in the study of pancreatic islets and diabetes

Alcazar, O., Hernandez, L. F., Tschiggfrie, A., Muehlbauer, M. J., Bain, J. R., Buchwald, P. & Abdulreda, M. H., Oct 2019, In : Metabolites. 9, 10, 207.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2 Scopus citations

How to develop a drug target ontology: KNowledge acquisition and representation methodology (KNARM)

Küçük McGinty, H., Visser, U. & Schürer, S., 2019, Methods in Molecular Biology. Humana Press Inc., p. 49-69 21 p. (Methods in Molecular Biology; vol. 1939).

Research output: Chapter in Book/Report/Conference proceedingChapter

Identification of suppressor of Clathrin deficiency-1 (SCD1) and its connection to Clathrin-mediated endocytosis in Saccharomyces cerevisiae

Moorthy, B. T., Sharma, A., Boettner, D. R., Wilson, T. E. & Lemmon, S. K., Mar 1 2019, In : G3: Genes, Genomes, Genetics. 9, 3, p. 867-877 11 p.

Research output: Contribution to journalArticle

Open Access
Open Access
3 Scopus citations

Inflammasome activation induces pyroptosis in the retina exposed to ocular hypertension injury

Pronin, A., Pham, D., An, W., Dvoriantchikova, G., Reshetnikova, G., Qiao, J., Kozhekbaeva, Z., Reiser, A. E., Slepak, V. Z. & Shestopalov, V. I., Feb 12 2019, In : Frontiers in Molecular Neuroscience. 12, 36.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing

Kumar, A., Birnbaum, M. D., Moorthy, B. T., Singh, J., Palovcak, A., Patel, D. M. & Zhang, F., Jul 24 2019, In : BMC genomics. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice

Abdulreda, M. H., Molano, R. D., Faleo, G., Lopez-Cabezas, M., Shishido, A., Ulissi, U., Fotino, C., Hernandez, L. F., Tschiggfrie, A., Aldrich, V. R., Tamayo-Garcia, A., Bayer, A. S., Ricordi, C., Caicedo, A., Buchwald, P., Pileggi, A. & Berggren, P. O., Jul 1 2019, In : Diabetologia. 62, 7, p. 1237-1250 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Micro- and Macrovascular Complications in Diabetes Mellitus: Preclinical and Clinical Studies

Rangel, É. B., Rodrigues, C. O. & De Sá, J. R., 2019, In : Journal of Diabetes Research. 2019, 2161085.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

MicroRNA-25 protects smooth muscle cells against corticosterone-induced apoptosis

Zhang, B., Zhang, G., Wei, T., Yang, Z., Tan, W., Mo, Z., Liu, J., Li, D., Wei, Y., Zhang, L., Webster, K. A. & Wei, J., 2019, In : Oxidative Medicine and Cellular Longevity. 2019, 2691514.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

MicroRNA-92a regulates the expression of aphid bacteriocyte-specific secreted protein 1

Feng, H., Park, J. S., Zhai, R. G. & Wilson, A. C. C., Sep 30 2019, In : BMC Research Notes. 12, 1, 638.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

MicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing

Park, J., Zhu, Y., Tao, X., Brazill, J. M., Li, C., Wuchty, S. & Zhai, R. G., Sep 27 2019, In : iScience. 19, p. 1048-1064 17 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Neuronal nitric oxide synthase (nNOS) splice variant function: Insights into nitric oxide signaling from skeletal muscle

Balke, J. E., Zhang, L. & Percival, J. M., Jan 1 2019, In : Nitric Oxide - Biology and Chemistry. 82, p. 35-47 13 p.

Research output: Contribution to journalReview article

6 Scopus citations

Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity

Zhu, Y., Li, C., Tao, X., Brazill, J. M., Park, J., Diaz-Perez, Z. & Grace Zhai, R., Sep 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 19165-19175 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Novel Curcumin inspired bis-chalcone promotes endoplasmic reticulum stress and glioblastoma neurosphere cell death

Sansalone, L., Veliz, E. A., Myrthil, N. G., Stathias, V., Walters, W., Torrens, I. I., Schürer, S. C., Vanni, S., Leblanc, R. M. & Graham, R. M., Mar 2019, In : Cancers. 11, 3, 357.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations