Molecular and Cellular Pharmacology

Research Output

2019

A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells

Qadir, M. M. F., Álvarez-Cubela, S., Belle, K., Sapir, T., Messaggio, F., Johnson, K. B., Umland, O., Hardin, D., Klein, D., Pérez-Álvarez, I., Sadiq, F., Alcázar, O., Inverardi, L. A., Ricordi, C., Buchwald, P., Fraker, C. A., Pastori, R. L. & Domínguez-Bendala, J., Mar 5 2019, In : Stem Cell Reports. 12, 3, p. 611-623 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A Gene Family-led Meta-Analysis of Drug-Target Interactions

Cheng, Q., Mehta, S. & Schuerer, S. C., Jan 21 2019, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. Schmidt, H., Griol, D., Wang, H., Baumbach, J., Zheng, H., Callejas, Z., Hu, X., Dickerson, J. & Zhang, L. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 1618-1623 6 p. 8621087. (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
2 Scopus citations

Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer

Zhao, N., Peacock, S. O., Lo, C. H., Heidman, L. M., Rice, M. A., Fahrenholtz, C. D., Greene, A. M., Magani, F., Copello, V. A., Martinez, M. J., Zhang, Y., Daaka, Y., Lynch, C. C. & Burnstein, K. L., Jan 1 2019, In : Science Translational Medicine. 11, 498, eaaw4636.

Research output: Contribution to journalArticle

2 Scopus citations

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Hutson, T. H., Kathe, C., Palmisano, I., Bartholdi, K., Hervera, A., De Virgiliis, F., McLachlan, E., Zhou, L., Kong, G., Barraud, Q., Danzi, M. C., Medrano-Fernandez, A., Lopez-Atalaya, J. P., Boutillier, A. L., Sinha, S. H., Singh, A. K., Chaturbedy, P., Moon, L. D. F., Kundu, T. K., Bixby, J. & 4 others, Lemmon, V., Barco, A., Courtine, G. & Giovanni, S. D., Apr 10 2019, In : Science Translational Medicine. 11, 487, eaaw2064.

Research output: Contribution to journalArticle

10 Scopus citations

CD40-targeting KGYY15 peptides do not efficiently block the CD40–CD40L interaction

Bojadzic, D. & Buchwald, P., Jan 1 2019, (Accepted/In press) In : Diabetologia.

Research output: Contribution to journalLetter

Open Access

Correction to: In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice (Diabetologia, (2019), 62, 7, (1237-1250), 10.1007/s00125-019-4879-0)

Abdulreda, M. H., Molano, R. D., Faleo, G., Lopez-Cabezas, M., Shishido, A., Ulissi, U., Fotino, C., Hernandez, L. F., Tschiggfrie, A., Aldrich, V. R., Tamayo-Garcia, A., Bayer, A. S., Ricordi, C., Caicedo, A., Buchwald, P., Pileggi, A. & Berggren, P. O., Jan 1 2019, In : Diabetologia.

Research output: Contribution to journalComment/debate

DrugCentral 2018: an update

Ursu, O., Holmes, J., Bologa, C. G., Yang, J. J., Mathias, S. L., Stathias, V., Nguyen, D. T., Schuerer, S. C. & Oprea, T., Jan 8 2019, In : Nucleic Acids Research. 47, D1, p. D963-D970

Research output: Contribution to journalArticle

9 Scopus citations

Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss

Li, C., Bademci, G., Subasioglu, A., Diaz-Horta, O., Zhu, Y., Liu, J., Mitchell, T. G., Abad, C., Seyhan, S., Duman, D., Cengiz, F. B., Tokgoz-Yilmaz, S., Blanton, S. H., Farooq, A., Walz, K., Zhai, R. G. & Tekin, M., Jan 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1347-1352 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Efficient proximal gradient algorithm for inference of differential gene networks

Wang, C., Gao, F., Giannakis, G. B., D'urso, G. & Cai, X., May 2 2019, In : BMC Bioinformatics. 20, 1, 224.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216), (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., Jermakowicz, A. M., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D. G., Watts, J., Vega, F. & Nimer, S. D., Jan 14 2019, In : Cancer Cell. 35, 1, 1 p.

Research output: Contribution to journalComment/debate

Feasibility of localized metabolomics in the study of pancreatic islets and diabetes

Alcazar, O., Hernandez, L. F., Tschiggfrie, A., Muehlbauer, M. J., Bain, J. R., Buchwald, P. & Abdulreda, M. H., Oct 2019, In : Metabolites. 9, 10, 207.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

How to develop a drug target ontology: KNowledge acquisition and representation methodology (KNARM)

Küçük McGinty, H., Visser, U. E. & Schuerer, S. C., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 49-69 21 p. (Methods in Molecular Biology; vol. 1939).

Research output: Chapter in Book/Report/Conference proceedingChapter

Identification of suppressor of Clathrin deficiency-1 (SCD1) and its connection to Clathrin-mediated endocytosis in Saccharomyces cerevisiae

Moorthy, B. T., Sharma, A., Boettner, D. R., Wilson, T. E. & Lemmon, S., Mar 1 2019, In : G3: Genes, Genomes, Genetics. 9, 3, p. 867-877 11 p.

Research output: Contribution to journalArticle

Open Access
Open Access
1 Scopus citations

Inflammasome activation induces pyroptosis in the retina exposed to ocular hypertension injury

Pronin, A., Pham, D., An, W., Dvoriantchikova, G., Reshetnikova, G., Qiao, J., Kozhekbaeva, Z., Reiser, A. E., Slepak, V. Z. & Shestopalov, V. I., Feb 12 2019, In : Frontiers in Molecular Neuroscience. 12, 36.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing

Kumar, A., Birnbaum, M. D., Moorthy, B. T., Singh, J., Palovcak, A., Patel, D. M. & Zhang, F., Jul 24 2019, In : BMC genomics. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice

Abdulreda, M. H., Molano, R. D., Faleo, G., Lopez-Cabezas, M., Shishido, A., Ulissi, U., Fotino, C., Hernandez, L. F., Tschiggfrie, A., Aldrich, V. R., Tamayo-Garcia, A., Bayer, A. L., Ricordi, C., Caicedo-Vierkant, D. A., Buchwald, P., Pileggi, A. & Berggren, P. O., Jan 1 2019, In : Diabetologia.

Research output: Contribution to journalArticle

1 Scopus citations

Neuronal nitric oxide synthase (nNOS) splice variant function: Insights into nitric oxide signaling from skeletal muscle

Balke, J. E., Zhang, L. & Percival, J. M., Jan 1 2019, In : Nitric Oxide - Biology and Chemistry. 82, p. 35-47 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Novel Curcumin inspired bis-chalcone promotes endoplasmic reticulum stress and glioblastoma neurosphere cell death

Sansalone, L., Veliz, E. A., Myrthil, N. G., Stathias, V., Walters, W., Torrens, I. I., Schürer, S. C., Vanni, S., Leblanc, R. M. & Graham, R. M., Mar 1 2019, In : Cancers. 11, 3, 357.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

OSCI: Standardized stem cell ontology representation and use cases for stem cell investigation

He, Y., Duncan, W. D., Cooper, D. J., Hansen, J., Iyengar, R., Ong, E., Walker, K., Tibi, O., Smith, S., Serra, L. M., Zheng, J., Sarntivijai, S., Schuerer, S. C., O'shea, K. S. & Diehl, A. D., Apr 25 2019, In : BMC Bioinformatics. 20, 180.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Parallel evaluation of two promising immunoisolation strategies for beta cell replacement: Conformal coating versus double alginate encapsulation

Toni, T. D., Stock, A. A., Safley, S. A., Weber, C., Alcazar, O., Buchwald, P. & Tomei, A., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Progenitor/Stem Cell Delivery by Suprarenal Aorta Route in Acute Kidney Injury

Rangel, É. B., Gomes, S. A., Kanashiro-Takeuchi, R. & Hare, J. M., Nov 1 2019, In : Cell Transplantation. 28, 11, p. 1390-1403 14 p.

Research output: Contribution to journalArticle

Open Access

Research Techniques Made Simple: Molecular Docking in Dermatology - A Foray into In Silico Drug Discovery

Issa, N. T., Badiavas, E. V. & Schürer, S., Dec 2019, In : Journal of Investigative Dermatology. 139, 12, p. 2400-2408.e1

Research output: Contribution to journalShort survey

Open Access

Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy

Parvatiyar, M. S., Brownstein, A. J., Takeuchi, R., Collado, J. R., Dieseldorff Jones, K. M., Gopal, J., Hammond, K. G., Marshall, J. L., Ferrel, A., Beedle, A. M., Chamberlain, J. S., Pinto, J. R. & Crosbie, R. H., Jun 6 2019, In : JCI Insight. 4, 11, e123855.

Research output: Contribution to journalArticle

Open Access

Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM

Yadav, S., Yuan, C. C., Kazmierczak, K., Liang, J., Huang, W., Takeuchi, L. M., Takeuchi, R. & Szczesna-Cordary, D., Jan 1 2019, In : Journal of Molecular Medicine.

Research output: Contribution to journalArticle

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit

Kepchia, D., Xu, P., Terryn, R., Castro, A., Schuerer, S. C., Leal, W. S. & Luetje, C. W., Dec 1 2019, In : Scientific reports. 9, 1, 4055.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Alterations of tumor microenvironment by nitric oxide impedes castration-resistant prostate cancer growth

Arora, H., Panara, K., Kuchakulla, M., Kulandavelu, S., Burnstein, K. L., Schally, A. V., Hare, J. & Ramasamy, R., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. 11298-11303 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency

Birnbaum, M. D., Nemzow, L., Kumar, A., Gong, F. & Zhang, F., Jan 1 2018, (Accepted/In press) In : Cell Chemical Biology.

Research output: Contribution to journalArticle

Can Chromatin Accessibility be Exploited for Axon Regeneration?

Danzi, M. C., O’Neill, N., Bixby, J. & Lemmon, V., Jan 1 2018, (Accepted/In press) In : Developmental Neurobiology.

Research output: Contribution to journalArticle

2 Scopus citations

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

7 Scopus citations

Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast

Isom, D. G., Page, S. C., Collins, L. B., Kapolka, N. J., Taghon, G. J. & Dohlman, H. G., Jan 1 2018, In : Journal of Biological Chemistry. 293, 7, p. 2318-2329 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: Integrated access to diverse large-scale cellular perturbation response data

Koleti, A., Terryn, R., Stathias, V., Chung, C., Cooper, D. J., Turner, J. P., VidoviÄ ‡, D., Forlin, M., Kelley, T. T., D'Urso, A., Allen, B. K., Torre, D., Jagodnik, K. M., Wang, L., Jenkins, S. L., Mader, C., Niu, W., Fazel, M., Mahi, N., Pilarczyk, M. & 9 others, Clark, N., Shamsaei, B., Meller, J., Vasiliauskas, J., Reichard, J., Medvedovic, M., Ma'Ayan, A., Pillai, A. & Schuerer, S. C., Jan 1 2018, In : Nucleic Acids Research. 46, D1, p. D558-D566

Research output: Contribution to journalArticle

33 Scopus citations

Design, synthesis, and evaluation of novel immunomodulatory small molecules targeting the CD40–CD154 costimulatory protein-protein interaction

Bojadzic, D., Chen, J., Alcazar, O. & Buchwald, P., Jan 1 2018, In : Molecules. 23, 5, 1153.

Research output: Contribution to journalArticle

3 Scopus citations

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schürer, S. C. & Ayad, N. G., Dec 1 2018, In : Nature Communications. 9, 1, 5315.

Research output: Contribution to journalArticle

7 Scopus citations

Drug repositioning in glioblastoma: A pathway perspective

Tan, S. K., Jermakowicz, A., Mookhtiar, A. K., Nemeroff, C., Schuerer, S. C. & Ayad, N., Mar 16 2018, In : Frontiers in Pharmacology. 9, MAR, 218.

Research output: Contribution to journalReview article

15 Scopus citations

Erratum: Unexplored therapeutic opportunities in the human genome (Nature reviews. Drug discovery (2018) 17 5 (317-332))

Oprea, T. I., Bologa, C. G., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., Gomez, S. M., Guha, R., Hersey, A., Holmes, J., Jadhav, A., Jensen, L. J., Johnson, G. L., Karlson, A., Leach, A. R., Ma'ayan, A., Malovannaya, A., Mani, S., Mathias, S. L., McManus, M. T. & 21 others, Meehan, T. F., von Mering, C., Muthas, D., Nguyen, D. T., Overington, J. P., Papadatos, G., Qin, J., Reich, C., Roth, B. L., Schürer, S. C., Simeonov, A., Sklar, L. A., Southall, N., Tomita, S., Tudose, I., Ursu, O., Vidovic, D., Waller, A., Westergaard, D., Yang, J. J. & Zahoránszky-Köhalmi, G., May 1 2018, In : Nature reviews. Drug discovery. 17, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
8 Scopus citations

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216) (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Nov 12 2018, In : Cancer Cell. 34, 5, 1 p.

Research output: Contribution to journalComment/debate

Erratum: Publisher Correction: Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome (Nature communications (2017) 8 1 (1257))

Li, C., Brazill, J. M., Liu, S., Bello, C., Zhu, Y., Morimoto, M., Cascio, L., Pauly, R., Diaz-Perez, Z., Malicdan, M. C. V., Wang, H., Boccuto, L., Schwartz, C. E., Gahl, W. A., Boerkoel, C. F. & Zhai, R. G., Jan 18 2018, In : Nature Communications. 9, 1, 1 p.

Research output: Contribution to journalComment/debate

Far away from the lamppost

Oprea, T. I., Jan, L., Johnson, G. L., Roth, B. L., Ma’ayan, A., Schuerer, S. C., Shoichet, B. K., Sklar, L. A. & McManus, M. T., Dec 1 2018, In : PLoS Biology. 16, 12, e3000067.

Research output: Contribution to journalArticle

3 Scopus citations

High content screening of mammalian primary cortical neurons

Motti, D., Blackmore, M., Bixby, J. & Lemmon, V., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1683. p. 293-304 12 p. (Methods in Molecular Biology; vol. 1683).

Research output: Chapter in Book/Report/Conference proceedingChapter

Identification of an oncogenic network with prognostic and therapeutic value in prostate cancer

Magani, F., Bray, E. R., Martinez, M. J., Zhao, N., Copello, V. A., Heidman, L., Peacock, S. O., Wiley, D. J., D'urso, G. & Burnstein, K. L., Aug 1 2018, In : Molecular Systems Biology. 14, 8, e8202.

Research output: Contribution to journalArticle

3 Scopus citations

Kidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria

Rangel, E. B., Gomes, S. A., Takeuchi, R., Saltzman, R. G., Wei, C., Ruiz, P., Reiser, J. & Hare, J., Dec 1 2018, In : Scientific Reports. 8, 1, 14723.

Research output: Contribution to journalArticle

4 Scopus citations

Mutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2

Lassuthova, P., Rebelo, A. P., Ravenscroft, G., Lamont, P. J., Davis, M. R., Manganelli, F., Feely, S. M., Bacon, C., Brožková, D. Š., Haberlova, J., Mazanec, R., Tao, F., Saghira, C., Abreu, L., Courel, S., Powell, E., Buglo, E., Bis, D. M., Baxter, M. F., Ong, R. W. & 14 others, Marns, L., Lee, Y. C., Bai, Y., Isom, D. G., Barro-Soria, R., Chung, K. W., Scherer, S. S., Larsson, H. P., Laing, N. G., Choi, B. O., Seeman, P., Shy, M. E., Santoro, L. & Zuchner, S., Mar 1 2018, In : American Journal of Human Genetics. 102, 3, p. 505-514 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy

Brazill, J. M., Cruz, B., Zhu, Y. & Zhai, R. G., Jun 1 2018, In : DMM Disease Models and Mechanisms. 11, 6, dmm.032938.

Research output: Contribution to journalArticle

5 Scopus citations

Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

Dvoriantchikova, G., Pronin, A., Kurtenbach, S., Toychiev, A., Chou, T. H., Yee, C. W., Prindeville, B., Tayou, J., Porciatti, V., Sagdullaev, B. T., Slepak, V. Z. & Shestopalov, V. I., Dec 1 2018, In : Scientific Reports. 8, 1, 5797.

Research output: Contribution to journalArticle

2 Scopus citations