Cell Biology & Anatomy

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2020

Targeting the kynurenine pathway for the treatment of cisplatin-resistant lung cancer

Nguyen, D. J. M., Theodoropoulos, G., Li, Y. Y., Wu, C., Sha, W., Feun, L. G., Lampidis, T. J., Savaraj, N. & Wangpaichitr, M., Jan 1 2020, In : Molecular Cancer Research. 18, 1, p. 105-117 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Mycobacterium abscessus—Bronchial Epithelial Cells Cross-Talk Through Type I Interferon Signaling

Zhang, C., Asif, H., Holt, G. E., Griswold, A. J., Campos, M., Bejarano, P., Fregien, N. L. & Mirsaeidi, M., Dec 9 2019, In : Frontiers in immunology. 10, 2888.

Research output: Contribution to journalArticle

Open Access
2018

A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone

Jimenez, J. J., Delcanto, G. M., Popovics, P., Perez, A., Vila Granda, A., Vidaurre, I., Cai, R. Z., Rick, F. G., Swords, R. T. & Schally, A. V., Jan 1 2018, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

3 Scopus citations

BODIES R US: Ethical Views on the Commercialization of the Dead in Medical Education and Research

Champney, T., Hildebrandt, S., Gareth Jones, D. & Winkelmann, A., Jan 1 2018, (Accepted/In press) In : Anatomical Sciences Education.

Research output: Contribution to journalArticle

10 Scopus citations

Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study

Swords, R. T., Azzam, D., Al-Ali, H., Lohse, I., Volmar, C. H., Watts, J., Perez, A., Rodriguez, A., Vargas, F., Elias, R., Vega, F., Zelent, A. Z., Brothers, S. P., Abbasi, T., Trent, J., Rangwala, S., Deutsch, Y., Conneally, E., Drusbosky, L., Cogle, C. R. & 1 others, Wahlestedt, C. R., Jan 1 2018, In : Leukemia Research. 64, p. 34-41 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Overexpression of PGC-1α in aging muscle enhances a subset of young-like molecular patterns

Garcia, S., Nissanka, N., Mareco, E. A., Rossi, S. G., Peralta, S., Diaz, F., Rotundo, R. L., Carvalho, R. F. & Moraes, C. T., Jan 1 2018, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

15 Scopus citations
2017

A case of AML characterized by a novel t(4;15)(q31;q22) translocation that confers a growth-stimulatory response to retinoid-based therapy

Watts, J., Perez, A., Pereira, L., Fan, Y-S., Brown, G., Vega, F., Petrie, K., Swords, R. T. & Zelent, A. Z., Jul 11 2017, In : International Journal of Molecular Sciences. 18, 7, 1492.

Research output: Contribution to journalArticle

2 Scopus citations

Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes?

Cicciarelli, J. C., Lemp, N. A., Chang, Y., Koss, M., Hacke, K., Kasahara, N., Burns, K. M., Min, D. I., Naraghi, R. & Shah, T., 2017, In : Journal of Immunology Research. 2017, 1652931.

Research output: Contribution to journalArticle

10 Scopus citations

Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity

Hiraoka, K., Inagaki, A., Kato, Y., Huang, T. T., Mitchell, L. A., Kamijima, S., Takahashi, M., Matsumoto, H., Hacke, K., Kruse, C. A., Ostertag, D., Robbins, J. M., Gruber, H. E., Jolly, D. J. & Kasahara, N., Jul 1 2017, In : Neuro-Oncology. 19, 7, p. 918-929 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

2-deoxy-glucose downregulates endothelial AKT and ERK via interference with N-linked glycosylation, induction of endoplasmic reticulum stress, and GSK3β activation

Kovacs, K., Decatur, C., Toro, M., Pham, D. G., Liu, H., Jing, Y., Murray, T. G., Lampidis, T. & Merchan, J. R., Feb 1 2016, In : Molecular Cancer Therapeutics. 15, 2, p. 264-275 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

Liu, H., Kurtoglu, M., León-Annicchiarico, C. L., Munoz-Pinedo, C., Barredo, J., Leclerc, G., Merchan, J. R., Liu, X. & Lampidis, T., 2016, In : Oncotarget. 7, 24, p. 36461-36473 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
8 Scopus citations
4 Scopus citations

Optimal lentivirus production and cell culture conditions necessary to successfully transduce primary human bronchial epithelial cells

Baumlin-Schmid, N., Salathe, M. A. & Fregien, N. L., Jul 22 2016, In : Journal of Visualized Experiments. 2016, 113, e54176.

Research output: Contribution to journalArticle

8 Scopus citations

Risk stratification system for oral cancer screening

Pereira, L. H. M., Reis, I., Reategui, E. P., Gordon, C., Saint-Victor, S., Duncan, R., Gomez-Fernandez, C., Bayers, S., Fisher, P., Perez, A., Goodwin, W. J., Hu, J. & Franzmann, E. J., Jun 1 2016, In : Cancer Prevention Research. 9, 6, p. 445-455 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells

Leõn-Annicchiarico, C. L., Ramírez-Peinado, S., Domínguez-Villanueva, D., Gonsberg, A., Lampidis, T. & Muñoz-Pinedo, C., Sep 1 2015, In : FEBS Journal. 282, 18, p. 3647-3658 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

Leclerc, G. J., DeSalvo, J., Du, J., Gao, N., Leclerc, G. M., Lehrman, M. A., Lampidis, T. & Barredo, J., May 13 2015, (Accepted/In press) In : Leukemia Research.

Research output: Contribution to journalArticle

5 Scopus citations
4 Scopus citations
2014

Erratum to H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm [Cell Reports 8, (2014) 1989-2002]

Zhang, Y., Xie, S., Zhou, Y., Xie, Y., Liu, P., Sun, M., Xiao, H., Jin, Y., Sun, X., Chen, Z., Huang, Q. & Chen, S., 2014, In : Cell Reports. 9, 3, p. 1171 1 p.

Research output: Contribution to journalArticle

H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm

Zhang, Y., Xie, S., Zhou, Y., Xie, Y., Liu, P., Sun, M., Xiao, H., Jin, Y., Sun, X., Chen, Z., Huang, Q. & Chen, S., Sep 25 2014, In : Cell Reports. 8, 6, p. 1989-2002 14 p.

Research output: Contribution to journalArticle

38 Scopus citations

Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose

Philips, K. B., Kurtoglu, M., Leung, H. J., Liu, H., Gao, N., Lehrman, M. A., Murray, T. G. & Lampidis, T. J., Feb 2014, In : Cancer Chemotherapy And Pharmacology. 73, 2, p. 349-361 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response

Lin, A. H., Timberlake, N., Logg, C. R., Liu, Y., Kamijima, S., Diago, O., Wong, K., Gammon, D. K., Ostertag, D., Hacke, K., Yang, E. C., Gruber, H., Kasahara, N. & Jolly, D. J., Aug 1 2014, In : Human gene therapy. 25, 8, p. 759-771 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Submersion and hypoxia inhibit ciliated cell differentiation in a Notch-dependent manner

Gerovac, B. J., Valencia, M., Baumlin, N., Salathe, M., Conner, G. E. & Fregien, N. L., Oct 1 2014, In : American journal of respiratory cell and molecular biology. 51, 4, p. 516-525 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

Sullivan, E. J., Kurtoglu, M., Brenneman, R., Liu, H. & Lampidis, T. J., Feb 2014, In : Cancer Chemotherapy And Pharmacology. 73, 2, p. 417-427 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

A phase i dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

Raez, L. E., Papadopoulos, K., Ricart, A. D., Chiorean, E. G., Dipaola, R. S., Stein, M. N., Rocha Lima, C. M., Schlesselman, J. J., Tolba, K., Langmuir, V. K., Kroll, S., Jung, D. T., Kurtoglu, M., Rosenblatt, J. & Lampidis, T. J., Feb 1 2013, In : Cancer Chemotherapy And Pharmacology. 71, 2, p. 523-530 8 p.

Research output: Contribution to journalArticle

175 Scopus citations

CD44 interacts with EGFR and promotes head and neck squamous cell carcinoma initiation and progression

Perez, A., Neskey, D. M., Wen, J., Pereira, L., Reategui, E. P., Goodwin, W. J., Carraway, K. L. & Franzmann, E. J., Apr 1 2013, In : Oral oncology. 49, 4, p. 306-313 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells

Liu, H., Kurtoglu, M., Cao, Y., Xi, H., Kumar, R., Axten, J. M. & Lampidis, T. J., Jul 1 2013, In : Cancer Chemotherapy And Pharmacology. 72, 1, p. 251-262 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
40 Scopus citations
2 Scopus citations

Reduction of HLA class I expression by ribonucleic acid interference mitigates allogenicity of human primary and Immortalized cells.

Lemp, N. A., Haga, K., Hacke, K., Treger, J. A., Bogan, B. T., Faure-Kumar, E., Logg, C. R., Kruse, C. A., Cicciarelli, J. C. & Kasahara, N., 2013, In : Clinical transplants. p. 93-101 9 p.

Research output: Contribution to journalArticle

Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool

Wang, X., Pickrell, A. M., Rossi, S. G., Pinto, M., Dillon, L. M., Hida, A., Rotundo, R. L. & Moraes, C. T., Oct 1 2013, In : Human molecular genetics. 22, 19, p. 3976-3986 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

XSET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53

Tang, Z., Chen, W. Y., Shimada, M., Nguyen, U. T. T., Kim, J., Sun, X. J., Sengoku, T., McGinty, R. K., Fernandez, J. P., Muir, T. W. & Roeder, R. G., Jul 18 2013, In : Cell. 154, 2, 1 p.

Research output: Contribution to journalArticle

96 Scopus citations
2012

Biglycan is an extracellular MuSK binding protein important for synapse stability

Amenta, A. R., Creely, H. E., Mercado, M. L. T., Hagiwara, H., McKechnie, B. A., Lechner, B. E., Rossi, S. G., Wang, Q., Owens, R. T., Marrero, E., Mei, L., Hoch, W., Young, M. F., McQuillan, D. J., Rotundo, R. L. & Fallon, J. R., Feb 15 2012, In : Journal of Neuroscience. 32, 7, p. 2324-2334 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow

Hacke, K., Szakmary, A., Cuddihy, A. R., Rozengurt, N., Lemp, N. A., Aubrecht, J., Lawson, G. W., Rao, N. P., Crooks, G. M., Schiestl, R. H. & Kasahara, N., Jan 2012, In : Experimental Hematology. 40, 1, p. 3-13.e3

Research output: Contribution to journalArticle

9 Scopus citations

Inhibition of Akt potentiates 2-DG - Induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia

DeSalvo, J., Kuznetsov, J. N., Du, J., Leclerc, G. M., Leclerc, G. J., Lampidis, T. J. & Barredo, J. C., Jul 1 2012, In : Molecular Cancer Research. 10, 7, p. 969-978 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Retinoblastoma treatment: Impact of the glycolytic inhibitor 2-deoxy-d-glucose on molecular genomics expression in LH BETAT AG retinal tumors

Piña, Y., Houston, S. K., Murray, T. G., Koru-Sengul, T., Decatur, C., Scott, W. K., Nathanson, L., Clarke, J. & Lampidis, T. J., May 27 2012, In : Clinical Ophthalmology. 6, 1, p. 817-830 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Retinoblastoma treatment: Utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-d-glucose (2-FG), to target the chemoresistant hypoxic regions in LH BETAT AG retinal tumors

Piña, Y., Decatur, C., Murray, T. G., Houston, S. K., Lopez-Cavalcante, M., Hernandez, E., Celdran, M., Shah, N., Feuer, W. & Lampidis, T., Feb 1 2012, In : Investigative Ophthalmology and Visual Science. 53, 2, p. 996-1002 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

The relationship of thioredoxin-1 and cisplatin resistance: Its impact on ROS and oxidative metabolism in lung cancer cells

Wangpaichitr, M., Sullivan, E. J., Theodoropoulos, G., Wu, C., You, M., Feun, L. G., Lampidis, T. J., Kuo, M. T. & Savaraj, N., Mar 1 2012, In : Molecular cancer therapeutics. 11, 3, p. 604-615 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

The role of tumour necrosis factor-α and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity

Westbrook, A. M., Wei, B., Hacke, K., Xia, M., Braun, J. & Schiestl, R. H., Jan 1 2012, In : Mutagenesis. 27, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

Xi, H., Kurtoglu, M., Liu, H., Wangpaichitr, M., You, M., Liu, X., Savaraj, N. & Lampidis, T. J., Apr 1 2011, In : Cancer Chemotherapy And Pharmacology. 67, 4, p. 899-910 12 p.

Research output: Contribution to journalArticle

106 Scopus citations

Advanced retinoblastoma treatment: Targeting hypoxia by inhibition of the mammalian target of rapamycin (mTOR) in LHBETATAG retinal tumors

Piña, Y., Decatur, C., Murray, T. G., Houston, S. K., Gologorsky, D., Cavalcante, M., Cavalcante, L., Hernandez, E., Celdran, M., Feuer, W. & Lampidis, T., Mar 25 2011, In : Clinical Ophthalmology. 5, 1, p. 337-343 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

A proposal for a policy on the ethical care and use of cadavers and their tissues

Champney, T. H., Jan 1 2011, In : Anatomical Sciences Education. 4, 1, p. 49-52 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Effects of 1 GeV/nucleon Fe particles on longevity, carcinogenesis and neuromotor ability in Atm-deficient mice.

Yamamoto, M. L., Hafer, K., Reliene, R., Fleming, S., Kelly, O., Hacke, K. & Schiestl, R. H., Feb 1 2011, In : Radiation research. 175, 2, p. 231-239 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Novel retinoblastoma treatment avoids chemotherapy: The effect of optimally timed combination therapy with angiogenic and glycolytic inhibitors on LHBETATAG retinoblastoma tumors

Houston, S. K., Piña, Y., Murray, T. G., Boutrid, H., Cebulla, C., Schefler, A. C., Shi, W., Celdran, M., Feuer, W., Merchan, J. & Lampidis, T. J., Feb 7 2011, In : Clinical Ophthalmology. 5, 1, p. 129-137 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Rapid nongenomic actions of inhaled corticosteroids on long-acting β 2-agonist transport in the airway

Horvath, G., Mendes, E. S., Schmid, N., Schmid, A., Conner, G. E., Fregien, N. L., Salathe, M. & Wanner, A., Dec 1 2011, In : Pulmonary Pharmacology and Therapeutics. 24, 6, p. 654-659 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Salivary markers and risk factor data: A multivariate modeling approach for head and neck squamous cell carcinoma detection

Pereira, L. H. M., Adebisi, I. N., Perez, A., Wiebel, M., Reis, I., Duncan, R., Goodwin, W. J., Hu, J. J., Lokeshwar, V. B. & Franzmann, E. J., Dec 1 2011, In : Cancer Biomarkers. 10, 5, p. 241-249 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation

Wang, L., Gural, A., Sun, X. J., Zhao, X., Perna, F., Huang, G., Hatlen, M. A., Vu, L., Liu, F., Xu, H., Asai, T., Xu, H., Deblasio, T., Menendez, S., Voza, F., Jiang, Y., Cole, P. A., Zhang, J., Melnick, A., Roeder, R. G. & 1 others, Nimer, S. D., Aug 5 2011, In : Science. 333, 6043, p. 765-769 5 p.

Research output: Contribution to journalArticle

132 Scopus citations

Translational regulation of acetylcholinesterase by the RNA-binding protein pumilio-2 at the neuromuscular synapse

Marrero, E., Rossi, S. G., Darr, A., Tsoulfas, P. & Rotundo, R. L., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36492-36499 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Antiangiogenic activity of 2-deoxy-D-glucose

Merchan, J. R., Kovács, K., Railsback, J. W., Kurtoglu, M., Jing, Y., Piña, Y., Gao, N., Murray, T. G., Lehrman, M. A. & Lampidis, T. J., Nov 17 2010, In : PloS one. 5, 10, e13699.

Research output: Contribution to journalArticle

69 Scopus citations

Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation

Schmid, A., Sutto, Z., Schmid, N., Novak, L., Ivonnet, P., Horvath, G., Conner, G., Fregien, N. & Salathe, M., Sep 24 2010, In : Journal of Biological Chemistry. 285, 39, p. 29998-30007 10 p.

Research output: Contribution to journalArticle

34 Scopus citations