Cell Biology & Anatomy

Research Output 1964 2019

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2018
3 Citations (Scopus)

A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone

Jimenez, J. J., Delcanto, G. M., Popovics, P., Perez, A., Vila Granda, A., Vidaurre, I., Cai, R. Z., Rick, F. G., Swords, R. T. & Schally, A. V., Jan 1 2018, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

Growth Hormone-Releasing Hormone
Acute Myeloid Leukemia
Cell Line
Myeloid Cells
Neoplasms
10 Citations (Scopus)

BODIES R US: Ethical Views on the Commercialization of the Dead in Medical Education and Research

Champney, T., Hildebrandt, S., Gareth Jones, D. & Winkelmann, A., Jan 1 2018, (Accepted/In press) In : Anatomical Sciences Education.

Research output: Contribution to journalArticle

Medical Education
Human Body
Biomedical Research
Commodification
Cremation
11 Citations (Scopus)

Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study

Swords, R. T., Azzam, D., Al-Ali, H., Lohse, I., Volmar, C. H., Watts, J., Perez, A., Rodriguez, A., Vargas, F., Elias, R., Vega, F., Zelent, A. Z., Brothers, S. P., Abbasi, T., Trent, J., Rangwala, S., Deutsch, Y., Conneally, E., Drusbosky, L., Cogle, C. R. & 1 others, Wahlestedt, C. R., Jan 1 2018, In : Leukemia Research. 64, p. 34-41 8 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Pharmaceutical Preparations
Precision Medicine
Therapeutics
Physicians
13 Citations (Scopus)

Overexpression of PGC-1α in aging muscle enhances a subset of young-like molecular patterns

Garcia, S., Nissanka, N., Mareco, E. A., Rossi, S. G., Peralta, S., Diaz, F., Rotundo, R. L., Carvalho, R. F. & Moraes, C. T., Jan 1 2018, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Muscles
Skeletal Muscle
Muscle Proteins
Organelle Biogenesis
Neuromuscular Junction
2017
1 Citation (Scopus)

A case of AML characterized by a novel t(4;15)(q31;q22) translocation that confers a growth-stimulatory response to retinoid-based therapy

Watts, J., Perez, A., Pereira, L., Fan, Y-S., Brown, G., Vega, F., Petrie, K., Swords, R. T. & Zelent, A. Z., Jul 11 2017, In : International Journal of Molecular Sciences. 18, 7, 1492.

Research output: Contribution to journalArticle

leukemias
Retinoids
Tretinoin
Acute Myeloid Leukemia
therapy
10 Citations (Scopus)

Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes?

Cicciarelli, J. C., Lemp, N. A., Chang, Y., Koss, M., Hacke, K., Kasahara, N., Burns, K. M., Min, D. I., Naraghi, R. & Shah, T., 2017, In : Journal of Immunology Research. 2017, 1652931.

Research output: Contribution to journalArticle

Immunoglobulin G
Tissue Donors
Transplants
Kidney
Antibodies
14 Citations (Scopus)

Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity

Hiraoka, K., Inagaki, A., Kato, Y., Huang, T. T., Mitchell, L. A., Kamijima, S., Takahashi, M., Matsumoto, H., Hacke, K., Kruse, C. A., Ostertag, D., Robbins, J. M., Gruber, H. E., Jolly, D. J. & Kasahara, N., Jul 1 2017, In : Neuro-Oncology. 19, 7, p. 918-929 12 p.

Research output: Contribution to journalArticle

Genetic Therapy
Prodrugs
Immunity
Recurrence
Neoplasms
2016
13 Citations (Scopus)

2-deoxy-glucose downregulates endothelial AKT and ERK via interference with N-linked glycosylation, induction of endoplasmic reticulum stress, and GSK3β activation

Kovacs, K., Decatur, C., Toro, M., Pham, D. G., Liu, H., Jing, Y., Murray, T. G., Lampidis, T. & Merchan, J. R., Feb 1 2016, In : Molecular Cancer Therapeutics. 15, 2, p. 264-275 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Deoxyglucose
Glycosylation
Down-Regulation
Endothelial Cells
7 Citations (Scopus)

Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

Liu, H., Kurtoglu, M., León-Annicchiarico, C. L., Munoz-Pinedo, C., Barredo, J., Leclerc, G., Merchan, J. R., Liu, X. & Lampidis, T., 2016, In : Oncotarget. 7, 24, p. 36461-36473 13 p.

Research output: Contribution to journalArticle

Fenofibrate
Endoplasmic Reticulum Stress
Deoxyglucose
Cell Death
Glucose
8 Citations (Scopus)
smoke
Epidermal Growth Factor Receptor
Smoke
Protein-Tyrosine Kinases
tyrosine
4 Citations (Scopus)
Janus Kinases
Interleukin-13
Transcription
Transducers
Cell Differentiation
7 Citations (Scopus)

Optimal lentivirus production and cell culture conditions necessary to successfully transduce primary human bronchial epithelial cells

Baumlin-Schmid, N., Salathe, M. A. & Fregien, N. L., Jul 22 2016, In : Journal of Visualized Experiments. 2016, 113, e54176.

Research output: Contribution to journalArticle

Lentivirus
Cell culture
Cell Culture Techniques
Epithelial Cells
Transgenes
6 Citations (Scopus)

Risk stratification system for oral cancer screening

Pereira, L. H. M., Reis, I., Reategui, E. P., Gordon, C., Saint-Victor, S., Duncan, R., Gomez-Fernandez, C., Bayers, S., Fisher, P., Perez, A., Goodwin, W. J., Hu, J. & Franzmann, E. J., Jun 1 2016, In : Cancer Prevention Research. 9, 6, p. 445-455 11 p.

Research output: Contribution to journalArticle

Oropharyngeal Neoplasms
Early Detection of Cancer
Proteins
Hospital Design and Construction
Health Services Needs and Demand
2015
15 Citations (Scopus)

ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells

Leõn-Annicchiarico, C. L., Ramírez-Peinado, S., Domínguez-Villanueva, D., Gonsberg, A., Lampidis, T. & Muñoz-Pinedo, C., Sep 1 2015, In : FEBS Journal. 282, 18, p. 3647-3658 12 p.

Research output: Contribution to journalArticle

Deoxyglucose
Necrosis
Apoptosis
Glucose
Cell death
4 Citations (Scopus)

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

Leclerc, G. J., DeSalvo, J., Du, J., Gao, N., Leclerc, G. M., Lehrman, M. A., Lampidis, T. & Barredo, J., May 13 2015, (Accepted/In press) In : Leukemia Research.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Down-Regulation
AMP-Activated Protein Kinases
MAP Kinase Signaling System
Glucose
3 Citations (Scopus)
Acetylcholinesterase
Muscle
Skeletal Muscle
Stabilization
Peptides
2014

Erratum to H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm [Cell Reports 8, (2014) 1989-2002]

Zhang, Y., Xie, S., Zhou, Y., Xie, Y., Liu, P., Sun, M., Xiao, H., Jin, Y., Sun, X., Chen, Z., Huang, Q. & Chen, S., 2014, In : Cell Reports. 9, 3, p. 1171 1 p.

Research output: Contribution to journalArticle

Endoderm
Embryonic Stem Cells
Cell Differentiation
histone methyltransferase
7 Citations (Scopus)

Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose

Philips, K. B., Kurtoglu, M., Leung, H. J., Liu, H., Gao, N., Lehrman, M. A., Murray, T. G. & Lampidis, T., Jan 1 2014, In : Cancer Chemotherapy and Pharmacology. 73, 2, p. 349-361 13 p.

Research output: Contribution to journalArticle

Glycogen Phosphorylase
Starvation
Tumor Cell Line
Tumors
Protein Isoforms
20 Citations (Scopus)

Submersion and hypoxia inhibit ciliated cell differentiation in a Notch-dependent manner

Gerovac, B. J., Valencia, M., Baumlin, N., Salathe, M. A., Conner, G. E. & Fregien, N. L., Jan 1 2014, In : American Journal of Respiratory Cell and Molecular Biology. 51, 4, p. 516-525 10 p.

Research output: Contribution to journalArticle

Immersion
Cell Differentiation
Cells
Amyloid Precursor Protein Secretases
Gene expression
24 Citations (Scopus)

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

Sullivan, E. J., Kurtoglu, M., Brenneman, R., Liu, H. & Lampidis, T., Jan 1 2014, In : Cancer Chemotherapy and Pharmacology. 73, 2, p. 417-427 11 p.

Research output: Contribution to journalArticle

Cisplatin
Tumors
Cells
Neoplasms
Cell Line
40 Citations (Scopus)

The wonders of 2-deoxy-d-glucose

Xi, H., Kurtoglu, M. & Lampidis, T., Jan 1 2014, In : IUBMB Life. 66, 2, p. 110-121 12 p.

Research output: Contribution to journalArticle

Glucose
Virus Diseases
Epilepsy
Neoplasms
Aging of materials
2013
165 Citations (Scopus)

A phase i dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

Raez, L. E., Papadopoulos, K., Ricart, A. D., Chiorean, E. G., Dipaola, R. S., Stein, M. N., Rocha Lima, C. M., Schlesselman, J. J., Tolba, K., Langmuir, V. K., Kroll, S., Jung, D. T., Kurtoglu, M., Rosenblatt, J. D. & Lampidis, T., Feb 1 2013, In : Cancer Chemotherapy and Pharmacology. 71, 2, p. 523-530 8 p.

Research output: Contribution to journalArticle

docetaxel
Tumors
Glucose
Neoplasms
Pharmacokinetics
37 Citations (Scopus)

CD44 interacts with EGFR and promotes head and neck squamous cell carcinoma initiation and progression

Perez, A., Neskey, D. M., Wen, J., Pereira, L., Reategui, E. P., Goodwin, W. J., Carraway, K. L. & Franzmann, E. J., Apr 1 2013, In : Oral Oncology. 49, 4, p. 306-313 8 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Cisplatin
Cell Movement
Carcinogenesis
Cell Proliferation
9 Citations (Scopus)

Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells

Liu, H., Kurtoglu, M., Cao, Y., Xi, H., Kumar, R., Axten, J. M. & Lampidis, T., Jul 1 2013, In : Cancer Chemotherapy and Pharmacology. 72, 1, p. 251-262 12 p.

Research output: Contribution to journalArticle

Deoxyglucose
Cell death
Tumors
Cell Death
Cells
39 Citations (Scopus)
Calcium-Calmodulin-Dependent Protein Kinase Kinase
AMP-Activated Protein Kinases
Endoplasmic Reticulum Stress
Autophagy
Deoxyglucose
15 Citations (Scopus)

Models and discovery strategies for new therapies of retinoblastoma

Houston, S. K., Lampidis, T. & Murray, T. G., Apr 1 2013, In : Expert Opinion on Drug Discovery. 8, 4, p. 383-394 12 p.

Research output: Contribution to journalArticle

Retinoblastoma
Translational Medical Research
Animal Models
Neoplasms
Intraocular Injections
26 Citations (Scopus)

Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool

Wang, X., Pickrell, A. M., Rossi, S. G., Pinto, M., Dillon, L. M., Hida, A., Rotundo, R. L. & Moraes, C. T., Oct 1 2013, In : Human Molecular Genetics. 22, 19, p. 3976-3986 11 p.

Research output: Contribution to journalArticle

Muscles
Sarcopenia
Premature Aging
Phenotype
Frail Elderly
2012
44 Citations (Scopus)

Biglycan is an extracellular MuSK binding protein important for synapse stability

Amenta, A. R., Creely, H. E., Mercado, M. L. T., Hagiwara, H., McKechnie, B. A., Lechner, B. E., Rossi, S. G., Wang, Q., Owens, R. T., Marrero, E., Mei, L., Hoch, W., Young, M. F., McQuillan, D. J., Rotundo, R. L. & Fallon, J. R., Feb 15 2012, In : Journal of Neuroscience. 32, 7, p. 2324-2334 11 p.

Research output: Contribution to journalArticle

Biglycan
Synapses
Carrier Proteins
Receptor Protein-Tyrosine Kinases
Muscles
41 Citations (Scopus)

Inhibition of Akt potentiates 2-DG - Induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia

DeSalvo, J., Kuznetsov, J. N., Du, J., Leclerc, G. M., Leclerc, G. J., Lampidis, T. & Barredo, J., Jul 1 2012, In : Molecular Cancer Research. 10, 7, p. 969-978 10 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Deoxyglucose
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Down-Regulation
Apoptosis
11 Citations (Scopus)

Retinoblastoma treatment: Utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-d-glucose (2-FG), to target the chemoresistant hypoxic regions in LH BETAT AG retinal tumors

Piña, Y., Decatur, C., Murray, T. G., Houston, S. K., Lopez-Cavalcante, M., Hernandez, E., Celdran, M., Shah, N., Feuer, W. J. & Lampidis, T., Feb 1 2012, In : Investigative Ophthalmology and Visual Science. 53, 2, p. 996-1002 7 p.

Research output: Contribution to journalArticle

Retinal Neoplasms
Retinoblastoma
Tumor Burden
Glucose
Therapeutics
4 Citations (Scopus)

Retinoblastoma treatment: Impact of the glycolytic inhibitor 2-deoxy-d-glucose on molecular genomics expression in LH BETAT AG retinal tumors

Piña, Y., Houston, S. K., Murray, T. G., Sengul, T., Decatur, C., Scott, W. K., Nathanson, L., Clarke, J. & Lampidis, T., May 27 2012, In : Clinical Ophthalmology. 6, 1, p. 817-830 14 p.

Research output: Contribution to journalArticle

Retinal Neoplasms
Retinoblastoma
Genomics
Deoxyglucose
Glucose
40 Citations (Scopus)

The relationship of thioredoxin-1 and cisplatin resistance: Its impact on ROS and oxidative metabolism in lung cancer cells

Wangpaichitr, M., Sullivan, E. J., Theodoropoulos, G., Wu, C., You, M., Feun, L. G., Lampidis, T., Kuo, M. T. & Savaraj, N., Mar 1 2012, In : Molecular Cancer Therapeutics. 11, 3, p. 604-615 12 p.

Research output: Contribution to journalArticle

Thioredoxins
Cisplatin
Reactive Oxygen Species
Lung Neoplasms
Acetyl-CoA Carboxylase
2011
105 Citations (Scopus)

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

Xi, H., Kurtoglu, M., Liu, H., Wangpaichitr, M., You, M., Liu, X., Savaraj, N. & Lampidis, T., Apr 1 2011, In : Cancer Chemotherapy and Pharmacology. 67, 4, p. 899-910 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Autophagy
Adenosine Triphosphate
Glucose
Cells
14 Citations (Scopus)

Advanced retinoblastoma treatment: Targeting hypoxia by inhibition of the mammalian target of rapamycin (mTOR) in LHBETATAG retinal tumors

Piña, Y., Decatur, C., Murray, T. G., Houston, S. K., Gologorsky, D., Cavalcante, M., Cavalcante, L., Hernandez, E., Celdran, M., Feuer, W. J. & Lampidis, T., Mar 25 2011, In : Clinical Ophthalmology. 5, 1, p. 337-343 7 p.

Research output: Contribution to journalArticle

Retinal Neoplasms
Retinoblastoma
Sirolimus
Tumor Burden
Therapeutics
34 Citations (Scopus)

A proposal for a policy on the ethical care and use of cadavers and their tissues

Champney, T., Jan 1 2011, In : Anatomical Sciences Education. 4, 1, p. 49-52 4 p.

Research output: Contribution to journalArticle

Cadaver
Anatomists
Ethics
Organizations
Guidelines
10 Citations (Scopus)

Novel retinoblastoma treatment avoids chemotherapy: The effect of optimally timed combination therapy with angiogenic and glycolytic inhibitors on LHBETATAG retinoblastoma tumors

Houston, S. K., Piña, Y., Murray, T. G., Boutrid, H., Cebulla, C., Schefler, A. C., Shi, W., Celdran, M., Feuer, W. J., Merchan, J. R. & Lampidis, T., Feb 7 2011, In : Clinical Ophthalmology. 5, 1, p. 129-137 9 p.

Research output: Contribution to journalArticle

Angiogenesis Inhibitors
Retinoblastoma
Deoxyglucose
Drug Therapy
Tumor Burden
16 Citations (Scopus)

Rapid nongenomic actions of inhaled corticosteroids on long-acting β 2-agonist transport in the airway

Horvath, G., Mendes, E., Schmid, N., Schmid, A., Conner, G. E., Fregien, N. L., Salathe, M. A. & Wanner, A., Dec 1 2011, In : Pulmonary Pharmacology and Therapeutics. 24, 6, p. 654-659 6 p.

Research output: Contribution to journalArticle

Adrenal Cortex Hormones
Smooth Muscle Myocytes
Muscle
Cells
Bronchodilator Agents
12 Citations (Scopus)

Salivary markers and risk factor data: A multivariate modeling approach for head and neck squamous cell carcinoma detection

Pereira, L. H. M., Adebisi, I. N., Perez, A., Wiebel, M., Reis, I., Duncan, R., Goodwin, W. J., Hu, J., Lokeshwar, V. B. & Franzmann, E. J., Dec 1 2011, In : Cancer Biomarkers. 10, 5, p. 241-249 9 p.

Research output: Contribution to journalArticle

Demography
Interleukin-8
Proteins
Biomarkers
Logistic Models
13 Citations (Scopus)

Translational regulation of acetylcholinesterase by the RNA-binding protein pumilio-2 at the neuromuscular synapse

Marrero, E., Rossi, S. G., Darr, A., Tsoulfas, P. & Rotundo, R. L., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36492-36499 8 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Acetylcholinesterase
Synapses
Muscle
RNA
2010
64 Citations (Scopus)

Antiangiogenic activity of 2-deoxy-D-glucose

Merchan, J. R., Kovács, K., Railsback, J. W., Kurtoglu, M., Jing, Y., Piña, Y., Gao, N., Murray, T. G., Lehrman, M. A. & Lampidis, T., Nov 17 2010, In : PLoS One. 5, 10, e13699.

Research output: Contribution to journalArticle

Deoxyglucose
Glycosylation
glucose
angiogenesis
Endothelial cells
33 Citations (Scopus)

Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation

Schmid, A., Sutto, Z., Schmid, N., Novak, L., Ivonnet, P., Horvath, G., Conner, G. E., Fregien, N. L. & Salathe, M. A., Sep 24 2010, In : Journal of Biological Chemistry. 285, 39, p. 29998-30007 10 p.

Research output: Contribution to journalArticle

Bicarbonates
Adenylyl Cyclases
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Acidification
12 Citations (Scopus)

Focal, periocular delivery of 2-deoxy-d-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma

Piña, Y., Houston, S. K., Murray, T. G., Boutrid, H., Celdran, M., Feuer, W. J., Shi, W., Hernandez, E. & Lampidis, T., Dec 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 12, p. 6149-6156 8 p.

Research output: Contribution to journalArticle

Retinoblastoma
Adjuvant Chemotherapy
Carboplatin
Glucose
Tumor Burden
11 Citations (Scopus)

High endoplasmic reticulum activity renders Multiple myeloma cells hypersensitive to mitochondrial inhibitors

Kurtoglu, M., Philips, K., Liu, H., Boise, L. H. & Lampidis, T., May 1 2010, In : Cancer Chemotherapy and Pharmacology. 66, 1, p. 129-140 12 p.

Research output: Contribution to journalArticle

troglitazone
Carbonyl Cyanide m-Chlorophenyl Hydrazone
Multiple Myeloma
Endoplasmic Reticulum
Fenofibrate
69 Citations (Scopus)

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

Monzon, M. E., Fregien, N. L., Schmid, N., Falcon, N. S., Campos, M. A., Casalino-Matsuda, S. M. & Forteza, R. M., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 26126-26134 9 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Hyaluronic Acid
Reactive Oxygen Species
Glycosylphosphatidylinositols
Epithelial Cells
1 Citation (Scopus)

The cadaver on the cover

Champney, T., Mar 1 2010, In : Academic Medicine. 85, 3

Research output: Contribution to journalArticle

Cadaver
2009
35 Citations (Scopus)
Muscle Neoplasms
Cations
hypoxia
cations
Deoxyglucose
15 Citations (Scopus)

Increased hypoxia following vessel targeting in a murine model of retinoblastoma

Boutrid, H., Pin ̃a, Y., Cebulla, C. M., Feuer, W. J., Lampidis, T., Jockovich, M. E. & Murray, T. G., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 12, p. 5537-5543 7 p.

Research output: Contribution to journalArticle

Retinoblastoma
Injections
Carboplatin
Retinal Neoplasms
Intraocular Injections
450 Citations (Scopus)
Sarcopenia
Metabolic Diseases
Skeletal Muscle
Muscles
Neuromuscular Junction
13 Citations (Scopus)

Molecular heterogeneity and alternative splicing of human lactoperoxidase

Fragoso, M. A., Torbati, A., Fregien, N. L. & Conner, G. E., Feb 1 2009, In : Archives of Biochemistry and Biophysics. 482, 1-2, p. 52-57 6 p.

Research output: Contribution to journalArticle

Lactoperoxidase
Alternative Splicing
Exons
Glycosylation
Messenger RNA
60 Citations (Scopus)

Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli

Gattas, M. V., Forteza, R., Fragoso, M. A., Fregien, N. L., Salas, P. J., Salathe, M. A. & Conner, G. E., Nov 15 2009, In : Free Radical Biology and Medicine. 47, 10, p. 1450-1458 9 p.

Research output: Contribution to journalArticle

Lactoperoxidase
Messenger RNA
Flagellin
Pseudomonas aeruginosa
Small Interfering RNA